The Bulletin of Contemporary Clinical Medicine最新文献

{"title":"POTENTIAL ВIOMARKERS OF ENDOMETRIOSIS: THE SEARCH IS UNDERWAY","authors":"A. Zaripova, R. Gabidullina, F. F. Minnullina, D. I. Akhmetova, Yurij V. Orlov","doi":"10.20969/vskm.2023.16(6).103-109","DOIUrl":"https://doi.org/10.20969/vskm.2023.16(6).103-109","url":null,"abstract":"Abstract. Introduction. Endometriosis is a chronic estrogen-dependent disease characterized by the presence of endometrial-like tissue outside the uterine cavity and most often manifested by pelvic pain and infertility. It affects up to 10% of women of reproductive age, which is about 190 million women worldwide, and it is a serious medical and social issue. In the clinical context, it is advisable to search for biomarkers of the disease to ensure early noninvasive diagnosis. Current literature on potential biomarkers of endometriosis is already quite extensive. However, despite many publications, there is no consensus on and no similar approaches to defining such markers. Therefore, the search for potential biomarkers of endometriosis is still relevant. Aim: To summarize the information of contemporary literature on possible biomarkers of endometriosis that can be used in its early diagnosis and treatment. Materials and Methods. This is a review of publications based on search results in electronic resources in Russian and international systems, such as eLibrary, PubMed, MedLine, Crossref, etc., over the past 8 years (2015-2023). Results and Discussion. A constantly improving palette of the latest technologies that include and combine metabolomics, genomics, and proteomics, can be the key to success in finding reliable biomarkers. For such a complex and heterogeneous disease as endometriosis, a panel of biomarkers is likely to be more accurate than a single marker, both for the diagnosis and probably for helping classify subtypes of the disease. Conclusion. Current literature on potential biomarkers is quite extensive, but the desired result has not been achieved yet. Further research is needed.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SERUM LIPOCALIN IN PATIENTS WITH ACUTE PANCREATITIS","authors":"Nellya A. Safina, V. F. Chikaev, Denis M. Petukhov, Yurij V. Bondarev","doi":"10.20969/vskm.2023.16(6).46-51","DOIUrl":"https://doi.org/10.20969/vskm.2023.16(6).46-51","url":null,"abstract":"Abstract. Introduction. Acute pancreatitis is a severe inflammatory disease of the pancreas. In case of severe acute pancreatitis, mortality rate reaches 36-50%. The most challenging issue is the prediction of its severity and clinical outcome due to the limitations of clinical scoring systems and biochemical markers, which are still being studied intensely. Aim: To study serum lipocalin levels in patients with acute pancreatitis of varying severity. Materials and Methods. Our study included 68 patients diagnosed with acute pancreatitis and treated in the inpatient facility of Kazan City Clinical Hospital 7 over the years 2017-2019. Patients were stratified by severity, gender, and age. As a comparison group, 20 healthy volunteers without any gastrointestinal issues were examined. Specimen to be studied were the sera of patients with acute pancreatitis and those of healthy volunteers. Blood was sampled from the patients upon admission to the hospital and before their discharge from it. Lipocalin levels were registered using BioVendor’s Human Lipocalin-2/NGAL ELISA kit. The findings were processed statistically at their normal distribution. Results and Discussion. Our study showed a significant excess of lipocalin levels in patients with acute pancreatitis as compared with healthy volunteers. In healthy volunteers this value varied within 4.91±6.55 ng/ml, while it was 78.19±89.09 ng/ml (p<0.05) in acute pancreatitis patients. Conclusions. Our study of serum lipocalin in patients with acute pancreatitis showed a significant and statistically reliable excess of this indicator as compared to healthy volunteers. The highest lipocalin levels were found in patients with severe acute pancreatitis. Conventional therapy reduced these levels in mild, moderate, and severe cases, although there was no statistically significant difference before and after treatment. Keywords: pancreatic necrosis, lipocalin, prediction.