Current Osteoporosis Reports最新文献_第4页

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-08-01 DOI: 10.1007/s11914-023-00803-9

Isidora Panez-Toro, Javier Muñoz-García, Jorge W Vargas-Franco, Axelle Renodon-Cornière, Marie-Françoise Heymann, Frédéric Lézot, Dominique Heymann

{"title":"Advances in Osteosarcoma.","authors":"Isidora Panez-Toro, Javier Muñoz-García, Jorge W Vargas-Franco, Axelle Renodon-Cornière, Marie-Françoise Heymann, Frédéric Lézot, Dominique Heymann","doi":"10.1007/s11914-023-00803-9","DOIUrl":"https://doi.org/10.1007/s11914-023-00803-9","url":null,"abstract":"Purpose of review: This article gives a brief overview of the most recent developments in osteosarcoma treatment, including targeting of signaling pathways, immune checkpoint inhibitors, drug delivery strategies as single or combined approaches, and the identification of new therapeutic targets to face this highly heterogeneous disease.Recent findings: Osteosarcoma is one of the most common primary malignant bone tumors in children and young adults, with a high risk of bone and lung metastases and a 5-year survival rate around 70% in the absence of metastases and 30% if metastases are detected at the time of diagnosis. Despite the novel advances in neoadjuvant chemotherapy, the effective treatment for osteosarcoma has not improved in the last 4 decades. The emergence of immunotherapy has transformed the paradigm of treatment, focusing therapeutic strategies on the potential of immune checkpoint inhibitors. However, the most recent clinical trials show a slight improvement over the conventional polychemotherapy scheme. The tumor microenvironment plays a crucial role in the pathogenesis of osteosarcoma by controlling the tumor growth, the metastatic process and the drug resistance and paved the way of new therapeutic options that must be validated by accurate pre-clinical studies and clinical trials.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"21 4","pages":"330-343"},"PeriodicalIF":4.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9931090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Disparities in the Prevalence of Osteoporosis and Osteopenia in Men and Women Living in Sub-Saharan Africa, the UK, and the USA. 生活在撒哈拉以南非洲、英国和美国的男性和女性骨质疏松症和骨质疏松症患病率的差异。

IF 4.2 2区医学

Current Osteoporosis Reports Pub Date : 2023-08-01 Epub Date: 2023-06-23 DOI: 10.1007/s11914-023-00801-x

Kate A Ward, Camille M Pearse, Tafadzwa Madanhire, Alisha N Wade, June Fabian, Lisa K Micklesfield, Celia L Gregson

{"title":"Disparities in the Prevalence of Osteoporosis and Osteopenia in Men and Women Living in Sub-Saharan Africa, the UK, and the USA.","authors":"Kate A Ward, Camille M Pearse, Tafadzwa Madanhire, Alisha N Wade, June Fabian, Lisa K Micklesfield, Celia L Gregson","doi":"10.1007/s11914-023-00801-x","DOIUrl":"10.1007/s11914-023-00801-x","url":null,"abstract":"Purpose: To review the rising prevalence of osteopenia and osteoporosis in sub-Saharan Africa and the challenges this poses to governments and healthcare services. Using existing studies, we compare the prevalence of osteopenia and osteoporosis in men and women from sub-Saharan Africa to US and UK cohorts. Context-specific disparities in healthcare are discussed particularly the challenges in diagnosis and treatment of osteoporosis.Recent findings: There are few epidemiological data describing the burden of osteoporosis in sub-Saharan Africa. In the studies and cohorts presented here, osteoporosis prevalence varies by sex, country and area of residence, but is generally higher in African populations, than has previously been appreciated. Risk factors contributing to poorer bone health include HIV, malnutrition and \"inflammaging.\" Reprioritization towards care of ageing populations is urgently required. Equitable access to implementable preventative strategies, diagnostic services, treatments and pathways of care for bone health (for example embedded within HIV services) need now to be recognized and addressed by policy makers.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"21 4","pages":"360-371"},"PeriodicalIF":4.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9952746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image Registration in Longitudinal Bone Assessment Using Computed Tomography. 使用计算机断层扫描进行纵向骨骼评估的图像注册

IF 4.2 2区医学

Current Osteoporosis Reports Pub Date : 2023-08-01 Epub Date: 2023-06-02 DOI: 10.1007/s11914-023-00795-6

