衰老相关退行性疾病中的肌因子和骨因子：肌-骨-脑轴的调节网络。

IF 11.8 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine & Growth Factor Reviews Pub Date : 2025-09-07 DOI:10.1016/j.cytogfr.2025.09.001

Shang Gao , Nianhu Li , Lijie Qi , Xin Li , Jie Zhang , Zhaoqi Zhang , Zhaoyao Xu , Songlin Liang , Weiming Zhu , Wei Liu

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引用次数: 0

摘要

本文综述了关键的肌因子（Irisin、Apelin、CLCF1和Myostatin）和骨因子（Osteocalcin、Sclerostin、FGF23和RANKL/OPG系统）的生物学特性。本研究深入分析了以“保护因子（鸢尾素、CLCF1和未羧化骨钙素）下调-促退行性因子（肌生长抑制素、硬化蛋白和FGF23）上调-炎症驱动放大”为特征的年龄相关网络失衡机制，揭示了这种网络失衡导致肌肉减少症、骨质疏松症和神经退行性疾病共病的机制。此外，本文还评估了肌成骨因子调节神经营养因子（BDNF、NGF和GDNF）的交叉调控网络和分子途径，并提出了基于这些交叉调控网络的干预策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Myokines and osteokines in aging-related degenerative diseases: Regulatory networks in the muscle-bone-brain axis

This review summarizes the biological properties of key myokines (Irisin, Apelin, CLCF1, and Myostatin) and osteokines (Osteocalcin, Sclerostin, FGF23 and the RANKL/OPG system). This work provides an in-depth analysis of the age-related network imbalance mechanism characterized by "downregulation of protective factors (Irisin, CLCF1, and uncarboxylated Osteocalcin) – upregulation of pro-degenerative factors (Myostatin, Sclerostin, and FGF23) – inflammation-driven amplification", and reveals the mechanism by which this network imbalance contributes to the comorbidity of sarcopenia, osteoporosis, and neurodegenerative diseases. Furthermore, the review evaluates the intersecting regulatory networks and molecular pathways through which myo-osteogenic factors modulate neurotrophic factors (BDNF, NGF and GDNF), and proposes intervention strategies based on these intersecting regulatory networks.

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.