Current Research in Pharmaceutical Sciences最新文献_第5页

COMPARATIVE IN VITRO EVALUATION OF SOME COMMERCIAL BRANDS OF RAMIPRIL TABLETS MARKETED IN INDIA 在印度销售的一些商业品牌雷米普利片的比较体外评价

Current Research in Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.24092/crps.2022.120105

G. P D, S. K L, V. V, S. V, V. ., K. a, M. K, T. T

引用次数: 0

PROCESS VALIDATION AND GC ANALYSIS OF PATHADISURA, A FERMENTED AYURVEDIC PRODUCT USED IN SHWAS VYADHI [BRONCHIAL ASTHMA] 用于治疗支气管哮喘的阿育吠陀发酵产品pathadisura的工艺验证及gc分析

Current Research in Pharmaceutical Sciences Pub Date : 2022-01-08 DOI: 10.24092/crps.2021.110405

M. Pawar, Neelakantha Khadatar

引用次数: 0

A SHORT REVIEW ON ADVANCEMENT IN FAST DISSOLVING ORAL THIN FILMS 口腔快溶薄膜研究进展综述

Current Research in Pharmaceutical Sciences Pub Date : 2022-01-08 DOI: 10.24092/crps.2021.110404

Lakshita Rathore, Narendra Gehalot, V. Jain

{"title":"A SHORT REVIEW ON ADVANCEMENT IN FAST DISSOLVING ORAL THIN FILMS","authors":"Lakshita Rathore, Narendra Gehalot, V. Jain","doi":"10.24092/crps.2021.110404","DOIUrl":"https://doi.org/10.24092/crps.2021.110404","url":null,"abstract":"The pharmaceutical industry is pursuing the development of thin films as a novel method of drug administration. Thin films as an alternative to standard dosage forms have been described. They are a very adaptable platform capable of producing immediate, local, or systemic effects. Additionally, these systems are self-administered, which is advantageous for patients with dysphagia, elderly, pediatric, or bedridden patients and those who cannot administer with water. Thin film drug delivery methods are available for oral, buccal, sublingual, ophthalmic, and transdermal administration. This review explores oral thin films in all of their elements from a contemporary standpoint and provides insight into the world's expanding market share due to the expansion of study areas and technical advancements. Simultaneously, it presents an overview of the essential parameters that affect formulation design that affects thin films, including thin-film design, anatomical and physiological constraints, and the selection of suitable manufacturing processes, characterization methodologies, and the physicochemical properties of polymers and drugs are all covered in this section. Additionally, it provides insight onto the most recent thin-films produced by various pharmaceutical companies. KEYWORDS: Fast dissolving films, patient compliance, dysphagia, oral, buccal,sublingual.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88805168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A REVIEW ON IN SITU GELLING SYSTEM FOR OPHTHALMIC DRUG DELIVERY 眼内给药原位胶凝系统研究进展

Current Research in Pharmaceutical Sciences Pub Date : 2022-01-08 DOI: 10.24092/crps.2021.110402

Urvashi Vyas, Narendra Gehalot, V. Jain, S. Mahajan

{"title":"A REVIEW ON IN SITU GELLING SYSTEM FOR OPHTHALMIC DRUG DELIVERY","authors":"Urvashi Vyas, Narendra Gehalot, V. Jain, S. Mahajan","doi":"10.24092/crps.2021.110402","DOIUrl":"https://doi.org/10.24092/crps.2021.110402","url":null,"abstract":"Ophthalmic drug delivery systems are both fascinating and problematic due to the normal physiological properties of the eyes, which restrict ocular product bioavailability. The development of novel ocular dosage forms for current drugs in order to enhance efficacy and bioavailability, as well as patient compliance and convenience, has become a major focus in the pharmaceutical business. Ocular In-situ gelling systems are a novel type of eye drug delivery systems that begin as a solution but rapidly convert into a thick gel when implanted or inserted into an ocular cavity where active pharmaceuticals are continually delivered. This sol-to-gel phase conversion is influenced by a range of variables, including variations in pH, the presence of ions, and temperature fluctuations. Post-transplantation gel is chosen for its viscosity and bio adhesive qualities, which prolongs the gel's presence in the ocular area and also ensures that the medicine is released slowly and continuously, in contrast to typical eye drops and ointments. This article provides an overview of situ gels, their numerous techniques of gelling, the many types of polymers utilized in situ gels, their gel-based methodologies, and the polymeric testing of situ gels. KEYWORDS: Ophthalmic, In situ gel, bioavailability, polymers, novel, sol-to-gel phase","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79958089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VALUATING CLINICAL APPLICATIONS OF LIQUID BIOPSY BY COMBINING CIRCULATING TUMOR DNA AND TUMOR CELLS 循环肿瘤DNA与肿瘤细胞结合液体活检的临床应用价值评价

