FORMULATION AND EVALUATION OF EFAVIRENZ TABLET USING MORINGA OLEIFERA AS A NATURAL POLYMER

Abstract

This study describes a systemic approach for the formulation and evaluation of Efavirenz tablets and has been done in this work using Moringa Oleifera as a natural polymer at different concentrations. In order to identify the medication, melting point, solubility, and FTIR analysis were used. DSC was used for investigating the drug polymer interactions. Consequently, no interaction between the medicine and polymer used in the formulation was detected. The formulations were created by blending medication and excipients, then analysing them for Angle of repose, Bulk density, Tapered bulk density, Hausner's ratio, and Carr's compressibility index. The powder blends passed all of these tests with flying colours. Direct compression was used to make the seven batches of Efavirenz pills. Thickness, hardness, friability, weight variation, and drug content were all measured on the manufactured tablets. All of the values were found to be within the parameters. All seven batches were subjected to in-vitro dissolving tests. Because Formulation F7 has the largest percentage of medication release, it has been chosen as the best formulation. Stability tests were performed on the optimised formulation F7, and the findings showed no significant changes throughout the course of the three-month investigation. KEYWORDS: Efavirenz, Moringa oleifera, Formulation, Evaluation studies