Developmental biology最新文献

{"title":"Corrigendum to “Avian bioresources for developmental biology: Transgenic chicken and quail resources in the United Kingdom, France, and Japan” [Dev. Biol. 521 (2025) 1–13]","authors":"Lindsay Henderson , Yuya Okuzaki , Christophe Marcelle , Mike J. McGrew , Ken-ichi Nishijima","doi":"10.1016/j.ydbio.2025.03.003","DOIUrl":"10.1016/j.ydbio.2025.03.003","url":null,"abstract":"","PeriodicalId":11070,"journal":{"name":"Developmental biology","volume":"522 ","pages":"Page 30"},"PeriodicalIF":2.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information","authors":"","doi":"10.1016/S0012-1606(25)00065-X","DOIUrl":"10.1016/S0012-1606(25)00065-X","url":null,"abstract":"","PeriodicalId":11070,"journal":{"name":"Developmental biology","volume":"521 ","pages":"Page OBC"},"PeriodicalIF":2.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching the science of life: A multidisciplinary educational approach to reproductive technology debates through the lens of developmental biology","authors":"Jovany Azzi ,&nbsp;Zeinab Wehbi ,&nbsp;Philippe Hussein Kobeissy ,&nbsp;Racha Kerek","doi":"10.1016/j.ydbio.2025.03.005","DOIUrl":"10.1016/j.ydbio.2025.03.005","url":null,"abstract":"<div><div>In vitro fertilization, cryopreservation and pre-implantation genetic testing are transformative reproductive technologies offering hope for individuals facing fertility challenges. Scientifically, understanding the science of developmental biology is essential for comprehending the mechanisms and implications of these technologies. In embryological sciences, biological perspectives identify life as a series of developmental stages ranging from conception to viability, each potentially representing a different ‘beginning’ of life. However, the concept of ensoulment, rooted in religious and cultural beliefs, introduces a speculative dimension ultimately influencing how legal systems worldwide define and protect human life in the context of reproductive decision-making. Legally, high-profile cases such as ‘Sofia Vergara v. Nick Loeb’ or ‘Quintavalle v. Human Fertilization and Embryology Authority’ raise questions about both parental and fetal reproductive rights and consent. This paper highlights the importance of a multidisciplinary approach in developmental biology education for responsible and equitable practices of reproductive technologies. It underscores the importance of incorporating these considerations into the classroom teaching as case study discussions aligned with the DEI approach, to better equip students for the controversies they may encounter in their roles of developmental biologists.</div></div>","PeriodicalId":11070,"journal":{"name":"Developmental biology","volume":"522 ","pages":"Pages 31-39"},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geldanamycin inhibits in vivo and in vitro chick skeletal myogenesis","authors":"Kayo Moreira Bagri ,&nbsp;Bruna Vessados Aprigio ,&nbsp;Matthias Guillo,&nbsp;José Brito,&nbsp;Manoel Luis Costa,&nbsp;Claudia Mermelstein","doi":"10.1016/j.ydbio.2025.02.018","DOIUrl":"10.1016/j.ydbio.2025.02.018","url":null,"abstract":"<div><div>During skeletal muscle development catabolic and anabolic events are finely orchestrated by several heat shock proteins (HSP). HSP90 are molecular chaperones which play an essential role in maintaining cellular homeostasis. Although HSP90 proteins have been widely studied in cancer cells, their role during skeletal myogenesis has not been completely explored. Here, we studied the role of HSP90 during <em>in vivo and in vitro</em> development of embryonic chick muscle fibers. First, we analyzed the effects of the inhibition of HSP90 by geldanamycin in skeletal muscle tissues in chick embryos <em>in vivo</em>. Geldanamycin was applied to E2 chicken embryos <em>in vivo</em>, and six days later, we observed a reduction in desmin-positive cells in the pectoral muscle. To deeper analyze the role of HSP90 during myogenesis, we used primary cultures of chick pectoral muscle cells which contain myoblasts, myotubes and muscle fibroblasts. We observed an intense accumulation of HSP90 in the perinuclear region of myoblasts and myotubes, but not in muscle fibroblasts. In myotubes, besides the perinuclear localization, HSP90 was found colocalized with myofibers, whereas in myoblasts and fibroblasts HSP90 was found as a mesh of small filaments and aggregates in the cytoplasm. Fibroblasts showed lower HSP90 expression, as compared to myoblasts and myotubes. Inhibition of HSP90 by geldanamycin reduced the size of myotubes, the number of nuclei within myotubes and myoblast fusion index, indicating an inhibition of myogenesis. Furthermore, geldanamycin induces both an increase in the number of fibroblasts and the formation of giant binucleated fibroblasts, suggesting that HSP90 inhibition induces cytokinesis block in muscle fibroblasts by interfering in actin and myosin activity. The collection of our results shows that the inhibition of HSP90 hinders <em>in vivo</em> and <em>in vitro</em> chick skeletal myogenesis, and differentially affects muscle and non-muscle cells, underlying different functions of HSP90 in different cell types.