Current organic synthesis最新文献_第8页

Recent progress in free radical transformations of allenamides 烯酰胺自由基转化的最新进展

IF 1.8 4区化学

Current organic synthesis Pub Date : 2024-01-04 DOI: 10.2174/0115701794269961231027054854

Yongchun Liu, Zimin Wang, Rui Li, Yinhai Yao, Zhichuan Shi, Qin Sun, Guowei Deng

引用次数: 0

Heteroaromatization of Coumarin Part I: Design, Synthesis, Reactions, Antitumor Activities of Novel Pyridine and Naphthyridine Derivatives 香豆素的异芳香化第一部分：新型吡啶和萘啶衍生物的设计、合成、反应和抗肿瘤活性

IF 1.8 4区化学

Current organic synthesis Pub Date : 2024-01-02 DOI: 10.2174/0115701794265924230920061222

Rita Mohammed Ahmed Borik, Ashraf Hassan Fekry Abd El-Wahab

{"title":"Heteroaromatization of Coumarin Part I: Design, Synthesis, Reactions, Antitumor Activities of Novel Pyridine and Naphthyridine Derivatives","authors":"Rita Mohammed Ahmed Borik, Ashraf Hassan Fekry Abd El-Wahab","doi":"10.2174/0115701794265924230920061222","DOIUrl":"https://doi.org/10.2174/0115701794265924230920061222","url":null,"abstract":": A novel series of chromen-3-yl-pyridine moieties were synthesized. IR, NMR, and MS spectroscopy were used to confirm the structure of these novel compounds and study antitumor activity of these compounds. The structure-activity relationship investigation demonstrated that 2,4-diamino-5-(3- methoxyphenyl)-7-(2-oxo-2H-chromen-3-yl)-1,8-naphthyridine-3-carbonitrile (16), naphthyridine-3- carbonitrile derivatives 17, 18 and pyrido[2,3-d]pyrimidine derivative 12 were found to be more effective, while compounds 5a,b, 9c, 11, 13 and 14 showed moderate activity for antitumor activities. Objectives: The objective was to design a series of new chromen-3-yl-pyridine and pyrido[2,3-d]pyrimidine derivatives and study the antitumor of these compounds. Materials and Methods: The condensation reaction of 3-acetyl-2H-chromen-2-one with 3-methoxy benzaldehyde and malononitrile or ethyl cyanoacetate in the presence of ammonium acetate and acetic acid under reflux to give the corresponding chromen-3-yl pyridine-3-carbonitrile derivatives. Results: In this study, the antitumor activity of the synthesized compounds chromen-3-yl-pyridine derivatives has been determined for the broad spectrum of cytotoxic activity toward the investigated three cell lines and 5-Fluorouracil, as reference drugs. Conclusion: A series of new chromen-3-yl-pyridine and pyrido[2,3-d]pyrimidine derivatives were synthesized in this work. All compounds were evaluated for cytotoxic activity.","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":"39 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139084097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Sustainable Green Synthesis of Pyrimidine Derivatives: Review on Multicomponent Synthesis, Catalysts and Techniques. 嘧啶衍生物的可持续绿色合成:多组分合成、催化剂和技术综述。

IF 1.8 4区化学

Current organic synthesis Pub Date : 2024-01-01 DOI: 10.2174/1570179420666230330081211

Elshimaa Mohmed Eid

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Thematic Issue: Emerging Aspects of Click Chemistry. 专题：点击化学的新兴方面。

IF 1.8 4区化学

Current organic synthesis Pub Date : 2024-01-01 DOI: 10.2174/157017942104240218204834

Vinod K Tiwari, Diganta Sarma

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Green Approach Toward Triazole Forming Reactions for Developing Anticancer Drugs. 开发抗癌药物的三唑形成反应绿色方法

IF 1.8 4区化学

Current organic synthesis Pub Date : 2024-01-01 DOI: 10.2174/1570179420666230508125144

Shiva K Rastogi, Veronica C Ciliberto, Monica Z Trevino, Brooke A Campbell, William J Brittain

{"title":"Green Approach Toward Triazole Forming Reactions for Developing Anticancer Drugs.","authors":"Shiva K Rastogi, Veronica C Ciliberto, Monica Z Trevino, Brooke A Campbell, William J Brittain","doi":"10.2174/1570179420666230508125144","DOIUrl":"10.2174/1570179420666230508125144","url":null,"abstract":"Compounds containing triazole have many significant applications in the dye and ink industry, corrosion inhibitors, polymers, and pharmaceutical industries. These compounds possess many antimicrobial, antioxidant, anticancer, antiviral, anti-HIV, antitubercular, and anticancer activities. Several synthetic methods have been reported for reducing time, minimizing synthetic steps, and utilizing less hazardous and toxic solvents and reagents to improve the yield of triazoles and their analogues synthesis. Among the improvement in methods, green approaches towards triazole forming biologically active compounds, especially anticancer compounds, would be very important for pharmaceutical industries as well as global research community. In this article, we have reviewed the last five years of green chemistry approaches on click reaction between alkyl azide and alkynes to install 1,2,3-triazole moiety in natural products and synthetic drug-like molecules, such as in colchicine, flavanone cardanol, bisphosphonates, thiabendazoles, piperazine, prostanoid, flavonoid, quinoxalines, C-azanucleoside, dibenzylamine, and aryl-azotriazole. The cytotoxicity of triazole hybrid analogues was evaluated against a panel of cancer cell lines, including multidrug-resistant cell lines.","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":" ","pages":"380-420"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Iodoxybenzoic Acid (IBX) in Organic Synthesis: A Septennial Review. 碘氧基苯甲酸（IBX）在有机合成中的应用：九年回顾。

