Current Traditional Medicine最新文献

{"title":"The Impact of Carrageenan on Pharmascience","authors":"Akanksha Bhatt, Nidhi Nainwal, Priyank Purohit","doi":"10.2174/0122150838266638231117180516","DOIUrl":"https://doi.org/10.2174/0122150838266638231117180516","url":null,"abstract":"\u0000\u0000Carrageenan (CG) a sulfated polysaccharide (SP) is produced using a variety of seaweeds from the Rhodophyceae family. This type of seaweed is available in areas, like the Atlantic Ocean close to Great Britain, Europe, and North America. Carrageenan has been permitted\u0000for the use as food items with the European additive E-number E407. Carrageenan is a widely\u0000used polysaccharide derived from red seaweed and is known for its various applications in the\u0000chemical, biological, and pharmaceutical fields. It delves into its versatile applications across\u0000various sub areas, spanning from the food to the pharmaceutical industry. A significant emphasis\u0000is placed on the intricate roles of carrageenan in pharmaceutical science, where it serves as both\u0000a drug carrier agent and an active ingredient, owing to its noteworthy biological activity. This\u0000review aims to provide a comprehensive overview of carrageenan`s versatile applications, with a\u0000focus on its chemical properties, biological activities, and pharmaceutical uses. The\u0000pharmaceutical applications of carrageenan are further categorized into various subparts,\u0000including its role in treating diseases and its use in drug delivery systems, such as topical, oral,\u0000nasal, and unconventional routes. The review also incorporates the most recent developments in\u0000clinical trials involving carrageenan and its updated applications, drawing from authoritative\u0000sources. This comprehensive analysis aims to offer readers a clear understanding of\u0000carrageenan's multifaceted nature and its evolving significance in diverse industries.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"12 9","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139438698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-oxidant Effects of Repeatedly Heated Sunflower Oil and the Possible\u0000Ameliorative Potential of Elaeodendron transvaalense Leaf Powder in\u0000Sprague Dawley Rats","authors":"T. Kwape, Kabo Masisi, Laone Kelaotswe, Keagile Bati, Phazha Baeti","doi":"10.2174/0122150838268705230928080148","DOIUrl":"https://doi.org/10.2174/0122150838268705230928080148","url":null,"abstract":"\u0000\u0000Repeated heating of cooking oils induces the overproduction of reactive\u0000oxygen species with an overwhelmed cellular antioxidant defense system, resulting in oxidative\u0000stress, the known cause of cardiovascular diseases. Elaeodendron transvaalense is a medicinal\u0000plant believed to have phytochemicals that help ameliorate the effects of oxidative stress.\u0000\u0000\u0000\u0000This study investigated the pro-oxidant effects of repeatedly heated sunflower oil and\u0000the possible ameliorative potential of Elaeodendron transvaalense leaf powder in Sprague Dawley\u0000rats.\u0000\u0000\u0000\u0000Four groups of male Sprague Dawley rats were fed for 4-weeks a standard diet supplemented\u0000without (a) control or with (b) 15% (w/w) repeatedly heated sunflower oil (RHSO),\u0000(c) 15% (w/w) non-heated sunflower oil, (d) 15% (w/w) RHSO and 1.5% ETLP.\u0000\u0000\u0000\u0000Endogenous antioxidants: Catalase and SOD activities were observed to rise significantly\u0000(p <0.05) in Group 2 when compared to Group 1 and Group 3 respectively. A significant\u0000decline in the SOD and catalase activities was observed in group 4 fed RHSO + ETLP. No significant\u0000differences were observed in the body, liver, and kidney weights of Group 2 when compared\u0000with Groups 1, 3 and 4 respectively, and no significant differences were observed when\u0000comparing Group 4 to Groups 1, 2 and 3. The levels of Lipid profiles; Low-density Lipoproteins\u0000(LDL), Total cholesterol (TC), and Triglycerides (TG) were observed to rise significantly (p\u0000<0.05) in Group 2 when compared to Group 1 and 3, while their significant (p <0.05) decline\u0000was observed in Group 4 fed with RHSO + ETLP. The levels of HDL showed no significant difference\u0000across all groups because the p-values for the difference between groups exceeded the\u0000null hypothesis (p <0.05).\u0000\u0000\u0000\u0000The findings of this experiment indicate the possible ameliorative potential of\u0000ETLP observed in the significantly (p <0.05) reduced SOD and catalase activities. A significant\u0000(p <0.05) decline in the TC, TG, and LDL to desirable levels further indicated the ameliorative\u0000effects.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"89 2","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139388153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Euclea natalensis Suppresses Postprandial Hyperglycemia in Rats via the\u0000Inhibition of α-Glucosidase: In vitro, in vivo, and Molecular Docking Studies","authors":"Keagile Bati, R. Majinda, Goabaone Gaobotse, T. Kwape","doi":"10.2174/0122150838259363230922033947","DOIUrl":"https://doi.org/10.2174/0122150838259363230922033947","url":null,"abstract":"\u0000\u0000Postprandial hyperglycemia is a key factor in type 2 diabetes, and its\u0000management is critical in alleviating the deleterious consequences of diabetes and its associated\u0000micro and macrovascular complications.