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139294680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSING EXERCISE TOLERANCE CHANGES IN PATIENTS AFTER ACUTE CORONARY SYNDROME AT THE STAGE OF RESIDENTIAL REHABILITATION","authors":"L. Gumarova, R. A. Bodrova, Ivan V. Gorelkin, Olga V. Romanova, Gulnaz G. Usmanova, Lidiya I. Sabirova, A. Akhmetzianova","doi":"10.20969/vskm.2023.16(6).25-30","DOIUrl":"https://doi.org/10.20969/vskm.2023.16(6).25-30","url":null,"abstract":"Abstract. Introduction. It is proven that integrated cardiac rehabilitation helps reduce mortality and hospital readmission rates and improves the quality of life of patients with acute coronary syndrome experience. Key aspect of integrated cardiac rehabilitation is aerobic training contributing to higher exercise tolerance. Aim. This research aims at assessing the changes in exercise tolerance in acute coronary syndrome patients at the second stage of medical rehabilitation. Materials and Methods. The research involved 162 patients of the Department of Medical Rehabilitation of Adult Patients with Somatic Diseases, who have experienced acute coronary syndrome. To assess the patients’ exercise tolerance, we used the six-minute walk test under electrocardiography control with the Accordix system (Neurosoft, Russia) upon their admission and immediately before their discharge from the hospital. Along with drug therapy, the personalized medical rehabilitation plans included electrocardiography-controlled aerobic training, laser therapy, psychological intervention, and occupational therapy classes. Rehabilitation efficiency was assessed by six-minute walk test (m) and Functional Independence Measurement (FIM) scale (score). The findings were analyzed statistically using nonparametric criteria. Results and Discussion. There were reduced exercise tolerance and limited daily activities in a significant part of cardiological patients before admission to the hospital. Upon completion of the medical rehabilitation course, the patients’ exercise tolerance increased significantly, resulting in better individual exercise tolerances, longer distances covered within the six-minute walk test, and the larger total amount of daily activities the patients can perform. Conclusions. Electrocardiography-controlled physical training based on the patient’s initial stamina level promotes increasing their exercise tolerance, their tolerance to daily activities, their mobility, independence, and, accordingly, their life quality.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEPRESSIVE DISORDERS AND PROGNOSIS IN PATIENTS WITH ISCHEMIA-INDUCED CHRONIC HEART FAILURE","authors":"Violetta M. Iakubova, Olga V. Bulashova, Elena V. Khazova","doi":"10.20969/vskm.2023.16(6).88-94","DOIUrl":"https://doi.org/10.20969/vskm.2023.16(6).88-94","url":null,"abstract":"Abstract. Introduction. Clinical depression occurs in 21.5% of patients with heart failure, aggravating both the clinical course and the prognosis of the disease. The aim is to present the findings of the clinical course of chronic heart failure in patients with depressive disorders and to study their prognoses. Material and Methods. The study included 78 patients with heart failure, functional classes 1-4. The degree of depressive disorders was assessed using the Hospital Anxiety and Depression Scale (HADS). Life quality was assessed using the Minnesota Living with Heart Failure Questionnaire. All patients passed a 6-minute walk test and echocardiography. The patient’s clinical condition was assessed according to the clinical condition assessment scale. Prognoses were assessed after 1 year of study. Results and Discussion. Depression level analysis has shown that the clinically pronounced depression is common in patients with heart failure, which corresponds to 9.0 (6.0;11.0) points. In a closer consideration of the structure of disorders, no depression was found in 37.2 % of cases, subclinical depression was found less frequently in patients with heart failure (26.9 %), while clinical depression was found in 35.9 %. All-cause mortality was observed in 7.7 % of cases, while cardiovascular mortality occurred in 4.6 %. Pronounced depression was registered in patients with chronic heart failure, in case of hospital admission. Conclusions. Average depression level in patients with heart failure is 9.0 (6.0; 11.0) points, which corresponds with clinical depression. Depression occurs in 62.8 % of cases and associated with worse clinical condition. Overt clinical depression occurs more frequently in patients with chronic heart failure, who have come up to the event of hospitalization.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139304763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROLE OF EPIGENETIC FACTORS IN THE DEVELOPMENT AND DIAGNOSIS OF CORONARY HEART DISEASE","authors":"Aida R. Sadykova, Aida R. Safiullina, Kamila R. Nuriakhmetova, Maxim A. Makarov, Alsu M. Sadykova, S. S. kriVONOsOVa","doi":"10.20969/vskm.2023.16(6).123-129","DOIUrl":"https://doi.org/10.20969/vskm.2023.16(6).123-129","url":null,"abstract":"Abstract. Introduction. Understanding the role of epigenetic regulation and studying how it affects the pathogenesis of many polygenic diseases have become a breakthrough in modern medicine over the past decade. Today, it is obvious that epigenetic mechanisms, despite their inheritable nature, can become modified under the influence of lifestyle and environment. Epigenetics is the science of inherited body properties that are not related to any changes in the actual nucleotide DNA sequence and can be encoded in the genome rather indirectly than directly. Gaining