Phytosomal Drug Delivery System: A detailed study

IF 0.6 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Current Traditional Medicine Pub Date : 2023-05-31 DOI:10.2174/2215083810666230531163053

Srikala Kamireddy, S. Sangeetha, Sreya Kosanam

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引用次数: 0

Abstract

Nature contains a diverse range of phytoconstituents that possess several pharmacological properties. However, the effectiveness of herbal formulations is limited due to the poor bioavailability of phytoconstituents, which makes it difficult for them to pass through the cell membrane. Phytosomes are a modern type of herbal formulation that comprises therapeutically active phytoconstituents extracted from medicinal plants and enclosed by phospholipids. By combining phytoconstituents with phospholipids, phytosomes are able to enhance bioavailability and reduce side effects. Various techniques such as solvent evaporation, rotatory evaporation, anti-solvent precipitation, freeze-drying, and solvent ether injection can be used to prepare phytosomes. Phytosomes can be evaluated using methods such as UV-Spectra, DSC, drug entrapment and loading capacity, surface tension activity measurement, and in-vitro/in-vivo studies. This review discusses different methods for preparing phytosomal formulations and their advantages, which have been found to significantly improve the bioavailability of phytoconstituents. Phytosomes have high entrapment efficiency and do not compromise the safety of nutrients. By utilizing phytosomal drug delivery, issues associated with conventional drug delivery may be overcome. Therefore, it is important to combine Indian Ayurvedic medicine with novel drug delivery systems to improve drug delivery technologies

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植物体给药系统的详细研究

自然界含有多种植物成分，具有多种药理特性。然而，由于植物成分的生物利用度低，使其难以通过细胞膜，因此草药制剂的有效性有限。植物体是一种现代类型的草药制剂，包括从药用植物中提取并被磷脂包裹的具有治疗活性的植物成分。通过将植物成分与磷脂结合，植物体能够提高生物利用度并减少副作用。可以使用溶剂蒸发、旋转蒸发、抗溶剂沉淀、冷冻干燥和溶剂醚注射等多种技术来制备植物体。植物体可以使用紫外线光谱、DSC、药物包埋和负载能力、表面张力活性测量和体外/体内研究等方法进行评估。这篇综述讨论了制备植物体制剂的不同方法及其优点，这些方法已被发现可以显著提高植物成分的生物利用度。植物体具有很高的包封效率，并且不会损害营养物质的安全性。通过利用植物体药物递送，可以克服与传统药物递送相关的问题。因此，将印度阿育吠陀医学与新型药物递送系统相结合以改进药物递送技术是很重要的

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来源期刊

Current Traditional Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Current Traditional Medicine covers all the aspects of the modernization and standardization research on traditional medicine of the world, e.g. chemistry, pharmacology, molecular mechanism, systems biology, proteomics, genomics, metabolomics, safety, quality control, clinical studies of traditional Chinese, Ayurvedic, Unani, Arabic and other ethnomedicine. Each issue contains updated comprehensive in-depth/mini reviews along with high quality original experimental research articles. Current Traditional Medicine is a leading and important international peer-reviewed journal reflecting the current outstanding scientific research progresses of the global traditional, indigenous, folk and ethnologic medicine. It provides a bridge connected the tradition medicine system to the modern life science with the efforts of top scientists, as well as a resource to pursuit the solutions for the existing common issues in the traditional medicine.