Cutaneous and Ocular Toxicology最新文献

{"title":"Biological activity of pumpkin pulp extracts: cytoprotection, anti-inflammatory effects, and photoprotection in human skin cells.","authors":"Milorad Miljic, Sanja Vlaisavljevic Krstic, Mirjana Nacka-Aleksic, Aleksandra Jovanovic, Dragana Dekanski, Jelena Antic Stankovic, Dragana D Bozic, Milica Jovanovic Krivokuca, Zanka Bojic Trbojevic, Andrea Pirkovic","doi":"10.1080/15569527.2025.2570195","DOIUrl":"https://doi.org/10.1080/15569527.2025.2570195","url":null,"abstract":"<p><strong>Background: </strong>Pumpkin extracts are rich in vitamins and bioactive compounds, offering antioxidative, anti-inflammatory, and wound-healing properties, making them valuable in dermatology and cosmetics, however pumpkin pulp extracts have not been evaluated before for their cutaneous biological activities.</p><p><strong>Methods and results: </strong>This study evaluated the biological activity of methanolic pumpkin pulp extracts from six Serbian accessions of <i>Cucurbita (C.) maxima</i> and <i>C. moschata</i> on normal keratinocytes (HaCaT) and melanoma (FemX) cells. The extracts showed no cytotoxicity to normal cells up to 1000 μg/mL and exhibited concentration-dependent cytotoxicity to melanoma cells (determined by MTT assay). They also demonstrated antioxidative effects against H₂O₂-induced oxidative stress in H₂DCFDA assay, and reduced tumor necrosis factor -α/interferon-gamma-γ-induced expression of pro-inflammatory cytokine interleukine-1β in HaCaT cells, as shown in the cell-based ELISA assay. Sun protection factor (SPF) calculations for all six accessions confirmed the photoprotective potential of the extracts, with noticeable differences in SPF values between species and varieties. The highest SPF value was observed in the <i>C. moschata</i> variety.</p><p><strong>Conclusion: </strong>Significant variations in biological activities among the examined accessions were noted, with <i>C. maxima</i> extracts showing pronounced antioxidant and antiinflammatory properties while <i>C. moschata</i> extract showed the highest SPF values. These findings represent the first report on the skin-beneficial effects of pumpkin pulp extracts, identifying them as sustainable sources of safe, bioactive compounds with antioxidant, anti-inflammatory, and photoprotective properties for dermatological or cosmetic applications.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of response to omalizumab in chronic spontaneous urticaria: a retrospective cohort study.","authors":"Özge Zorlu, Hülya Albayrak, Sema Aytekin","doi":"10.1080/15569527.2025.2570199","DOIUrl":"https://doi.org/10.1080/15569527.2025.2570199","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Although omalizumab is a highly effective treatment against chronic spontaneous urticaria (CSU), the treatment duration for response varies among patients. Thus, determining easy-to-access predictive biomarkers of omalizumab response is essential.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to investigate the value of baseline hematological and inflammatory parameters and patient-specific features as predictive markers of response to standard-dose omalizumab.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This single-center retrospective cohort study was conducted on 242 patients with CSU treated with omalizumab 300 mg every 4 weeks for at least 6 months between 2014 and 2025. The demographics, clinical features, treatment responses, and baseline laboratory tests were assessed. Response to omalizumab was evaluated based on the weekly Urticaria Activity Score (UAS7). Patients were categorized as early responder (ER, within 3 months), late responder (LR, after 3 months), and nonresponder (NR).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of patients, 180 (74.4%) were classified as ER, 28 (11.6%) as LR, and 34 (14%) as NR. ERs had higher white blood cell (WBC) and lymphocyte counts (&lt;i&gt;p&lt;/i&gt; = 0.047 and &lt;i&gt;p&lt;/i&gt; = 0.005, respectively) and lower mean platelet volume (MPV)/lymphocyte ratio (MPVLR) (&lt;i&gt;p&lt;/i&gt; = 0.008). LRs had higher mean corpuscular hemoglobin concentration (MCHC) and platelet/lymphocyte ratio (PLR) (&lt;i&gt;p&lt;/i&gt; = 0.023 and &lt;i&gt;p&lt;/i&gt; = 0.014, respectively) and lower MPV levels (&lt;i&gt;p&lt;/i&gt; = 0.043). The platelet distribution width (PDW) was higher in the NRs (&lt;i&gt;p&lt;/i&gt; = 0.011). Red cell distribution width-coefficient of variation (RDW-CV) [odds ratio (OR): 0.793, 95% confidence interval (CI): 0.641-0.980, &lt;i&gt;p&lt;/i&gt; = 0.032], WBC count (OR: 1.418, 95% CI: 1.093-1.840, &lt;i&gt;p&lt;/i&gt; = 0.009), and PDW (OR: 0.813, 95% CI: 0.693-0.954, &lt;i&gt;p&lt;/i&gt; = 0.011) were found to be the independent