Dental materials journal最新文献_第3页

Biochemical and transcriptomic characterization of low-molecular-weight fucoidan with potential applications in oral biomaterials. 低分子量岩藻糖聚糖在口腔生物材料中的潜在应用的生化和转录组学表征。

IF 1.8 4区医学

Dental materials journal Pub Date : 2026-07-25 Epub Date: 2026-06-20 DOI: 10.4012/dmj.2025-314

Shunya Oka, Takashi Kameda, Daisuke Torii, Takeo W Tsutsui, Shuichi Tsubura, Akane Imai

{"title":"Biochemical and transcriptomic characterization of low-molecular-weight fucoidan with potential applications in oral biomaterials.","authors":"Shunya Oka, Takashi Kameda, Daisuke Torii, Takeo W Tsutsui, Shuichi Tsubura, Akane Imai","doi":"10.4012/dmj.2025-314","DOIUrl":"10.4012/dmj.2025-314","url":null,"abstract":"Fucoidan is a sulfated polysaccharide from brown algae with potential as a marine-derived biomaterial for oral healthcare. This study compared crude fucoidan, purified fucoidan, and low-molecular-weight fucoidan (LMF) to clarify the relationship between physicochemical properties and biological activity. Iodine content was quantified by mass spectrometry, collagenase inhibition against MMP-8 and MMP-13 and antioxidant capacity were evaluated using biochemical assays, and cellular responses were assessed in oral squamous carcinoma (SAS) cells and normal fibroblasts. Among the preparations, LMF showed the highest iodine content and the strongest inhibition of collagenases and reactive oxygen species. Fucoidan selectively reduced the viability of SAS cells while sparing fibroblasts. RNA sequencing revealed activation of apoptosis-related pathways and suppression of survival signaling in SAS cells, whereas fibroblasts exhibited stress-adaptive transcriptional profiles. These results indicate that LMF exerts selective cytotoxic and tissue-protective effects, supporting its application as a functional dental biomaterial.","PeriodicalId":11065,"journal":{"name":"Dental materials journal","volume":" ","pages":"437-449"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monomer conversion, surface microhardness, elemental release, surface mineral precipitation, and cytotoxicity of ion-releasing resin sealant. 离子释放树脂密封胶的单体转化、表面显微硬度、元素释放、表面矿物沉淀和细胞毒性。

IF 1.8 4区医学

Dental materials journal Pub Date : 2026-07-25 Epub Date: 2026-06-26 DOI: 10.4012/dmj.2025-299

Papitchaya Boonpatumpong, Thanya Sitthisettapong, Piyaporn Pultanasarn, Parichart Naruphontjirakul, Anne M Young, Piyaphong Panpisut

{"title":"Monomer conversion, surface microhardness, elemental release, surface mineral precipitation, and cytotoxicity of ion-releasing resin sealant.","authors":"Papitchaya Boonpatumpong, Thanya Sitthisettapong, Piyaporn Pultanasarn, Parichart Naruphontjirakul, Anne M Young, Piyaphong Panpisut","doi":"10.4012/dmj.2025-299","DOIUrl":"10.4012/dmj.2025-299","url":null,"abstract":"This study evaluated the monomer conversion (DC), surface microhardness, elemental release, and cytotoxicity of experimental dental sealants containing monocalcium phosphate monohydrate (MCPM), strontium/fluoride-bioactive glass nanoparticles (Sr/F-BAGs), and ε-polylysine. Experimental sealants with (TS1) and without additives (TS0) were compared to commercial sealants (Clinpro and BeautiSealant). DC was measured after light-curing for 40 s. Surface microhardness and elemental release in deionized water were determined after 4-week water storage. Cell viability of the extract was also examined. TS1 exhibited a DC of 82%, significantly higher than commercial materials (65-73%, p<0.05). Surface microhardness of TS1 (14.8 VHN) was comparable to commercial sealants (p>0.05). TS1 released Ca, Sr, and P ions, while commercial materials released mainly fluoride. All materials showed >70% cell viability. The experimental dental sealant demonstrated satisfactory polymerization and mechanical properties with enhanced multi-ion release, suggesting potential for improved bioactivity of the material to help prevent caries associated with restoration and sealant (CARS).","PeriodicalId":11065,"journal":{"name":"Dental materials journal","volume":" ","pages":"491-499"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of strontium-incorporated micro-nano structured titanium surfaces on osseointegration through mediating macrophage polarization. 锶掺入微纳结构钛表面通过介导巨噬细胞极化对骨整合的影响。

