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Therapeutic potential of the herbal plant Uncaria gambir: A systematic review 中药钩藤的治疗潜力:系统综述
IF 0.6
Current Traditional Medicine Pub Date : 2023-08-30 DOI: 10.2174/2215083810666230830125306
Farina Pramanik, M. Satari, A. Azhari
{"title":"Therapeutic potential of the herbal plant Uncaria gambir: A systematic review","authors":"Farina Pramanik, M. Satari, A. Azhari","doi":"10.2174/2215083810666230830125306","DOIUrl":"https://doi.org/10.2174/2215083810666230830125306","url":null,"abstract":"\u0000\u0000Uncaria gambir is an Indonesian medicinal herb with healing effects. This plant contains flavonoids, which can be used as antioxidants and anti-inflammatory agents to accelerate healing. In Indonesia, Uncaria gambir is widely accessible, simple to grow, and has a long history of use as an alternative medicine. Following this, studies are conducted in the medical industry using Uncaria gambir.\u0000\u0000\u0000\u0000This study aimed to comprehensively review the use of Uncaria gambir extract as an herbal plant for treating experimental animals.\u0000\u0000\u0000\u0000This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and the risk of bias was evaluated by modifying the ARRIVE guidelines.\u0000\u0000\u0000\u0000A report was presented on review articles from 12 publications sourced from PubMed, ScienceDirect, Wiley Online Library, ProQuest, EBSCO Host, and other relevant studies. The Uncaria gambir isolates tested were catechin and ethyl acetate, used primarily for lesions, pain, edema, and diabetes in experimental Wistar rats.\u0000\u0000\u0000\u0000Uncaria gambir is an herbal plant that contains flavonoids, which can be used as anti-inflammatory, antioxidant, antibacterial, and hepatoprotective agents and can potentially be applied in the medical field as adjuvant therapy.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44361760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does Vitamin E Supplementation Alter Hormonal Levels in Polycystic Ovary Syndrome: A Systematic Review of Randomized Controlled Trials 补充维生素E是否会改变多囊卵巢综合征患者的激素水平:随机对照试验的系统评价
IF 0.6
Current Traditional Medicine Pub Date : 2023-08-28 DOI: 10.2174/2215083810666230828113447
S. M, Rukaiah Fatma Begum, S. Suresh, V. S. Devi, Muralidhar Moka
{"title":"Does Vitamin E Supplementation Alter Hormonal Levels in Polycystic Ovary Syndrome: A Systematic Review of Randomized Controlled Trials","authors":"S. M, Rukaiah Fatma Begum, S. Suresh, V. S. Devi, Muralidhar Moka","doi":"10.2174/2215083810666230828113447","DOIUrl":"https://doi.org/10.2174/2215083810666230828113447","url":null,"abstract":"Vitamin E influences hormonal parameters in women, but the evidence concerning its effectiveness in polycystic ovarian syndrome (PCOS) are constrained. The objective of this systematic review is to perceive the mechanism behind the hormonal effects of vitamin E in PCOS and explore the effectiveness of vitamin E by analyzing the clinical studies. Electronic bibliographic databases, such as PubMed, Scopus, ProQuest, DOAJ, ScienceDirect, and Cochrane Library, were searched for clinical studies scrutinizing the effect of vitamin E supplementation on PCOS. The systematic review protocol is registered in PROSPERO (CRD42021272963) and was performed as per the PRISMA guidelines. Records analyzing the hormonal parameters were included. For individual study, the risk of bias was ascertained with NHLBI protocol for controlled randomized studies. There were 1438 records identified, of which seven records were retrieved which met the inclusion criteria. Bibliographic details, number of participants, the dose of vitamin E, duration of the treatment and trial, parameters analyzed, and outcome of each study were extracted comprehensively. In the review, the majority of the studies embraced high-quality studies, which included double-blinded controlled trials, open-label controlled studies, and cohort studies. Vitamin E implies having a progesterone-like impression with estrogenic and androgenic properties. Furthermore, the ability of vitamin E as an antioxidant is also advantageous in PCOS women. However, there is a lack of empirical evidence on its mechanism, and the inadequacy of large-scale concerns about different age groups against PCOS is requisite.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"10 1-2","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41301872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on the Effective Implications of Plant-generated Polyphenols as Novel Therapeutic Agents against Neurodegenerative Diseases 植物多酚作为新型神经退行性疾病治疗剂的有效意义综述
