Current Research in Pharmaceutical Sciences最新文献_第6页

A REVIEW ON AN EMERGIN TREND BILAYER FLOATING DRUG DELIVERY SYSTEM 新型双层漂浮给药系统的研究进展

Current Research in Pharmaceutical Sciences Pub Date : 2021-07-08 DOI: 10.24092/crps.2021.110201

Anjali Chourasiya, Narendra Gehalot, S. Mahajan

{"title":"A REVIEW ON AN EMERGIN TREND BILAYER FLOATING DRUG DELIVERY SYSTEM","authors":"Anjali Chourasiya, Narendra Gehalot, S. Mahajan","doi":"10.24092/crps.2021.110201","DOIUrl":"https://doi.org/10.24092/crps.2021.110201","url":null,"abstract":"NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. Novel drug delivery system have been developed to overcome the limitation of conventional drug delivery systems, such as of gastric retention by decreasing fluctuations in the concentration of the drug in blood,resulting in the reduction in unwanted toxicity and poor efficiency. As compared to traditional dosage forms bilayer tablets are more efficient for sequential release of two drugs that can be different or identical. Bilayer tablet is also capable of separating two incompatible substances and also for sustained release. Gastro retentive drug delivery system retains the period of dosage forms in the stomach or upper gastro intes-tinal tract ,as to improve bioavailability and the therapeutic efficacy of the drugs. Mainly the bilayer drug delivery system is suitable for drugs whose therapethic windows are narrow in the gastrointestinal tract (GIT) and also they have low elimination half life: 3-4 h. The purpose of this review is to disclose the challenges faced during the formulation of bilayer tablets. Finally, the whole article is firmly analyzed in a concluding paragraph. KEYWORDS: Conventional drug delivery systems, Bilayer tablet, Gastro retentive, Bioavailability","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86465917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Characterization and Antimicrobial Evaluation of some 1,2,4-Triazolo-5-Thione Derivatives 1,2,4-三唑-5-硫酮衍生物的合成、表征及抗菌性能评价

Current Research in Pharmaceutical Sciences Pub Date : 2021-05-10 DOI: 10.24092/CRPS.2021.110103

Gurdeep Singh, N. Jain, K. Sahu

引用次数: 0

Formulation and Evaluation of Curcumin Loaded Nanoliposome on Brain Targeted 脑靶向姜黄素纳米脂质体的制备与评价

Current Research in Pharmaceutical Sciences Pub Date : 2021-05-10 DOI: 10.24092/CRPS.2021.110104

J. Kumari, Lovely Chaurasia

{"title":"Formulation and Evaluation of Curcumin Loaded Nanoliposome on Brain Targeted","authors":"J. Kumari, Lovely Chaurasia","doi":"10.24092/CRPS.2021.110104","DOIUrl":"https://doi.org/10.24092/CRPS.2021.110104","url":null,"abstract":"The present work aimed to produce Curcumin based nanoliposomes that nanoliposome can target the site via the brain in a controlled manner. Nanoliposomes are important in controlling the carriage; Curcumin which is an active constituent of curcuminoids thus also provides an effective treatment for the central nervous system and plays a crucial role. The interaction of the drug was ruled out by FT-IR studies and no incompatibility and lipids and surfactant. To optimize the formulation, factors affecting the physical appearance of Nanoliposomes were investigated. Curcumin-loaded Nanoliposomes were formulated using cholesterol by physical dispersion method and characterized for particle size, drug content, stability, production yield. Prepared nanoliposomes gave the better physical, morphological concerning the concentration of the lipids, surfactant, and ratio of lipid and surfactant. Six different formulations of Nanoliposomes F1-F6 were formulated to obtain the optimized formulation. The TEM (Transmission Electron Microscopy) of Nanoliposomes showed that they were rounded in shape and porous in texture. In-vitro drug release of formulation indicates that formulation F6 was selected as an optimized formulation for incorporation into the nanoliposomes among all the six formulations and liposome showed drug release in a controlled manner at the end of 10 hours. Keywords: Curcumin, Nanoliposomes, Physical Dispersion Method, Brain Targeting, Blood-Brain Barrier, Cholesterol, Bioavailability, In vitro Release.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90744695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A brief Overview of a Fatal Disease Namely Cancer 一种致命疾病即癌症的简要概述

Current Research in Pharmaceutical Sciences Pub Date : 2021-04-08 DOI: 10.24092/CRPS.2021.110102

Himanshu, Pradumn Kumar Maddheshiya, Mukesh Kumar

引用次数: 0

FORMULATION, DEVELOPMENT AND CHARACTERIZATION OF EFFECTIVE NIOSOMAL DRUG DELIVERY SYSTEM FOR THE TREATMENT OF DIABETES MELLITUS 治疗糖尿病的有效niosomal给药系统的研制与表征

Current Research in Pharmaceutical Sciences Pub Date : 2020-12-31 DOI: 10.24092/crps.2020.100402

Nida Musheer, Vikrant Gupta

{"title":"FORMULATION, DEVELOPMENT AND CHARACTERIZATION OF EFFECTIVE NIOSOMAL DRUG DELIVERY SYSTEM FOR THE TREATMENT OF DIABETES MELLITUS","authors":"Nida Musheer, Vikrant Gupta","doi":"10.24092/crps.2020.100402","DOIUrl":"https://doi.org/10.24092/crps.2020.100402","url":null,"abstract":"In the present study, gliclazide-loaded niosomes are formulated and evaluated for their in vitro as well as in vivo characteristic in an attempt to improve the oral bioavailability of the drug. Formulation of niosomes was optimized for highest percentage of drug entrapment. Microscopic observation confirmed that all particles were uniform in size and shape. The entrapment efficiency was determined by separating the unentrapped drug using dialysis. The in vitro release studies of drug from niosomes exhibited a prolonged drug release as observed over a period of 24 h. The positive values of zeta potential indicated that the gliclazide niosomes were stabilized by electrostatic repulsive forces. Results from stability study have shown that the drug leakage from the vesicles was least at 4ºC followed by 25 and 37ºC. The niosomes showing maximum entrapment and suitable release rate were selected for in vivo evaluation. In conclusion, the niosomal formulation could be a promising delivery system for gliclazide with improved bioavailability and prolonged drug release profile. KEYWORDS: Heme Oxygenase Inhibitor, HO-1, 2D QSAR, 3D QSAR, kNN-MFA","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88544283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FORMULATION AND DEVELOPMENT OF BILAYER FLOATING TABLET OF AMOXICILLIN 阿莫西林双层漂浮片的研制

