Cutaneous and Ocular Toxicology最新文献

{"title":"Ocular irritation reversibility assessment of a laundry detergent using the Porcine Corneal Opacity Reversibility Assay (PorCORA): a focused study.","authors":"Puneet Vij, Ashley Brinkman, Rachael M Koch, George DeGeorge, Matthew Wolter","doi":"10.1080/15569527.2023.2284146","DOIUrl":"10.1080/15569527.2023.2284146","url":null,"abstract":"<p><p>Consumer product manufacturers utilise a spectrum of alternative ocular irritation assays, as these tests do not require the use of live animals. Despite their usefulness, no regulatory-accepted assay assesses the reversibility of ocular damage, a key criterion of GHS ocular classification, like the rabbit eye test (i.e., Draize Rabbit Eye Test [DRET]) . The Porcine Corneal Opacity Reversibility Assay (PorCORA), an <i>ex vivo</i> intact corneal tissue culture model, predicts the reversibility of damage by ocular irritants. Inclusion of the damage reversibility endpoint in the PorCORA supplements other alternative test methods for ocular irritation, by assessing induced eye damage and the ability of this damage to reverse (heal) without the use of live animals to distinguish between Globally Harmonised System of Classification and Labelling of Chemicals (GHS) ocular classifications. In this focused study, results of a Bovine Corneal Opacity and Permeability (BCOP) test of a laundry detergent, neat and 10% dilution, (product mixture from S.C. Johnson & Son, Inc. [SCJ]) classified the product into GHS Category 1; however, the BCOP test cannot assess the reversibility of ocular damage. The laundry detergent was evaluated using the PorCORA, where ocular damage induced by the detergent was fully reversed within seven days. Evaluation of the reversibility of ocular damage using the PorCORA in this focused study can add strength to the weight-of-evidence (WoE) analysis approach in ocular hazard assessment. This WoE approach strengthens the argument that the PorCORA can be used to supplement BCOP data, and that this laundry detergent is not an irreversible eye irritant.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"75-86"},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity of superparamagnetic iron oxide nanoparticles on retinoblastoma mitochondria.","authors":"Enayatollah Seydi, Ghazaleh Tahmasebi, Abdollah Arjmand, Jalal Pourahmad","doi":"10.1080/15569527.2023.2275030","DOIUrl":"10.1080/15569527.2023.2275030","url":null,"abstract":"<p><strong>Purpose: </strong>Retinoblastoma (RB) is one of the most important cancers in children with a higher rate of prevalence in developing countries. Despite different approaches to the treatment of RB, it seems necessary to discover a new approach to its treatment. Today, mitochondria are recognised as an important target in the treatment of cancer. Superparamagnetic iron oxide nanoparticles (SPIONs) have been studied by researchers due to their important biological effects.</p><p><strong>Methods: </strong>In this study, the effects of SPIONs on mitochondria isolated from Y79 retinoblastoma cells were investigated.</p><p><strong>Results: </strong>The results showed that SPIONs were able to increase the reactive oxygen species (ROS) level and subsequently damage the mitochondrial membrane and release cytochrome c a as one of the important pro-apoptotic proteins of RB mitochondria. Furthermore, the results indicated a decrease in cell viability and an increase in caspase-3 activity in Y79 retinoblastoma cells.</p><p><strong>Conclusions: </strong>These events can lead to the killing of cancerous mitochondria. Our results suggest that SPIONs can cause mitochondrial dysfunction and death in RB mitochondria.