An Overview of Julia-lythgoe Olefination.

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC

Current organic synthesis Pub Date : 2024-01-01 DOI:10.2174/1570179420666230510104114

Vijayan Varsha, Sankaran Radhika, Gopinathan Anilkumar

引用次数: 0

Abstract

Julia-Lythgoe olefination (or simply Julia olefination) is an olefination process between phenyl sulfones and aldehydes (or ketones) to give alkenes after alcohol functionalization and reductive elimination using sodium amalgam or SmI2. It is mainly used to synthesize E-alkenes and is a key step in numerous total syntheses of many natural products. This review exclusively deals with the Julia-Lythgoe olefination and concentrates mainly on the applications of this reaction in natural product synthesis covering literature up to 2021.

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Julia-lythgoe烯烃概述

Julia- lythgoe烯烃(或简称Julia烯烃)是苯基砜与醛(或酮)之间的烯烃化过程，经过醇功能化和用汞齐钠或sm2还原消除生成烯烃。它主要用于合成e -烯烃，是许多天然产物全合成的关键步骤。本综述专门讨论Julia-Lythgoe烯化反应，主要集中在该反应在天然产物合成中的应用，涵盖截至2021年的文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current organic synthesis 化学-有机化学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Organic Synthesis publishes in-depth reviews, original research articles and letter/short communications on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.