Cytokine & Growth Factor Reviews最新文献

LC3B: A microtubule-associated protein influences disease progression and prognosis.

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-12 DOI: 10.1016/j.cytogfr.2024.11.006

Yan Chen, Hong Yi, Shan Liao, Junyu He, Yanhong Zhou, Yan Lei

引用次数: 0

Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases.

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-09 DOI: 10.1016/j.cytogfr.2024.12.001

Haritha Manoj, Sarah Michael Gomes, Pooja Yedehalli Thimmappa, Prabhakara R Nagareddy, Colin Jamora, Manjunath B Joshi

{"title":"Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases.","authors":"Haritha Manoj, Sarah Michael Gomes, Pooja Yedehalli Thimmappa, Prabhakara R Nagareddy, Colin Jamora, Manjunath B Joshi","doi":"10.1016/j.cytogfr.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.cytogfr.2024.12.001","url":null,"abstract":"Neutrophils, as essential component of the innate immune response, form a crucial part in the defence mechanisms through the release of extracellular traps (NETs). These web-like structures, composed of chromatin and antimicrobial proteins, are essential for the entrapment and inactivation of pathogens. However, either constitutive formation or inefficient clearance of NETs leads to adverse effects such as fibrosis, thrombosis, delayed wound healing and tissue damage in multiple diseases associated with sterile inflammation. This dichotomy casts NETs as both protective agents and harmful factors in several diseases such as autoimmune diseases, metabolic syndromes, systemic infections, and malignancies. Besides microbes and their products, variety of stimulants including pro-inflammatory cytokines induce NETs. The complex interactions and cross talk among the pro-inflammatory cytokines including IL-8, IL-6, GM-CSF, TNF-α, IFNs, and IL-1β activate neutrophils to form NETs and also contributes to a vicious circle of inflammatory cascade, leading to increased inflammation, oxidative stress, and thrombotic events. Emerging evidence indicates that the dysregulated cytokine milieus in diseases, such as diabetes mellitus, obesity, atherosclerosis, stroke, rheumatoid arthritis, and systemic lupus erythematosus, potentiate NETs release, thereby promoting disease development. Thus, neutrophils represent both critical effectors and potential therapeutic targets, underscoring their importance in the context of cytokine-mediated therapies for a spectrum of diseases. In the present review, we describe various cytokines and associated signalling pathways activating NETs formation in different human pathologies. Further, the review identifies potential strategies to pharmacologically modulate cytokine pathways to reduce NETs.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanisms of regulation of IL-1 and its receptors. 调节 IL-1 及其受体的分子机制。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-10-05 DOI: 10.1016/j.cytogfr.2024.09.004

J V Zhukova, J A Lopatnikova, A A Alshevskaya, S V Sennikov

引用次数: 0

Adeno-associated virus therapies: Pioneering solutions for human genetic diseases. 腺相关病毒疗法：人类遗传疾病的开创性解决方案。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-09-19 DOI: 10.1016/j.cytogfr.2024.09.003

Dequan Liu, Tian Li, Lei Liu, Xiangyu Che, Xiaorui Li, Chang Liu, Guangzhen Wu

引用次数: 0

Mechanisms of Rho GTPases in regulating tumor proliferation, migration and invasion. Rho GTPases 调节肿瘤增殖、迁移和侵袭的机制。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-09-13 DOI: 10.1016/j.cytogfr.2024.09.002

Cheng Liu, Shutao Chen, Yu Zhang, Xinyi Zhou, Haiwei Wang, Qigui Wang, Xi Lan

引用次数: 0

Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance. 胶质母细胞瘤相关巨噬细胞：克服胶质母细胞瘤耐药性的关键靶点

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-10-31 DOI: 10.1016/j.cytogfr.2024.10.009

Aymane Kricha, Najat Bouchmaa, Sanae Ben Mkaddem, Abdellatif Abbaoui, Reda Ben Mrid, Rachid El Fatimy