\u0000\u0000\u0000\u0000The current study aims to determine the effect of Euclea natalensis leaf extracts on α-\u0000glucosidase inhibition in vitro and postprandial hyperglycemia in vivo in rats.\u0000\u0000\u0000\u0000Sequentially extracted leaf extracts of Euclea natalensis were evaluated for their inhibitory\u0000effects on α-glucosidase in vitro and the suppression of postprandial hyperglycemia in\u0000normoglycemic rats. The extracts were fingerprinted using a Fourier-transform infrared spectrophotometer\u0000(FTIR), and the bioactive compounds were evaluated by molecular docking for their\u0000interaction with α-glucosidase.\u0000\u0000\u0000\u0000FTIR fingerprinting of the extracts showed that they contain functional groups of important\u0000bioactive phytochemicals. The extracts inhibited α-glucosidase in vitro, with the methanol\u0000extract (1 mg/mL) showing the highest inhibitory effect of 93.52 ± 1.50% compared to\u000069.62% ± 1.45 of the standard drug acarbose (0.05 mg/mL). The extracts also reduced postprandial\u0000hyperglycemia in rats in a sucrose tolerance test, where the hexane and methanol extracts\u0000performed similarly to Acarbose. Molecular docking studies showed that 20(29)-lupene-3β-\u0000isoferulate 3 is the most potent α-glucosidase inhibitor with the lowest binding energy of -10.79\u0000kcal/mol, 2 hydrogen bonds with residues ASP1526 and ASP1157, and numerous Van der Waal\u0000interactions with amino acids in the binding pocket of α-glucosidase.\u0000\u0000\u0000\u0000Euclea natalensis leaf extracts were found to suppress postprandial hyperglycemia\u0000by inhibiting α-glucosidase activity; thus, it has a promising potential for use as an antidiabetic\u0000agent.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"26 10","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139452228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and Standardisation of Ayurvedic Lepa - A Traditional Lepa\u0000Chikitsa Therapy: An Ayurveda Cosmetology from Traditional to Modern\u0000Perspective","authors":"Shuvendhu Gupta, A. Singh, Alok Sharma","doi":"10.2174/0122150838226522231113073535","DOIUrl":"https://doi.org/10.2174/0122150838226522231113073535","url":null,"abstract":"\u0000\u0000The skin is the largest and most important organ in the human body.\u0000Taking care of the skin is crucial for maintaining beauty and preventing skin issues.\u0000\u0000\u0000\u0000Recently, Ayurvedic Cosmetology has become very popular due to its availability,\u0000affordability, and long-lasting benefits. Simple formulations like herbal pastes made from natural\u0000substances, peels, juices, and extracts are applied to the face. An ancient Ayurvedic text called\u0000\"The Sharangdhara Samhita\" provides detailed information about skin care, preventing skin disorders,\u0000and enhancing beauty. This text specifically focuses on \"The Lepa,\" which refers to topical\u0000applications for skincare and beauty. It mentions a total of 94 types of lepa, including 26 for\u0000treating skin disorders.\u0000\u0000\u0000\u0000The present work is aimed to formulate four different lepa, which are mentioned\u0000in ancient text and standardization was carried out to confirm its identity and quality. Different\u0000parameters such as loss on drying, total ash, acid insoluble ash value, extraction, pH, and\u0000solubility were performed.\u0000\u0000\u0000\u0000This work highlights a neglected section of Ayurveda that has the potential for future\u0000advancements in skincare and more phytochemical studies are required for the lead identification\u0000of lead molecule.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"7 2","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138980162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vyadhi-Kshamatava: An Immunotherapeutic Concept in Ayurveda","authors":"Rashmi Singh, Alok Sharma","doi":"10.2174/0122150838211267231113074710","DOIUrl":"https://doi.org/10.2174/0122150838211267231113074710","url":null,"abstract":"\u0000\u0000Ayurveda mainly focuses on treating diseases which aims at disease prevention. According\u0000to ayurveda, a disease is caused by inappropriate intellect, constitution, moral conduct,\u0000karma, and inappropriate contact with sensory perceptions such as sound, touch, vision, taste,\u0000and smell. These factors influence how diseases present themselves, whether they are mild, severe,\u0000acute, chronic, easily treatable, or incurable. The concept of \"Vyadhikshamatva\" in Ayurveda\u0000represents the fundamental principles of immunity. Ayurveda uses the terms \"Vyadhi\" and\u0000\"Kshamatva\" to describe illness and adaptation, respectively. According to Ayurveda, an imbalance\u0000in the Doshas leads to the development of diseases. In Ayurveda, immunity is referred to as\u0000\"Vyadhikshamatva\" and according to ayurvedic biology, Vyadhikshamatva can be correlated\u0000with the concept of immunity. Sahaja bala, Kalaja and yuktikrita bala refer to innate immunity\u0000and acquired immunity. The current work is focused on the concept of immunity in ayurveda.