IF 1.8 4区医学

Dental materials journal Pub Date : 2026-07-25 Epub Date: 2026-06-24 DOI: 10.4012/dmj.2025-109

Zening Wei, Wang Fei, Yu Liu, Xiao Wang

{"title":"Impacts of strontium-incorporated micro-nano structured titanium surfaces on osseointegration through mediating macrophage polarization.","authors":"Zening Wei, Wang Fei, Yu Liu, Xiao Wang","doi":"10.4012/dmj.2025-109","DOIUrl":"10.4012/dmj.2025-109","url":null,"abstract":"Titanium implants require surface modifications to overcome biological inertia and enhance osteointegration. Macrophage polarization is critical in regulating osteogenesis which affects inflammation and tissue repair. Strontium has been shown to enhance bone formation, and Sr2+ ions have also been found to influence immune responses and inflammation, suggesting potential applications in bone repair and regeneration. Our research utilized phase-transited lysozyme (PTL) surface modification to immobilize Sr2+ ions within the PTL coating, thereby obtaining two distinct morphological coatings: Sr-incorporation PTL-nanofilm (PSR-nanofilm) and Sr-incorporation PTL-coating (PSR-coating). Through a combination of in vitro and in vivo experimental approaches, this study demonstrated that PSR-coating implants with rough titanium surfaces enhance osteogenesis compared to PSR-nanofilm implants. This effect is attributed to their ability to polarize macrophages into the pro-inflammatory M1 phenotype during the early stage of implantation, followed by a transition to the anti-inflammatory M2 phenotype at a later stage via the sustained release of Sr2+.","PeriodicalId":11065,"journal":{"name":"Dental materials journal","volume":" ","pages":"530-540"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved biostability of collagen in sound and caries-affected dentin using an integrated crosslinking-remineralization treatment. 使用交联-再矿化综合治疗改善健全和龋齿影响牙本质中胶原蛋白的生物稳定性。

IF 1.8 4区医学

Dental materials journal Pub Date : 2026-07-25 Epub Date: 2026-05-23 DOI: 10.4012/dmj.2025-154

Nisar Saleha, Viviane Hass, Yong Wang

{"title":"Improved biostability of collagen in sound and caries-affected dentin using an integrated crosslinking-remineralization treatment.","authors":"Nisar Saleha, Viviane Hass, Yong Wang","doi":"10.4012/dmj.2025-154","DOIUrl":"10.4012/dmj.2025-154","url":null,"abstract":"This study investigated a combined strategy using collagen crosslinking and polymer-induced liquid precursors (PILP)-based remineralization to enhance collagen biostability and resistance to collagenase degradation in sound (SD), denatured (DD), and caries-affected dentin (CAD). Ultra-thin demineralized collagen films and acid-etched dentin beams with demineralized layers (DL) were treated with 1% cranberry-extract (CR) collagen crosslinker for 30 s, followed by PILP remineralization for 1-7 days. Biostability was assessed by collagenase-induced weight loss and hydroxyproline release; structural and remineralization changes were evaluated via electron microscopes. Both CR and PILP individually improved collagen biostability, with greater effects in SD than DD. CR crosslinking was more effective than PILP alone. Notably, the combined CR-PILP approach produced the greatest enhancement in biostability. Electron microscopes confirmed that this dual treatment preserved the DL from enzymatic digestion and dramatically accelerated mineral deposition in both SD and CAD. These findings support the potential of this synergistic strategy for improving dentin restoration durability.","PeriodicalId":11065,"journal":{"name":"Dental materials journal","volume":" ","pages":"385-395"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-functional TiO₂-containing phosphate glass prepared by the liquid phase method: Ion release and photocatalysis. 液相法制备双功能二氧化钛磷酸盐玻璃：离子释放和光催化。

IF 1.8 4区医学

Dental materials journal Pub Date : 2026-07-25 Epub Date: 2026-07-02 DOI: 10.4012/dmj.2026-084

Hayato Asano, Shota Shiraki, Makoto Sakurai, Fukue Nagata, Kumiko Yoshihara, Sungho Lee

