关于 1,3,4-恶二唑抗炎观点的最新报告鸟瞰。

IF 1.7 4区 化学 Q3 CHEMISTRY, ORGANIC
Tarun Chaudhary, Prabhat Kumar Upadhyay
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引用次数: 0

摘要

消炎药可抑制炎症介质,如前列腺素、前列环素、细胞因子、血栓素、组胺、缓激肽、COX-I 和 COX-II、5-LOX 及其他物质。当组织受到创伤、细菌、热量、毒素或其他因素的伤害时,这些炎症化学物质就会产生炎症反应。这些炎症反应可能导致液体从血管流入组织,造成肿胀。当人们认识到这些对临床有益的药物在治疗炎症方面的重要作用时,就促使人们发明了更强大、更重要的分子。噁二唑衍生物是非常强效的非甾体抗炎药,被广泛使用。全面的生物化学、结构-活性关系和药理学研究表明,这些 1,3,4-噁二唑化合物具有抗炎特性。本综述文章概述了用于治疗炎症的 1,3,4-恶二唑的合成方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Bird's Eye Review of Recent Reports on 1,3,4-oxadiazoles' Anti-inflammatory Insights Perspectives.

Anti-inflammatory agents suppress inflammatory mediators such as prostaglandins, prostacyclins, cytokines, thromboxane, histamine, bradykinins, COX-I and COX-II, 5-LOX, and other substances. These inflammatory chemicals create inflammatory responses when tissue is injured by trauma, bacteria, heat, toxins, or other factors. These inflammatory reactions may result in fluid flow from the blood vessels into the tissues, resulting in swelling. When the therapeutic importance of these clinically beneficial medications in treating inflammation was recognized, it spurred the invention of even more powerful and important molecules. Oxadiazole derivatives are exceptionally potent NSAIDs, and they are widely used. Comprehensive biochemical, structure-activity-relationship and pharmacological investigations have demonstrated that these 1,3,4-oxadiazole compounds exhibit anti-inflammatory properties. This review article outlines the synthesis scheme for 1,3,4-oxadiazole used in treating inflammation.

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来源期刊
Current organic synthesis
Current organic synthesis 化学-有机化学
CiteScore
3.40
自引率
5.60%
发文量
86
审稿时长
6-12 weeks
期刊介绍: Current Organic Synthesis publishes in-depth reviews, original research articles and letter/short communications on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.
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