Current Traditional Medicine最新文献

{"title":"A Comprehensive Review on Chemistry and Contribution of Chinese Herb Epimedium brevicornum Maxim in Medicine","authors":"N. Agrawal, Deepika Goyal, Dimple Bansal","doi":"10.2174/2215083810666230607151656","DOIUrl":"https://doi.org/10.2174/2215083810666230607151656","url":null,"abstract":"\u0000\u0000Traditional Chinese medicine (TCM) is a complete medical system that has been used for more than 2,000 years and it is effective to use Epimedium Brevicornum (EB) Maxim, one of the Chinese herbs belonging to the family Berberidaceae is of major use because of its bioactive compound Icariin (ICA).\u0000\u0000\u0000\u0000This review aims on providing a collective report of the description, taxonomy, therapeutic uses, bioactive compounds, and the different pharmacological activities of the plant EB for future research.\u0000\u0000\u0000\u0000Data was obtained from various informative tools like PubMed, ScienceDirect, Google Scholar, and the botanical information sites for different plants.\u0000\u0000\u0000\u0000This literature review shows that the Chinese herb EB possesses various therapeutic effects and can be used in the prophylaxis of different ailments. The extract of different parts of EB contains many bioactive compounds such as phenols, flavonoids, and lignans. They show a wide range of pharmacological activities which include anti-inflammatory, anti-infertility, anti-cancer, and effective against Alzheimer’s disease and osteoporosis. ICA was found to be the major constituent of this herbal plant aiding in almost every pharmacological activity\u0000.\u0000\u0000\u0000\u0000The review covers every activity the plant holds and indicates that the plant is a useful source in eradicating a variety of ailments. Researchers have performed invitro and invivo experiments to explore plant capabilities. The plant could be of very much use in botanical and pharmacological fields. For experts aiming to research EB, this review could be a great source of information.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42920121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mini-review on the Structural Characteristics and Anticancer \u0000Activity of Nagilactones","authors":"Canzhong Lu, Yuchen Xiao, Jianping Yong","doi":"10.2174/2215083810666230607093151","DOIUrl":"https://doi.org/10.2174/2215083810666230607093151","url":null,"abstract":"\u0000\u0000Natural products provide abundant resources for the development of new drugs. Podocarpus nagi is an arbor of Podocarpus L'Hér. ex Persoon. Its fruits, leaves, and roots exhibit a broad spectrum of pharmacological activities (such as antitumor, plant growth regulation, termite killing, and insect larval toxicity), which have been used in Yao folk for a long history. Nagilactone is one of the key components discovered in Podocarpus nagi, which has a variety of structures and a broad spectrum of antitumor activities. In this mini-review, the structures and spectral characteristics, together with the antitumor activities and the structure-activity relationships of nagilactones, are summarized by searching the database in order to provide detailed references for researchers to elucidate and modify their structures.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43069723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-viral Application of Ganoderma Lucidum in COVID-19","authors":"H. Babavalian, F. Shakeri, Hamideh Moghimi, M. Afsharian, Aida Alipashazadeh, Sahar Zuhuriyan Izadi","doi":"10.2174/2215083810666230602152743","DOIUrl":"https://doi.org/10.2174/2215083810666230602152743","url":null,"abstract":"\u0000\u0000Ganoderma lucidum (Lingzhi), a common medicinal fungus, has been utilized in China since ancient times for health promotion and longevity. It has anti-inflammatory, antiviral, antitumor, antioxidant, and antiallergic activities. The antioxidant and immunomodulatory effects of this mushroom have shown promising impacts in the treatment of some viral diseases. COVID-19 is a life-threatening disease caused by SARS-CoV-2 that has recently been pandemic. Modern medicines have not been very efficient in the direct treatment of these viral infections, and although vaccination is effective in preventing viral infections, the incidence of acute respiratory infection can be reduced only slightly. Thus, alternative therapies are required, and in this regard, stimulating the immune system can be an effective way to prevent these infections. This study reports the potential of natural fungus-derived compounds that can possibly be used to fight SARS-CoV-2 infections.