Current Research in Pharmaceutical Sciences最新文献_第4页

A Simulation Based Screening on Different Coloring Agents used in Cosmetics and Pharmaceutical Industry for their Safety Profile 化妆品和制药工业中不同着色剂安全性的模拟筛选

Current Research in Pharmaceutical Sciences Pub Date : 2022-07-08 DOI: 10.24092/crps.2022.120203

Tanya Mehra, A. Mishra, Nidhi Mishra

{"title":"A Simulation Based Screening on Different Coloring Agents used in Cosmetics and Pharmaceutical Industry for their Safety Profile","authors":"Tanya Mehra, A. Mishra, Nidhi Mishra","doi":"10.24092/crps.2022.120203","DOIUrl":"https://doi.org/10.24092/crps.2022.120203","url":null,"abstract":"Coloring agents are inseparable part of cosmetic, pharmaceutical Industry and food industry. A study conducted by Food Dyes Health Effects Assessment OEHHA in 2020 reported The percentage of US children and adolescents diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) increased from an estimated 6.1% to 10.2% in the past 20 years. Several studies revealed that Attention Deficit Hyperactivity Disorder could be caused by Artificial Food dyes In This study an attempt was made to perform the in silico safety analysis of Ferric ferrocyanide, caramel, Carmine, Betanine, Erythrosine,Tartrazine, Indigotine, Allura red, sunset yellow, Brillant blue, Curcumin, lawsone and Juglone coded in Python 2.7. The properties generated by the software were analyzed were molecular Weight (MW)Volume,TPSA, LogS, LogP, LogD, Caco-2 permeability, HIA, Protein binding, BBB permeability, skin sensitivity, carcinogenicity, eye irritation, respiratory toxicity, genotoxicity, non biodegrability and aquatic toxicity. The result of this study revealed a totally new dimension of the safety of these dyes and pigment which are widely used in the cosmetic, Food and Pharmaceutical Industry. Key words: in silico, prediction, Pigment, toxicity.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"23 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90927767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A COMPARATIVE REVIEW ON EPILEPSY AND ITS TREATMENT OPTIONS 癫痫及其治疗方案的比较综述

Current Research in Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.24092/crps.2022.120102

Y. Sinha, Rohit Kumar Kumar Bijauliya, Sunny Patel, Danishta Asif

引用次数: 0

EVALUATION OF ANTIDEPRESSANT EFFECT OF 6-SHOGAOL IN ANIMAL MODELS 6-shogaol抗抑郁作用的动物模型评价

Current Research in Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.24092/crps.2022.120107

Payal Rahangdale, Deepak Kumar Basediya, V. Thakur, B. Dubey

{"title":"EVALUATION OF ANTIDEPRESSANT EFFECT OF 6-SHOGAOL IN ANIMAL MODELS","authors":"Payal Rahangdale, Deepak Kumar Basediya, V. Thakur, B. Dubey","doi":"10.24092/crps.2022.120107","DOIUrl":"https://doi.org/10.24092/crps.2022.120107","url":null,"abstract":"The objective of the study was therefore to evaluate the role of 6-shogaol in the antidepressant effect Zingiber officinale using two different animal models viz., tail suspension test and forced swim test. Ginger rhizomes were extracted using water-methanol (80/20) as the solvent using maceration and 6-shogaol was isolated from the extract using mixture of n-hexane-diethyl ether (70/30, v/v) in column chromatography. The yield of the isolated 6-shogaol after column chromatographic isolation of the aqueous methanolic ginger extract was found to be 1.3%. The isolated 6-shogaol was of pale-yellow color and the texture appeared to be fine and crystalline. The forced swim test revealed that the immobility time was significantly reduced at all the administered doses of 6-shogaol in a dose dependent manner. The swimming time was found to increase in a similar fashion but was not significantly increased at a dose of 30 mg/kg of 6-shogaol. ANOVA analysis of the tail suspension test revealed that the reduction of immobility time was not significant at a dose of 30 mg/kg 6-shogoal whereas at doses of 100 and 300 mg/kg, the reduction was significant as compared to the control group. KEYWORDS: Shogaol, extract, tail suspension, forced swim, antidepressant, isolation.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74031391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PLANT CHEMISTRY AND PHARMACOLOGICAL APPLICATIONS OF BAUHINIA VARIEGATA LINN. (CAMEL FOOT TREE): A REVIEW 紫荆的植物化学及药理应用。(骆驼脚树):复习