Current Research in Pharmaceutical Sciences Pub Date : 2022-01-08 DOI: 10.24092/crps.2021.110403

Vishnu P. Tripathi, M. K. Aneebuddin, C. Alex, Keshav Moharir

{"title":"VALUATING CLINICAL APPLICATIONS OF LIQUID BIOPSY BY COMBINING CIRCULATING TUMOR DNA AND TUMOR CELLS","authors":"Vishnu P. Tripathi, M. K. Aneebuddin, C. Alex, Keshav Moharir","doi":"10.24092/crps.2021.110403","DOIUrl":"https://doi.org/10.24092/crps.2021.110403","url":null,"abstract":"\"Liquid biopsy\" concentrates on the identification of ‘Circulating Tumor Cells (CTC) as well as ‘Cell-free Tumor DNA’ (ctDNA) in the systemic circulation of individuals suffering from cancer, has received a lot of interest due to its evident clinical implications for individualized therapy. CTC and ctDNA studies have created fresh diagnostic approaches and are now the foundations of liquid biopsy. The existing study concentrates on cancer diagnoses, prognosis prediction in people having treatable diseases, observing systemic therapy, and patient categorization depending on the identification of aimed therapeutics or resistance mechanisms. Although the use of CTCs and ctDNA for initial cancer diagnosis is gaining popularity, existing techniques experience major challenges in terms of particularity and sensitivity. Prognosis projection in people with the treatable disease so far realized in some cancer entities, especially in breast cancer. Sequential assessments of CTCs or ctDNA can also be used to monitor the progress or non-success of systemic medicines (such as hormone and chemotherapy as well as various targeted therapies).To integrate liquid diagnostic tests into personalized medicine, interventional studies on therapy stratification based on CTC and ctDNA analyses are required. KEYWORDS: Tumor cells, DNA, Circulating cells, Chemotherapy, Liquid biopsy","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78232672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RECENT ADVANCEMENT AND CHALLENGES IN BILAYER TABLET TECHNOLOGY: AN OVERVIEW 双层片剂技术的最新进展和挑战:综述

Current Research in Pharmaceutical Sciences Pub Date : 2022-01-08 DOI: 10.24092/crps.2021.110401

Farida Nizami, Yogendra Malviya

{"title":"RECENT ADVANCEMENT AND CHALLENGES IN BILAYER TABLET TECHNOLOGY: AN OVERVIEW","authors":"Farida Nizami, Yogendra Malviya","doi":"10.24092/crps.2021.110401","DOIUrl":"https://doi.org/10.24092/crps.2021.110401","url":null,"abstract":"Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermined release of two drugs in combination, separating two incompatible substances, and sustained-release tablets with one layer serving as the loading dose and the second layer serving as the maintenance dose. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. However, bilayer tablet technology is resource-intensive. A thorough selection of excipients and manufacturing conditions for each technical stage is also required. The purpose of this paper is to summarize the state of art in bilayer tablet technology and to highlight the difficulties encountered during bilayer tablet manufacture, as well as the possible solutions for these obstacles. KEYWORDS: Bilayer tablet, Conventional release, Controlled release, Sustained release, Maintenance dose","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88180196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

TULSI: A MIRACLE HERB USED IN THE TREATMENT OF MANY ILLNESSES: A REVIEW 图尔西:一种神奇的草药，用于治疗许多疾病:回顾

Current Research in Pharmaceutical Sciences Pub Date : 2021-10-08 DOI: 10.24092/crps.2021.110301

Prabhakar Maurya, M. Naim, R. K. Singh, J. Bashar, Radhe Shyam

引用次数: 0

ROLE OF DRUG DISCOVERY IN CENTRAL NERVOUS SYSTEM DISORDERS: AN OVERVIEW 药物发现在中枢神经系统疾病中的作用:综述

