Dementia and Geriatric Cognitive Disorders最新文献

{"title":"Digital Cognitive Assessment for Older Adults: Validation of an Automated Three-Module Tool for Mild Cognitive Impairment and Dementia Screening.","authors":"Dong-Ni Pan, Hailun Xie, Juejing Ren, Ji Shen, Jing Li, Yanjia Zeng, Wen Wang, Dingyao Fan, Gui Xue","doi":"10.1159/000549530","DOIUrl":"10.1159/000549530","url":null,"abstract":"<p><strong>Introduction: </strong>With the aging global population, effective screening tools for age-related cognitive disorders are urgently needed. Mild cognitive impairment (MCI), a transitional stage between normal aging and dementia, requires early detection for timely intervention.</p><p><strong>Methods: </strong>The current research developed an innovative electronic assessment tool designed with three task modules targeting executive function, memory binding, and spatial navigation to quickly screen for MCI in older adults. A validation study was conducted with 271 older participants, aged 56 to 89, comprising 138 individuals with MCI and 133 cognitively normal controls. An independent dataset from a community hospital was used for further confirmation.</p><p><strong>Results: </strong>The validation study indicated excellent reliability and validity, achieving 72% accuracy in distinguishing MCI from cognitively normal individuals, with excellent screening power (AUC = 0.807; 95% CI: 0.756-0.858). This performance surpasses that of the paper-and-pencil Mini-Mental State Examination (MMSE). The independent dataset from a community hospital further confirmed that the tool achieved a good accuracy rate of 93% (26/28) in predicting MCI.</p><p><strong>Conclusion: </strong>These results provide strong tool support for the early identification of MCI, enhancing the effective management of cognitive decline in at-risk elderly individuals.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-17"},"PeriodicalIF":1.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and Psychometric Properties of the Vietnamese Version of the Neuropsychiatric Inventory in Community-Dwelling Older Adults with Dementia.","authors":"Huong Thu Vu, Hung Trong Nguyen, Anh Trung Nguyen","doi":"10.1159/000551358","DOIUrl":"10.1159/000551358","url":null,"abstract":"<p><strong>Introduction: </strong>Behavioral and psychological symptoms of dementia (BPSD) substantially contribute to functional decline and caregiver burden, yet culturally validated assessment tools remain limited in Vietnam. This study aimed to translate, culturally adapt, and assess the reliability and selected aspects of construct validity of the Vietnamese version of the Neuropsychiatric Inventory (V-NPI).</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 399 individuals with dementia and their caregivers in Hai Duong province. The V-NPI was administered alongside the Clinical Dementia Rating (CDR), Geriatric Depression Scale-15 (GDS-15), and Pittsburgh Sleep Quality Index (PSQI). Internal consistency, domain-level associations, and convergent and discriminant validity were assessed.</p><p><strong>Results: </strong>The V-NPI demonstrated excellent internal consistency for both the severity (Cronbach's α = 0.91) and caregiver distress (Cronbach's α = 0.93) subscales. Domain-total correlations ranged from 0.44 to 0.64, indicating moderate internal convergence alongside meaningful heterogeneity across symptom domains. The depression domain showed a modest correlation with the GDS-15, and the night-time disturbances domain showed a weak but statistically significant correlation with the PSQI, supporting domain-level construct validity. Neuropsychiatric symptoms were highly prevalent, with night-time disturbances (71.2%), apathy/indifference (60.2%), and depression/dysphoria (59.6%) being the most frequently reported domains.</p><p><strong>Conclusion: </strong>The V-NPI appears to be a reliable and culturally appropriate instrument for assessing BPSD and caregiver distress among older adults with dementia in Vietnam, supporting its use in both clinical practice and research.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of CSF Total Tau Protein in Patients with Familial and Sporadic Creutzfeldt-Jakob Disease.","authors":"Yacov Balash, Esther Kahana, Hanna Rosenmann, Nurit Omer, Ronit Gilad, Anda Eilam, Shmuel Appel, Amos D Korczyn","doi":"10.1159/000551359","DOIUrl":"10.1159/000551359","url":null,"abstract":"<p><strong>Introduction: </strong>Elevated total tau protein (t-τ) in the cerebrospinal fluid (CSF) is routinely used as a marker of Creutzfeldt-Jakob disease (CJD). We hypothesized that CSF t-τ and patients' age may anticipate survival time (ST) also in subjects with familial CJD (f-CJD) as has been shown previously in sporadic CJD (s-CJD).