{"title":"Dual-functional TiO2-containing phosphate glass prepared by the liquid phase method: Ion release and photocatalysis.","authors":"Hayato Asano, Shota Shiraki, Makoto Sakurai, Fukue Nagata, Kumiko Yoshihara, Sungho Lee","doi":"10.4012/dmj.2026-084","DOIUrl":"10.4012/dmj.2026-084","url":null,"abstract":"The objective of the work was to prepare dual-functional TiO2-containing phosphate glasses to integrate ion-releasing ability and photocatalytic activity into a single material system. The glasses were prepared using the liquid phase method. The obtained glasses exhibited an amorphous structure and were composed of orthophosphate and pyrophosphate groups, which can therefore be classified as phosphate invert glasses. Structural analyses showed that titanium existed in both TiO4 tetrahedral and TiO6 octahedral coordination environments. The aging process promoted the formation of TiO6-rich phases on the glass surface. Glasses that were heat-treated at 600°C exhibited partial crystallization of anatase TiO2 while retaining the amorphous phosphate glass matrix. The heat-treated glass exhibited photocatalytic activity under UV irradiation, as confirmed by methylene blue degradation, while maintaining sustained ion release. Therefore, TiO2-containing phosphate glasses exhibit dual functionality, combining therapeutic ion release and photocatalytic activity. The properties of the obtained glasses may stimulate beneficial physiological responses and provide antibacterial effects, supporting their potential application as dual-functional dental biomaterials.","PeriodicalId":11065,"journal":{"name":"Dental materials journal","volume":" ","pages":"508-519"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The antibacterialactivity of Barangan (Musa acuminata Colla) peel on Streptococcus mutans: In silico and in vitro study. 芭蕉果皮对变形链球菌的抑菌活性：体外和体外研究。

IF 1.8 4区医学

Dental materials journal Pub Date : 2026-07-25 Epub Date: 2026-06-13 DOI: 10.4012/dmj.2026-010

Astrid Yudhit, Sondang Pintauli, Ellyza Herda, Aminah Dalimunthe

引用次数: 0

Engineering bio-selectivity: Novel denture coatings for targeted inhibition of denture-associated pathogens. 工程生物选择性：用于义齿相关病原体靶向抑制的新型义齿涂层。

IF 1.8 4区医学

Dental materials journal Pub Date : 2026-07-25 Epub Date: 2026-07-01 DOI: 10.4012/dmj.2026-037

Yulong Zhang, Tingxi Wu, Erica Dorigatti de Avila, Renate Lux, Wenyuan Shi, Benjamin M Wu

{"title":"Engineering bio-selectivity: Novel denture coatings for targeted inhibition of denture-associated pathogens.","authors":"Yulong Zhang, Tingxi Wu, Erica Dorigatti de Avila, Renate Lux, Wenyuan Shi, Benjamin M Wu","doi":"10.4012/dmj.2026-037","DOIUrl":"10.4012/dmj.2026-037","url":null,"abstract":"The increasing prevalence of denture use, particularly among the elderly population, necessitates effective strategies against Candida-containing polymicrobial biofilms. This study investigated novel temporary (biocompatible hydrogel) and permanent (sealant) denture coatings designed to selectively inhibit associated pathogens. Seven biomaterials were screened using minimum inhibitory concentration (MIC) assays against Candida albicans, Fusobacterium nucleatum, and Streptococcus mutans. Coatings were applied to acrylic surfaces and evaluated for physicochemical properties and antimicrobial efficacy using biofilm models and colony-forming unit (CFU) counting. Results demonstrated that poly(ethylene glycol) diacrylate / titanium dioxide (PEGDA/TiO2) and Sealant/TiO2 formulations exhibited significant, selective antimicrobial activity. This efficacy is attributed to altered surface hydrophilicity and the specific mechanisms of incorporated agents. These findings underscore the potential of biocompatible, bio-selective coatings in preventing denture-associated infections. Additional research involving a broader spectrum of oral microbes is required to further validate these preventive applications.","PeriodicalId":11065,"journal":{"name":"Dental materials journal","volume":" ","pages":"481-490"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of β-tricalcium phosphate/polyacrylic acid composite granules as a potential bone substitute. 作为潜在骨替代品的β-磷酸三钙/聚丙烯酸复合颗粒的制备。

IF 1.8 4区医学

Dental materials journal Pub Date : 2026-07-25 Epub Date: 2026-07-01 DOI: 10.4012/dmj.2025-318