predictors of responders. The lymphocyte count (OR: 1.713, 95% CI: 1.122-2.613, &lt;i&gt;p&lt;/i&gt; = 0.013) and MPVLR (OR: 0.427, 95% CI: 0.218-0.837, &lt;i&gt;p&lt;/i&gt; = 0.013) were independent predictors of ER, whereas MCHC (OR: 2.368, 95% CI: 1.522-3.686, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and PLR (OR: 1.010, 95% CI: 1.003-1.017, &lt;i&gt;p&lt;/i&gt; = 0.003) were independent predictors of LR. The receiver operating characteristic curve analysis results showed that the predictive strengths of RDW-CV, WBC count, PDW, lymphocyte count, MPVLR, MCHC, and PLR were low (the area under the curve values 0.634, 0.620, 0.672, 0.656, 0.621, 0.649, and 0.624, respectively; all &lt;i&gt;p&lt;/i&gt; &lt; 0.05), suggesting the limited use of these parameters in clinical practice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study limitations: &lt;/strong&gt;The limitations of this study included its single-center, retrospective design, lack of external validation, and reliance solely on UAS7 for assessing disease activity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;WBC and lymphocyte counts, RDW-CV, PDW, MPVLR, MCHC, and PLR can be considered when appraising the omalizumab re","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relation between demographic status and clinical characteristics of Kaposi sarcoma: a single centre study.","authors":"Ayşe Türkmen Dedeoğlu, Selen Gezmen, Ümit Türsen, Yasemin Yuyucu Karabulut","doi":"10.1080/15569527.2025.2564432","DOIUrl":"https://doi.org/10.1080/15569527.2025.2564432","url":null,"abstract":"<p><p>Kaposi sarcoma (KS) is a vascular tumour with four main clinical types-classic, endemic, iatrogenic, and epidemic-all linked to infection by human herpesvirus 8 (HHV-8). This retrospective cohort study assessed the relationship between demographic factors and clinical characteristics in 73 patients with biopsy-proven KS treated at a single dermatology centre between 2009 and 2023. Demographic and clinical data, including age, gender, birthplace, blood type, smoking, alcohol use, HIV status, tumour site, and disease stage, were collected and statistically analysed. Most patients were male (77%), with a mean age of 61 years, and the classic KS subtype predominated (86%). The majority (75%) had tumours localised to the extremities. HIV-positive status was diagnosed in 14% of cases and was strongly associated with non-extremity tumour location and increased visceral involvement. Notably, blood type showed a significant association with tumour localisation: 0Rh- and ARh- blood groups were less common in KS patients with extremity tumours. This is the first study to demonstrate a significant relationship between blood group and KS tumour site, introducing a novel epidemiological association. Smoking and alcohol consumption were each significantly linked to higher HIV positivity rates. Patients from the Mediterranean region had a higher frequency of HIV-positive KS, although birthplace did not correlate with disease stage. No associations were observed between gender and disease type. The study is limited by its retrospective design and missing data for certain variables, but it identifies potentially novel patterns-including a possible link between blood group and tumour location-and confirms known associations, such as HIV status with advanced disease. These findings underscore the complexity of KS presentation and suggest that demographic, clinical, and lifestyle factors may shape disease patterns. Prospective, multicentre studies are needed to validate these findings and guide personalised approaches to KS management.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effective features of chitosan alginate hydrogel wound dressing containing <i>Hypericum scabrum</i> plant extract.","authors":"Alireza Khajeh-Amiri, Saeed Qasemi","doi":"10.1080/15569527.2025.2564428","DOIUrl":"https://doi.org/10.1080/15569527.2025.2564428","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the development of a chitosan-alginate hydrogel wound dressing enriched with <i>Hypericum scabrum</i> extract due to its antioxidant and antimicrobial properties. Natural polymer-based hydrogels are ideal for wound healing due to their biocompatibility and capacity for controlled drug delivery.</p><p><strong>Methods: </strong>Methanolic, ethanolic, and aqueous extracts of <i>H. scabrum</i> were evaluated for antioxidant and phenolic content. Cytotoxicity was assessed using MTT assay, and antimicrobial activity was determined by MIC testing. Physicochemical properties, including swelling, drug release, porosity (SEM), and molecular interactions (FTIR), were analysed.