</p><p><strong>Methods: </strong>We analyzed data from the Israeli National CJD Registry from 1991 to 2022. The data included cases of both f-CJD and s-CJD in whom demographic data and CSF t-τ levels were measured, and the date of death was available. Using X-tile software, we determined the optimal cut-off points for continuous variables in survival analysis and found the cut-points for t-τ level and patients' age.</p><p><strong>Results: </strong>We analyzed data on 183 sequential CJD patients. The data included definite (n = 9), probable (n = 165), and possible (n = 9) CJD cases of whom 120 (61 males) were f-CJD (65.6%) and 63 (35 males) patients were s-CJD (34.4%). The cut-off value of CSF t-τ level was found to be 1,226 pg/mL. It separated ST into two groups, 105 days (interquartile ranges [IQR]: 59-305) in the lower group vs. 59 days (IQR: 29.5-147.5) in the higher, p = 0.0005. Cox analyses showed that for every 100 pg/mL increase in CSF t-τ, ST shortened by 3% in days (Exp β = 1.0003; 95% confidence interval: 1.0001-1.0005). Age had no direct prognostic value but correlated with CSF t-τ levels (rho = 0.243, p < 0.001).</p><p><strong>Conclusions: </strong>Age and CSF t-τ levels above the cut-off value predict ST shortening in patients with both f-CJD and s-CJD.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-8"},"PeriodicalIF":2.5,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ageing, Wealth, and Diet: A Global Cross-National Analysis of Cereal Consumption and Dementia Risk.","authors":"Wenpeng You, Luisa Garcia, Shyama G K Ratnayake, Bashir Sumar, Maciej Henneberg, Shuhuan Feng, Hui-Chen Chang","doi":"10.1159/000551241","DOIUrl":"10.1159/000551241","url":null,"abstract":"<p><strong>Introduction: </strong>Global variation in dementia incidence reflects demographic and socioeconomic forces, yet the role of staple dietary patterns remains less defined. While population ageing is a key determinant of dementia burden, differences in cereal consumption, particularly rice, wheat, and maize, have received limited attention. This ecological study examined whether national cereal consumption patterns are associated with dementia incidence across countries independent of confounding factors.</p><p><strong>Methods: </strong>Country-level data from 204 nations were compiled, with complete case analyses conducted in 184 countries. Alzheimer's disease and other dementias incidence in 2021 served as the outcome variable. Predictors included per capita consumptions of total cereals, rice, wheat, and maize, alongside genetic predisposition, economic affluence, urban living, ageing indexed by life expectancy at age sixty, and meat consumption. Pearson and partial correlations, principal component analysis, and stepwise multiple regression were applied.</p><p><strong>Results: </strong>Wheat consumption was positively associated with dementia incidence, affluence, and longevity, whereas rice and maize consumption showed inverse associations. Partial correlations confirmed a persistent inverse association for rice consumption and a weaker inverse association for total cereal consumption after adjustment. Principal component analysis identified a socioeconomic component aligned with wheat consumption and ageing, while rice and maize loaded inversely. Stepwise regression demonstrated that ageing was the strongest predictor of dementia incidence, while rice and total cereal consumption retained small independent inverse associations.</p><p><strong>Conclusions: </strong>Global dementia incidence is driven primarily by population ageing and socioeconomic development. Cereal type reflects distinct developmental contexts, with rice-based patterns associated with a modestly lower dementia burden.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-18"},"PeriodicalIF":2.