Cytokine & Growth Factor Reviews最新文献

Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets.

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2025-03-22 DOI: 10.1016/j.cytogfr.2025.03.001

Harapriya Baral, Ravinder K Kaundal

{"title":"Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets.","authors":"Harapriya Baral, Ravinder K Kaundal","doi":"10.1016/j.cytogfr.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.cytogfr.2025.03.001","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) is a major global health concern and a leading cause of morbidity and mortality. Neuroinflammation is a pivotal driver of both the acute and chronic phases of TBI, with pattern recognition receptors (PRRs) playing a central role in detecting damage-associated molecular patterns (DAMPs) and initiating immune responses. Key PRR subclasses, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and cGAS-like receptors (cGLRs), are abundantly expressed in central nervous system (CNS) cells and infiltrating immune cells, where they mediate immune activation, amplify neuroinflammatory cascades, and exacerbate secondary injury mechanisms. This review provides a comprehensive analysis of these PRR subclasses, detailing their distinct structural characteristics, expression patterns, and roles in post-TBI immune responses. We critically examine the molecular mechanisms underlying PRR-mediated signaling and explore their contributions to neuroinflammatory pathways and secondary injury processes. Additionally, preclinical and clinical evidence supporting the therapeutic potential of targeting PRRs to mitigate neuroinflammation and improve neurological outcomes is discussed. By integrating recent advancements, this review offers an in-depth understanding of the role of PRRs in TBI pathobiology and underscores the potential of PRR-targeted therapies in mitigating TBI-associated neurological deficits.</p>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forgetting COVID-19 - Introduction to the special issue.

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2025-03-19 DOI: 10.1016/j.cytogfr.2025.03.002

John Hiscott

引用次数: 0

Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration.

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2025-02-19 DOI: 10.1016/j.cytogfr.2025.02.001

Zhixin Wei, Kiya Babkirk, Song Chen, Ming Pei

{"title":"Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration.","authors":"Zhixin Wei, Kiya Babkirk, Song Chen, Ming Pei","doi":"10.1016/j.cytogfr.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.cytogfr.2025.02.001","url":null,"abstract":"<p><p>The epithelial-mesenchymal transition transcription factors (EMT-TFs)-ZEB, SNAI, and TWIST families-have been extensively studied in embryonic development and tumor metastasis, providing valuable insight into their roles in cell behavior and transformation. These EMT-TFs have garnered increasing attention in the context of mesenchymal tissue regeneration, potentially contributing an approach for cell therapy. Given that dysregulated EMT-TF expression can impair cell survival and lineage differentiation, controlled regulation of their expression could offer significant advantages for tissue regeneration. However, there is a lack of comprehensive reviews to summarize the influence of the EMT-TFs on mesenchymal tissue regeneration and potential molecular mechanisms. This review explores the regulatory roles of ZEB, SNAI, and TWIST in the regeneration of bone, adipose, cartilage, muscle, and other mesenchymal tissues, with a focus on the underlying molecular signaling mechanisms. Gaining a deeper understanding of how EMT-TFs regulate cell proliferation, apoptosis, migration, and differentiation may offer new insights into the management of mesenchymal tissue repair and open novel avenues for enhancing tissue regeneration.</p>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders 妊娠障碍中子宫 NK 细胞的细胞因子调节和免疫调节。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.cytogfr.2024.11.007

Jun Zhou , Ping Yan , Wenxue Ma , Jing Li

{"title":"Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders","authors":"Jun Zhou , Ping Yan , Wenxue Ma , Jing Li","doi":"10.1016/j.cytogfr.2024.11.007","DOIUrl":"10.1016/j.cytogfr.2024.11.007","url":null,"abstract":"<div><div>Uterine natural killer (uNK) cells play a pivotal role in promoting placental development and supporting maternal-fetal immune tolerance, primarily through cytokine regulation and growth factor production. While the importance of uNK cells in pregnancy is well-established, the mechanisms of their interactions with trophoblasts and contributions to various pregnancy complications remain incompletely understood. This review highlights recent advancements in understanding uNK cell functions, with a focus on cytokine production, growth factor secretion, and receptor-ligand interactions, particularly involving killer immunoglobulin-like receptors (KIR) and human leukocyte antigen-C (HLA-C). We explore how uNK cell dysfunction contributes to pregnancy complications, including preeclampsia, recurrent pregnancy loss, and placenta accreta spectrum (PAS) disorders, emphasizing their roles in immune tolerance and placental health. By detailing the distinct cytokine signaling pathways and functional subtypes of uNK cells, this review provides insights into their regulatory mechanisms essential for pregnancy maintenance. Additionally, we discuss emerging therapeutic strategies targeting uNK-trophoblast interactions and propose future research directions, including the development of non-invasive biomarkers and personalized interventions. This comprehensive review addresses critical knowledge gaps, aiming to advance research in reproductive immunology and guide therapeutic innovations in maternal health.</div></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"81 ","pages":"Pages 40-53"},"PeriodicalIF":9.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LC3B: A microtubule-associated protein influences disease progression and prognosis LC3B：一种微管相关蛋白影响疾病进展和预后。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.cytogfr.2024.11.006