Tansza Setiana Putri, Dianayu Noviani Soesianto Putri, Eddy, Abida Zhafira Inayasary, Rosalina Tjandrawinata, Dewi Liliany Margaretta, Le Thi Bang

{"title":"Fabrication of β-tricalcium phosphate/polyacrylic acid composite granules as a potential bone substitute.","authors":"Tansza Setiana Putri, Dianayu Noviani Soesianto Putri, Eddy, Abida Zhafira Inayasary, Rosalina Tjandrawinata, Dewi Liliany Margaretta, Le Thi Bang","doi":"10.4012/dmj.2025-318","DOIUrl":"10.4012/dmj.2025-318","url":null,"abstract":"Composite granules of β-tricalcium phosphate (βTCP) derived from limestone were fabricated by mixing with polyacrylic acid (PAA) for potential bone substitute applications. Samples with varying ratios were evaluated using X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), porosity analysis, and diametral tensile strength (DTS) testing. XRD confirmed the crystalline nature of βTCP, with peak intensities increasing as βTCP content increased. FTIR showed C=O stretching of -COOH and symmetric COO- vibrations, with νs(COO-) bands appearing in composites, indicating interactions between PAA and βTCP through Ca2+-carboxylate coordination. SEM revealed a porous structure in the composite granules, with pore size increased with βTCP content. Porosity was higher in all composite granules compared to PAA granules, while DTS values improved with increasing βTCP, indicating enhanced mechanical strength. In conclusion, composite granules were successfully fabricated by mixing βTCP derived from limestone with PAA, exhibiting promising characteristics as synthetic bone substitutes.","PeriodicalId":11065,"journal":{"name":"Dental materials journal","volume":" ","pages":"464-469"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of environmental humidity during bonding on the bond strength of self-etch adhesives. 粘接时环境湿度对自蚀刻胶粘剂粘接强度的影响。

IF 1.8 4区医学

Dental materials journal Pub Date : 2026-07-25 Epub Date: 2026-06-13 DOI: 10.4012/dmj.2025-275

Takaaki Sato, Maho Shiozawa, Masaomi Ikeda

引用次数: 0

Analysis and optimization of Biodentine with cefixime-loaded zinc oxide nanoparticles in terms of mechanical properties and hydrolytic degradation. 头孢昔肟氧化锌纳米颗粒生物奥登汀的力学性能和水解降解分析与优化。

IF 1.8 4区医学

Dental materials journal Pub Date : 2026-07-25 Epub Date: 2026-06-20 DOI: 10.4012/dmj.2025-306

Abida Saleem, Hafiz Mohammad Mutee Ur Rehman, Nosheen Fatima Rana, Asmaa Ejaz Khan, Gotam DAS, Ghazala Suleman, Rania A Sharif, Tahira Saleem

{"title":"Analysis and optimization of Biodentine with cefixime-loaded zinc oxide nanoparticles in terms of mechanical properties and hydrolytic degradation.","authors":"Abida Saleem, Hafiz Mohammad Mutee Ur Rehman, Nosheen Fatima Rana, Asmaa Ejaz Khan, Gotam DAS, Ghazala Suleman, Rania A Sharif, Tahira Saleem","doi":"10.4012/dmj.2025-306","DOIUrl":"10.4012/dmj.2025-306","url":null,"abstract":"This study focuses on optimizing Biodentine by incorporating zinc oxide nanoparticles (ZnO NPs) loaded with the antimicrobial agent cefixime to enhance both its mechanical properties and antibacterial efficacy. ZnO NPs were synthesized using zinc acetate dihydrate and oxalic acid via the sol-gel method, and cefixime was loaded through solvent-mediated techniques. Characterization via Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), UV-visible spectrophotometry (UV-Vis), and zeta potential confirmed the successful formation and stability of the nanoparticles. These drug-loaded NPs were then integrated into Biodentine for mechanical and structural evaluation. Results showed improved surface area, microhardness (Vickers), compressive strength, and reduced solubility without significantly altering the setting time. Energy dispersive X-ray spectroscopy (EDX) and SEM analyses confirmed uniform nanoparticle dispersion and elemental composition, while pH remained within safe limits. The modified Biodentine demonstrated superior performance and antimicrobial potential, making it promising for long-term dental restorations. The study concludes that ZnO-cefixime nanocomposite Biodentine offers dual advantages of mechanical strength and infection control.","PeriodicalId":11065,"journal":{"name":"Dental materials journal","volume":" ","pages":"470-480"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0