\u0000Various literatures have been collected from various sources such as ancient textbooks and references\u0000to highlight ayurvedic immunity concept and the management of disease by executing different\u0000ayurvedic principles. The result highlights the concept of Vyadhikshamatva as mentioned\u0000in Ayurvedic text which is considered Immunity. Therefore, the present work could contribute to\u0000ayurvedic biology and explore the concept of Vyadhikshamatva with the immunity in future.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"18 6","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138978765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunity Boosting Herbs For Fighting COVID-19","authors":"Prerna Sharma, N. Rani, Vikas Sharma, Nitin Goel, Sanchit Dhankhar","doi":"10.2174/0122150838237067231010041602","DOIUrl":"https://doi.org/10.2174/0122150838237067231010041602","url":null,"abstract":"Ever since the global outbreak of COVID-19, which is an infectious disease caused by the novel SARS-CoV-2 (Novel Coronavirus (nCov-19), scientists and researchers across the globe have been looking and searching for a cure that is quick, efficient and affordable. SARSCoV- 2 spread in 215 countries and territories around the globe with +15 million reported cases and +670k deaths worldwide until July 24, 2020. Healthcare facilities across the globe are trying to manage, control, and prevent the spread of this submicroscopic entity entering the macroscopic cosmos. Patients infected with COVID-19 frequently present with a respiratory infection that is similar to pneumonia and a cough. We do not yet have an effective vaccination to battle the sickness; therefore, the only treatment option for patients is symptomatic therapy. In the meantime, however, it could be useful to have a look at the most recent research on immuneenhancing herbs and how they might be incorporated into daily life if the impact of nCov-19 on an individual cannot be stopped entirely but can at least be mitigated.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"262 ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139239702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Traditional Medicines and Natural Products for COVID-19: A Review","authors":"Rahul Kumar Sharma, Ramandeep Kaur, Ajay Singh Khushwah, Shailesh Sharma, Neelam Sharma, Punam Gaba","doi":"10.2174/0122150838264297231026111437","DOIUrl":"https://doi.org/10.2174/0122150838264297231026111437","url":null,"abstract":"Abstract: he global threat posed by the COVID-19 pandemic has intensified the search for innovative treatments, sparking interest in the potential of natural materials as sources for antiviral medications. This paper delves into the realm of natural medicine, examining the utilization of plant extracts and microbial compounds to combat viral diseases like COVID-19. While these sources hold promise, safety remains paramount. Just as with conventional drugs, natural medications can yield adverse effects and interactions, necessitating rigorous evaluation. To mitigate potential risks, techniques to reduce after-effects are explored, emphasizing the importance of standardization and quality control. Integrating traditional knowledge with modern scientific methods presents an opportunity to discover novel therapies. The development of potent and effective natural antiviral medications and vaccines, crucial for managing future outbreaks, demands interdisciplinary collaboration, regulatory oversight, and comprehensive clinical trials. In navigating the dynamic landscape of viral diseases, the exploration of natural sources complements conventional approaches, underlining the need for a holistic and balanced strategy.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"102 46","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135136666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization and Awareness of Unani Medicine among Adults in Delhi, India: A Survey-Based Study","authors":"Asim Ali Khan, Rajiv Janardhanan, Jugal Kishore, Shazina Saeed, B.C Das, Shagufta Parveen, Prashant Kesharwani, Ritu Karwasra, Amirhossein Sahebkar, W. Selvamurthy","doi":"10.2174/0122150838252861231019101920","DOIUrl":"https://doi.org/10.2174/0122150838252861231019101920","url":null,"abstract":"Objectives:: The objective of this study is to assess the level of knowledge, practice, and usage of Unani medicine among 250 participants in different areas of New Delhi, India. Materials and Methods:: A cross-sectional, observational descriptive survey with a sample size of 250 people was carried out in New Delhi utilizing a pretested, predesigned, and structured questionnaire to evaluate the awareness and usage patterns of Unani medicine. The study was conducted at three different spots in different regions of New Delhi. Results:: With a mean age of 40.056 ± 10.77 years and a range of 18 to 65 years, the 250 participants were divided into 66% men and 34% women. 