Dementia and Geriatric Cognitive Disorders最新文献

{"title":"Understanding Discrepancies and Predictors of Self- versus Proxy-Rated Quality of Life in Chinese Community-Dwelling Older Adults with Mild Dementia: A Cross-Sectional Study.","authors":"Dandan Xue, Jinling Peng, Ling Yue, Wenwen Qi","doi":"10.1159/000553237","DOIUrl":"https://doi.org/10.1159/000553237","url":null,"abstract":"<p><strong>Background: </strong>Accurate evaluation of quality of life (QoL) is essential for optimal dementia management, yet notable discrepancies exist between patient self-rated and proxy-rated QoL. This study aimed to analyse the discrepancies and agreement between self-rated and proxy-rated QoL and identify their independent predictors among community-dwelling persons with mild dementia (PwMD).</p><p><strong>Methods: </strong>This cross-sectional study included 129 PwMD and their primary caregivers. Assessments included sociodemographic information, the QoL-Alzheimer's Disease scale, Mini-Mental State Examination, Geriatric Depression Scale, Activities of Daily Living, Functional Activities Questionnaire and Neuropsychiatric Inventory Questionnaire. Differences and agreement were analyzed using Wilcoxon tests, Spearman correlations, and intraclass correlation coefficients (ICC). Independent predictors were identified through multiple linear regression.</p><p><strong>Results: </strong>Patients rated their QoL significantly higher than their caregivers did, with poor-to-fair agreement at the total, dimensional and item levels (ICC = 0.11-0.50). Higher depressive symptoms (β = -0.354, p = 0.001), lower severity of elation (β = 0.214, p = 0.013), and greater disinhibition (β = -0.174, p = 0.041) independently predicted poorer self-rated QoL. By contrast, greater neuropsychiatric symptom severity (β = -0.283, p < 0.001), poorer Activities of Daily Living function (β = -0.230, p = 0.006), and polypharmacy (β = -0.208, p = 0.009) predicted lower proxy-rated QoL.</p><p><strong>Conclusion: </strong>Self- and proxy-rated QoL reflect distinct evaluative perspectives in PwMD. Self-reports are influenced by emotional and psychological states, whereas proxy ratings are shaped by observable symptoms, functional dependency and treatment burden. These findings suggest the need to integrate both assessment perspectives in clinical practice.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-19"},"PeriodicalIF":2.5,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148327396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Investigation of the Psychometric Properties of the Farsi Version of the Saint Louis University Mental Status Examination.","authors":"Fariba Faghani, Mahgol Tavakoli, Tayebeh Makaremi, Javad Abbasi Jondani","doi":"10.1159/000552580","DOIUrl":"10.1159/000552580","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the psychometric properties of the Farsi version of the Saint Louis University Mental Status (SLUMS) examination, marking the first such investigation.</p><p><strong>Methods: </strong>The sample comprised 200 participants: 75 with normal cognition, 74 with mild cognitive impairment (MCI), and 51 with dementia. Concurrent validity was assessed using the MMSE and NUCOG; divergent validity employed the GDS-15.</p><p><strong>Results: </strong>Exploratory factor analysis showed a unidimensional structure. Internal consistency (Cronbach's α = 0.719) and test-retest reliability (intraclass correlation coefficient = 0.717) were satisfactory. SLUMS correlated highly with MMSE (r = 0.787) and NUCOG (r = 0.861), but moderately with GDS-15 (r = -0.376). It effectively discriminated dementia from MCI but showed limited ability to differentiate normal cognition from MCI.</p><p><strong>Conclusion: </strong>The Farsi SLUMS is a suitable screening tool for detecting dementia, though caution is advised when distinguishing MCI from normal cognition.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Decision to Take a Dementia Risk Test: Considerations for Privacy in Screening At-Home.","authors":"Alexandra M Reed, Andrew Hooyman, Nicole M Lee, Elizabeth B Fauth, Jill W Love, Diane E Adamo, Sydney Y Schaefer","doi":"10.1159/000552767","DOIUrl":"10.1159/000552767","url":null,"abstract":"<p><strong>Introduction: </strong>Early methods for screening and monitoring Alzheimer's disease and other dementias are being developed in response to emerging interventions that target preclinical disease stages. This study aimed to determine adults' willingness to be screened for dementia risk, and the extent to which privacy of results relative to medical or insurance providers impacted their decision.</p><p><strong>Methods: </strong>Amazon MTurk was used to survey 527 adults nationwide.</p><p><strong>Results: </strong>Logistic regression and random forest models identified that, overall, participants were willing to take such a test, with older age being associated with increased willingness. However, non-white participants were over 3 times more likely than white participants to agree to be screened only if their results were not shared with a medical provider/insurer.