Current topics in medicinal chemistry最新文献_第5页

γCyclodextrin-assisted Aqueous Extract of Cinnamon for Cancer and Stress Management. γ环糊精辅助的肉桂水提取物用于癌症和压力管理。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-08-20 DOI: 10.2174/0115680266309291240808114508

Yang Shi, Huifu He, Huayue Zhang, Tian Yuan, Zhenya Zhang, Ranil DeSilva, Yoshiyuki Ishida, Keiji Terao, Sunil C Kaul, Renu Wadhwa

{"title":"γCyclodextrin-assisted Aqueous Extract of Cinnamon for Cancer and Stress Management.","authors":"Yang Shi, Huifu He, Huayue Zhang, Tian Yuan, Zhenya Zhang, Ranil DeSilva, Yoshiyuki Ishida, Keiji Terao, Sunil C Kaul, Renu Wadhwa","doi":"10.2174/0115680266309291240808114508","DOIUrl":"https://doi.org/10.2174/0115680266309291240808114508","url":null,"abstract":"Aim: Our goal was to investigate the use of Cyclodextrin in creating an aqueous extract of Cinnamon with a high content of its bioactive ingredients, validated by cell-based assays.Background: Due to their safety and cost-effectiveness, natural compounds have garnered attention for cancer therapy, which often faces challenges related to drug toxicity and resistance. Cinnamon (Cinnamomum verum; also known as Ceylon Cinnamon) is a commonly used spice with a history in folk medicine for treating various ailments. However, its active ingredients suffer from poor solubility, stability, and bioavailability, which limits its use and benefits.Objective: We prepared γCyclodextrin (γCD)-assisted aqueous extract of Cinnamon (CD-CIN) and compared its activity with the DMSO extract (DM-CIN).Methods: The cells were exposed to CD-CIN and DM-CIN extracts under normal and stressed (oxidative, metal, and hypoxic) conditions and then analyzed for stress and cancerous phenotypes using various molecular assays.Results: We found that CD-CIN possesses considerable anticancer activity that involves the activation of tumor suppressor proteins and DNA damage response. Low, non-toxic concentrations of DM-CIN and CD-CIN caused comparable inhibition of migration and invasion capability of cells, supported by molecular marker analyses. Furthermore, protection against oxidative, metal, and hypoxia stress, as well as induction of differentiation, was recorded in both DM-CIN and CD-CIN treated cells, as compared to the control.Conclusion: We report CD-CIN as a new economic and easy Cinnamon-derived resource that possesses considerable anticancer and antistress activities and hence warrants further chemical, in vitro, and in vivo studies.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in Computational Approaches for Antidiabetic Drug Discovery: A Review. 抗糖尿病药物发现计算方法的进展：综述。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-08-19 DOI: 10.2174/0115680266311132240807065631

Bouchra Rossafi, Oussama Abchir, Mhammed El Kouali, Samir Chtita

{"title":"Advancements in Computational Approaches for Antidiabetic Drug Discovery: A Review.","authors":"Bouchra Rossafi, Oussama Abchir, Mhammed El Kouali, Samir Chtita","doi":"10.2174/0115680266311132240807065631","DOIUrl":"https://doi.org/10.2174/0115680266311132240807065631","url":null,"abstract":"Diabetes mellitus (DM) manifests as a complex and chronic metabolic disorder, posing a significant threat to global public health and contributing substantially to mortality rates. It is characterized by elevated blood glucose levels or hyperglycemia and requires effective preventive and therapeutic strategies. One promising approach involves targeting the inhibition of α- glucosidase and α-amylase, key enzymes responsible for carbohydrate hydrolysis. Inhibiting these enzymes proves beneficial in reducing postprandial glucose levels and mitigating postprandial hyperglycemia. However, existing antidiabetic medications are associated with undesirable side effects, highlighting the need to develop new molecules with increased efficacy and reduced side effects. Traditional methods for designing such molecules are often lengthy and costly. To address this, computer-based molecular modeling tools offer a promising approach to evaluate the antidiabetic activities of chemical compounds. This review aims to compile information on chemical compounds assessed for their anti-diabetic activities through molecular modeling, with a particular focus on the period from 2020 to 2023.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-Induced Synthesis of Bioactive Nitrogen Heterocycles. 微波诱导合成具有生物活性的氮杂环。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-08-19 DOI: 10.2174/0115680266315936240807101931