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiating Behavioural Presentations of Biomarker-Confirmed Alzheimer's Disease from Frontotemporal Lobar Degeneration Using the Addenbrooke's Cognitive Examination-III.","authors":"Joshua Flavell, Emily G M Ahern, Benignus Logan, Thomas B Shaw, Robert J Adam, Caitlin A T McElligott, Peter J Nestor","doi":"10.1159/000551258","DOIUrl":"10.1159/000551258","url":null,"abstract":"<p><strong>Introduction: </strong>Differentiating frontotemporal lobar degeneration (FTLD) from Alzheimer's disease (AD), particularly when presenting with overlapping behavioural symptoms, remains clinically challenging. This study assessed the utility of Addenbrooke's Cognitive Examination-III (ACE-III)-derived ratios in distinguishing these conditions.</p><p><strong>Methods: </strong>A retrospective cohort of 115 patients (n = 52 biomarker-confirmed AD, n = 63 FTLD) with overlapping behavioural symptoms was analysed. ACE-III scores and behavioural profiles were examined, and novel ratios were tested.</p><p><strong>Results: </strong>The novel Phonemic Fluency/Orientation-Memory (PFOM) ratio outperformed existing ACE-III metrics, achieving an area under the curve of 0.85 (sensitivity 84.1%, specificity 73.1%) for differentiating FTLD from AD. Notably, longer symptom duration in AD, but not in FTLD, was associated with worsening frontal and cognitive symptoms. Patients with AD were significantly older than those with FTLD.</p><p><strong>Conclusion: </strong>These novel ratios showed robust diagnostic performance, regardless of disease duration, and better reflect FTLDs cognitive profile. They may offer improved clinical utility over traditional ACE-III measures.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-Cause Mortality Associated with Antipsychotic Use in People Living with Dementia and Neuropsychiatric Symptoms: Secondary Analysis of a Systematic Review and Meta-Analysis.","authors":"Kevin O'Hara-Veintimilla, Javier González, Marta Lorente-Escudero, Carlota Higueras, Miguel Germán Borda","doi":"10.1159/000550953","DOIUrl":"10.1159/000550953","url":null,"abstract":"<p><strong>Introduction: </strong>Neuropsychiatric symptoms (NPS) are highly prevalent in dementia and represent a major driver of functional decline, caregiver burden, and mortality. When symptoms become severe or refractory to non-pharmacological measures, antipsychotics are frequently introduced despite ongoing safety concerns. Their impact on survival in community-dwelling patients with NPS, however, remains uncertain. This study aimed to examine the association between antipsychotic use and all-cause mortality in older adults with dementia and NPS.</p><p><strong>Methods: </strong>This analysis was registered in PROSPERO (CRD42024621462), conducted in accordance with the Cochrane Handbook, and reported following PRISMA 2020 guidelines. Eligible observational studies included community-dwelling adults aged ≥65 years with dementia and documented NPS, reporting adjusted hazard ratios (aHRs) for antipsychotic use and all-cause mortality. Pooled estimates were derived using fixed-effects models.</p><p><strong>Results: </strong>Five observational cohort studies including 14,183 participants were analyzed. Antipsychotic use was not significantly associated with all-cause mortality (pooled aHR = 1.06; 95% CI: 0.97-1.16; p = 0.21; I2 = 43%). Subgroup analyses showed aHR = 0.79 (95% CI: 0.62-1.01) for typical antipsychotics and aHR = 1.23 (95% CI: 0.97-1.56) for atypical agents, with a significant difference between classes (p = 0.03).</p><p><strong>Conclusions: </strong>In community-dwelling older adults with dementia and NPS, no statistically significant association between antipsychotic use and all-cause mortality was observed. However, the available evidence is limited and imprecise, resulting in substantial uncertainty. These findings should therefore be interpreted with caution. This study is a secondary analysis of a previously published systematic review and meta-analysis [O'Hara-Veintimilla et al. Am J Geriatr Psychiatry. 2025;23(25):S1064-7481].</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education-Adjusted Interpretation of MMSE for Diagnostic Validity of Cognitive Disorders.","authors":"Donghyun Kim, Woong Jin Lee, Daniel Hyojae Jeon, Kyoungjoo Cho","doi":"10.1159/000550745","DOIUrl":"10.1159/000550745","url":null,"abstract":"<p><strong>Introduction: </strong>The Mini-Mental State Examination (MMSE) is widely utilized in clinical settings for cognitive screening, yet its diagnostic accuracy is often influenced by demographic factors such as educational attainment. This study investigates the educational gradient in MMSE performance and evaluates whether uniform cutoff scores adequately distinguish cognitively normal (CN), mild cognitive impairment (MCI), and Alzheimer's disease (AD) patients across different educational strata.