</p><p><strong>Results: </strong>The methanolic extract showed the highest antioxidant activity (95.41%) and phenolic content (118 mg GAE/g). It was non-toxic up to 1000 ppm (73.6% cell viability). When loaded into the hydrogel, MIC decreased from 6.25 mg to 0.781 mg. The hydrogel showed a swelling ratio of 4016.6%, 80% drug release in 48 hours, reduced porosity (32.26% to 11.59%), and confirmed chitosan-alginate interactions via FTIR.</p><p><strong>Discussion: </strong>The hydrogel formulation demonstrates strong antimicrobial, antioxidant, and biocompatible properties, making it a promising wound dressing. To improve the manuscript, more detailed methodology, statistical support for cytotoxicity, enhanced FTIR visualisation, and inclusion of recent literature and mechanistic discussion are recommended.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"1-12"},"PeriodicalIF":1.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel marker to monitor potential cardiac arrhythmic effects of isotretinoin therapy: Frontal QRS-T angle.","authors":"Emre Zekey","doi":"10.1080/15569527.2025.2564430","DOIUrl":"https://doi.org/10.1080/15569527.2025.2564430","url":null,"abstract":"<p><strong>Background: </strong>. . . . Isotretinoin is widely used to treat acne vulgaris. Although primarily targeting the skin, it exerts systemic effects, including rare cardiac manifestations such as arrhythmia. Electrocardiography (ECG) is the standard tool for rhythm monitoring. The frontal QRS-T angle, a novel ECG-based parameter, reflects ventricular depolarisation-repolarisation heterogeneity and has been recognised as a predictor of arrhythmic events. This study aimed to evaluate electrophysiological and biochemical changes associated with isotretinoin, focusing on the frontal QRS-T angle, basic ECG parameters, hemograms, and lipid profiles.</p><p><strong>Methods: </strong>Forty patients receiving oral isotretinoin (0.5-1 mg/kg/day) for acne vulgaris were prospectively followed. The frontal QRS-T angle, ECG parameters, hemograms, lipid values, heart rate, and blood pressure were recorded at baseline, 3 months, and 6 months.</p><p><strong>Results: </strong>At 6 months, statistically significant increases were observed in the frontal QRS-T angle and QRS duration, though both remained within accepted reference ranges. P wave duration, PR interval, QTc interval, heart rate, and blood pressure showed no significant changes. Lipid alterations were notable: HDL decreased, while total cholesterol, LDL, and triglycerides increased significantly. Hematological analysis showed stable leukocyte counts, with platelets rising transiently at 3 months and declining at 6 months.</p><p><strong>Discussion: </strong>.Isotretinoin therapy was associated with measurable changes in cardiac electrophysiology and lipid metabolism. The frontal QRS-T angle may provide an early ECG marker of arrhythmic risk, supporting its inclusion in dermatologic pharmacovigilance. Concurrent lipid alterations may enhance arrhythmic vulnerability, underscoring the importance of cardiac and metabolic monitoring during isotretinoin treatment.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco ethanol extract accelerates wound healing through anti-inflammation and promoting angiogenesis.","authors":"Fuqin He, Yongjun Liu, Ruiying Yu, Tianli Zhang, Fang Guo, Xiayu Wu, Yi Fan, Xuedong Zhu, Qianyi Zhou, Dan Shu","doi":"10.1080/15569527.2025.2559680","DOIUrl":"https://doi.org/10.1080/15569527.2025.2559680","url":null,"abstract":"<p><strong>Objective: </strong>Wound repair remains a significant challenge in the field of regenerative medicine. Notably, while numerous studies have investigated the effects of isolated nicotine or chlorogenic acid, the systematic evaluation of tobacco ethanol extract (TEE) on cutaneous wound healing has remained uncharted territory. Therefore, this study aims to systematically explore TEE's multifaceted effect on wound healing.</p><p><strong>Methods: </strong>The hepatorenal toxicity of 5% TEE was evaluated in 6-7-week-old ICR mice. Subsequently, full-thickness 6 mm wounds were created, and images were captured on days 0, 3, 6, 9, and 12. Tissues were collected for H&E staining, Masson trichrome staining, and immunohistochemistry to assess wound healing.</p><p><strong>Results: </strong>The TEE we prepared showed little hepatorenal toxicity (<i>p</i> > 0.05). By day 12, the wound closure rate in the TEE group reached 95.26%, significantly higher than that in the vehicle group (89.20%, <i>p</i> < 0.05). Histopathological analysis demonstrated that TEE reduced neutrophil infiltration in the wound tissues, accelerated granulation tissue formation, and increased collagen content by 20.99% compared to the vehicle group (<i>p</i> < 0.05). Immunohistochemical staining revealed that on day 6, the positive areas of IL-6 and TNF-α in the TEE group were 5.91% and 4.87% lower than those in the vehicle group (<i>p</i> < 0.05), respectively. On day 9, CD31 expression in the TEE group (8.58%) was significantly higher than that in the vehicle group (5.54%) (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>This study reveals that TEE accelerates wound healing, providing new insights into effective topical therapies for skin wounds while highlighting the potential for tobacco waste valorization.