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"69-74"},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of heavy metals contamination in cosmetics.","authors":"Opoku Gyamfi, James Aboko, Edward Ankapong, Jemima Tiwaa Marfo, Nana Yaa Awuah-Boateng, Kofi Sarpong, Emmanuel Dartey","doi":"10.1080/15569527.2023.2268197","DOIUrl":"10.1080/15569527.2023.2268197","url":null,"abstract":"<p><p><b>Background:</b> Globally, the consumption and use of cosmetics have increased exponentially. The presence of hazardous metals raises worries about their potential long-term impacts on human health. <b>Objective:</b> This review's primary goal is to shed light on the presence and ranges of heavy metal concentrations in diverse cosmetic samples as well as the instrumental techniques used by various authors to analyse the hazardous metals in the articles under evaluation. <b>Methodology:</b> This analysis concentrated on 16 publications that measured the levels of heavy metals like lead, cadmium, iron, nickel, chromium, and mercury in various cosmetic samples that were published between the years 2012 and 2020. <b>Results:</b> The study's findings support the existence of these metals as pollutants or components in cosmetics, both of which pose substantial health hazards. The regulations and acceptable limits vary across different countries, which is a significant challenge for the cosmetic industry. <b>Conclusion:</b> Therefore, there is a pressing need to standardise the acceptable limits of these toxic metals in cosmetics. Instrumental techniques such as AAS, GFAAS, ICP-OES/ICP-AES, and ICP-MS were employed by Researchers to analyse the toxic metals in cosmetics.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"5-12"},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of peripapillary choroidal vascularity index in young smokers.","authors":"Mehmet Tahir Eski,&nbsp;Taha Sezer,&nbsp;Havvanur Bayraktar,&nbsp;Emir Altıkardeşler","doi":"10.1080/15569527.2023.2249096","DOIUrl":"10.1080/15569527.2023.2249096","url":null,"abstract":"<p><p><b>Purpose:</b> This retrospective study aimed to compare the peripapillary choroidal vascularity index (CVI) between young smokers who smoked less than 5 packs/year and non-smokers.<b>Methods:</b> The study included 52 smokers and 67 non-smokers, and comprehensive eye examinations were performed on all participants. Axial lengths (AL) were measured, and peripapillary enhanced depth imaging optical coherence tomography (EDI-OCT) images were obtained and evaluated using the Open Source ImageJ software. The CVI, total choroidal area (TCA), luminal area (LA), stromal area (SA), and retinal nerve fibre layer (RNFL) quadrants were compared between the two groups.<b>Results:</b> The mean age of the smokers was 23.76 ± 1.84 years, and for non-smokers, it was 23.98 ± 2.18 years. The mean peripapillary CVI for smokers was 0.65 ± 0.08, and for non-smokers, it was 0.67 ± 0.03. No statistically significant difference in CVI was observed between the two groups. However, statistically significant differences were found in the temporal inferior (TI), temporal superior (TS), nasal inferior (NI), and nasal superior (NS) quadrants of the RNFL between the two groups (<i>p</i> < 0.05). There was no correlation between the number of packs/year and CVI values in the smoking group (<i>r</i> = 0.031, <i>p</i> = 0.826).<b>Conclusion:</b> The study revealed no significant difference in CVI among young smokers who smoked less than 5 packs/year compared to non-smokers. However, there was a statistically significant decrease in the TI, TS, NI, and NS quadrants of the RNFL in early-age smokers.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"258-263"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10152028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging of the skin in pseudoexfoliation syndrome.","authors":"Hakan Cinal,&nbsp;Halil İbrahim Yener","doi":"10.1080/15569527.2023.2234024","DOIUrl":"10.1080/15569527.2023.2234024","url":null,"abstract":"<p><strong>Background: </strong>It was reported that pseudoexfoliative material deteriorates iris, brain, heart and lung functions. This material is also found in the skin.</p><p><strong>Aims: </strong>The purpose of this study was to investigate the possible effects of pseudoexfoliation material on the aging of the facial skin.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>Forty pseudoexfoliation syndrome (PES) cases and 40 age- and gender-matched controls were evaluated. Job, cigarette use and the presence of any systemic diseases as well as the duration of sun exposure for all the cases were recorded. All of the cases underwent facial skin examination with Wrinkle Assessment Scale as per Lemperle G et al. and Pinch Test.