Yan Chen , Hong Yi , Shan Liao , Junyu He , Yanhong Zhou , Yan Lei

{"title":"LC3B: A microtubule-associated protein influences disease progression and prognosis","authors":"Yan Chen , Hong Yi , Shan Liao , Junyu He , Yanhong Zhou , Yan Lei","doi":"10.1016/j.cytogfr.2024.11.006","DOIUrl":"10.1016/j.cytogfr.2024.11.006","url":null,"abstract":"<div><div>Microtubule-associated protein 1 light chain 3B (MAP1LC3B, also known as LC3B) is a mammalian homolog of the autophagy-related protein 8 (ATG8) family. It plays a crucial role in cellular autophagy and is involved in several vital biological processes, including apoptosis and differentiation. Additionally, LC3B regulates immune responses. Due to its close association with malignant tumors and neurodegenerative diseases, and its potential as a prognostic indicator and therapeutic target, LC3B has become a significant research focus. This article aims to provide a comprehensive and systematic understanding of LC3B's role and mechanisms in autophagy, its impact on apoptosis and the underlying mechanisms, its regulation of cellular differentiation and transdifferentiation, its modulation of immune and inflammatory responses, the influence of upstream regulatory factors on LC3B's function, and its relevance to disease diagnosis, treatment, and prognosis. The goal is to establish a solid foundation for understanding LC3B's role in cellular processes and its regulatory mechanisms.</div></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"81 ","pages":"Pages 16-26"},"PeriodicalIF":9.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis 激活素-软骨素系统：肾脏发育、再生、炎症和纤维化的关键调节因子

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.cytogfr.2024.11.004

Izumi Nagayama , Yoshinori Takei , Shunsuke Takahashi , Mari Okada , Akito Maeshima

{"title":"The activin-follistatin system: Key regulator of kidney development, regeneration, inflammation, and fibrosis","authors":"Izumi Nagayama , Yoshinori Takei , Shunsuke Takahashi , Mari Okada , Akito Maeshima","doi":"10.1016/j.cytogfr.2024.11.004","DOIUrl":"10.1016/j.cytogfr.2024.11.004","url":null,"abstract":"<div><div>Activins, multifunctional cytokines of the transforming growth factor–beta superfamily, play critical roles in the regulation of growth and differentiation in multiple biological systems. Activin activity is finely regulated by the endogenous antagonist follistatin. Early studies reported that activins are involved in renal organogenesis, but subsequent research demonstrated that activins also play a significant role in kidney regeneration following injury. The results of more recent studies suggest activins play roles in both inflammatory kidney diseases and renal fibrosis, conditions that often culminate in end-stage renal disease. Given these findings, the inhibition of activin activity represents a promising therapeutic approach for treating a range of kidney disorders. This review discusses the latest discoveries concerning the role of the activin-follistatin system in renal development and pathophysiology and explores the potential therapeutic implications of targeting this system in the management of kidney diseases.</div></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"81 ","pages":"Pages 1-8"},"PeriodicalIF":9.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases 中性粒细胞胞外陷阱形成中的细胞因子信号传导：对健康和疾病的影响。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.cytogfr.2024.12.001

Haritha Manoj , Sarah Michael Gomes , Pooja Yedehalli Thimmappa , Prabhakara. R. Nagareddy , Colin Jamora , Manjunath B. Joshi

{"title":"Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases","authors":"Haritha Manoj , Sarah Michael Gomes , Pooja Yedehalli Thimmappa , Prabhakara. R. Nagareddy , Colin Jamora , Manjunath B. Joshi","doi":"10.1016/j.cytogfr.2024.12.001","DOIUrl":"10.1016/j.cytogfr.2024.12.001","url":null,"abstract":"<div><div>Neutrophils, as essential component of the innate immune response, form a crucial part in the defence mechanisms through the release of extracellular traps (NETs). These web-like structures, composed of chromatin and antimicrobial proteins, are essential for the entrapment and inactivation of pathogens. However, either constitutive formation or inefficient clearance of NETs leads to adverse effects such as fibrosis, thrombosis, delayed wound healing and tissue damage in multiple diseases associated with sterile inflammation. This dichotomy casts NETs as both protective agents and harmful factors in several diseases such as autoimmune diseases, metabolic syndromes, systemic infections, and malignancies. Besides microbes and their products, variety of stimulants including pro-inflammatory cytokines induce NETs. The complex interactions and cross talk among the pro-inflammatory cytokines including IL-8, IL-6, GM-CSF, TNF-α, IFNs, and IL-1β activate neutrophils to form NETs and also contributes to a vicious circle of inflammatory cascade, leading to increased inflammation, oxidative stress, and thrombotic events. Emerging evidence indicates that the dysregulated cytokine milieus in diseases, such as diabetes mellitus, obesity, atherosclerosis, stroke, rheumatoid arthritis, and systemic lupus erythematosus, potentiate NETs release, thereby promoting disease development. Thus, neutrophils represent both critical effectors and potential therapeutic targets, underscoring their importance in the context of cytokine-mediated therapies for a spectrum of diseases. In the present review, we describe various cytokines and associated signalling pathways activating NETs formation in different human pathologies. Further, the review identifies potential strategies to pharmacologically modulate cytokine pathways to reduce NETs.</div></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"81 ","pages":"Pages 27-39"},"PeriodicalIF":9.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights RON受体酪氨酸激酶的核易位。新的机制和功能见解。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.cytogfr.2024.12.004