IF 0.6
Current Traditional Medicine Pub Date : 2023-08-23 DOI: 10.2174/2215083810666230823094940
Diptayan Adhikari, Jayati Biswas, Bitihotra De, Bani Kumar Pathak
{"title":"A Review on the Effective Implications of Plant-generated Polyphenols as Novel Therapeutic Agents against Neurodegenerative Diseases","authors":"Diptayan Adhikari, Jayati Biswas, Bitihotra De, Bani Kumar Pathak","doi":"10.2174/2215083810666230823094940","DOIUrl":"https://doi.org/10.2174/2215083810666230823094940","url":null,"abstract":"\u0000\u0000Various neurodegenerative diseases have become a serious threat to human health all around the world. The progressive loss of functionality of active neurons causes neurodegenerative disease. Current research suggests that plant-derived foods, such as fruits and vegetables, are a good source of natural polyphenols, which can be effective in reducing the risk factors of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), etc. These polyphenols exhibit cognitive repair and can reduce the production of reactive oxygen species (ROS) to establish neuroprotection. Various animal models were developed to understand the neuromodulatory and therapeutic activities of polyphenols for the treatment of AD, PD, HD, etc. Moreover, polyphenols indirectly modulate the gut microbiome to generate neuroprotection. Although there is a disadvantage to the low oral bioavailability of these polyphenols, the conjugation can enhance the efficiency of these compounds with nanoparticles. The present review gives an outline of plant-generated polyphenols and highlights their effects in the treatment of various neurodegenerative diseases. As a result, the prevention of aging-related disorders through natural products certainly shows excellent therapeutic efficiency soon. For this study, various reviews as well as original research articles from PubMed describing the possible therapeutic effects of dietary polyphenols to cure neurodegenerative diseases are used.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45622294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cuphea Genus: A Systematic Review on the Traditional Uses, Phytochemistry, Pharmacology, and Toxicology Cuphea属:传统用途、植物化学、药理学和毒理学的系统综述
IF 0.6
Current Traditional Medicine Pub Date : 2023-08-22 DOI: 10.2174/2215083810666230822100119
Marí Castro Santos, A. Mendez, A. Henriques
{"title":"Cuphea Genus: A Systematic Review on the Traditional Uses, Phytochemistry, Pharmacology, and Toxicology","authors":"Marí Castro Santos, A. Mendez, A. Henriques","doi":"10.2174/2215083810666230822100119","DOIUrl":"https://doi.org/10.2174/2215083810666230822100119","url":null,"abstract":"\u0000\u0000Species from the Cuphea genus (Lythraceae) have wide usage in traditional medicine for the treatment of various diseases. Cuphea comprises about 260 species distributed worldwide among five continents.\u0000\u0000\u0000\u0000This systematic review aimed to synthesize the information available about the traditional uses, phytochemistry, pharmacology, and toxicology of Cuphea spp. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria, with a search in the scientific databases, namely Scopus, Web of Science, PubMed, and ScienceDirect, using keywords, such as “Cuphea”, “sete-sangrias”, “Cuphea” and “polyphenols”, “Cuphea” and “flavonoid”, “Cuphea” and “pharmacology”, “Cuphea” and “traditional uses”, “Cuphea” and “toxicology”, and all references found were analyzed. Among 1438 publications identified in the initial screening, 86 studies were included based on eligibility criteria. The chemical composition of Cuphea spp. is mainly polyphenols related to therapeutic use, especially as an antioxidant, antimicrobial, antitumoral, anti-inflammation, and antihypertensive.\u0000\u0000\u0000\u0000In summary, this systematic review provides an overview of the active compounds responsible for the pharmacological actions of the genus, often linked to traditional use.\u0000\u0000\u0000\u0000However, its safety and potential toxicology need to be further studied, along with the bioactive mechanisms and discussion of the structure-activity relationship, besides future clinical studies for novel drug development.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42043664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Attributes of Hesperidin 橙皮苷的药理特性
IF 0.6