Aparna Das, Devalina Ray, Muhammad Waqar Ashraf, Bimal Krishna Banik

{"title":"Microwave-Induced Synthesis of Bioactive Nitrogen Heterocycles.","authors":"Aparna Das, Devalina Ray, Muhammad Waqar Ashraf, Bimal Krishna Banik","doi":"10.2174/0115680266315936240807101931","DOIUrl":"https://doi.org/10.2174/0115680266315936240807101931","url":null,"abstract":"There are many different applications of heterocyclic molecules in the pharmaceutical and materials science fields, which make them an important family of compounds. Among these heterocyclic compounds, nitrogen-containing heterocyclic (N-heterocyclic) compounds have attracted a lot of interest among researchers due to their various applications across a wide variety of fields. Many studies have been performed over the past few years to study the synthesis of N-heterocycles under different reaction conditions, such as solvent-free, catalytic, reactants immobilized on a solid support, one-pot synthesis, and microwave irradiation. It has been demonstrated by our research group that microwaves can be utilized for rapid and efficient synthesis of biologically active compounds. In this review, we provide an overview of the microwave-assisted non-catalytic and catalytic preparation of nitrogen-containing heterocycles, mostly polycyclic N-heterocycles, five-membered N-heterocycles, six-membered N-heterocycles, and fused N-heterocycles. Mostly in this article, we explore the microwave-assisted preparation of biologically important compounds, such as pyrimidines, thiazoles, imines, tetrazoles, steroidal derivatives, quinolines, indolizine, triazoles, beta-lactams, pyrroles and quinoxalines.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Synthetic and Pharmacological Developments in the Hybrid Quinazolinone Moiety: An Updated Review. 混合喹唑啉酮分子的绿色合成和药理学发展：最新综述。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-08-19 DOI: 10.2174/0115680266313354240807051401

Shivangi Jaiswal, Kanika Verma, Anamika Srivastva, Nikilesh Arya, Jaya Dwivedi, Swapnil Sharma

引用次数: 0

Impact of Artificial Intelligence on Drug Development and Delivery. 人工智能对药物开发和交付的影响。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-08-12 DOI: 10.2174/0115680266324522240725053634

Chintan Aundhia, Ghanshyam Parmar, Chitrali Talele, Niyati Shah, Dipali Talele

引用次数: 0

Synthesis of Isatin-derived Heterocycles with Promising Anticancer Activities. 合成具有良好抗癌活性的伊沙廷衍生杂环。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-08-08 DOI: 10.2174/0115680266311332240722065652

Bubun Banerjee, Aditi Sharma, Arvind Singh, Manmeet Kaur, Anu Priya

引用次数: 0

CADD Methods for Developing Novel Compounds Synthesized to Inhibit Tyrosine Kinase Receptors. 开发合成抑制酪氨酸激酶受体的新型化合物的 CADD 方法。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-08-07 DOI: 10.2174/0115680266312422240712053821

Amal Bouribab, Abdelkbir Errougui, Samir Chtita

引用次数: 0

Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies. 铬烯衍生物的生态友好型方法：绿色合成策略综述。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-08-06 DOI: 10.2174/0115680266305231240712104736

Vidhi Patel, Tushar Bambharoliya, Drashti Shah, Dharti Patel, Maitri Patel, Umang Shah, Mehul Patel, Swayamprakash Patel, Nilay Solanki, Anjali Mahavar, Afzal Nagani, Harnisha Patel, Mrudangsinh Rathod, Bhargav Bhimani, Vasisth Bhavsar, Shantilal Padhiyar, Shailesh Koradia, Chandni Chandarana, Bhavesh Patel, Ranjitsinh C Dabhi, Ashish Patel