Han Liu, Pholpat Durongbhan, Catherine E Davey, Kathryn S Stok

{"title":"Image Registration in Longitudinal Bone Assessment Using Computed Tomography.","authors":"Han Liu, Pholpat Durongbhan, Catherine E Davey, Kathryn S Stok","doi":"10.1007/s11914-023-00795-6","DOIUrl":"10.1007/s11914-023-00795-6","url":null,"abstract":"Purpose of review: Rigid image registration is an important image processing tool for the assessment of musculoskeletal chronic disease. In this paper, we critically review applications of rigid image registration in terms of similarity measurement methods over the past three years (2019-2022) in the context of monitoring longitudinal changes to bone microstructure and mechanical properties using computed tomography. This review identifies critical assumptions and trade-offs underlying different similarity measurement methods used in image registration and demonstrates the effect of using different similarity measures on registration outcomes.Recent findings: Image registration has been used in recent studies for: correcting positional shifts between longitudinal scans to quantify changes to bone microstructural and mechanical properties over time, developing registration-based workflows for longitudinal assessment of bone properties in pre-clinical and clinical studies, and developing and validating registration techniques for longitudinal studies. In evaluating the recent literature, it was found that the assumptions at the root of different similarity measures used in rigid image registration are not always confirmed and reported. Each similarity measurement has its advantages and disadvantages, as well as underlying assumptions. Breaking these assumptions can lead to poor and inaccurate registration results. Thus, care must be taken with regards to the choice of similarity measurement and interpretation of results. We propose that understanding and verifying the assumptions of similarity measurements will enable more accurate and efficient quantitative assessments of structural changes over time.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"21 4","pages":"372-385"},"PeriodicalIF":4.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9985051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-Fracture Care Program: Pharmacological Treatment of Osteoporosis in Older Adults with Fragility Fractures. 骨折后护理计划:老年脆性骨折患者骨质疏松症的药物治疗。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-08-01 DOI: 10.1007/s11914-023-00791-w

Yasser El Miedany, Mathias Toth, Walaa Elwakil, Sally Saber

{"title":"Post-Fracture Care Program: Pharmacological Treatment of Osteoporosis in Older Adults with Fragility Fractures.","authors":"Yasser El Miedany, Mathias Toth, Walaa Elwakil, Sally Saber","doi":"10.1007/s11914-023-00791-w","DOIUrl":"https://doi.org/10.1007/s11914-023-00791-w","url":null,"abstract":"Purpose of review: To present and discuss the recently published scientific evidence on the approach, mode of action, and timing of osteoporosis therapy initiation after fragility fractures.Recent findings: A comprehensive management approach is required to reduce mortality and morbidity associated with fragility fractures. This will help to reduce the risk of missing the diagnosis of osteoporosis as the underlying disorder while at the same time promoting the timely treatment of osteoporosis. The target is to minimize the incidence of post-traumatic disability and to reduce the imminent fracture risk. This article will present a Bone-Care algorithm for the diagnosis and management of fragility fractures in patients presenting for trauma surgery. This algorithm has been developed based on recently published national as well as international guidelines for implementation in standard clinical practice. International figures revealed that only a small proportion of those patients at high risk of sustaining a fragility fracture receive osteoporosis therapy. Based on the best currently available evidence, it is safe to start osteoporosis therapy in the acute post-fracture period (the optimal therapeutic window of romosozumab is the late endochondral phase/throughout bone remodeling). The right Bone-Care pathway ensures the delivery of a comprehensive management approach that meets the global call to action. All parameters including risk, benefit, compliance, and cost should be considered on an individual base for all kinds of therapy.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"21 4","pages":"472-484"},"PeriodicalIF":4.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10280777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Checkpoint Inhibitors in Bone Metastatic Disease in Solid Tumors. 检查点抑制剂在实体瘤骨转移疾病中的应用。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-08-01 DOI: 10.1007/s11914-023-00798-3

Victoria Wytiaz, Catherine Van Poznak

引用次数: 0

The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone. 骨细胞TGFβ信号传导对骨的骨骼和骨骼外功能的多方面影响。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-08-01 DOI: 10.1007/s11914-023-00802-w

M Carroll, T Alliston, N Dole

{"title":"The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone.","authors":"M Carroll, T Alliston, N Dole","doi":"10.1007/s11914-023-00802-w","DOIUrl":"https://doi.org/10.1007/s11914-023-00802-w","url":null,"abstract":"Purpose of review: To summarize the fundamental role of transforming growth factor beta (TGFβ) signaling in osteocytes and highlight the physiological and pathophysiological conditions stemming from the deregulation of this pathway in osteocytes.Recent findings: Osteocytes perform a myriad of skeletal and extraskeletal functions, including mechanosensing, coordinating bone remodeling, local bone matrix turnover, and maintaining systemic mineral homeostasis and global energy balance. Transforming growth factor-beta (TGFβ) signaling, which is crucial for embryonic and postnatal bone development and maintenance, has been found to be essential for several osteocyte functions. There is some evidence that TGFβ might be accomplishing these functions through crosstalk with the Wnt, PTH, and YAP/TAZ pathways in osteocytes, and a better understanding of this complex molecular network can help identify the pivotal convergence points responsible for distinct osteocyte functions. This review provides recent updates on the interwoven signaling cascades coordinated by TGFβ signaling within osteocytes to support their skeletal and extraskeletal functions and highlights physiological and pathophysiological conditions implicating the role of TGFβ signaling in osteocytes.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"21 4","pages":"414-425"},"PeriodicalIF":4.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9901955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Amino Acid Metabolism in Bone Metastatic Disease. 骨转移性疾病中的氨基酸代谢