</div></div>","PeriodicalId":11070,"journal":{"name":"Developmental biology","volume":"522 ","pages":"Pages 20-29"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A career as a biologist-a lifelong morphogenetic process","authors":"David R. Sherwood","doi":"10.1016/j.ydbio.2025.03.002","DOIUrl":"10.1016/j.ydbio.2025.03.002","url":null,"abstract":"<div><div>How life emerged, how species diversify and interact, how cells work individually and collectively, and how a single cell gives rise to the trillions that constitute us all, are some of life's most profound questions. For the last 20 years, I've been a professor in the Biology Department at Duke University and spent summers teaching at the Marine Biological Laboratory in Woods Hole. I use the small nematode worm <em>C</em>. <em>elegans</em> in my research to understand cell-extracellular matrix interactions, and I've taught and mentored hundreds of undergraduate students, graduate students, postdocs and many junior faculty. Young scientists often become discouraged during their training—the modest pay, the long hours, and the herculean task and many setbacks that occur conducting research, writing grants and papers, teaching, and managing a lab. It can seem to be an impossible challenge and leads many young scientists to curtail their training and leave fulfilling scientific careers. A core element to success is that scientific skills and expertise evolve slowly over an entire career through engagement—learning by doing—and requires patience, acceptance of failures, continual exploration, and a flexible growth mindset. Everyone also takes a unique path and there is no simple rulebook. This is difficult to convey through courses and workshops. By sharing some tools and approaches I've learned through my own setbacks, observations, and reading, I hope to help junior scientists view challenges in this career more as lifelong opportunities for building new skillsets and growth, much like the emergence of form and function that occurs during developmental morphogenesis. Embracing constant change and evolution can lead to a deeply meaningful and fulfilling career.</div></div>","PeriodicalId":11070,"journal":{"name":"Developmental biology","volume":"522 ","pages":"Pages 1-3"},"PeriodicalIF":2.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anlagen of evo-devo in Fritz Müller's Für Darwin (1864)","authors":"Scott F. Gilbert ,&nbsp;Beatrice Steinert","doi":"10.1016/j.ydbio.2025.03.001","DOIUrl":"10.1016/j.ydbio.2025.03.001","url":null,"abstract":"<div><div><em>Für Darwin</em>, written in the early 1860s by the German zoologist and Darwinist Fritz Müller, articulates many of the concepts foundational to the contemporary field of evolutionary developmental biology, or evo-devo. Working on the Brazilian coast offered him refuge from both religious conservatism and the “great market\" of Prussian academic science. Here, Müller studied the developmental stages of crustacea and used these meticulous observations to critique the extant literature on classification. In so doing, he both provided evidence for Darwin's theory, and extended it to larval forms. In this essay, we situate <em>Für Darwin</em>, published in English as <em>Facts and Arguments for Darwin</em> in 1869, within the landscape of nineteenth century biology. We propose that <em>Für Darwin</em> is a remarkably prophetic text in the history of developmental biology given its sharp insight into the relationship between development and evolution (ontogeny and phylogeny), its many contributions to crustacean biology, and Müller's deep appreciation of the danger of scientific dogma.</div></div>","PeriodicalId":11070,"journal":{"name":"Developmental biology","volume":"522 ","pages":"Pages 4-7"},"PeriodicalIF":2.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"mRNA splicing variants of the transcription factor Blimp1 differentially regulate germline genes in echinoderms","authors":"Gerardo Reyes,&nbsp;Nathalie Oulhen,&nbsp;Gary Wessel","doi":"10.1016/j.ydbio.2025.02.016","DOIUrl":"10.1016/j.ydbio.2025.02.016","url":null,"abstract":"<div><div>Germ cell specification is an essential step in sexually reproducing animals. Echinoderms possess diverse representatives of the main mechanisms that result in this cell fate determination. Sea urchins use an inherited mechanism, whereas sea stars rely on the ancestral, induced mechanism. Blimp1 (B lymphocyte-induced maturation protein-1) is a transcriptional regulator reported in mice to function in the induction of germline cells. Here, we identify the dynamic function of Blimp1 during development in a comparative approach using the purple sea urchin, <em>Strongylocentrotus purpuratus</em> (inherited germline) and the batstar, <em>Patiria miniata</em> (induced germline). We found that Blimp1 is important for germ cell specification in both species and that multiple Blimp1 isoforms result from differential mRNA splicing in each animal. Each isoform of Blimp1 functions in distinct expression of germline determinants, including Vasa and Nanos. These results show that Blimp1 is a conserved and key regulator for germ cell specification, but divergent in function as a result of post-transcriptional modification. Overall, we conclude that Blimp1 is an intersectional node in diverse germline specification strategies and supports the concept that differential mRNA splicing is an essential mechanism in germ cell formation.