Post-Fracture Care Program: Pharmacological Treatment of Osteoporosis in Older Adults with Fragility Fractures.

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Yasser El Miedany, Mathias Toth, Walaa Elwakil, Sally Saber
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引用次数: 1

Abstract

Purpose of review: To present and discuss the recently published scientific evidence on the approach, mode of action, and timing of osteoporosis therapy initiation after fragility fractures.

Recent findings: A comprehensive management approach is required to reduce mortality and morbidity associated with fragility fractures. This will help to reduce the risk of missing the diagnosis of osteoporosis as the underlying disorder while at the same time promoting the timely treatment of osteoporosis. The target is to minimize the incidence of post-traumatic disability and to reduce the imminent fracture risk. This article will present a Bone-Care algorithm for the diagnosis and management of fragility fractures in patients presenting for trauma surgery. This algorithm has been developed based on recently published national as well as international guidelines for implementation in standard clinical practice. International figures revealed that only a small proportion of those patients at high risk of sustaining a fragility fracture receive osteoporosis therapy. Based on the best currently available evidence, it is safe to start osteoporosis therapy in the acute post-fracture period (the optimal therapeutic window of romosozumab is the late endochondral phase/throughout bone remodeling). The right Bone-Care pathway ensures the delivery of a comprehensive management approach that meets the global call to action. All parameters including risk, benefit, compliance, and cost should be considered on an individual base for all kinds of therapy.

Abstract Image

骨折后护理计划:老年脆性骨折患者骨质疏松症的药物治疗。
综述的目的:介绍和讨论最近发表的关于脆性骨折后骨质疏松症治疗的方法、作用方式和时机的科学证据。最近的研究发现:需要一种综合的管理方法来降低与脆性骨折相关的死亡率和发病率。这将有助于减少骨质疏松症作为潜在疾病的漏诊风险,同时促进骨质疏松症的及时治疗。目标是尽量减少创伤后残疾的发生率,并减少即将发生的骨折风险。这篇文章将提出一个骨护理算法的诊断和管理脆性骨折的病人提出创伤手术。该算法是根据最近公布的国家和国际标准临床实践实施指南开发的。国际数据显示,只有一小部分易碎性骨折高危患者接受骨质疏松治疗。根据目前可获得的最佳证据,在骨折后急性期开始骨质疏松症治疗是安全的(romosozumab的最佳治疗窗口是软骨内晚期/整个骨重塑)。正确的骨护理途径确保提供符合全球行动呼吁的综合管理方法。所有的参数,包括风险、获益、依从性和成本,都应该在个体基础上考虑各种治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Osteoporosis Reports
Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
8.80
自引率
2.30%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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