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42349519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the Most Important Fruits in the Prevention and Treatment of Cardiovascular Diseases in Persian Traditional Medicine","authors":"M. Yousefi, M. Abazari, A. Gholoobi, A. Derakhshan, Shahin Saeedinejat","doi":"10.2174/2215083810666230602163727","DOIUrl":"https://doi.org/10.2174/2215083810666230602163727","url":null,"abstract":"\u0000\u0000Cardiovascular diseases (CVD) are the leading cause of health problems worldwide. CVD are defined as conditions affecting the heart and blood vessels. Mortality due to cardiovascular diseases has increased in recent years. However, they can be easily controlled by reducing risk factors, including lipid profile, blood pressure, tobacco, alcohol, and low physical activity. Fruits have an important role in improving the risk factors of CVD. Ancient medical sources can play an important role in generating ideas for new research. In this study, the most common fruits that have been recommended by Persian traditional physicians in patients with CVD were reviewed. New documents supporting these effects were also extracted through a search on electronic databases. The findings showed that some fruits have a therapeutic role in CVD, according to Persian traditional medicine. Old Persian traditional physicians, such as Avicenna, advised fruits, including apples, lemon, pomegranate, pineapple, quince, cucumber, plums, and citron, for the treatment of CVDs. Several studies have been carried out on the effects of the above fruits, including apple (Malus pumila), pomegranate (Punica granatum), pineapple (Ananas comosus), Quince (Cydonia oblonga Mill.), fig (Ficus carica L.), and olive (Olea europaea). Modulation of signaling pathways and molecular properties that leads to reducing lipid metabolism disorders, correcting endothelial dysfunction, reducing blood pressure, reducing oxidative stress, and suppressing inflammation responses are the major mechanisms conducted by these fruits in preventing CVD. These pieces of evidence show that the opinion of Iranian medicine physicians regarding choosing fruits for treating CVD is worthy of consideration and an entry for deriving hypotheses for future studies.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41463802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Immunology – Ayurveda Perspective","authors":"Geethu Balakrishnan, A. Shukla","doi":"10.2174/2215083810666230601144116","DOIUrl":"https://doi.org/10.2174/2215083810666230601144116","url":null,"abstract":"\u0000\u0000Immunity can be defined as the ability of the human body to resist almost all types of organisms or toxins that tend to damage tissues and organs. Ayurveda, one of the oldest health sciences has its perspectives and practices on immunology delineated under the heads of Vyadhikshmatwa (tolerance against disease), Ojas (the quintessence of all bodily tissues that is responsible for natural bio-strength, vitality and immunity), Bala (strength), and Vikaravighata Bhavas (disease-resisting factors).\u0000\u0000\u0000\u0000For the present review, the materials were collected from the Ayurvedic literature, including the three major classical texts Brihatrayees Charaka Samhita, Sushruta Samhita, Ashtanga Samgraha and Ashtanga Hridaya, and their important commentaries by Chakrapani, Arunadutta, Hemadri, Indu, and Dalhana. Information from the current scientific literature, articles published in PubMed, and authentic webpages has also been incorporated into this study. Subsequently, an independent analysis of immunology from Ayurvedic classical texts is presented in this review.\u0000\u0000\u0000\u0000Ayurvedic compendia have vividly described the perspectives and practices of immunity and the promotion of disease-resisting factors. In addition to being the repository of age-old medical practices and the treasure trove of herbal drugs, the immunomodulatory effects of these disease-resisting factors hold up even when bridging with new models based on modern science and technology.\u0000\u0000\u0000\u0000Rather than being a complementary science, Ayurveda is enriched with the concepts and practices of immunology. In order to free humanity from the grip of infections, it is important to explore the standalone and integrative aspects of science now.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42826128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytosomal Drug Delivery System: A detailed study","authors":"Srikala Kamireddy, S. Sangeetha, Sreya Kosanam","doi":"10.2174/2215083810666230531163053","DOIUrl":"https://doi.org/10.2174/2215083810666230531163053","url":null,"abstract":"\u0000\u0000Nature contains a diverse range of phytoconstituents that possess several pharmacological properties. However, the effectiveness of herbal formulations is limited due to the poor bioavailability of phytoconstituents, which makes it difficult for them to pass through the cell membrane. Phytosomes are a modern type of herbal formulation that comprises therapeutically active phytoconstituents extracted from medicinal plants and enclosed by phospholipids. By combining phytoconstituents with phospholipids, phytosomes are able to enhance bioavailability and reduce side effects. Various techniques such as solvent evaporation, rotatory evaporation, anti-solvent precipitation, freeze-drying, and solvent ether injection can be used to prepare phytosomes. Phytosomes can be evaluated using methods such