Yi-Lin Chen , Chien-An Chu , Jiu-Yao Wang , Wan-Li Chen , Yi-Wen Wang , Chung-Liang Ho , Chung-Ta Lee , Nan-Haw Chow

{"title":"Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights","authors":"Yi-Lin Chen , Chien-An Chu , Jiu-Yao Wang , Wan-Li Chen , Yi-Wen Wang , Chung-Liang Ho , Chung-Ta Lee , Nan-Haw Chow","doi":"10.1016/j.cytogfr.2024.12.004","DOIUrl":"10.1016/j.cytogfr.2024.12.004","url":null,"abstract":"<div><div>Receptor tyrosine kinases (RTKs) are membrane sensors that monitor alterations in the extracellular milieu and translate this information into appropriate cellular responses. Epidermal growth factor receptor (EGFR) is the most well-known model in which gene expression is upregulated by mitogenic signals through the activation of multiple signaling cascades or by nuclear translocation of the full-length EGFR protein. RON (Receptuer d’Origine Nantatise, also known as macrophage stimulating 1 receptor, MST1R) has recently gained attention as a therapeutic target for human cancer. This review summarizes the recent understanding of the unusual nuclear translocation of uncleaved RON receptor proteins in response to cellular stresses, such as serum starvation, hormonal deprivation, hypoxia, and genotoxicity. This nonligand mechanism, achieved by RON <em>per se</em> or by interaction with EGFR, may directly activate the transcriptional machinery necessary for cancer cells to survive. <em>In vitro</em> experiments have demonstrated the importance of tyrosine kinase of RON in binding to and activating the c-JUN promoter, HIF-1α, DNA helicase 2, DNA-dependent protein kinase catalytic subunit, and other stress-responsive networks. Nuclear RON-activated nonhomologous end joining repair confers chemoresistance to drugs that induce double-strand breaks (DSBs) in cancer cells. Tyrosine kinase inhibitors or monoclonal antibodies targeting RON kinase may therefore be useful treatments for patients with RON-overexpressing tumors. DSB-inducing anticancer drugs are not recommended for these cancer patients. Moreover, multi-RTK inhibition is a more rational strategy for patients with RON- and RTK-coexpressing human cancer.</div></div>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":"81 ","pages":"Pages 9-15"},"PeriodicalIF":9.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy 粒细胞巨噬细胞集落刺激因子在病毒-宿主相互作用及其对免疫治疗的意义。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.cytogfr.2024.12.002

Nasry Zane Bouzeineddine, Alecco Philippi, Katrina Gee, Sam Basta

引用次数: 0

Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders.

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2025-01-23 DOI: 10.1016/j.cytogfr.2025.01.002

Anushka Saran, Daisuke Nishizaki, Scott M Lippman, Shumei Kato, Razelle Kurzrock

{"title":"Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders.","authors":"Anushka Saran, Daisuke Nishizaki, Scott M Lippman, Shumei Kato, Razelle Kurzrock","doi":"10.1016/j.cytogfr.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.cytogfr.2025.01.002","url":null,"abstract":"<p><p>IL-17A, referred to as IL-17, is the founding member of a family of pro-inflammatory cytokines, including IL-17B, IL-17C, IL-17D, IL-17E (or IL-25), and IL-17F, which act via receptors IL-17RA to IL-17RE, and elicit potent cellular responses that impact diverse diseases. IL-17's interactions with various cytokines include forming a heterodimer with IL-17F and being stimulated by IL-23's activation of Th17 cells, which can lead to inflammation and autoimmunity. IL-17 is implicated in infectious diseases and inflammatory disorders such as rheumatoid arthritis and psoriasis, promoting neutrophil recruitment and anti-bacterial immunity, but potentially exacerbating fungal and viral infections, revealing its dual role as protective and pathologic. IL-17 is also involved in various cancers, including breast, colon, cervical, prostate, and skin cancer, contributing to proliferation, immune invasion, and metastases, but also playing a protective role in certain instances. Four FDA-approved drugs-secukinumab (for ankylosing spondylitis, enthesitis-related arthritis, hidradenitis suppurativa, non-radiographic axial spondyloarthritis, plaque psoriasis, and psoriatic arthritis), ixekizumab (for ankylosing spondylitis, non-radiographic axial spondyloarthritis, plaque psoriasis, and psoriatic arthritis), brodalumab (for plaque psoriasis), and bimekizumab (for plaque psoriasis)-suppress the IL-17 pathway, with more in development, including netakimab, sonelokimab, izokibep, and CJM112. These agents and others are being studied across a spectrum of disorders. Understanding the complicated interplay between IL-17 and other immune mediators may yield new treatments for inflammatory/autoimmune conditions and malignancies.</p>","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0