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-08-01 DOI: 10.1007/s11914-023-00797-4

Deanna N Edwards

引用次数: 1

Bone Health in Young Athletes: a Narrative Review of the Recent Literature. 年轻运动员的骨骼健康：近期文献的叙述性回顾。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-08-01 Epub Date: 2023-06-08 DOI: 10.1007/s11914-023-00796-5

Aubrey Armento, Marc Heronemus, Daniel Truong, Christine Swanson

{"title":"Bone Health in Young Athletes: a Narrative Review of the Recent Literature.","authors":"Aubrey Armento, Marc Heronemus, Daniel Truong, Christine Swanson","doi":"10.1007/s11914-023-00796-5","DOIUrl":"10.1007/s11914-023-00796-5","url":null,"abstract":"Purpose of review: The aim of this review is to discuss the most recent published scientific evidence regarding bone health in the pediatric athlete.Recent findings: Pediatric athletes commonly suffer from overuse injuries to the physes and apophyses, as well as bone stress injuries, for which magnetic resonance imaging grading of the severity of injuries may be useful in guiding return to sport. Adolescent athletes, particularly those who train indoors and during the winter season, are at risk for vitamin D deficiency, which has important implications for bone mineral density. However, the relationship between vitamin D status and traumatic fracture risk is still unclear. While the female athlete triad is a well-established condition, the current work has led to the recognition of parallel pathophysiology in male athletes, referred to as the male athlete triad. Recent evidence suggests that transdermal 17β-estradiol treatment in amenorrhoeic female athletes is an effective adjunctive treatment to improve bone mineral density in treatment of the female athlete triad. Young athletes are at risk for musculoskeletal injuries unique to the growing skeleton. Optimizing nutritional intake, particularly related to adequate vitamin D intake and prevention of the athlete triad, is critical to optimize bone health in the young athlete.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"21 4","pages":"447-458"},"PeriodicalIF":4.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9904213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Health in the Transgender and Gender Diverse Youth Population. 变性和性别多元化青少年群体的骨骼健康。

IF 4.2 2区医学

Current Osteoporosis Reports Pub Date : 2023-08-01 Epub Date: 2023-07-03 DOI: 10.1007/s11914-023-00799-2

Janet Y Lee

引用次数: 0

Influence of Osteocyte Lacunar-Canalicular Morphology and Network Architecture on Osteocyte Mechanosensitivity. 骨细胞腔隙-小管形态和网络结构对骨细胞机械敏感性的影响。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-08-01 DOI: 10.1007/s11914-023-00792-9

Wen Sang, Ani Ural

{"title":"Influence of Osteocyte Lacunar-Canalicular Morphology and Network Architecture on Osteocyte Mechanosensitivity.","authors":"Wen Sang, Ani Ural","doi":"10.1007/s11914-023-00792-9","DOIUrl":"https://doi.org/10.1007/s11914-023-00792-9","url":null,"abstract":"Purpose of review: The goal of this review is to summarize recent findings related to modifications in osteocyte lacunar and canalicular morphology due to physiological and pathological conditions. In addition, this review aims to outline how these modifications may influence the local mechanical environment of osteocytes and their mechanosensitivity.Recent findings: Reduction in lacunar density with age and increasing lacunar size with lactation are confirmed in multiple studies in human and murine bone. There is also evidence of a reduction in canalicular density, length, and branching, as well as increasing sphericity and smaller lacunae with aging and disease. However, while some studies have found modifications in lacunar density, size, shape, and orientation, as well as canalicular density, length, and size due to specific physiological and pathological conditions, others have not observed any differences. Recent finite element models provide insights into how observed modifications in the lacunar-canalicular network (lacunar and canalicular density) and lacunar-canalicular morphology (lacunar area/volume, shape, and orientation as well as canalicular diameter and length) may influence the fluid flow and local strains around the lacunar-canalicular network and modify the local mechanical environment of osteocytes. Modifications in the lacunar-canalicular network morphology may lead to significant changes in the strains received by osteocytes and may influence bone's response to mechanical stimulation as osteocytes are the primary mechanosensing bone cells. Further experimental and computational studies will continue to improve our understanding of the relationship between lacunar-canalicular network morphology and osteocyte mechanosensitivity.","PeriodicalId":11080,"journal":{"name":"Current Osteoporosis Reports","volume":"21 4","pages":"401-413"},"PeriodicalIF":4.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9977914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1