Current Research in Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.24092/crps.2022.120101

Charu Bharti, N. A. Farooqui, Raj Kumar, Shrestha Sharma, Pankaj Gupta

{"title":"PLANT CHEMISTRY AND PHARMACOLOGICAL APPLICATIONS OF BAUHINIA VARIEGATA LINN. (CAMEL FOOT TREE): A REVIEW","authors":"Charu Bharti, N. A. Farooqui, Raj Kumar, Shrestha Sharma, Pankaj Gupta","doi":"10.24092/crps.2022.120101","DOIUrl":"https://doi.org/10.24092/crps.2022.120101","url":null,"abstract":"Bauhinia variegata Linn. (Camel foot tree) is an average sized deciduous tree. It is commonly known as “kachnar”. It belongs to the most nascent family “caesalpiniaceae”. It is a medicinal plant and widely used by the Indian tribes in the form of extract of leaves, buds, flowers, stem bark, stem, root bark, root and seeds. Mountain ebony is popular in Unani, Ayurveda and Homeopathy system of medicine for curing different types of disease. All crudes have been evaluated (alcoholic and aqueous extract) of aerial parts of B. variegate Linn. for in-vitro and in-vivo activity. Various chemical constituents have been isolated from plant parts like flavonoids, glycoside, steroids, tannins and reducing sugar. The numerous prominent pharmacological activities have been also reported like antioxidant, antimicrobial, antitumor, anti-diabetic, anti-inflammatory, anti-ulcer, nephroprotective action, immunomodulatory and wound healing effect. In this review, a detail inclusive screening study of chemical constituents of B. variegata Linn. and their pharmacological importance are discussed. KEYWORDS: Mountain Ebony, Phytochemical screening, Aerial plant parts, Kachnar, Pharmacological activity","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84924714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FORMULATION AND EVALUATION OF FLOATING TABLET OF THIOCOLCHICOSIDE 硫代秋糖苷漂浮片剂的研制及评价

Current Research in Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.24092/crps.2022.120109

Dixit Ashish, Sahani Vibhu

引用次数: 0

FORMULATION AND EVALUATION OF EFAVIRENZ TABLET USING MORINGA OLEIFERA AS A NATURAL POLYMER 以辣木为天然聚合物的依非韦伦片的研制及评价

Current Research in Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.24092/crps.2022.120108

V. A, S. Kl, Gokulan Pd, S. V, V. ., T. M., S. K, P. D

{"title":"FORMULATION AND EVALUATION OF EFAVIRENZ TABLET USING MORINGA OLEIFERA AS A NATURAL POLYMER","authors":"V. A, S. Kl, Gokulan Pd, S. V, V. ., T. M., S. K, P. D","doi":"10.24092/crps.2022.120108","DOIUrl":"https://doi.org/10.24092/crps.2022.120108","url":null,"abstract":"This study describes a systemic approach for the formulation and evaluation of Efavirenz tablets and has been done in this work using Moringa Oleifera as a natural polymer at different concentrations. In order to identify the medication, melting point, solubility, and FTIR analysis were used. DSC was used for investigating the drug polymer interactions. Consequently, no interaction between the medicine and polymer used in the formulation was detected. The formulations were created by blending medication and excipients, then analysing them for Angle of repose, Bulk density, Tapered bulk density, Hausner's ratio, and Carr's compressibility index. The powder blends passed all of these tests with flying colours. Direct compression was used to make the seven batches of Efavirenz pills. Thickness, hardness, friability, weight variation, and drug content were all measured on the manufactured tablets. All of the values were found to be within the parameters. All seven batches were subjected to in-vitro dissolving tests. Because Formulation F7 has the largest percentage of medication release, it has been chosen as the best formulation. Stability tests were performed on the optimised formulation F7, and the findings showed no significant changes throughout the course of the three-month investigation. KEYWORDS: Efavirenz, Moringa oleifera, Formulation, Evaluation studies","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87155693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DEVELOPMENT AND VALIDATION OF RP-HPLC BASED ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND BILASTINE IN TABLET DOSAGE FORM 基于反相高效液相色谱法同时测定片剂中孟鲁司特和bilastine含量的方法的建立与验证