{"title":"Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies.","authors":"Vidhi Patel, Tushar Bambharoliya, Drashti Shah, Dharti Patel, Maitri Patel, Umang Shah, Mehul Patel, Swayamprakash Patel, Nilay Solanki, Anjali Mahavar, Afzal Nagani, Harnisha Patel, Mrudangsinh Rathod, Bhargav Bhimani, Vasisth Bhavsar, Shantilal Padhiyar, Shailesh Koradia, Chandni Chandarana, Bhavesh Patel, Ranjitsinh C Dabhi, Ashish Patel","doi":"10.2174/0115680266305231240712104736","DOIUrl":"https://doi.org/10.2174/0115680266305231240712104736","url":null,"abstract":"Synthetic routes of chromene are an area of thrust research due to its wide application as pigments, agrochemicals, cosmetics, and an important nucleus scaffold for various pharmaco-logically active drugs. The chromene nucleus is an important moiety for the discovery of new drug candidates owing to its broad range of pharmacological actions like antitumor, anti-inflammatory, antiviral, and many others. However, traditional synthesis techniques frequently use unsafe reagents and produce hazardous waste, presenting environmental issues. The eco-friendly production of chromene derivatives utilizes sustainable raw materials, non-toxic cata-lysts, and gentle reaction conditions to reduce ecological consequences. Innovative methods like microwave irradiation, ultrasound synthesis, the use of environmentally friendly solvents, a cata-lyst-based approach with minimal environmental impact, and mechanochemistry-mediated syn-thesis are implemented. These approaches provide benefits in scalability, cost-effectiveness, and ease of purification. This review compiles and presents various recently reported green synthetic strategies of chromene and its derivatives and gives the reader a clear idea of the detailed and crit-ical aspects of various synthetic protocols described.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Delivery Systems for Natural Medicines in Cancer Therapy. 癌症治疗中天然药物的给药系统。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-07-31 DOI: 10.2174/0115680266315985240710063754

P K Hashim, Naseef Punnoth Poonkuzhi, Nusaiba Madappuram Cheruthu, Mohamed Saher Kuruniyan

{"title":"Drug Delivery Systems for Natural Medicines in Cancer Therapy.","authors":"P K Hashim, Naseef Punnoth Poonkuzhi, Nusaiba Madappuram Cheruthu, Mohamed Saher Kuruniyan","doi":"10.2174/0115680266315985240710063754","DOIUrl":"https://doi.org/10.2174/0115680266315985240710063754","url":null,"abstract":"Cancer stands as a prominent global cause of mortality, with chemotherapy using synthetic drugs being the predominant treatment method. Despite its high success rate, this approach is constrained by substantial side effects. Herbal medicines, known for their diverse bioactive components, exhibit promising anticancer attributes. The drug delivery systems can improve the precision of delivering these herbal compounds, enhancing efficacy while minimizing potential side effects. Various platforms, such as nanoparticle-based carriers, liposomes, and polymeric micelles, are investigated for encapsulating and delivering herbal components to cancer cells. These systems not only enhance the bioavailability of herbal compounds but also facilitate controlled release, sustained drug circulation, and improved cellular uptake. This comprehensive review focuses on the recent advancement in the field of drug delivery systems employed in the delivery of plant-derived anticancer compounds. It categorizes carriers into organic and inorganic nanoparticles, addressing their application in enhancing the safety and efficacy of plant-derived anticancer compounds alongside associated challenges. The review concludes by outlining recent investigations into drug delivery systems aimed at increasing the efficacy of plant-derived anticancer compounds. Future research in this field should emphasize experiments in animal models and potential clinical translation.","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Synthesis of Bioactive Pyrrole Derivatives via Heterogeneous Catalysts Since 2010. 通过异构催化剂绿色合成具有生物活性的吡咯衍生物，自 2010 年起。

IF 2.9 4区医学

Current topics in medicinal chemistry Pub Date : 2024-07-26 DOI: 10.2174/0115680266307696240708115422

Berrichi Amina, Bachir Redouane

引用次数: 0