</p><p><strong>Methods: </strong>A total of 300 older adults (CN = 100; MCI = 100; AD = 100) were retrospectively recruited from the Severance Hospital memory clinic, intentionally balanced to ensure statistical power and avoid class-imbalance bias across diagnostic groups. All participants completed the Korean version of MMSE and the Seoul Neuropsychological Screening Battery-II (SNSB-II) and underwent 3T brain MRI for hippocampal volumetry. Education level was categorized as low (≤6 years), medium (7-12 years), and high (≥13 years). MMSE diagnostic accuracy was evaluated using receiver operating characteristic (ROC) curve analyses stratified by education. Interaction effects were tested via multiple linear regression, and correlations with hippocampal volume were assessed.</p><p><strong>Results: </strong>MMSE scores showed a significant educational gradient, with higher education associated with higher performance (p < 0.001). MMSE scores demonstrated a pronounced educational gradient, with particularly reduced performance in individuals with low educational attainment, suggesting potential overestimation of cognitive impairment when uniform MMSE cutoffs are applied. ROC analyses revealed only moderate diagnostic accuracy of MMSE in the higher education groups (area under the curve [AUC] = 0.83 and 0.78). The AUC was 0.73 (95% CI: 0.58-0.88) in the low-education group; the AUC was 0.83 (95% CI: 0.75-0.91) in the middle-education group and 0.78 (95% CI: 0.70-0.87) in the high-education group, suggesting only moderate diagnostic accuracy of MMSE. Conversely, lower education groups showed underperformance potentially unrelated to pathology. Regression models confirmed that education and diagnosis had additive but noninteracting effects on MMSE scores. MMSE correlated strongly with hippocampal volume (r = 0.739, p < 0.001), validating its general neuroanatomical relevance.</p><p><strong>Conclusion: </strong>MMSE performance is substantially modulated by education, with uniform cutoffs yielding differential diagnostic validity across educational strata. We suggest education-adjusted interpretation of MMSE and emphasize the need for integrative diagnostic approaches combining cognitive testing with neuroimaging biomarkers.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Impairment in Patients with Acute Ischemic Stroke after Mechanical Thrombectomy.","authors":"Toru Nakagami, Takehiro Katano, Satoshi Suda, Ryutaro Kimura, Shinichiro Numao, Yuji Nishi, Akihito Kutsuna, Kentaro Suzuki, Tomonari Saito, Junya Aoki, Kazumi Kimura","doi":"10.1159/000550771","DOIUrl":"10.1159/000550771","url":null,"abstract":"<p><strong>Introduction: </strong>Post-stroke cognitive impairment is associated with increased mortality and healthcare costs. However, its characteristics in patients with large vessel occlusion after mechanical thrombectomy (MT) remain unclear. In this study, we aimed to evaluate the feasibility of administering the Montreal Cognitive Assessment (MoCA) in the acute phase after MT and examine its association with long-term cognitive outcomes.</p><p><strong>Methods: </strong>We retrospectively analyzed patients with acute ischemic stroke (AIS) who underwent MT and completed MoCA within 5 days of admission, using data from a prospective registry. Patients were classified into acute MoCA feasible and non-feasible groups. Clinical characteristics and cognitive outcomes were compared between the groups, including MoCA and modified Rankin Scale (mRS) scores post-MT.</p><p><strong>Results: </strong>In total, 161 patients were enrolled: 77 (median age, 73 years; 56 men) in the feasible group and 84 (median age, 77 years; 50 men) in the non-feasible group. Multivariate analysis showed that higher National Institute of Health Stroke Scale score on admission (odds ratio [OR] 1.09, 95% confidence interval [CI] 1.03-1.14; p < 0.01) and left-sided occlusion (OR 2.17, 95% CI 2.17-4.00, p = 0.01) were independently associated with MoCA feasibility. Among 51 patients assessed at 6 months, over 80% had persistent cognitive impairment. The chronic MoCA score in the feasible group was 24 and in the non-feasible group was 17. Both groups achieved a favorable functional outcome (mRS score ≤2).