{"title":"Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance.","authors":"Aymane Kricha, Najat Bouchmaa, Sanae Ben Mkaddem, Abdellatif Abbaoui, Reda Ben Mrid, Rachid El Fatimy","doi":"10.1016/j.cytogfr.2024.10.009","DOIUrl":"10.1016/j.cytogfr.2024.10.009","url":null,"abstract":"Glioblastoma multiforme (GBM) is recognized as the most aggressive and malignant form of brain cancer, characterized by a highly heterogeneous phenotype, poor prognosis, and a median survival time of less than 16 months. Recent studies have highlighted the critical role of glioblastoma-associated macrophages (GAMs) in promoting tumor progression and resistance not only to immunotherapy but also to radiotherapy and chemotherapy. GAMs actively suppress immune responses, promote angiogenesis, facilitate tumor metastasis, and induce therapy resistance, through various mechanisms such as cytokines production, signaling pathways regulation, and angiogenesis. In this context, understanding these regulatory mechanisms is essential for developing efficient therapies. Preclinical studies have investigated diverse approaches to target these cells, both as monotherapies or in combination with other treatments. While these approaches have shown promise in strengthening antitumor immune responses in animal models, their clinical success remains to be fully determined. Herein, we provide a comprehensive overview of GAMs's role in GBM therapeutic resistance and summarizes existing approaches to target GAMs in overcoming tumor resistance.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":"97-108"},"PeriodicalIF":9.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct roles of MIF in the pathogenesis of ischemic heart disease. MIF 在缺血性心脏病发病机制中的不同作用。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-10-16 DOI: 10.1016/j.cytogfr.2024.10.005

Ling Zhao, Bang-Hao Zhao, Amanguli Ruze, Qiu-Lin Li, An-Xia Deng, Xiao-Ming Gao

{"title":"Distinct roles of MIF in the pathogenesis of ischemic heart disease.","authors":"Ling Zhao, Bang-Hao Zhao, Amanguli Ruze, Qiu-Lin Li, An-Xia Deng, Xiao-Ming Gao","doi":"10.1016/j.cytogfr.2024.10.005","DOIUrl":"10.1016/j.cytogfr.2024.10.005","url":null,"abstract":"The role of macrophage migration inhibitory factor (MIF) as a multifunctional cytokine in immunomodulation and inflammatory response is increasingly appreciated. Ischemic heart disease (IHD), the leading cause of global mortality, remains a focal point of research owing to its intricate pathophysiology. MIF has been identified as a critical player in IHD, where it exerts distinct roles. On one hand, MIF plays a protective role by enhancing energy metabolism through activation of AMPK, resisting oxidative stress, inhibiting activation of the JNK pathway, and maintaining intracellular calcium ion homeostasis. Additionally, MIF exerts protective effects through mesenchymal stem cells and exosomes. On the other hand, MIF can assume a pro-inflammatory role, which contributes to the exacerbation of IHD's development and progression. Furthermore, MIF levels significantly increase in IHD patients, and its genetic polymorphisms are positively correlated with prevalence and severity. These findings position MIF as a potential biomarker and therapeutic target in the management of IHD. This review summarizes the structure, source, signaling pathways and biological functions of MIF and focuses on its roles and clinical characteristics in IHD. The genetic variants of MIF associated with IHD is also discussed, providing more understandings of its complex interplay in the disease's pathology.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":"121-137"},"PeriodicalIF":9.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

I don't know about you, but I'm feeling IL-22. 我不知道你怎么想，但我感觉到了 IL-22。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1016/j.cytogfr.2024.11.001

Logan S Dean, Alissa N Threatt, Kaylee Jones, Emmanuel O Oyewole, Morgan Pauly, Maëlis Wahl, Melea Barahona, Rose W Reiter, Tara M Nordgren

{"title":"I don't know about you, but I'm feeling IL-22.","authors":"Logan S Dean, Alissa N Threatt, Kaylee Jones, Emmanuel O Oyewole, Morgan Pauly, Maëlis Wahl, Melea Barahona, Rose W Reiter, Tara M Nordgren","doi":"10.1016/j.cytogfr.2024.11.001","DOIUrl":"10.1016/j.cytogfr.2024.11.001","url":null,"abstract":"Defense of the human body against damaging and pathogenic insults is a heavily regulated affair. A primary mechanism of defense at sites of insult are soluble mediators whose defensive maneuvers increase barrier integrity and promote pro-reparative and resolution processes. IL-22 is a cytokine in the IL-10 cytokine family that has garnered increased attention in recent years due to its intimate link in promoting resolution of inflammatory insults, while simultaneously being over expressed in certain fibrotic and chronic inflammatory-skewed diseases. The spatial action of IL-22 centers around the barrier sites of the body, including the skin, lungs, and gut mucosa. As such, a detailed understanding of the role of this cytokine, the producers and responders, and the diseases resulting from over- or under-expression have prominent impacts on a variety of disease outcomes. Herein we present a comprehensive review of IL-22; from historical perspectives and initial discovery, as well as more recent data that dramatically expands on the cellular sources and impact of this cytokine. We aim to showcase the duality of IL-22 and highlight addressable gaps in the field of IL-22 crosstalk and impacts at the ever-important mucosal and tissue barrier sites.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":"1-11"},"PeriodicalIF":9.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of transforming growth factor β in cervical carcinogenesis. 转化生长因子β在宫颈癌变中的作用。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1016/j.cytogfr.2024.10.006