Current Research in Pharmaceutical Sciences Pub Date : 2020-12-31 DOI: 10.24092/crps.2020.100403

Priyanka Jartolia, S. Kondalkar, A. Kondalkar, Muraree Lal

{"title":"FORMULATION AND DEVELOPMENT OF BILAYER FLOATING TABLET OF AMOXICILLIN","authors":"Priyanka Jartolia, S. Kondalkar, A. Kondalkar, Muraree Lal","doi":"10.24092/crps.2020.100403","DOIUrl":"https://doi.org/10.24092/crps.2020.100403","url":null,"abstract":"Bilayer floating tablet of amoxicillin was formulated successfully and evaluated under suitable parameters. All the batches of tablet produced were found to exhibit short floating lag times. The tablet of batch F2 exhibited a longer floating lag time of 23 minutes. Relationship between the dependent and independent variables was further elucidated using contour and response surface plots. Dissolution profiles that the tablets of batch F3, F7, and F12 exhibits initial burst phase during the first hour of dissolution. The burst phase was followed by a limited drug release for the rest of the period. Also it was observed during the dissolution studies that tablets of all three batches eroded quickly with increased effervescence. Time required for 50 % drug to get released (T50%) and %CR10hrs were found to be in the range of 0.7 to 8.6 hours and 57.35 ± 3.89 to 99.93 ± 0.07 respectively, value of “Prob > F” less than 0. 05. Response surface plots and Contour plot indicated that at a fixed level of B (35 mg) and low level of A (amount of HPMC), % CR10hrs increases from 68.11 to 90.00 % and T50% decrease from 6.86 to 1.66 as the amount of citric acid (C) increases from 0 to 10 mg. Stability study was performed for optimized formulation and it was found that formulation was stable for 6 week at 25 °C/ 60% RH. KEYWORDS: Bilayer floating tablet, amoxicillin, Evaluated, Multi-layered tablet, Stability","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88400688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE ROLE, SCOPE, HEALTH BENEFITS AND MARKET GROWTH OF NUTRACEUTICALS: AN OVERVIEW 营养保健品的作用、范围、健康效益和市场增长:概述

Current Research in Pharmaceutical Sciences Pub Date : 2020-10-08 DOI: 10.24092/crps.2020.100301

Ramila Prajapati, Sanjeev Kumar

{"title":"THE ROLE, SCOPE, HEALTH BENEFITS AND MARKET GROWTH OF NUTRACEUTICALS: AN OVERVIEW","authors":"Ramila Prajapati, Sanjeev Kumar","doi":"10.24092/crps.2020.100301","DOIUrl":"https://doi.org/10.24092/crps.2020.100301","url":null,"abstract":"Nutraceuticals are products used as medicines in addition to nutrition. Nutraceuticals can be defined as substances that have physiological benefits or provide protection against chronic disease. Nutraceuticals can be used to improve health, slow down the aging process, prevent chronic diseases, increase life expectancy or support body structure or function. Nutraceuticals are getting a lot of attention these days because of their potential nutritional, safety and therapeutic benefits. Recent studies have shown that these compounds have promising results in various complications. In this review, we have made a great effort in proposing new concepts for nutraceuticals based on disease indications. Highlights herbal remedies that are effective for harsh therapeutic conditions associated with oxidative stress, including allergies, Alzheimer's disease, cardiovascular disease, cancer, diabetes, eye, immunity, inflammation, and Parkinson's disease and obesity. These nutraceuticals are used in various diseases, their application, and current market demand. Examples of fish oil preparations, prebiotics and probiotics reviewed. KEYWORDS: Nutraceutical, Dietary supplements, Antioxidants, Probiotics, Health benefits","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84924313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVALUATION OF ANTHELMINTIC ACTIVITY OF BAUHINIA VARIEGATA LINN METHANOLIC ROOT EXTRACT ON PHERETIMA POSTHUMA 紫荆花甲醇根提取物对后脑虫的驱虫活性评价

Current Research in Pharmaceutical Sciences Pub Date : 2020-10-08 DOI: 10.24092/crps.2020.100302

A. Jain

引用次数: 0

PHARMACOLOGICAL INVESTIGATIONS OF CYPERUS ROTUNDUS TUBER EXTRACT IN MONOSODIUM GLUTAMATE INDUCED EXPERIMENTAL ANIMAL 香附提取物对味精诱导实验动物的药理作用研究

Current Research in Pharmaceutical Sciences Pub Date : 2020-04-08 DOI: 10.24092/crps.2020.100102

Munesh Kumar, M. Rani, B. Meher

引用次数: 0

NANOSPONGES: A PROMISING NANOCARRIER SYSTEMS FOR DRUG DELIVERY 纳米海绵:一种很有前途的药物递送纳米载体系统

Current Research in Pharmaceutical Sciences Pub Date : 2020-04-08 DOI: 10.24092/crps.2020.100101

Mukesh Kumar, Priya, Anoop Kumar, Shobhit Kumar

引用次数: 2