</p><p><strong>Conclusion: </strong>Findings suggest that more inclusive and affordable methods for dementia risk screening and monitoring need to be developed for real-world at-home use without engaging medical providers or insurance.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiving Models and Cognitive Decline in Middle-Aged and Older Adults with Limitations in Activities of Daily Living: A CHARLS Cohort Study (2011-2020).","authors":"Ying Zhong, Rumeng Liu","doi":"10.1159/000552833","DOIUrl":"10.1159/000552833","url":null,"abstract":"<p><strong>Introduction: </strong>Limitations in activities of daily living represent a crucial risk factor for cognitive decline, while the role of caregiving models in this process remains unclearly elucidated. To examine the correlation between different caregiving models and cognitive decline of people aged 45 and above with basic activity of daily living (BADL)/instrumental activities of daily living (IADL) limitations.</p><p><strong>Methods: </strong>Data were derived from the China Health and Retirement Longitudinal Study database covering the period 2011-2020. Using multiple linear regression models and linear mixed effect models (LMM), the association between different nursing models and cognitive function trajectories was systematically evaluated, and subgroup analyses were conducted to test the robustness and heterogeneity of the results.</p><p><strong>Results: </strong>Multiple regression analysis indicated that spousal care was negatively associated with Mini-Mental State Examination (MMES) scores (OR = 0.68, 95% CI: 0.12-1.24, p = 0.017), whereas care provided by children, other relatives, and hired caregivers notably improved MMSE scores (p < 0.05), with hired care yielding the greatest improvement (OR = 4.61, 95% CI: 2.08-7.14, p < 0.001). The LMM further revealed that, compared to no care, all other care types were substantially related to the rate of change in MMSE scores over time. Subgroup analysis demonstrated pronounced interactions in sex and chronic disease subgroups (P for interaction <0.05).</p><p><strong>Conclusion: </strong>This work provides empirical evidence for optimizing long-term care services, highlighting the importance of integrating professional care support to delay cognitive decline among individuals aged 45 and older with BADL/IADL limitations.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148194641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Fox and Reverse Fox Finger Imitation Tasks for Screening Cognitive Impairment in Older Adults: A Neuroimaging Study.","authors":"Shinichiro Maeshima, Keita Sakurai, Aiko Osawa, Hidenori Arai, Yuto Uchida","doi":"10.1159/000552423","DOIUrl":"10.1159/000552423","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the usefulness of the fox finger and reverse fox finger imitation tasks as screening tools for detecting cognitive impairment, including mild cognitive impairment (MCI) and dementia.</p><p><strong>Methods: </strong>A total of 132 older adults visiting a memory clinic were classified into four groups: cognitively normal (CN; n = 16), MCI (n = 43), Alzheimer's dementia (n = 60), and non-Alzheimer's dementia (n = 13). Participants completed both imitation tasks, and performance was compared across groups. Sensitivity and specificity were calculated, and voxel-based morphometry was used to identify brain atrophy associated with task performance.</p><p><strong>Results: </strong>The fox finger task was successfully completed by 77.5% of participants, with significantly higher success in the CN group. The reverse fox finger task was more challenging, completed by only 21.7%. The sensitivity of the reverse fox finger task for detecting dementia and MCI was 88.5% and 79.1%, respectively, whereas the fox finger task showed lower sensitivity (36.1% and 13.9%, respectively) but higher specificity (100% vs. 62.5%). Fox finger failure was associated with atrophy in the bilateral inferior frontal gyri and left frontal pole. Reverse fox finger failure was linked to more widespread atrophy, including the left angular gyrus, right hippocampus, and right posterior cingulate gyrus. Binary logistic regression confirmed that reduced gray matter volume in these regions significantly predicted task failure (p < 0.05).</p><p><strong>Conclusion: </strong>The reverse fox finger task offers high sensitivity for detecting early cognitive decline, while the fox finger task provides high specificity, supporting their clinical use as rapid, noninvasive screening tools.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Practice toward Alzheimer's Disease Prevention among Middle-Aged and Elderly Individuals: A Cross-Sectional Study.","authors":"Feiyang Wu, Chao Yang, Feifan Wu, Zixuan Sun","doi":"10.1159/000552507","DOIUrl":"10.1159/000552507","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to examine the knowledge, attitude, and practice (KAP) toward Alzheimer's disease (AD) prevention among middle-aged and elderly individuals in the community.