Kleber Paiva Trugilo, Guilherme Cesar Martelossi Cebinelli, Eliza Pizarro Castilha, Mariane Ricciardi da Silva, Fernanda Costa Brandão Berti, Karen Brajão de Oliveira

{"title":"The role of transforming growth factor β in cervical carcinogenesis.","authors":"Kleber Paiva Trugilo, Guilherme Cesar Martelossi Cebinelli, Eliza Pizarro Castilha, Mariane Ricciardi da Silva, Fernanda Costa Brandão Berti, Karen Brajão de Oliveira","doi":"10.1016/j.cytogfr.2024.10.006","DOIUrl":"10.1016/j.cytogfr.2024.10.006","url":null,"abstract":"Human papillomavirus (HPV) is involved in virtually all cases of cervical cancer. However, HPV alone is not sufficient to cause malignant development. The effects of chronic inflammation and the interaction of immune components with the microenvironment infected with the high-risk HPV type (HR) may contribute to cancer development. Transforming growth factor β (TGFB) appears to play an important role in cervical carcinogenesis. Protein and mRNA levels of this cytokine gradually increase as normal tissue develops into malignant tissue and are closely related to the severity of HPV infection. At the onset of infection, TGFB can inhibit the proliferation of infected cells and viral amplification by inhibiting cell growth and downregulating the transcriptional activity of the long control region (LCR) of HPV, thereby reducing the expression of early genes. When infected cells progress to a malignant phenotype, the response to the cell growth inhibitory effect of TGFB1 is lost and the suppression of E6 and E7 expression decreases. Subsequently, TGFB1 expression is upregulated by high levels of E6 and E7 oncoproteins, leading to an increase in TGFB1 in the tumor microenvironment, where this molecule promotes epithelial-to-mesenchymal transition (EMT), cell motility, angiogenesis, and immunosuppression. This interaction between HPV oncoproteins and TGFB1 is an important mechanism promoting the development and progression of cervical cancer.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":"12-23"},"PeriodicalIF":9.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholecystokinin and gastrin as immune modulating hormones: Implications and applications. 胆囊收缩素和胃泌素是免疫调节激素：意义和应用。

IF 9.3 2区医学

Cytokine & Growth Factor Reviews Pub Date : 2024-12-01 Epub Date: 2024-11-18 DOI: 10.1016/j.cytogfr.2024.11.003

Gustav van Niekerk, Lara Kelchtermans, Elias Broeckhoven, Lotte Coelmont, Yeranddy A Alpizar, Kai Dallmeier

{"title":"Cholecystokinin and gastrin as immune modulating hormones: Implications and applications.","authors":"Gustav van Niekerk, Lara Kelchtermans, Elias Broeckhoven, Lotte Coelmont, Yeranddy A Alpizar, Kai Dallmeier","doi":"10.1016/j.cytogfr.2024.11.003","DOIUrl":"10.1016/j.cytogfr.2024.11.003","url":null,"abstract":"Cholecystokinin (CCK) and gastrin are gastrointestinal hormones traditionally recognised for their roles in digestion. However, it has been recognised that these hormones may also modulate immune function. Here, we examine the immune-modulating effects of CCK and gastrin, and explore the functional significance of this dual role. In addition to the direct effect of these hormones on immune cell function, we discuss why hormones that regulate complex physiological and behavioural aspects of digestion might also influence immune responses. Notably, recent findings highlight the importance of these hormones in promoting a tolerogenic hepatic environment, particularly as the liver encounters gut-derived inflammogens following a meal. Additionally, the neuro-immune crosstalk mediated by CCK suggests that this hormone may influence immune responses indirectly via the gut-brain axis, especially in the context of infection or inflammation. Furthermore, the role of CCK in inducing feeding cessation and satiety appears to be repurposed during sickness behaviour, such as the loss of appetite during infection. Collectively, these observations suggest that nutritional strategies, including permissive underfeeding or fasting, could have important clinical implications. A deeper understanding of the dual roles of CCK and gastrin in digestion and immunity may pave the way for novel therapeutic approaches that leverage these pathways for improved disease management and treatment outcomes.","PeriodicalId":11132,"journal":{"name":"Cytokine & Growth Factor Reviews","volume":" ","pages":"37-46"},"PeriodicalIF":9.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0