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micronutrient levels and thyroid functions in scarring alopecias: Do they play a role in disease pathogenesis?","authors":"Rüveyda Gönülal Bak, Ceren Çetin, Fadime Kılınç, Ayşe Akbaş, Gülhan Aksoy Saraç","doi":"10.1080/15569527.2025.2559677","DOIUrl":"https://doi.org/10.1080/15569527.2025.2559677","url":null,"abstract":"<p><strong>Objective: </strong>Scarring alopecias are chronic inflammatory disorders characterised by irreversible hair follicle destruction. In this study, we aimed to evaluate the potential roles of serum ferritin, folate, vitamin B12, vitamin D levels and thyroid function markers in the pathogenesis of scarring alopecias.</p><p><strong>Aterials and methods: </strong>Between 2020 and 2025, a total of 68 patients over the age of 18 who were diagnosed with scarring alopecia based on clinical and/or histopathological findings and whose medical records were accessible retrospectively were included in the study, along with 68 healthy control subjects. Serum levels of ferritin, folate, vitamin B12, vitamin D, and thyroid function markers were recorded and statistically compared between groups.</p><p><strong>Results: </strong>Among patients with scarring alopecia, 91.2% were female (<i>n</i> = 62), with a mean age of 47.25 ± 12.98 years. The average disease duration was 34.37 ± 24.22 months (min: 3, max: 144). The distribution of diagnoses among patients was as follows; lichen planopilaris in 45.6% (<i>n</i> = 21), frontal fibrosing alopecia in 29.4% (<i>n</i> = 20), pseudopelade in 16.2% (<i>n</i> = 11), discoid lupus erythematosus in 7.4% (<i>n</i> = 5), and folliculitis decalvans in 1.5% (<i>n</i> = 1). There were no statistically significant differences between patients with scarring alopecia and the control group regarding serum vitamin B12 (340.19 ± 107.950 vs. 357.04 ± 107.549 ng/L, <i>p</i> = 0.373), folate (11.89 ± 6.11 vs. 12.23 ± 6.53 ng/mL, <i>p</i> = 0.767), ferritin (34.75 ± 38.05 vs. 39.89 ± 66.74 µg/L, <i>p</i> = 0.593), and vitamin D (54.3 ± 26.57 vs. 58.59 ± 37.38 nmol/L, <i>p</i> = 0.434) levels. Thyroid function tests (TSH and free T4) were also similar between the two groups (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Our study demonstrated that serum ferritin, folate, vitamin B12, vitamin D levels and thyroid function in patients with scarring alopecia were similar to those in the healthy control group.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of erythropoietin in methanol induced optic neuropathy: a systematic review.","authors":"Abdulrahman Hameed Alsubhi, Asmaa Mohammedsaleh, Jehad Alorainy, Nooran Badeeb","doi":"10.1080/15569527.2025.2559681","DOIUrl":"https://doi.org/10.1080/15569527.2025.2559681","url":null,"abstract":"<p><strong>Purpose: </strong>Methanol toxicity outbreaks have been a recurring problem around the world, and the recent pandemic has contributed to an increase in their incidence. The resulting toxic optic neuropathy may lead to complete permanent blindness. Erythropoietin (EPO) has demonstrated potential neuroprotective and neuroregenerative capabilities, which may improve the outcomes of patients with methanol-induced optic neuropathy (MTON). This work aimed to understand the efficacy and practical applications of EPO in cases of MTON.</p><p><strong>Materials and methods: </strong>We included all original studies if they had patients with MTON, treated with EPO, and reported the outcomes of interest for clinical questions, including the end visual outcome. MEDLINE, Embase, Cochrane Library, and Web of Science databases were searched with no date restriction to obtain records.</p><p><strong>Results: </strong>We included 9 articles in our review, with a total of 192 patients, all of whom had been diagnosed with MTON. Erythropoietin treatment started 2 to 29 days after the onset of visual symptoms. Most studies reported an improvement in visual acuity compared to baseline. However, compared to the standard corticosteroid treatment alone, the results of EPO were conflicting. No adverse events were reported.