the knowledge on these mechanisms opened up new opportunities for understanding the origin of some cardiovascular diseases. Promoting this trend has serious consequences for the development and progression of diseases, as well as creates possible new strategies for preventing cardiovascular diseases. Due to this, some fundamental epigenetic regulation mechanisms in the development of coronary heart disease were identified in recent years, which disease is one of the leading causes of mortality in today’s context. Aim. To study the role of the epigenetic mechanisms of early vascular inflammation in the development of coronary heart disease and the prognostic value of epigenetic biomarkers in diagnosing this disease. Material and Methods. We analyzed the findings of studies conducted in 2001-2022 regarding epigenetic mechanisms and their role in the pathogenesis and diagnosis of coronary heart disease, using new epigenetic markers. Sources. PubMed, ResearchGate, eLibrary, Cyberleninka. Results and Discussion. Among all epigenetic mechanisms, DNA methylation, histone modification, and transcription of non-coding RNA sequences, particularly micro-RNA, are currently considered to be most extensively studied and most significant. Conclusion Understanding the basic regulation mechanisms of epigenetic modifications in the development of coronary heart disease will increase knowledge about the etiopathogenesis of this disease and facilitate the transition to personalized medicine.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"161 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF ROAD TRAFFIC INJURIES ON PUBLIC TRANSPORT IN THE REPUBLIC OF TATARSTAN OVER THE YEARS 2018-2022","authors":"M. I. Timerzyanov, Artur M. Delyan, Nail N. Khairutdinov, A. R. Sharafutdinova","doi":"10.20969/vskm.2023.16(6).52-58","DOIUrl":"https://doi.org/10.20969/vskm.2023.16(6).52-58","url":null,"abstract":"Report. Introduction. Road traffic accidents involving passenger transport vehicles are characterized by highly severe consequences and usually cause massive public outcry. Major accidents involving public transport occur infrequently, but they are always characterized by many victims, injured and dead. Aim of this paper is to study the injury degree of road traffic accidents involving passenger transport vehicles, such as buses, trolleybuses, or trams. Materials and Methods. The study is based on the data made available via the federal statistical observation over road accidents involving motor and public transport in the Republic of Tatarstan over the years 2018-2022. For this purpose, we used generalization methods and quantitative, qualitative, and comparative analysis techniques. Mathematical simulation techniques were used to analyze the data with the computational tools of the MS Excel electronic package. Необходимо повышение осведомленности пассажиров о правилах безопасности и процедурах эвакуации в случае чрезвычайного проис- шествия. Results and Discussion. An acute problem of modern society is the lack of effectively ensuring passenger transport safety, which leads to more frequent road accidents and injuries on the roads. Transporting passengers by urban public transport is one of the most important industries in the economy of the Republic of Tatarstan. Road safety issues are a priority in many strategic and program documents of the socio-economic development of the Republic. Human factor is one of the key factors in ensuring road safety. The most common causes of such accidents are speed limit violations and drivers’ inattention and negligence. Eventually, drivers’ failure to comply with the work-rest ratio leads to accidents and loss of life. There is a need for raising passengers’ awareness of safety rules and emergency evacuation procedures. Conclusions. There are still serious shortcomings in traffic management, leading to accidents with many dead and injured. Implementing measures aimed at preventing road accidents will help enhance road safety and significantly reduce the number of accidents.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139302825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE OF INAPPROPRIATE LEFT VENTRICULAR MASS IN PATIENTS WITH VARIOUS DISEASES","authors":"Aygul R. Shamkina, A. Akhmetzianova, A. R. Gaziev, Maxim A. Makarov","doi":"10.20969/vskm.2023.16(6).130-140","DOIUrl":"https://doi.org/10.20969/vskm.2023.16(6).130-140","url":null,"abstract":"Abstract. Introduction. According to the inappropriate left ventricular mass concept proposed by G. de Simone et al. (1998), in some cases, an increment in the left ventricular myocardium mass occurs inadequately to the hemodynamic load of high blood pressure. Studying the prevalence and interrelation of disproportionately high left ventricular myocardia ВЕСТНИК СОВРЕМЕННОЙ КЛИНИЧЕСКОЙ МЕДИЦИНЫ 2023 Том 16, вып. 6 131ОБЗОРЫ mass continues to remain topical to the present, due to the increased risk of cardiovascular events among