Current Research in Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.24092/crps.2022.120110

P. Vyas, V. S. Thakur, D. Basedia, B. Dubey

{"title":"DEVELOPMENT AND VALIDATION OF RP-HPLC BASED ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND BILASTINE IN TABLET DOSAGE FORM","authors":"P. Vyas, V. S. Thakur, D. Basedia, B. Dubey","doi":"10.24092/crps.2022.120110","DOIUrl":"https://doi.org/10.24092/crps.2022.120110","url":null,"abstract":"A new RP-HPLC method was developed for the estimation of bilastine and montelukast in tablets and it was validated as per ICH guidelines. The chromatogram for was found to be satisfactory on symmetry C-18 (4.6×150mm, 5µ Thermosil column) using phosphate buffer (pH 4.5) and acetonitrile in the ratio of 30:70 v/v at a flow rate of 0.8 ml/min. The retention time of montelukast and bilastine were found to be 7.03 min and 9.50 min respectively. The system suitability parameters proved that the proposed method is suitable for simultaneous estimation of bilastine and montelukast. Tailing factor for the peak was found to be 1.003 and 1.258 for montelukast and bilastine respectively and the theoretical plates for separation were found to be 3409 and 7365 respectively montelukast and bilastine. The method was found to be linear in the range of 10-50µg/ml for both the drugs. The precision of the method was good and the recovery of drugs is well within the acceptance limits of 80-120%. The LOD was found to be 0.003 µg/ml for montelukast and 0.09 µg/ml for bilastine while the LOQ ws found to be 0.012 µg/ml for montelukast and 0.3 µg/ml for bilastine. KEYWORDS: Montelukast, Bilastine, RP-HPLC, simultaneous estimation, validation, analytical method.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89246456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

DEVELOPMENT AND CHARACTERIZATION OF GASTRO RETENTIVE TABLETS OF CLARITHROMYCIN FOR ANTIULCER EFFECT 克拉霉素抗溃疡胃留置片的研制与表征

Current Research in Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.24092/crps.2022.120106

Rajesh Sharma, A. Mishra

{"title":"DEVELOPMENT AND CHARACTERIZATION OF GASTRO RETENTIVE TABLETS OF CLARITHROMYCIN FOR ANTIULCER EFFECT","authors":"Rajesh Sharma, A. Mishra","doi":"10.24092/crps.2022.120106","DOIUrl":"https://doi.org/10.24092/crps.2022.120106","url":null,"abstract":"Gastroretentive floating drug delivery system (GFDDS) is used to prolong the gastric residence time after oral administration, at a particular site and controlled or modified the release of drug from the formulation.The purpose of the present study is to develop a gastro retentive floating drug delivery system to achieving controlled release so that is improves bioavailability of the formulation, Structure activity relationship based on Biopharmaceutical Properties of Clarithromycin indicates good biopharmaceutical Properties. Floating dosage form of Clarithromycin was designed for the treatment of gastric ulcer caused by Helicobacter pylori. The granules were prepared by wet granulation method and evaluated for flow property, Carrs' index, bulk density, tapped density and Hausner ratio. The dosage form was designed by using polymers of different viscosity as gelling agents, sodium bicarbonate as gas generating agent and other excipients. The granules were further subjected to tablet preparation and the prepared tablets were subjected for evaluated on the basis of different evaluation parameters like hardness, in vitro buoyancy, in vitro drug release. Incorporation of gas generating agent together with polymer improved drug release Optimized formulation (F7) containing Clarithromycin, HPMC, 90 SH , HPMC K4M , sodium bicarbonate, released approximately 86.6% drug in 10 hrs. and the floating lag time was found to be 25 sec. KEYWORDS: GFDDS, Helicobacter pylori, gelling agents, in vitro buoyancy, HPMC, wet granulation.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83309136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