Current Traditional Medicine Pub Date : 2023-08-22 DOI: 10.2174/2215083810666230822113623
Y. Siddique, Iqra Subhan
{"title":"Pharmacological Attributes of Hesperidin","authors":"Y. Siddique, Iqra Subhan","doi":"10.2174/2215083810666230822113623","DOIUrl":"https://doi.org/10.2174/2215083810666230822113623","url":null,"abstract":"Hesperidin is a major flavonoid in sweet oranges and lemons. Aglycone form of hesperidin i.e., hesperetin, and their various derivatives possess significant potential as therapeutic agents for a wide range of diseases and disorders. No signs of toxicity have been observed with the normal intake of hesperidin or related compounds. Hesperidin has been reported to possess a wide range of pharmacological properties, which includes antioxidant, anti-viral, anticancer, antidiabetic, analgesic, organ protective, neuroprotective, antihypertensive, and cardioprotective effects. This needs to be effectively studied at the clinical level so as to firmly establish the usefulness of these compounds in the treatment or prevention of disease in humans. This paper reviews various aspects of hesperidin, including their chemistry, biosynthesis, and bioactivity.","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46111774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Sequelae of Sleeping Issues and their Management in Post COVID-19: A Unani and Contemporary Narrative Review 新冠肺炎后睡眠问题的后遗症及其管理:Unani与当代叙事评论
IF 0.6
Current Traditional Medicine Pub Date : 2023-08-22 DOI: 10.2174/2215083810666230822113646
Shaheen Akhlaq, A. Jamal, A. Siddiqui, S. Ara, Malik Itrat
{"title":"The Sequelae of Sleeping Issues and their Management in Post COVID-19: A Unani and Contemporary Narrative Review","authors":"Shaheen Akhlaq, A. Jamal, A. Siddiqui, S. Ara, Malik Itrat","doi":"10.2174/2215083810666230822113646","DOIUrl":"https://doi.org/10.2174/2215083810666230822113646","url":null,"abstract":"\u0000\u0000The Coronavirus disease (COVID-19) impacted not only physical health but also psychological health, including anxiety, depressive symptoms, and sleep issues. Disrupted sleep has now become a global concern and burden in the post-COVID period of recovery. The Unani system of medicine elaborated on sleeping issues and their management during the pandemic. However, the claims of the Unani system and its medications in improving the various domains of sleep quality during the revival period have not been investigated.\u0000\u0000\u0000\u0000A search of electronic databases on Pub Med, Scopus, Web of Science, and CINAHL, on sleep disorders, post-COVID-19 and a manual search of Unani classical text related to sleep quality improvement methods was conducted.\u0000\u0000\u0000\u0000Recent scientific evidence has found a positive association between COVID-19 and sleep disorders. Unani medicine suggests improvement of sleep issues by maintaining six essential factors, dieto-therapy, pharmacotherapy, and regimens (like Nutool (irrigation), Hamam (Turkish bath), and Dalk (massage). Several pre-clinical and clinical trials done on Unani herbs (single and poly-herbal preparations) have elucidated the scientific rationale for improving sleep quality.\u0000\u0000\u0000\u0000Unani therapy has sufficient potential for improving sleep outcomes for COVID-19 patients as they are efficacious, safe and affordable therapeutic options. Additionally, there is still a need for evidence to support the validity of Unani psychotherapy as a multifaceted and holistic approach.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46444003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current regulations of Herbal medicines in the US and EU 美国和欧盟草药的现行法规
IF 0.6
Current Traditional Medicine Pub Date : 2023-08-22 DOI: 10.2174/2215083810666230822113615
P. D. Krishna, M. P. Gowrav, Mahendran Bhaskaran, M. R. Kruthika
{"title":"Current regulations of Herbal medicines in the US and EU","authors":"P. D. Krishna, M. P. Gowrav, Mahendran Bhaskaran, M. R. Kruthika","doi":"10.2174/2215083810666230822113615","DOIUrl":"https://doi.org/10.2174/2215083810666230822113615","url":null,"abstract":"\u0000\u0000If a herbal pharmaceutical is intended to impact the function of the human organism, it is categorized as a medication or a nutritional supplement. According to the FDA, the medicine must be offered under a New Drug Application (NDA). The European Medicine Agency (EMA) has established two methods for registering herbal medicals: Under Directive 2001/83/EC, a full marketing authorization (MA) is obtained by submitting a dossier containing data about the quality, safeness, and effectiveness of pharmaceuticals, which include physical and chemical, biological, or microbiological tests, as well as pharmacological, toxicological, and clinical trial documentation; There is a simplest technique under Directive 2004/24/EC for classical herbals that do not needs professional monitoring and where the indication of long history use of pharmaceuticals exists and appropriate relevant journals to illustrate a very well medicinal usage is not provided.