The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Osteoporosis Reports Pub Date : 2023-08-01 DOI:10.1007/s11914-023-00802-w

M Carroll, T Alliston, N Dole

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引用次数: 1

Abstract

Purpose of review: To summarize the fundamental role of transforming growth factor beta (TGFβ) signaling in osteocytes and highlight the physiological and pathophysiological conditions stemming from the deregulation of this pathway in osteocytes.

Recent findings: Osteocytes perform a myriad of skeletal and extraskeletal functions, including mechanosensing, coordinating bone remodeling, local bone matrix turnover, and maintaining systemic mineral homeostasis and global energy balance. Transforming growth factor-beta (TGFβ) signaling, which is crucial for embryonic and postnatal bone development and maintenance, has been found to be essential for several osteocyte functions. There is some evidence that TGFβ might be accomplishing these functions through crosstalk with the Wnt, PTH, and YAP/TAZ pathways in osteocytes, and a better understanding of this complex molecular network can help identify the pivotal convergence points responsible for distinct osteocyte functions. This review provides recent updates on the interwoven signaling cascades coordinated by TGFβ signaling within osteocytes to support their skeletal and extraskeletal functions and highlights physiological and pathophysiological conditions implicating the role of TGFβ signaling in osteocytes.

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骨细胞TGFβ信号传导对骨的骨骼和骨骼外功能的多方面影响。

综述目的:综述转化生长因子β (tgf - β)信号通路在骨细胞中的基本作用，并强调该通路在骨细胞中失调所引起的生理和病理生理条件。近期研究发现:骨细胞具有多种骨骼和骨骼外功能，包括机械传感、协调骨重塑、局部骨基质转换、维持全身矿物质稳态和全球能量平衡。转化生长因子- β (tgf - β)信号对胚胎和出生后骨发育和维持至关重要，已被发现对几种骨细胞功能至关重要。有证据表明，TGFβ可能通过与骨细胞中的Wnt、PTH和YAP/TAZ通路的串音来实现这些功能，更好地了解这个复杂的分子网络可以帮助确定负责不同骨细胞功能的关键会聚点。本文综述了骨细胞内由tgf - β信号协调的相互交织的信号级联反应的最新进展，以支持其骨骼和骨骼外功能，并强调了tgf - β信号在骨细胞中的作用的生理和病理生理条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.