Current Research in Pharmaceutical Sciences Pub Date : 2021-10-08 DOI: 10.24092/crps.2021.110302

Mohit Gupta, R. Shekhar, J. Sahu

{"title":"ROLE OF DRUG DISCOVERY IN CENTRAL NERVOUS SYSTEM DISORDERS: AN OVERVIEW","authors":"Mohit Gupta, R. Shekhar, J. Sahu","doi":"10.24092/crps.2021.110302","DOIUrl":"https://doi.org/10.24092/crps.2021.110302","url":null,"abstract":"Central nervous system (CNS) stimulants are drugs, which produce a response that could be used to alleviate a particular medical condition. These are the agents, which speed up to treat conditions characterized by lack of adrenergic stimulation, including narcolepsy and neonatal apnea. The majority of CNS stimulants is chemically similar to the neurohormone norepinephrine and simulates the traditional \"fight or flight\" syndrome associated with sympathetic nervous system arousal. A small figure of added members of the CNS stimulant class do not fall into definite chemical groups. The review on central nervous system stimulants gives detail study of CNS stimulant drugs, their mechanism of action and in vivo models of CNS stimulants. The brain is a delicate tissue, and advancement built very effective methods to guard it. Unfortunately, the same mechanisms that protect it against intrusive chemicals can also upset therapeutic interventions. Many current medications are rendered unsuccessful in the treatment of cerebral maladies due to our incapability to efficiently deliver and sustain them within the brain. KEYWORDS: CNS Stimulants, Blood brain barrier (BBB), Drug toxicity, Drug Safety","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82069536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LANSOPRAZOLE BY SOLUBILITY ENHANCEMENT TECHNIQUE 溶度增强法制备兰索拉唑快溶片及评价

Current Research in Pharmaceutical Sciences Pub Date : 2021-07-08 DOI: 10.24092/crps.2021.110203

Arti Choursiya, D. Pandit

{"title":"FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LANSOPRAZOLE BY SOLUBILITY ENHANCEMENT TECHNIQUE","authors":"Arti Choursiya, D. Pandit","doi":"10.24092/crps.2021.110203","DOIUrl":"https://doi.org/10.24092/crps.2021.110203","url":null,"abstract":"The present study was focused on preparation and evaluation of Lanzoprazole fast dissolving tablets. Lansoprazole (LAN) is a proton pump inhibitor drug and used for the treatment of gastric ulcer. Lansoprazole is acid labile drug and to avoid the acidic pH of the stomach LAN is formulated as oral fast dissolving tablets. Lansoprazole is the class II drug of the BCS classification and has a low aqueous solubility. Hence, to improve the solubility of the drug we have prepared Lansoprazole solid dispersion with poly ethylene glycol and complex with β cyclodextrin. Fast Dissolving tablets of LAN were formulated using different superdisintegrants like Sodium Starch Glycolate, Cross Povidone, Cross Carmellose Sodium by direct compression method. The prepared fast dissolving tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug content, wetting time, in-vitro drug release and short term stability studies. Percentage weight variation, hardness, friability and drug content uniformity were found to be within the approved range for all the formulations. The in-vitro release studies showed that 99.6% of LAN within 90 sec. Overall, in the formulations prepared by the direct compression method, F3, which contains 6% CCS as super disintegrants release 99% of (LAN) in 2 min was found to be the best formulation. The results concluded that fast dissolving tablets of LAN showing enhanced dissolution might lead to improved bioavailability and effective therapy for gastric ulcer. KEYWORDS: β cyclodextrin, Cross Povidone, Fast dissolving tablets, Gastric ulcer, Lanzoprazole, Solid dispersion","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81455625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

SIMULTANEOUS ESTIMATION OF LORNOXICAM AND PARACETAMOL IN COMBINED TABLET DOSAGE FORM USING REVERSE PHASE HIGH- PERFORMANCE LIQUID CHROMATOGRAPHY METHOD 反相高效液相色谱法同时测定复方片中氯诺昔康和扑热息痛的含量

Current Research in Pharmaceutical Sciences Pub Date : 2021-07-08 DOI: 10.24092/crps.2021.110202

Prabhakar Maurya, M. Naim, N. Sharma

引用次数: 0