IF 1.8 4区化学

Current organic synthesis Pub Date : 2024-01-01 DOI: 10.2174/0115701794263252230924074035

Ravi Varala, Vittal Seema, Mohammed Mujahid Alam, Narsimhaswamy Dubasi, Rama Devi Vummadi

引用次数: 0

Recent Progress on Synthesis of Functionalized 1,5-Disubstituted Triazoles. 功能化 1,5-二取代三唑合成的最新进展。

IF 1.8 4区化学

Current organic synthesis Pub Date : 2024-01-01 DOI: 10.2174/1570179420666230418123350

Manoj K Jaiswal, Abhishek Gupta, Faisal J Ansari, Vinay K Pandey, Vinod K Tiwari

{"title":"Recent Progress on Synthesis of Functionalized 1,5-Disubstituted Triazoles.","authors":"Manoj K Jaiswal, Abhishek Gupta, Faisal J Ansari, Vinay K Pandey, Vinod K Tiwari","doi":"10.2174/1570179420666230418123350","DOIUrl":"10.2174/1570179420666230418123350","url":null,"abstract":"Immediately after the invention of 'Click Chemistry' in 2002, the regioselective 1,2,3- triazole scaffolds resulted from respective organic azides and terminal alkynes under Cu(I) catalysis have been well recognized as the functional heterocyclic core at the centre of modern organic chemistry, medicinal chemistry, and material sciences. This CuAAC reaction has several notable features including excellent regioselectivity, high-to-excellent yields, easy to execute, short reaction time, modular in nature, mild condition, readily available starting materials, etc. Moreover, the resulting regioselective triazoles can serve as amide bond isosteres, a privileged functional group in drug discovery and development. More than hundreds of reviews had been devoted to the 'Click Chemistry' in special reference to 1,4-disubstituted triazoles, while only little efforts were made for an opposite regioisomer i.e., 1,5-disubstituted triazole. Herein, we have presented various classical approaches for an expeditious synthesis of a wide range of biologically relevant 1,5- disubstituted 1,2,3-triazole analogues. The syntheses of such a class of diversly functionalized triazoles have emerged as a crucial investigation in the domain of chemistry and biology. This tutorial review covers the literature assessment on the development of various synthetic protocols for the functionalized 1,5-disubstituted triazoles reported during the last 12 years.","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":"1 1","pages":"513-558"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68008492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Bird's Eye Review of Recent Reports on 1,3,4-oxadiazoles' Anti-inflammatory Insights Perspectives. 关于 1,3,4-恶二唑抗炎观点的最新报告鸟瞰。

IF 1.8 4区化学

Current organic synthesis Pub Date : 2024-01-01 DOI: 10.2174/1570179420666230508124847

Tarun Chaudhary, Prabhat Kumar Upadhyay

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Intramolecular Click Cycloaddition Reactions: Synthesis of 1,2,3-Triazoles. 分子内咔嗒环加成反应:1,2,3-三唑的合成。

IF 1.8 4区化学

Current organic synthesis Pub Date : 2024-01-01 DOI: 10.2174/1570179420666230407103320

Zahra Tashrifi, Mohammad Mohammadi Khanaposhtani, Saeed Bahadorikhalili, Bagher Larijani, Mohammad Mahdavi

引用次数: 0

Triazole-linked Nucleic Acids: Synthesis, Therapeutics and Synthetic Biology Applications. 三唑连接核酸：合成、治疗和合成生物学应用》（Triazole-linked Nucleic Acids: Synthesis, Therapeutics and Synthetic Biology Applications）。

IF 1.8 4区化学

Current organic synthesis Pub Date : 2024-01-01 DOI: 10.2174/1570179420666230502123950

Vivek K Sharma, Priyanka Mangla, Sunil K Singh, Ashok K Prasad

{"title":"Triazole-linked Nucleic Acids: Synthesis, Therapeutics and Synthetic Biology Applications.","authors":"Vivek K Sharma, Priyanka Mangla, Sunil K Singh, Ashok K Prasad","doi":"10.2174/1570179420666230502123950","DOIUrl":"10.2174/1570179420666230502123950","url":null,"abstract":"This article covers the triazole-linked nucleic acids where the triazole linkage (TL) replaces the natural phosphate backbone. The replacement is done at either a few selected linkages or all the phosphate linkages. Two triazole linkages, the four-atom TL1 and the six-atom TL2, have been discussed in detail. These triazole-modified oligonucleotides have found a wide range of applications, from therapeutics to synthetic biology. For example, the triazole-linked oligonucleotides have been used in the antisense oligonucleotide (ASO), small interfering RNA (siRNA) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology as therapeutic agents. Due to the ease of the synthesis and a wide range of biocompatibility, the triazole linkage TL2 has been used to assemble a functional 300-mer DNA from alkyne- and azide-functionalized 100-mer oligonucleotides as well as an epigenetically modified variant of a 335 base-pair gene from ten short oligonucleotides. These outcomes highlight the potential of triazole-linked nucleic acids and open the doors for other TL designs and artificial backbones to fully exploit the vast potential of artificial nucleic acids in therapeutics, synthetic biology and biotechnology.","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":" ","pages":"436-455"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9404578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0