</p><p><strong>Conclusion: </strong>Over 80% of patients with AIS who underwent MT experienced chronic cognitive impairment, even among those with favorable functional outcomes.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Preexisting Dementia Lead to Adverse Outcomes after Stroke? A Systematic Review and Meta-Analysis.","authors":"Xing Wang, Chao Lei","doi":"10.1159/000549953","DOIUrl":"10.1159/000549953","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this systematic review and meta-analysis was to assess the impact of pre-stroke dementia (PSD) on stroke outcomes.</p><p><strong>Methods: </strong>Embase, PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and Scopus were searched from inception till 15 February 2025. Outcomes pooled were short-term mortality (<6 months), long-term mortality (>6 months), poor functional outcomes, recurrence, and discharge to home.</p><p><strong>Results: </strong>Twenty studies were eligible. The pooled prevalence of PSD was 10.4% (95% CI: 7.5%-14.4%). Meta-analysis of crude and adjusted data showed a significant association between PSD and short-term mortality, long-term mortality, and poor functional outcomes. Pooled analysis showed decreased odds of discharge to home with PSD but without any significant effect on stroke recurrence. A separate analysis of ischemic stroke patients undergoing reperfusion therapy showed a significant association between PSD and short-term mortality on analysis of crude but not adjusted data. There was also an increased risk of symptomatic intracerebral hemorrhage (ICH) with PSD, but the risk of all ICH did not achieve statistical significance. Most outcomes had high inter-study heterogeneity.</p><p><strong>Conclusions: </strong>PSD is associated with increased mortality and poorer functional recovery after stroke, but this effect diminishes after adjustment for confounders. Dementia alone should not deter the use of reperfusion therapy, although careful monitoring for symptomatic ICH is advised. PSD should form an integral part of stroke assessment and prognostication and clinicians should incorporate dementia status into individualized treatment and rehabilitation plans, balancing the potential benefits and risks of aggressive therapies.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-17"},"PeriodicalIF":1.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analysis Reveals Consistently Positive Effects of Dementia Caregiver Interventions on Psychological Distress.","authors":"Lian Lian, Erxun Li, Qinming Yu, Lili Huang, Yang Jin, Hongsheng Bian, Shuang Yu, Miao Yu","doi":"10.1159/000546707","DOIUrl":"10.1159/000546707","url":null,"abstract":"<p><strong>Introduction: </strong>With the global increase in dementia due to demographic aging, dementia not only affects those diagnosed but also their primary caregivers, often leading to significant caregiver burden. This study aimed to synthesize existing interventions to understand their effectiveness in reducing psychological distress - specifically anxiety, depression, and subjective well-being (SWB) - among dementia caregivers.</p><p><strong>Methods: </strong>We conducted a multilevel meta-analysis of 175 studies involving 342 intervention treatments on caregivers. Interventions were categorized into various psychological outcomes. The effects of demographic characteristics on intervention effectiveness were also analyzed using multilevel meta-regression.</p><p><strong>Results: </strong>Interventions generally showed a significant reduction in anxiety and depression with varied effects on SWB. Training of the care recipient showed the largest observed effect on SWB, although this estimate is based on only 10 observations and should be regarded as promising rather than definitive. CBT also produced a robust positive effect. Younger, male, and non-spousal caregivers tended to experience greater reductions in anxiety and depression compared to older, female, or spousal caregivers.</p><p><strong>Conclusion: </strong>These findings highlight the importance of tailoring interventions to caregiver characteristics and outcome type. While interventions broadly reduce caregiver distress, the degree of benefit varies, indicating that personalized approaches may yield the best results. We also emphasize the need for rigorous methodology (e.g., handling nonindependence and publication bias) in future caregiver intervention research.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"71-82"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}