as UV-Spectra, DSC, drug entrapment and loading capacity, surface tension activity measurement, and in-vitro/in-vivo studies. This review discusses different methods for preparing phytosomal formulations and their advantages, which have been found to significantly improve the bioavailability of phytoconstituents. Phytosomes have high entrapment efficiency and do not compromise the safety of nutrients. By utilizing phytosomal drug delivery, issues associated with conventional drug delivery may be overcome. Therefore, it is important to combine Indian Ayurvedic medicine with novel drug delivery systems to improve drug delivery technologies\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44751968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoestrogens in menopausal hot flashes: A review Article","authors":"R. Salari, Rahele Kargozar, H. Azizi, M. Yousefi, Seyedeh Azam Pourhoseini, Hamideh Naghedi-Baghdar, S. Ghazanfari","doi":"10.2174/2215083810666230529123939","DOIUrl":"https://doi.org/10.2174/2215083810666230529123939","url":null,"abstract":"\u0000\u0000Menopause is a biopsychosocial phenomenon in a woman’s life, and it occurs at about the age of 48-55 years. Factors such as smoking, the number of children, early puberty, and social class can cause early natural menopause. Symptoms that occur during menopause include headache, mood disorders, insomnia, distraction, hot flashes, vaginal dryness, and sweating. The most common symptom is hot flashes, which affect 85% of women with menopause. Recently, people are showing more tendencies toward alternative therapies and herbs phytoestrogens.\u0000\u0000\u0000\u0000This review aims to introduce the mechanism of herbal phytoestrogens controlling hot flashes during menopause.\u0000\u0000\u0000\u0000Our searches were performed in the databases of PubMed, Scopus, and Cochrane. English clinical trials, that investigated the effects of phytoestrogen plants individually or in combination on the treatment of hot flashes in menopause were analyzed. After reviewing articles and meeting the inclusion and exclusion criteria, 18 articles were selected.\u0000\u0000\u0000\u0000In this study, 18 clinical trials of 2351 female patients were analyzed. The phytoestrogen plants studied include soy, red clover, cohosh, hops, flax, pomegranate, anise, and Vitex Agnus.\u0000\u0000\u0000\u0000Studies have shown the beneficial effects of phytoestrogens in controlling hot flashes, but in some cases, including soybeans, there are contradictory effects. Therefore, more clinical trials are needed to achieve reliable results to confirm the phytoestrogen effects of herbal medicines.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48411175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Integrated Risk Factors with Prevention and Prevalence of Asthma at the Global Level","authors":"R. Garg, Mona Piplani, Yogendra Pratap Singh, Pankaj Bhateja, R. Rana","doi":"10.2174/2215083810666230525153908","DOIUrl":"https://doi.org/10.2174/2215083810666230525153908","url":null,"abstract":"\u0000\u0000Bronchial asthma is one of the most common chronic illnesses in childhood, adulthood and pregnancy with a current occurrence of 6-9 percent, but at an alarming rate of increase. Asthma is a complex genetic disorder that is heavily affected by the environment. In association with significant morbidity, quality of life, and healthcare costs, it is putting an increasing strain on our society. Some factors related to pregnancy, i.e., diet-related, antibiotic uses, and stress; childhood risk factors, i.e., lung function, exposure to smoking, animal etc. and adulthood risk factor, i.e., pollution-related etc., are responsible for trends in incidence and mortality due to asthma at a Global level and Indian population. Data were collected from PubMed, Web of Sciences, CINHAL, WHO Clinical trial register, Google Scholar, and official websites of various asthma societies and statistically analyzed using ANOVA tests. Data were analyzed for India and the specific population of the northern region of India during the last five years. Risk factors related to asthma at different stages, i.e., genetic, pregnancy, childhood, and adulthood, were reviewed, and the prevalence of asthma at the Global level, India and northern India, was analyzed and compared. The mean Global prevalence of asthma was found to be 281.3±14.7 (SD), whereas, for India, it was 22.78±8.605. After applying One Way ANOVA, a significant difference (t=48.44, df=4) was found between the Global and Indian prevalence of asthma, i.e., the mean difference of 259.7±11.99. The mean value was found highest in Delhi and Rajasthan, having values of 19.74±11.79 and 13.58±9.47, whereas Chandigarh and Uttar Pradesh recorded asthma’s prevalence as 11.87±7.83 and 4.32±2.32 respectively. Himachal and Haryana acquired almost equal values of asthma at 1.67±0.13 and 1.23±0.33.