Herbal Medicines Genkwadaphnin as Therapeutic Agent for Cancers and Other Human Disorders: A Review of Pharmacological Activities through Scientific Evidence

IF 0.6 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Current Traditional Medicine Pub Date : 2023-05-23 DOI:10.2174/2215083810666230523155650

D. Patel, K. Patel

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引用次数: 0

Abstract

Daphnane-type diterpenes are an important class of phytochemicals found to be present in the family Euphorbiaceae and Thymelaeaceae. It has anti-leukaemic, anti-hyperglycaemic, and anti-fertility activities in medicine. Daphne genkwa is indigenous to the Yangtze River and Yellow River of China. Daphne genkwa contains significant amounts of daphnane-type diterpenes. Phytochemical analysis of Daphne genkwa led to the isolation of flavonoids, lignins, coumarins, caffeotannic acids, and genkwadaphnin. Present review highlighted the biological potential of genkwadaphnin in medicine. All the scientific data of Daphne genkwa, and genkwadaphnin were collected from Google, Google Scholar, Science Direct, Scopus, and PubMed and analyzed in the present work to know the therapeutic potential of genkwadaphnin in medicine. Detailed pharmacological activities of genkwadaphnin were analyzed in the present work through scientific data analysis of various research works. Genkwadaphnin is a daphnane diterpene ester molecule mainly isolated from the Daphne genkwa, Dendrostellera lessertii, Daphne odorata, Gnidia latifolia, and Gnidia glaucus. Genkwadaphnin has been reported to exert therapeutic potential against hepatocellular carcinoma, human colon cancer, squamous cell carcinoma, and leukemia. Further, it has a significant role in innate immunity, melanogenesis, skeletal diseases, inflammatory cytokines, and natural killer cell. However, pharmacokinetics and metabolomics aspects of genkwadaphnin were also discussed in the present work. Further, more scientific data on human clinical trials is needed to ensure the safety and efficacy of genkwadaphnin in medicine. In the present work, a successful review had been achieved by the above-mentioned scientific data, which signified the therapeutic potential of genkwadaphnin in medicine.

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草药根黄黄素作为癌症和其他人类疾病的治疗剂:通过科学证据的药理活性综述

二萜是一类重要的植物化学物质，存在于大戟科和百里香科中。在医学上具有抗白血病、抗高血糖、抗生育等作用。达芙妮根花是中国长江和黄河流域的土著植物。达芙妮根花含有大量的达芙妮型二萜。从芫花中分离出黄酮类化合物、木质素、香豆素、咖啡酸和芫花黄素。本文综述了丁香黄素在医学上的生物学潜力。本工作收集了谷歌、谷歌Scholar、Science Direct、Scopus、PubMed等网站上有关芫花和芫花素的所有科学资料，并对其进行分析，以了解芫花素在医学上的治疗潜力。本文通过对各种研究成果的科学数据分析，详细分析了黄芪黄素的药理活性。芫花水仙素是一种主要从芫花、小树蕨、臭芙蓉、荷叶蕨和青花蕨中分离得到的水仙烷二萜酯类分子。据报道，Genkwadaphnin对肝细胞癌、结肠癌、鳞状细胞癌和白血病具有治疗潜力。此外，它在先天免疫、黑色素生成、骨骼疾病、炎症细胞因子和自然杀伤细胞中具有重要作用。然而，在本工作中也讨论了药代动力学和代谢组学方面的问题。此外，还需要更多的人体临床试验的科学数据来确保根黄黄素在医学上的安全性和有效性。在本工作中，对上述科学数据进行了成功的综述，这表明了黄芪黄素在医学上的治疗潜力。

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来源期刊

Current Traditional Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Current Traditional Medicine covers all the aspects of the modernization and standardization research on traditional medicine of the world, e.g. chemistry, pharmacology, molecular mechanism, systems biology, proteomics, genomics, metabolomics, safety, quality control, clinical studies of traditional Chinese, Ayurvedic, Unani, Arabic and other ethnomedicine. Each issue contains updated comprehensive in-depth/mini reviews along with high quality original experimental research articles. Current Traditional Medicine is a leading and important international peer-reviewed journal reflecting the current outstanding scientific research progresses of the global traditional, indigenous, folk and ethnologic medicine. It provides a bridge connected the tradition medicine system to the modern life science with the efforts of top scientists, as well as a resource to pursuit the solutions for the existing common issues in the traditional medicine.