DEVELOPMENT OF REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF SILDENAFIL CITRATE AND DEPOXETINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION 反相高效液相色谱法同时测定制剂中柠檬酸西地那非和盐酸地西汀的含量

Current Research in Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.24092/crps.2022.120104

Shivanand Yadav, N. Sharma

{"title":"DEVELOPMENT OF REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF SILDENAFIL CITRATE AND DEPOXETINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION","authors":"Shivanand Yadav, N. Sharma","doi":"10.24092/crps.2022.120104","DOIUrl":"https://doi.org/10.24092/crps.2022.120104","url":null,"abstract":"Simple, accurate and precise reversed-phase high-performance liquid chromatographic (RP-HPLC) methods for simultaneous estimation of sildenafil citrate (SIL) and depoxetine hydrochloride (DAP) in combined tablet dosage form have been developed and validated. The RP-HPLC method uses a Shimadzu – 1800, Software Version – UV Prob 2.33 with BDS hypersil C18 column and mixture of Buffer pH 4.0 and ACN in the ratio of 40:60 as the mobile phase. The detection was carried out using a UV–Visible Detector: Shimadzu SPD–20AT diode array detector set at 229 nm. Linearity of chromatographic method was found in the concentration range of 50 - 150 ppm for Sildenafil and 30 - 90 ppm for Dapoxetine respectively. % recovery for SIL was found to be 99.3 – 100.5 %, while for DAP it was found to be in range of 99.1 – 100.4 % in HPLC methods respectively. Both methods may be used for routine analysis of the drugs in a pharmaceutical formulation. Results of analysis were validated statistically. KEYWORDS: Linearity, Validation, HPLC, Sildenafil, Depoxetine.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86092920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SEPARATION AND PURIFICATION OF PHARMACEUTICAL INDUSTRIAL WASTE WATER FOR REUSE BY TECHNIQUES OF ELECTRO-COAGULATION AND MICROBIAL ELECTROCHEMICAL CELL LYSIS PROCESS 电絮凝与微生物电化学细胞裂解技术分离纯化制药工业废水回用研究

Current Research in Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.24092/crps.2022.120103

P. S, C. C., P. P., S. S, S. P

{"title":"SEPARATION AND PURIFICATION OF PHARMACEUTICAL INDUSTRIAL WASTE WATER FOR REUSE BY TECHNIQUES OF ELECTRO-COAGULATION AND MICROBIAL ELECTROCHEMICAL CELL LYSIS PROCESS","authors":"P. S, C. C., P. P., S. S, S. P","doi":"10.24092/crps.2022.120103","DOIUrl":"https://doi.org/10.24092/crps.2022.120103","url":null,"abstract":"The Advancement of human living standards within the twenty-first century, the issues of worldwide global climate change, rapid population increase, and environmental pollution have grown increasingly critical. Human activities have put plenty of strain on the ecosystem. Water contamination is one amongst several environmental issues that has to be addressed immediately. The rise in water-related disorders provides a sensible estimate of the extent of environmental degradation. Humans can utilize it day by day. Water will be employed in a pharmaceutical laboratory or industry for the formulation, chemical synthesis, and cleaning, among other things. The ultimate wastewater in numerous pharmaceutical laboratories and industries is treated in a very sort of ways to get rid of effluent and pollutants. That water, on the opposite hand, are often used for gardening and planting. Compared to other traditional procedures like biological, physical, chemical, adsorption, and advanced oxidation processes, the mixture technique of Electro coagulation and Microbial Electro Cell lysis has high de-colorization efficiency, is economically attractive, and produces little sludge. Color, COD, BOD, turbidity, and metal ions are among the pollutants that will be far away from wastewater using the electro coagulation procedure. We are researching the processes of electro coagulation and microbial electro cell lysis in order to make a wastewater treatment system that is reusable and produces better outcomes. It is incredibly inexpensive and easy, with only some substances being utilized within the treatment and administration. We are considering the longer term when creating such a design. KEYWORDS: Laboratory waste water, Electro-coagulation, Microbial electro cell lysis, Electrodes.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83915101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0