</div></div>","PeriodicalId":11070,"journal":{"name":"Developmental biology","volume":"522 ","pages":"Pages 8-19"},"PeriodicalIF":2.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scientific case for revisiting the embryonic chicken model in biomedical research","authors":"Mike J. McGrew ,&nbsp;Tana Holmes ,&nbsp;Megan G. Davey","doi":"10.1016/j.ydbio.2025.02.013","DOIUrl":"10.1016/j.ydbio.2025.02.013","url":null,"abstract":"<div><div>The availability of fertilised chicken eggs and the accessibility and rapid development of the avian embryo, have been utilised in biomedical scientific research to make fundamental discoveries including of developmental processes that are common to all vertebrates, advances in teratology, the understanding of tumour growth and metastasis, angiogenesis, cancer drug assessment and vaccine development as well as advances in understanding avian specific biology. However, recent innovations in chicken transgenesis, genome engineering and surrogate host technology in chickens have only been utilised in a few of these fields of research, specifically some areas of developmental biology, avian sex determination and immunology. To understand why other biomedical fields have not adopted modern chicken transgenic tools, we investigated the non-technical summaries of projects granted in the <span>UK</span> under the Animals (Scientific Procedures) Act 1986 between 2017 and 2023 to assess when and how chicken embryos are used in research, and if they were considered as a Replacement model for other species.</div></div>","PeriodicalId":11070,"journal":{"name":"Developmental biology","volume":"522 ","pages":"Pages 220-226"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental life history transitions can be shaped by structural inequities: Insights from the sociology of race","authors":"Sarah McMenamin,&nbsp;Latrica Best","doi":"10.1016/j.ydbio.2025.02.017","DOIUrl":"10.1016/j.ydbio.2025.02.017","url":null,"abstract":"<div><div>Life history emerges as developmental processes play out over the lifespan of an organism, and the concept of life history intersects with evolutionary biology, ecology, demographics and sociology. Here, we briefly outline the interdisciplinary concept of life history, surveying some of the diversity in life history transitions across animal species, and exploring these transitions as genetically and hormonally-regulated developmental processes. We review some of the data suggesting that social structures are capable of shifting the timing of human life history transitions, with implications for lifetime health outcomes. Social and structural inequity in contemporary society tends to accelerate developmental life history processes, which can create temporal and physiological pressures that intersect with and amplify disadvantage. Focusing specifically on the experiences of Black women in the U.S., we examine the impacts of inequity on the timing of four developmental life history transitions: birth, puberty, first reproduction and menopause. We identify some of the important overlaps between developmental biology, sociology and public health, arguing that these disciplinary intersections can be introduced in many developmental biology classrooms. We propose some pedagogical frameworks designed to help students grow an awareness of how developmental processes can be affected by social inequities, with the ultimate goal of stimulating more cross-disciplinary conversations about life histories and their intersections with social structures.</div></div>","PeriodicalId":11070,"journal":{"name":"Developmental biology","volume":"522 ","pages":"Pages 40-50"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the 1948 discovery of the apical ectodermal ridge in proximal-distal limb development to FGF molecular signals","authors":"Lee A. Niswander","doi":"10.1016/j.ydbio.2025.02.015","DOIUrl":"10.1016/j.ydbio.2025.02.015","url":null,"abstract":"<div><div>This article, and indeed the foundation for much of the study of limb development, starts from the observations by then graduate student John Saunders. In 1948, Dr. Saunders published his thesis work “The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm”. These pioneering studies showed that the apical ectodermal ridge or AER is required for outgrowth and patterning of the chick limb. This mini-review highlights Dr. Saunders’ work and subsequent investigations to uncover the molecular mechanisms underlying proximal-distal development of the vertebrate limb.</div></div>","PeriodicalId":11070,"journal":{"name":"Developmental biology","volume":"521 ","pages":"Pages 149-152"},"PeriodicalIF":2.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}