</p><p><strong>Methods: </strong>This cross-sectional study enrolled middle-aged and elderly individuals in the community who visited Kaifeng Central Hospital (China) between November 2023 and December 2023. Demographic characteristics and KAP scores were collected using an investigator-designed questionnaire. Higher scores indicate better KAP. The factors influencing KAP were identified using multivariable logistic regression analyses. The relationships among KAP dimensions were tested using a structural equation modeling (SEM) analysis.</p><p><strong>Results: </strong>A total of 1,271 questionnaires were finally collected (mean age: 54.40 ± 7.45 years old; 62.71% males). The mean KAP scores were 13.02 ± 5.26 (possible range: 0-26), 38.70 ± 4.42 (possible range: 10-50), and 25.62 ± 3.93 (possible range: 11-55), respectively, indicating poor knowledge, favorable attitude, and poor practice. The SEM analysis showed that knowledge had a positive effect on attitude (β = 0.625, p < 0.001) and practice (β = 0.605, p < 0.001), and attitude positively influenced practice (β = 0.598, p < 0.001).</p><p><strong>Conclusions: </strong>Middle-aged and elderly individuals displayed poor knowledge, favorable attitudes, and poor practices toward AD prevention. Improving knowledge and attitude should translate into better AD prevention practices.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-14"},"PeriodicalIF":2.5,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the Incidence of Early- and Late-Onset Dementia in 2011-2019: A Nationwide Population-Based Study.","authors":"Miri Lutski, Inbar Zucker, Mikhail Rozenshmidt, Eshed Lin, Revital Gross-Nevo, Irit Laxer, Lital Keinan-Boker, Michal Bromberg","doi":"10.1159/000552194","DOIUrl":"10.1159/000552194","url":null,"abstract":"<p><strong>Introduction: </strong>Dementia is a leading cause of disability and a growing public health challenge worldwide. Monitoring incidence trends is essential for health service planning and policy development. This study examined secular trends in the incidence of early-onset (45-64 years) and late-onset (≥65 years) dementia in Israel between 2011 and 2019, with a focus on sex-specific patterns.</p><p><strong>Methods: </strong>A nationwide, population-based study using electronic health records from all four Israeli health maintenance organizations provides universal healthcare coverage. Incident cases were identified by International Classification of Diseases (ICD-9/10) codes and/or purchases of anti-dementia medications. Age- and sex-specific incidence rates were calculated, and Joinpoint regression models were used to assess trends over time.</p><p><strong>Results: </strong>Over the 9-year period, dementia incidence declined significantly in both early- and late-onset groups. Mean annual incidence per 100 individuals was 0.04 for early-onset dementia overall (0.05 in men, 0.04 in women) and 1.55 for late-onset dementia (1.35 in men, 1.72 in women). Statistically significant annual percentage changes were observed across most age-groups, with the sharpest declines in those aged 65-74 (-4.0% per year) and 75-84 (-4.1% per year). Among adults aged 85+, incidence was stable from 2011 to 2015, followed by a significant decline from 2015 to 2019 (-6.6% per year). These trends were consistent across sexes.</p><p><strong>Conclusion: </strong>These findings highlight important public health and community health implications, underscoring the need for continued dementia surveillance, early detection, and evidence-based policy to support healthy aging.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13341093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth Loss as a Modifiable Risk Factor for Mild Cognitive Impairment: A Systematic Review of Mechanisms and Evidence.","authors":"Dandan Sun, Janak L Pathak, Yanling Liang, Jieling Lin, Zirui Li, Jianwei Chen, Qiuhui Jiang, Yuqin Shen, Kongbin Yang, Yangbin Zeng","doi":"10.1159/000551780","DOIUrl":"10.1159/000551780","url":null,"abstract":"<p><strong>Introduction: </strong>The relationship between cognitive defects and missing teeth has drawn increasing research attention in recent years. However, little research has specifically demonstrated the correlation between mild cognitive impairment (MCI) and missing teeth, and existing findings remain inconsistent. Thus, we conducted a systematic review synthesizing current evidence on tooth loss and MCI, aiming to address this gap.</p><p><strong>Methods: </strong>The reviewers searched Embase, Scopus, and PubMed for relevant studies published up to May 2025. An updated search was conducted in December 2025. Dual-independent literature reviewing was performed at all stages, with conflicts resolved by consensus.</p><p><strong>Results: </strong>From an initial pool of 2,709 articles, 113 underwent full-text reading, and 10 met the inclusion criteria. Our findings suggest that missing teeth, including the number of teeth lost, the number of functional teeth remaining, categorized tooth loss, and the rate of tooth loss, are significantly associated with MCI. Potential mechanisms may involve periodontal inflammation triggering neuroinflammation, reduced chewing-related neural stimulation, impaired nutrient intake, and social isolation.