affected people, and at the same time independently of the presence of left ventricular hypertrophy. Aim. To analyze the scientific medical literature data obtained in studying the prevalence of disproportionately high left ventricular myocardial mass in patients with different diseases. Materials and Methods. We reviewed and analyzed the scientific results from national and foreign medical literature in electronic databases PubMed, Medline, and eLibrary over the years 1998- 2023. Results and Discussion. Research papers dealing with studying the prevalence of disproportionately high left ventricular myocardial mass mainly present patients with cardiovascular diseases. Prevalence of disproportionately high left ventricular myocardial mass in patients with arterial hypertension varies quite widely, from 9% to 82,4%; at the same time, gender and racial differences were found. It is also common in patients with coronary heart disease, aortic stenosis, chronic kidney disease, rheumatoid arthritis, type 2 diabetes mellitus, and primary aldosteronism. It turned out that the frequency of abnormally high left ventricular myocardial mass tends to increase in cases with a combination of chronic kidney disease and type 2 diabetes mellitus. Conclusions. To thoroughly study how disproportionately high left ventricular myocardial mass contributes to bad cardiovascular prognosis, further research is needed in this theme, including studying its prevalence in patients with different diseases, both isolated and combined.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139294373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ECONOMIC BURDEN OF COVID-19 IN THE REPUBLIC OF BASHKORTOSTAN","authors":"V. Timiryanova, I. A. Lakman, Damir A. Valishin, D. Gareeva, Bulat R. Sultanov, N. Zagidullin","doi":"10.20969/vskm.2023.16(6).59-66","DOIUrl":"https://doi.org/10.20969/vskm.2023.16(6).59-66","url":null,"abstract":"Abstract. Introduction. Extent of social losses due to the COVID-19 pandemic is still evaluated incompletely fully assessed despite its declared end. Aim. To study the socioeconomic burden of the novel coronavirus (COVID-19) in the Republic of Bashkortostan. Materials and Methods. In this study, we used the method of accounting for the economic burden caused by hospitalizations, sick leaves, and deaths. Four disease severity levels (mild, moderate, severe, and critical) and two treatment options (inpatient or outpatient) were considered. Direct costs were evaluated using the data provided by the Tariff Agreement on Compulsory Medical Insurance in the Republic of Bashkortostan. Indirect losses were evaluated considering the times of the patients’ incapacity to work and assessing the amounts of “underproduced” Gross Regional Product due to their premature deaths. Results and Discussion. The results obtained indicate that total direct medical costs related to the diagnosis and treatment of coronavirus infection increase annually, despite the reducing costs of each treatment stage. Based on published data alone, the three-year direct costs amounted to 0.3 billion rubles for outpatient treatment, 7.4 billion rubles in hospitals, and 4.6 billion rubles for PCR tests. In the loss structure, significant are indirect costs associated with incapacity periods (4.7 billion rubles) and mortality (2.3 billion). Conclusions. COVID-19 pandemic has led to large socioeconomic losses.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139296815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AGE-RELATED DIFFERENCES OF FORMING NEUTROPHIL EXTRACELLULAR TRAPS IN HEALTHY INDIVIDUALS AND IN TUBERCULOSIS PATIENTS","authors":"A. Mordyk, Alexander N. Zolotov, Dmitrij G. Novikov, Mariya А. Romanova, Anton V. Indutny, N. А. Kirichenko, A. O. Ptukhin","doi":"10.20969/vskm.2023.16(6).37-45","DOIUrl":"https://doi.org/10.20969/vskm.2023.16(6).37-45","url":null,"abstract":"Abstracts. Introduction. Forming a neutrophil extracellular trap (NET) from DNA (NETosis) is considered as a potentially significant marker in the diagnosis of tuberculosis. However, there is practically a lack of data regarding the age-related differences in forming extracellular traps in research publications. Aim. To determine the age-related differences of NETosis in healthy individuals and in tuberculosis (TB) patients. Materials and Methods. The ability of neutrophils to form extracellular traps was investigated in 4 groups: 1) 4-7-year-old children diagnosed with the primary tuberculosis complex, who fell ill within Omsk region; 2) healthy and uninfected children at the same age; 3) adults with tuberculosis, and 4) adults without tuberculosis. For this purpose, isolated fractions of neutrophils from peripheral blood of the groups under research were stimulated with a mixture of bacteria (probiotic) for 30 minutes. In the hanging-drop preparation, we analyzed the proportion of neutrophil extracellular traps and cells in the state of various motility degrees. Results and