</p><p><strong>Conclusion: </strong>The result of adding EPO to corticosteroid treatment in the management of MTON had variable improvements in visual acuity. EPO has potential beneficial effects if used early on in the acute phase of exposure to methanol. The role of repeating or maintaining therapy for a longer duration to enhance the protective effects or prevent relapses remains unknown. Future clinical trials to investigate these options.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teledermatology in cutaneous tumors: diagnostic accuracy, influencing factors, and the role of dermatoscopy.","authors":"Esranur Ünal, Muhammed Burak Yücel, Saadet Nurşah Gedikli, Kübra Gündüz, Bengü Çevirgen Cemil, Özlem Su Küçük, Ragıp Ertaş, Bengü Nisa Akay, Sinem Örnek Özdemir","doi":"10.1080/15569527.2025.2554785","DOIUrl":"https://doi.org/10.1080/15569527.2025.2554785","url":null,"abstract":"<p><strong>Introduction: </strong>Teledermatology, which utilizes communication technologies to remotely assess skin lesions, has become a vital tool in healthcare. This study aimed to compare the diagnostic accuracy of teledermatology versus face-to-face examination and explore factors influencing accuracy, such as teledermatoscopy use, dermatoscopy type, and clinical experience.</p><p><strong>Methods: </strong>Fifty-seven cutaneous tumors were evaluated using handheld or digital dermatoscopy in face-to-face examinations, and preliminary diagnoses were recorded. A definitive diagnosis was established through histopathological examination, which served as the reference standard. Macro and dermatoscopic images were then sent to six teledermatologists for remote diagnosis, and findings were analyzed statistically.</p><p><strong>Results: </strong>The preliminary diagnosis matched the histopathological diagnosis in 84.2% of face-to-face cases. Teledermatologists achieved 63.7% accuracy with macro images alone, increasing to 70.8% with dermatoscopic images. Teledermatology showed lower accuracy than face-to-face examination, regardless of whether teledermatoscopy was used (p < 0.05), but accuracy significantly improved with dermatoscopic images (p = 0.004). The teledermatology's accuracy for malignancy prediction was comparable to face-to-face examination (p > 0.05). Dermatoscopy type did not significantly impact accuracy (p > 0.05), while longer clinical experience correlated with higher accuracy (p < 0.05). Interrater reliability was poor for specific diagnoses but improved when categorizing lesions as malignant or benign (κ = 0.192, κ = 0.683).</p><p><strong>Conclusion: </strong>Although teledermatology performed below face-to-face examination in terms of specific diagnoses, it remained effective in distinguishing between benign and malignant cutaneous tumors. The inclusion of teledermatoscopy and longer clinical experience enhanced diagnostic accuracy.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145052124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying potential drug triggers for bullous pemphigoid: a disproportionality analysis of the FDA adverse event reporting system and systematic review of case reports.","authors":"Rathod Mahesh, Anjana Das K, Christy Thomas, Sudha Rani Kotakonda, Kadari Maheshwari, Krishna Undela","doi":"10.1080/15569527.2025.2554799","DOIUrl":"https://doi.org/10.1080/15569527.2025.2554799","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the potential risk of Bullous pemphigoid (BP) associated with antidiabetic agents, antimicrobials, diuretics, immune checkpoint inhibitors, and biological agents.</p><p><strong>Research design and methods: </strong>A retrospective pharmacovigilance data analysis was conducted using the FDA Adverse Event Reporting System (FAERS) between Q1/2004 and Q3/2024. Disproportionality analyses, viz. Proportional Reporting Ratio (PRR), Reporting Odds Ratio (ROR), and Information Component (IC) were performed to identify signals of BP. Additionally, a literature review of case reports of BP was conducted in PubMed, Google Scholar, and Scopus.</p><p><strong>Results: </strong>Disproportionality analysis identified 61 signals, and the following drugs exhibited the highest number of BP case associations: metformin (596 cases), vildagliptin (406 cases), nivolumab (376 cases), and furosemide (301 cases). Strong statistical correlation for signals was observed for vildagliptin [PRR = 295.8, LB (lower bound) ROR = 287.2, IC₀₂₅ = 7.5], dapsone [PRR = 20.7, LBROR = 14.4, IC₀₂₅ = 3.4], furosemide [PRR = 7.2, LBROR = 6.4, IC₀₂₅ = 2.6], and nivolumab [PRR = 31.5, LBROR = 28.5, IC₀₂₅ = 4.6]. These findings were supported by 106 identified case reports of BP.</p><p><strong>Conclusion: </strong>This study suggests a strong statistical correlation between vildagliptin, dapsone, furosemide, nivolumab, and the development of BP.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"1-33"},"PeriodicalIF":1.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}