</p><p><strong>Conclusions: </strong>Although limited evidence suggests an association between tooth loss and MCI, offering potential avenues for MCI prevention through oral health interventions, the overall quality of the research remains low. Further high-quality studies will be needed to validate these findings.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-15"},"PeriodicalIF":2.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Adverse Childhood Experiences with Later-Life Motoric Cognitive Risk Syndrome among Older Adults in China: Mediating Role of Depression and Chronic Pain.","authors":"Hongtao Cheng, Hexiao Ding, Jie Jiang, Qian Yu, Yangyang Wu, Zhengyang Hui, June Zhang","doi":"10.1159/000551688","DOIUrl":"10.1159/000551688","url":null,"abstract":"<p><strong>Introduction: </strong>Adverse childhood experiences (ACEs) may have long-term effects on cognitive and motor function in later life. This study examined the association between ACEs and motoric cognitive risk (MCR) syndrome among older adults in China and investigated whether depression and chronic pain mediate this relationship.</p><p><strong>Methods: </strong>This cross-sectional study analyzed 3,983 adults aged ≥60 years from the China Health and Retirement Longitudinal Study (CHARLS). Twelve ACE indicators were assessed across conventional, expanded, and new categories. MCR was diagnosed based on cognitive complaints and slow gait speed. Depression was evaluated using the 10-item Center for Epidemiologic Studies Depression Scale, and chronic pain through standardized questionnaires. Multivariable logistic regression models and parallel mediation analyses examined associations between ACEs and MCR.</p><p><strong>Results: </strong>The study included 3,983 older adults with a median age of 66 years (interquartile range: 63-71), of whom 59.3% were male. MCR was identified in 12.9% (n = 512) of participants, with emotional neglect (40.1%) and physical abuse (30.7%) being the most common ACEs. Participants with 1-3 ACEs (adjusted odds ratio [OR] = 1.41, 95% confidence interval [CI]: 1.05-1.93) and ≥4 ACEs (adjusted OR = 1.69, 95% CI: 1.19-2.43) showed significantly higher odds of MCR compared to those without ACEs. Depression and chronic pain mediated 14.3% and 21.4% of the total effect, respectively.</p><p><strong>Conclusion: </strong>ACEs demonstrated dose-dependent associations with MCR in Chinese older adults, partially mediated through depression and chronic pain. These findings suggest that screening for ACE exposure and addressing mental and physical health may be critical for preventing cognitive-motor decline in later life.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlational Validity and Biomarker Associations of the Korean Computerized Cognitive Function Test Relative to the Seoul Neuropsychological Screening Battery in MCI and Alzheimer's Disease.","authors":"Donghyun Kim, Woong Jin Lee, Daniel Hyojae Jeon, Hyungyu Lee, Minkyu Kang, Minsung Park, Min Kim, Seungho Ha, Kyoungjoo Cho","doi":"10.1159/000551744","DOIUrl":"10.1159/000551744","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluates the clinical validity of the Korean Computerized Cognitive Function Test (CFT-S) by comparing its domain-specific scores with those of the Seoul Neuropsychological Screening Battery-II (SNSB-II) in patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD).</p><p><strong>Methods: </strong>A total of 300 participants (MCI: n = 163; AD: n = 137) from Severance Hospital completed both CFT-S and SNSB-II assessments within a 2-week interval, along with brain MRI and APOE genotyping. Pearson correlations and multiple regression analyses examined relationships between cognitive scores and biomarker variables. Receiver operating characteristic curves assessed diagnostic accuracy. Bland-Altman plots evaluated agreement across five shared cognitive domains.</p><p><strong>Results: </strong>CFT-S index scores showed significant positive correlations with SNSB-II in attention, language, visuospatial, and executive domains (r = 0.59-0.71, p < 0.001). The memory domain showed a lower correlation in AD patients (r = 0.28), reflecting limitations under severe impairment. Hippocampal volume was positively associated with MMSE (r = 0.54), CFT-S Memory (r = 0.50), and SNSB Memory Scores (r = 0.52). Education correlated with MMSE (r = 0.32) but not with CFT-S or SNSB, suggesting minimal education bias. APOE-ε4 carriers had smaller hippocampal volumes, higher FBB-PET BAPL scores, and poorer cognitive outcomes. The Bland-Altman plots demonstrated acceptable agreement at the group level between CFT-S and SNSB-II across all cognitive domains, with small mean biases and symmetric distributions despite relatively wide limits of agreement.</p><p><strong>Conclusion: </strong>CFT-S index scores and Bland-Altman plot analysis demonstrated validity relative to SNSB-II, with significant associations to hippocampal atrophy and genetic risk factors. The findings support CFT-S as a viable and efficient cognitive assessment tool for diagnosing MCI and AD.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}