NANOSPONGES: A PROMISING NANOCARRIER SYSTEMS FOR DRUG DELIVERY

Abstract

Nanoengineered drug delivery system is generally used to solubilize the hydrophobic drugs. They also carry the drug to the target site and release the drug according to need of patient. These are very effective drug carriers which minimize and resolve the problems of drug toxicity and poor bioavailability as they can load both hydrophilic and hydrophobic drugs. Nanosponges are tiny in size with three dimensional networks. These are highly porous in nature and entrap active moieties and provide an advantage of programmable release. These are prepared by cross linking using many type of cyclodextrin with carbonyl and dicarboxylate compound like cross linker. Nanosponges are used for enhancing the bioavailability of drug and delivery of drug via oral, topical and parenteral routes. These are also used as a carrier for release of enzyme, protein, vaccines and antibiotics.