</p><p><strong>Results: </strong>Wrinkle Assessment Scale scores of the groups also were compared for all 8 facial locations. There were statistically significant differences found between Wrinkle Assessment Scale scores in PES and Control Group for all 8 locations. Mean Wrinkle Assessment Scale scores of women were 4.12 ± 0.74 in Control Group and 4.75 ± 0.37 in PES group (p = 0.0001). For men, mean Wrinkle Assessment Scale scores were 3.77 ± 0.72 in Control group and 4.54 ± 0.36 in PES group (p = 0.002).</p><p><strong>Conclusion: </strong>These results implies that there is quicker progression in aging of facial skin in PES than normals.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"204-208"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9923121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial loss following postoperative intracameral triamcinolone acetonide and subconjunctival dexamethasone injections.","authors":"Fatma Sali,&nbsp;Veysel Aykut,&nbsp;Ahmad Kunbaz,&nbsp;Ebubekir Durmus,&nbsp;Mustafa Hepokur,&nbsp;Halit Oguz,&nbsp;Fehim Esen","doi":"10.1080/15569527.2023.2239897","DOIUrl":"10.1080/15569527.2023.2239897","url":null,"abstract":"<p><strong>Objectives: </strong>To compare endothelial toxicity and efficacy of two local steroid injections (intracameral triamcinolone acetonide and subconjunctival dexamethasone) in controlling postoperative inflammation following pars plana vitrectomy (PPV) combined with phacoemulsification cataract surgery.</p><p><strong>Methods: </strong>This cohort included 54 patients that underwent combined surgery and received either intracameral triamcinolone acetonide injections (<i>n</i> = 27, IC-TA group) or subconjunctival dexamethasone (<i>n</i> = 27, Sc-Dex group) injections at the end of the surgery. All participants had at least 4 months or longer follow-up. A detailed ophthalmologic examination including intraocular pressure (IOP) measurement and specular microscopy was performed at every visit.</p><p><strong>Results: </strong>Endothelial cell density (ECD) reduced significantly in IC-TA group postoperatively (2418 vs. 2249, <i>p</i> = 0.019), while it did not change significantly in Sc-Dex group (2541 vs. 2492, <i>p</i> = 0.247). Postoperative ECD was also significantly lower in IC-TA group compared to Sc-Dex group (<i>p</i> = 0.011). Preoperative and postoperative IOP values remained unchanged both in IC-TA and Sc-Dex groups (<i>p</i> = 0.424 and <i>p</i> = 0.523, respectively). However, 4 patients in IC-TA group and 5 patients in the Sc-Dex group needed glaucoma medications. The postoperative need for glaucoma medications was similar between the groups (<i>p</i> = 0.347). Postoperative inflammation was well controlled in both groups and none of the patients developed fibrin membrane or synechiae postoperatively.</p><p><strong>Conclusion: </strong>Both treatments were effective in controlling postoperative inflammation, but patients in IC-TA group experienced significantly higher endothelial loss. Sc-Dex injections are safer in terms of endothelial loss and preferable to control postoperative inflammation following complex intraocular surgeries.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"237-242"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9893440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a simplified human embryonic stem cell-based retinal pre-organoid model for toxicity evaluations of common pollutants.","authors":"Yue Wang,&nbsp;Nuoya Yin,&nbsp;Renjun Yang,&nbsp;Miaomiao Zhao,&nbsp;Shichang Li,&nbsp;Shuxian Zhang,&nbsp;Yanyi Zhao,&nbsp;Francesco Faiola","doi":"10.1080/15569527.2023.2249988","DOIUrl":"10.1080/15569527.2023.2249988","url":null,"abstract":"<p><strong>Objective: </strong>To explore the retinal toxicity of pharmaceuticals and personal care products (PPCPs), flame retardants, bisphenols, phthalates, and polycyclic aromatic hydrocarbons (PAHs) on human retinal progenitor cells (RPCs) and retinal pigment epithelial (RPE) cells, which are the primary cell types at the early stages of retinal development, vital for subsequent functional cell type differentiation, and closely related to retinal diseases.