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47562768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal Medicines Genkwadaphnin as Therapeutic Agent for Cancers and Other Human Disorders: A Review of Pharmacological Activities through Scientific Evidence","authors":"D. Patel, K. Patel","doi":"10.2174/2215083810666230523155650","DOIUrl":"https://doi.org/10.2174/2215083810666230523155650","url":null,"abstract":"\u0000\u0000Daphnane-type diterpenes are an important class of phytochemicals found to be present in the family Euphorbiaceae and Thymelaeaceae. It has anti-leukaemic, anti-hyperglycaemic, and anti-fertility activities in medicine. Daphne genkwa is indigenous to the Yangtze River and Yellow River of China. Daphne genkwa contains significant amounts of daphnane-type diterpenes. Phytochemical analysis of Daphne genkwa led to the isolation of flavonoids, lignins, coumarins, caffeotannic acids, and genkwadaphnin.\u0000\u0000\u0000\u0000Present review highlighted the biological potential of genkwadaphnin in medicine. All the scientific data of Daphne genkwa, and genkwadaphnin were collected from Google, Google Scholar, Science Direct, Scopus, and PubMed and analyzed in the present work to know the therapeutic potential of genkwadaphnin in medicine. Detailed pharmacological activities of genkwadaphnin were analyzed in the present work through scientific data analysis of various research works.\u0000\u0000\u0000\u0000Genkwadaphnin is a daphnane diterpene ester molecule mainly isolated from the Daphne genkwa, Dendrostellera lessertii, Daphne odorata, Gnidia latifolia, and Gnidia glaucus. Genkwadaphnin has been reported to exert therapeutic potential against hepatocellular carcinoma, human colon cancer, squamous cell carcinoma, and leukemia. Further, it has a significant role in innate immunity, melanogenesis, skeletal diseases, inflammatory cytokines, and natural killer cell. However, pharmacokinetics and metabolomics aspects of genkwadaphnin were also discussed in the present work. Further, more scientific data on human clinical trials is needed to ensure the safety and efficacy of genkwadaphnin in medicine.\u0000\u0000\u0000\u0000In the present work, a successful review had been achieved by the above-mentioned scientific data, which signified the therapeutic potential of genkwadaphnin in medicine.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46903563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and Pharmacological Profile of Desmodium gangeticum (L.) DC.: A Comprehensive Review","authors":"M. Bora, S. Mandal, P. Singh, Himangi Das, Girindra Kumar Bora, D. Bora, D. Baruah, M. Gautam","doi":"10.2174/2215083810666230523145738","DOIUrl":"https://doi.org/10.2174/2215083810666230523145738","url":null,"abstract":"\u0000\u0000Desmodium gangeticum (L.) DC., commonly known as Shalparni in Ayurveda, has been\u0000used for treating various diseases. The plant is one among ten ingredients of classical Ayurvedic\u0000formulations Dasamula. Decoctions of root and leaf, root powder and leaf juice of D. gangeticum\u0000are used as tonics, febrifuge, digestive, antiemetic, astringent, anti-asthmatic, anti-diarrhoeal and anti-inflammatory agents in traditional medicinal practices of India and its neighbouring countries.\u0000Phytochemical investigations of this plant revealed the presence of many bioactive phytoconstituents. The present review was prepared with the objective of documenting the phytochemical and\u0000pharmacological profiles of D. gangeticum. The data presented here were collected from various\u0000sources like books, journals, various online databases, and monographs and internet search engines\u0000Google Scholar, PubMed, Science Direct, etc. Studies reported from phytochemical screening revealed that D. Gangeticum leaves and roots are rich in flavonoids, alkaloids, terpenoids, tannins,\u0000phenols, carbohydrates, steroids, phenylpropanoids, pterocarpans, coumarins, and volatile oil.\u0000Among the isolated compounds, major bio-active constituents are alkaloids, flavonoids and pterocarpans. All these phytochemicals are widely distributed in various parts of D. gangeticum. The\u0000other active constituents like desmodin, hordenine and gangetin are largely responsible for its broad\u0000spectrum of therapeutic potentiality. Desmodin belongs to the class of pterocarpans and is reported\u0000to have antifungal and antibacterial activities. Gangetin, which also belongs to the pterocarpans, is\u0000reported to have anti-inflammatory and analgesic effects. FTIR spectroscopy showed that D. gangeticum extracts are mainly rich in phenolic derivatives. Scientific experiments carried out in vitro\u0000as well as preclinical animal experimentations, showed that the plant and its bioactive chemicals\u0000exhibit various therapeutic activities. It is reported that D. gangeticum extracts showed potent antioxidant, antibacterial, hypoglycaemic, analgesic, hepatoprotective, anti-inflammatory and antiarthritic activities. Studies reported that D. gangeticum or its formulations are safe when used in appropriate therapeutic dosage.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42150794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}