60% of the population who had been adopted had knowledge of Unani medicine, and 54.6% of them relied on Unani medicine as a treatment regime. 40% of users reported Unani medicine due to lack of no or minimal side effects. Contrary to this, among non-user (n = 68), 51.4% populace considers Unani medicine as the slow onset of action medication. Although a small percentage of users (6.1%) chose to use Unani completely, most preferred it as an adjunct to allopathic care. Conclusion:: Findings in the survey-based study depict that the awareness of Unani medicines is better than the utilization pattern. There is an urge and opportunity to advance health education and change people's perceptions of the Unani medical system.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phthalate-induced Toxicity and its Mitigation by Natural Plant Products","authors":"Kajal Gaur, Yasir Hasan Siddique","doi":"10.2174/0122150838268882231006094411","DOIUrl":"https://doi.org/10.2174/0122150838268882231006094411","url":null,"abstract":"Abstract: Phthalates are common synthetic chemicals in various industrial and consumer products, including plastics, personal care products, and medical equipment. They are dangerous even at extremely low concentrations during the crucial stages of life, such as pregnancy, infancy, early childhood, and adolescence. In recent years, there has been increased interest in looking into natural plant components as potential phthalate toxicity mitigators. Phthalates have been related to a number of health problems, including endocrine disruption, reproductive and developmental disorders, and carcinogenicity. As a result, effective ways to decrease phthalate exposure and attenuate its negative effects are required. Natural plant products have shown the potential to reduce phthalate toxicity via various methods. These methods include antioxidant and anti- inflammatory properties, detoxifying enzyme regulation, and competition for phthalate binding sites. Certain plant-derived chemicals, such as polyphenols, flavonoids, terpenes, and alkaloids, have been shown to interact with phthalates and potentially limit their absorption, distribution, and metabolism inside the body. This review highlights the effects of several naturally occurring plant products, such as apigenin, taxifolin, vitamin C, and many more, on the toxicity of phthalates. Natural products use nowadays is increasing due to their non-toxic nature, so in the future, more focus should be in favor of increasing the use of these natural products that we obtained from plants.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"19 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135874582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Punica granatum L. (Punicaceae): An Insight into Phytochemistry and Pharmacology","authors":"Sonali Labhade, Pranali Jadhav, Ritesh Bhole, Sohan Chitlange","doi":"10.2174/0122150838249599231020074948","DOIUrl":"https://doi.org/10.2174/0122150838249599231020074948","url":null,"abstract":"Abstract: Punica granatum L. (Punicaceae) generally identified as pomegranate, seeded or granular fruit, has been widely used for centuries in many cultures. P. granatum exhibits a wide variety of medicinal activities, viz., anticancer, antioxidant, antimicrobial, anti-inflammatory, etc. A variety of ethnomedical uses of P. granatum in several formulations, like powder, pulp, decoction and extract on its own or in blend with additional herbs against various diseases, like inflammation, skin disorders, cancer, microbial infections, and asthma, have been recorded. A wide variety of phytochemicals, including polyphenols, terpenoids, fatty acids, sugars, amino acids, tocopherols, sterols, alkaloids, amino acids, etc., have been isolated and identified from P. granatum, amongst which punicalagin, the major polyphenolic component of pomegranate extract, has been well thought of as the main effective component of plant. Thorough information related to P. granatum was gathered using the keywords Punica granatum or pomegranate in various computerized databases, including Pubmed, ACS, Science Direct, Google Scholar, WoS, Springer Link, Sci Finder, and Wiley. All full-text articles and abstracts were reviewed. Additionally, book chapters and monographs were also screened. The current study has highlighted the botany, ethnopharmacology, phytochemical profile, pharmacological activity, and toxicological studies of P. granatum. The ethnopharmacological importance of pomegranate has been discussed in recent pharmacological studies, indicating its medicinal and nutritional benefits in varied human disorders. Moreover, inquiries related to various facets of P. granatum relating to safety, toxicity and quality control are yet unanswered. Additionally, the article has provided a thorough knowledge of the herb, including its mechanism of action, structure activity relationships, safety as well as toxicity, as reported in clinical studies.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135977602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}