\u0000\u0000\u0000\u0000A study about the regulatory status of herbal drugs/products was conducted in America and Europe to understand the various classes under which the sale of herbal goods is authorized and their premarketing criteria.\u0000\u0000\u0000\u0000This study has been performed by gathering information from the official websites of the USFDA and EMA.\u0000\u0000\u0000\u0000A thorough evaluation was carried out in order to identify the impediments to the harmonization of herbal goods.\u0000\u0000\u0000\u0000Aside from the challenges of herb supply and conservation, it has been shown that there is a lack of uniformity in the regulatory standards of herbal supplements globally. These are impeding international commerce and the expansion of the herbal goods market. USFDA classifies botanical items as pharmaceutical, nutrition, or dietary supplement based on the indications or ultimate use.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46792496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-depth chemistry and pharmacological potential of Propolis: A critical review of recent developments 蜂胶的深入化学和药理潜力:最近发展的重要回顾
IF 0.6
Current Traditional Medicine Pub Date : 2023-08-18 DOI: 10.2174/2215083810666230818092940
J. Dwivedi, Pranjal Sachan, P. Wal, A. Rai
{"title":"In-depth chemistry and pharmacological potential of Propolis: A critical review of recent developments","authors":"J. Dwivedi, Pranjal Sachan, P. Wal, A. Rai","doi":"10.2174/2215083810666230818092940","DOIUrl":"https://doi.org/10.2174/2215083810666230818092940","url":null,"abstract":"\u0000\u0000One of the most popular beekeeping products is propolis. The word \"propolis,\" which alludes to a beehive, has Greek sources and implies \"defense for the community.\" Propolis is a resinous material that honey worker bees (Apis mellifera L.) and other bee species make for a variety of uses. Since 300 BC, propolis has been used as a traditional remedy. Various pharmacological effects of distinct propolis extracts as well as those of its ingredients, including antioxidant, antiulcer, anticancer, antiviral, anti-microbial, anti-inflammatory, and antifungal characteristics, have recently been identified.\u0000\u0000\u0000\u0000In this review article, we focus on the origin, recent advances in the chemical constituents, and new therapeutic potential of propolis.\u0000\u0000\u0000\u0000An exhaustive analysis of the literature search was conducted. The standard keywords \"propolis,\" \"origin,\" \"chemical constituents,\" \"pharmacological activity,\" \"recent advances,\" and \"traditional uses\" have been used to search a variety of the standard databases, such as Scopus and Elsevier, PubMed, ScienceDirect, and Science Web, for research and review articles published between 1998 and 2023.\u0000\u0000\u0000\u0000This review article included over 150 articles (research and reviews) that were appraised and researched.\u0000\u0000\u0000\u0000Since 2012, more than 300 substances have been shown to have pharmacological action against a variety of illnesses, including cancer, inflammation, ulcers, wound healing, diabetes, bacterial, viral, and fungal infections, hepatic disorders, dental problems, brain diseases, etc. Overall, propolis may be considered a source of bioactive compounds for pharmaceutical development. Future studies should consider plant types, regional conditions, bee subspecies, and variations.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41650375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insight into the nutraceutical potential of garcinia species 藤黄属植物的营养潜力
IF 0.6
Current Traditional Medicine Pub Date : 2023-08-18 DOI: 10.2174/2215083810666230818092559
Shreyasi Karmakar, Urvashee Gogoi, Riya Saikia, Aparoop Das
