Pro-oxidant Effects of Repeatedly Heated Sunflower Oil and the Possible Ameliorative Potential of Elaeodendron transvaalense Leaf Powder in Sprague Dawley Rats

IF 0.6 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Current Traditional Medicine Pub Date : 2024-01-03 DOI:10.2174/0122150838268705230928080148

T. Kwape, Kabo Masisi, Laone Kelaotswe, Keagile Bati, Phazha Baeti

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引用次数: 0

Abstract

Repeated heating of cooking oils induces the overproduction of reactive oxygen species with an overwhelmed cellular antioxidant defense system, resulting in oxidative stress, the known cause of cardiovascular diseases. Elaeodendron transvaalense is a medicinal plant believed to have phytochemicals that help ameliorate the effects of oxidative stress. This study investigated the pro-oxidant effects of repeatedly heated sunflower oil and the possible ameliorative potential of Elaeodendron transvaalense leaf powder in Sprague Dawley rats. Four groups of male Sprague Dawley rats were fed for 4-weeks a standard diet supplemented without (a) control or with (b) 15% (w/w) repeatedly heated sunflower oil (RHSO), (c) 15% (w/w) non-heated sunflower oil, (d) 15% (w/w) RHSO and 1.5% ETLP. Endogenous antioxidants: Catalase and SOD activities were observed to rise significantly (p <0.05) in Group 2 when compared to Group 1 and Group 3 respectively. A significant decline in the SOD and catalase activities was observed in group 4 fed RHSO + ETLP. No significant differences were observed in the body, liver, and kidney weights of Group 2 when compared with Groups 1, 3 and 4 respectively, and no significant differences were observed when comparing Group 4 to Groups 1, 2 and 3. The levels of Lipid profiles; Low-density Lipoproteins (LDL), Total cholesterol (TC), and Triglycerides (TG) were observed to rise significantly (p <0.05) in Group 2 when compared to Group 1 and 3, while their significant (p <0.05) decline was observed in Group 4 fed with RHSO + ETLP. The levels of HDL showed no significant difference across all groups because the p-values for the difference between groups exceeded the null hypothesis (p <0.05). The findings of this experiment indicate the possible ameliorative potential of ETLP observed in the significantly (p <0.05) reduced SOD and catalase activities. A significant (p <0.05) decline in the TC, TG, and LDL to desirable levels further indicated the ameliorative effects.

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反复加热的葵花籽油的促氧化作用和横叶桉叶粉对布拉格道利大鼠的可能改善潜力

食用油的反复加热会导致活性氧的过度产生，细胞的抗氧化防御系统不堪重负，从而产生氧化应激，这是已知的心血管疾病的病因。本研究调查了反复加热的葵花籽油的促氧化作用以及 Elaeodendron transvaalense 叶粉在 Sprague Dawleyrats 中可能具有的改善潜力。给四组雄性 Sprague Dawley 大鼠喂食标准食物 4 周，同时添加（a）对照组或（b）15%（重量比）反复加热的葵花籽油（RHSO）、（c）15%（重量比）未加热的葵花籽油、（d）15%（重量比）RHSO 和 1.5% ETLP：与第 1 组和第 3 组相比，第 2 组的过氧化氢酶和 SOD 活性明显升高（p <0.05）。在饲喂 RHSO + ETLP 的第 4 组中，观察到 SOD 和过氧化氢酶活性明显下降。第 2 组的体重、肝脏和肾脏重量分别与第 1 组、第 3 组和第 4 组相比无明显差异，第 4 组与第 1 组、第 2 组和第 3 组相比也无明显差异。与第 1 组和第 3 组相比，观察到第 2 组的低密度脂蛋白（LDL）、总胆固醇（TC）和甘油三酯（TG）水平显著升高（p<0.05），而用 RHSO + ETLP 饲喂的第 4 组则显著下降（p<0.05）。本实验的结果表明，ETLP 可能具有改善潜力，因为 SOD 和过氧化氢酶活性显著降低（p <0.05）。总胆固醇、总胆固醇和低密度脂蛋白明显降低到理想水平（p <0.05），进一步表明了其改善作用。

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来源期刊

Current Traditional Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Current Traditional Medicine covers all the aspects of the modernization and standardization research on traditional medicine of the world, e.g. chemistry, pharmacology, molecular mechanism, systems biology, proteomics, genomics, metabolomics, safety, quality control, clinical studies of traditional Chinese, Ayurvedic, Unani, Arabic and other ethnomedicine. Each issue contains updated comprehensive in-depth/mini reviews along with high quality original experimental research articles. Current Traditional Medicine is a leading and important international peer-reviewed journal reflecting the current outstanding scientific research progresses of the global traditional, indigenous, folk and ethnologic medicine. It provides a bridge connected the tradition medicine system to the modern life science with the efforts of top scientists, as well as a resource to pursuit the solutions for the existing common issues in the traditional medicine.