Discussion. Age-related differences in the ability of neutrophils to form extracellular traps were characterized by a more pronounced response of neutrophils to the NETosis stimulant in children in the control group in comparison with neutrophils isolated from blood in the group of healthy adult volunteers: Neutrophils of children (Me=16.1; Q1=12.8; Q3=18.3) were statistically significantly more intense (p=0.0002) than those of adults (Me=8.6; Q1=7.1; Q3=10.5) and formed filamentous NETs. In the groups of pediatric and adult pulmonary TB patients, the response of neutrophils to the NETosis stimulant was diametrically opposite. Neutrophils of children with primary tuberculosis complex, as of those in the control group, predominantly formed filamentous NETs, but in greater amounts, while neutrophils of adults with infiltrative or focal form and with at most 2 segments involved mainly formed cloudy NETs, whereas filamentous NETs prevailed for the adults in the control group after stimulation. At the same time, proportion of cloudy NETs did not exceed 5% in healthy children and healthy adults. Comparing the findings of our study with literature data, we hypothesized that, most likely, there is a greater increase in PAD4 expression and more pronounced histone H3 citrullination in children’s neutrophils than in those of adults. Conclusions. Our findings indicate more pronounced ex vivo processes induced by NETosis stimulator in both groups of children (healthy individuals and TB patients) as compared to adults in the respective groups, which should be considered by the researchers interpreting the findings of the ability of neutrophils to form extracellular traps in tuberculosis.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139305363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY OF MEDICAL REHABILITATION FOR PATIENTS WITH TRAUMATIC INJURY CONSEQUENCES AND MUSCULOSKELETAL DISORDERS IN THE REPUBLIC OF TATARSTAN","authors":"Artur M. Delyan, R. A. Bodrova, Gusel I. Akhmetova, Aysylu M. Vagizova, Indira I. Galimullina","doi":"10.20969/vskm.2023.16(6).7-13","DOIUrl":"https://doi.org/10.20969/vskm.2023.16(6).7-13","url":null,"abstract":"Abstract. Introduction. Musculoskeletal and connective-tissue disorders rank the third among diseases leading to primary disablement among adults in the Republic of Tatarstan. They are characterized by long healing periods and contractures. Timely rehabilitation of patients allows preventing many complications and restoring their former activity levels. Aim: To assess changes in the medical rehabilitation for patients with musculoskeletal and peripheral nervous disorders in the Republic of Tatarstan in 2020-2022. Materials and Methods. Clinical and expert-assessment statistical processing techniques, generalization method, and comparative analysis were used to process the data of patients with musculoskeletal and peripheral nervous disorders, who underwent medical rehabilitation in the Republic of Tatarstan in 2020-2022. We also used the statistical data made available by the Head Office of Medical and Social Expert Assessment in the Republic of Tatarstan at the Ministry of Labor and Social Protection of the Russian Federation. Ministry of Health of the Republic of Tatarstan. Statistical analysis was performed using the GraphPad Prism 9 software. Quantitative variables are presented as medians and quartiles, while the qualitative one as percentages. Comparative analysis (for dependent samples) was based on identifying the statistical significance of differences between indicators using Wilcoxon criterion. Differences at p < 0.05 were considered statistically significant. Results and Discussion. In 2022, there was a 49-% increase in the number of patients who were provided with medical rehabilitation in the Republic of Tatarstan, including a 69-% increase in the number of patients with diseases relating to musculoskeletal and peripheral nervous systems. Number of first-declared disabled people (disability group 3) decreased by 3.8% in 2022, since as medical rehabilitation of patients with musculoskeletal and peripheral nervous disorders increased by 42% in inpatient hospital conditions and by 76% in outpatient and polyclinic conditions in 2022. Conclusions. Increasing number of patients with musculoskeletal and connective-tissue disorders, who had undergone medical rehabilitation at the inpatient and outpatient stages, led to a decrease in the number of first-declared enabled people (disability group 3) by 3.8%. This substantiates the need for further development of medical rehabilitation in traumatology and orthopedics to preserve the labor potential, stabilize the disability levels, return the patient to social and domestic activities, and create optimal conditions for their active engagement in social activities and health resumption.","PeriodicalId":110361,"journal":{"name":"The Bulletin of Contemporary Clinical Medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}