{"title":"Insight into the nutraceutical potential of garcinia species","authors":"Shreyasi Karmakar, Urvashee Gogoi, Riya Saikia, Aparoop Das","doi":"10.2174/2215083810666230818092559","DOIUrl":"https://doi.org/10.2174/2215083810666230818092559","url":null,"abstract":"\u0000\u0000A wide variety of Garcinia species have been used over decades, as traditional home remedies starting from their use in flavored food to the treatment of various ailments. The presence of the essential primary and secondary metabolite with curative properties in Garcinia has enhanced its value in the therapeutic world. These have captivated the use of Garcinia in expanding nutritional values and adding extra health benefits. Hereby, observing the potential of different Garcinia species for their use as nutraceuticals.\u0000\u0000\u0000\u0000The present-day lifestyle and current health trends are the reasons why the public has accumulated a lot of interest in the nutraceutical food market. Traditionally the various remedies used from plants, fruits, and fruit extracts used in the cure of multiple ailments since antiquity have now made their way into pharmaceutical nutraceuticals. The fruits of Garcinia species have many culinary, nutritional, and pharmaceutical uses. Therefore, the paper aims to focus on the different Garcinia species having nutritional potential along with various therapeutic properties.\u0000\u0000\u0000\u0000Studies of different Garcinia species are reviewed, with a focus on their nutritional and medicinal actions on ailments that are the reason for today's lifestyles and current health trends.\u0000\u0000\u0000\u0000Different varieties of Garcinia species are found to have various potential primary and secondary metabolites which have curative properties like anti-diabetic, anti-obesity, anti-microbial, anti-cancer, anti-inflammation, and anti-bacterial potential.\u0000\u0000\u0000\u0000The natural occurrences of the plant product with nutraceutical value have boosted the quality of life. The Garcinia species containing the essential primary and secondary constituents are accountable for numerous biological activities. Many of the Garcinia species are marketed these days for a better and healthy life. Thus, Garcinia could be used as a nutraceutical to alleviate several disease conditions.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48034861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fighting H. pylori with Medicinal Plants: A Study on Jordan's Traditional Remedies 用药用植物对抗幽门螺杆菌:约旦传统疗法研究
IF 0.6
Current Traditional Medicine Pub Date : 2023-08-16 DOI: 10.2174/2215083810666230816095403
Amal Mayyas, T. Aburjai, L. Abu-Qatouseh, Mohammad Abu Sini, Rula A Amr, Rand T. Akasheh, N. Alrabadi, R. Darwish
{"title":"Fighting H. pylori with Medicinal Plants: A Study on Jordan's Traditional Remedies","authors":"Amal Mayyas, T. Aburjai, L. Abu-Qatouseh, Mohammad Abu Sini, Rula A Amr, Rand T. Akasheh, N. Alrabadi, R. Darwish","doi":"10.2174/2215083810666230816095403","DOIUrl":"https://doi.org/10.2174/2215083810666230816095403","url":null,"abstract":"\u0000\u0000This study was designed to evaluate the antimicrobial activity of some medicinal plants used among Jordanians for the treatment of gastritis and gastric ulcers against H. pylori. Moreover, plants' inhibitory activity against the H. pylori urease enzyme was also evaluated.\u0000\u0000\u0000\u0000The activity of 11 medicinal plants used by common people and herbalists to treat ulcers was evaluated against H. pylori (NCTC 11916). Ethanol and essential oil extracts from the tested plants were evaluated using a standard agar dilution method and the MICs were determined. Furthermore, the potential inhibitory effect of each preparation was tested against the enzyme urease using a kinetic colorimetric assay.\u0000\u0000\u0000\u0000Cinnamomum cassia oil showed the highest efficiency against H. pylori with the lowest MIC (0.0122 mg.mL-1), followed by Origanum syriacum and Foeniculum vulgare (MICs of 0.39 mg.mL-1). Furthermore, significant urease inhibition activity was recorded for Carum carvi oil (IC50~0.45 mg.mL-1). C. cassia oil (IC50 ~2.8 mg.mL-1), Aloysia citriodora, and Artemisia Judaica (IC50 5.8 mg.mL-1) reported potential urease inhibition activities.\u0000\u0000\u0000\u0000Herbs used in Jordanian traditional medicine were found to have anti-H. pylori and significant urease inhibitory activity. These findings might support the use of medicinal plants as adjuvant or alternative therapy for the treatment of H. pylori.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43655694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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