</p><p><strong>Materials and methods: </strong>After 23 days of differentiation, human embryonic stem cell (hESC)-based retinal pre-organoids, containing RPCs and RPE cells, were exposed to 10, 100, and 1000 nM pesticides (butachlor, terbutryn, imidacloprid, deltamethrin, pendimethalin, and carbaryl), flame retardants (PFOS, TBBPA, DBDPE, and TDCIPP), PPCPs (climbazole and BHT), and other typical pollutants (phenanthrene, DCHP, and BPA) for seven days. Then, mRNA expression changes were monitored and compared.</p><p><strong>Results: </strong>(1) The selected pollutants did not show strong effects at environmental and human-relevant concentrations, although the effects of flame retardants were more potent than those of other categories of chemicals. Surprisingly, some pollutants with distinct structures showed similar adverse effects. (2) Exposure to pollutants induced different degrees of cell detachment, probably due to alterations in extracellular matrix and/or cell adhesion.</p><p><strong>Conclusions: </strong>In this study, we established a retinal pre-organoid model suitable for evaluating multiple pollutants' effects, and pointed out the potential retinal toxicity of flame retardants, among other pollutants. Nevertheless, the potential mechanisms of toxicity and the effects on cell detachment are still unclear and deserve further exploration. Additionally, this model holds promise for screening interventions aimed at mitigating the detrimental effects of these pollutants.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"264-272"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10081408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucocutaneous alterations and complications in amphetamine abusers: a narrative review.","authors":"Mahdi Balali-Mood,&nbsp;Rodney D Sinclair,&nbsp;Emadodin Darchini-Maragheh,&nbsp;Leila Etemad","doi":"10.1080/15569527.2023.2235425","DOIUrl":"10.1080/15569527.2023.2235425","url":null,"abstract":"<p><p>Amphetamines are the second most commonly used illicit drug worldwide. Amphetamine use can result in significant cutaneous morbidity. This review highlights the dermatological manifestations of amphetamine abuse.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"219-231"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10257797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of smoking on retinal ganglion cell-inner plexiform layer complex in male diabetes.","authors":"Lu Li,&nbsp;Xudong Peng,&nbsp;Nan Jiang,&nbsp;Meng Yan,&nbsp;Zhaoxia Zheng,&nbsp;Duo Zhang,&nbsp;Lina Zhang","doi":"10.1080/15569527.2023.2245034","DOIUrl":"10.1080/15569527.2023.2245034","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the influence of smoking on ganglion cell-inner plexiform layer complex (GC-IPL) thickness and central macular thickness (CMT) measured by spectral domain optical coherence tomography (OCT) in male diabetes.</p><p><strong>Methods: </strong>90 smoking and 90 never-smoking male subjects were included in this study. They were divided into six groups based on the diagnostic criteria for diabetes and the Early Treatment Diabetic Retinopathy Study (ETDRS) classification: smoking healthy subjects (SH, <i>n</i> = 20), non-smoking healthy subjects (NSH, <i>n</i> = 20), smoking diabetic patients without diabetic retinopathy (SNDR, <i>n</i> = 40), non-smoking diabetic patients without diabetic retinopathy (NSNDR, <i>n</i> = 40), smoking diabetic patients with diabetic retinopathy (SDR, <i>n</i> = 30), and non-smoking diabetic patients with diabetic retinopathy (NSDR, <i>n</i> = 30). After a full ophthalmologic examination, GC-IPL thickness and central macular thickness (CMT) were measured by OCT. Statistical analysis was performed to compare GC-IPL thickness and CMT between groups. Multiple linear regression equations were constructed to explore the potential risk factors of mean GC-IPL thickness.</p><p><strong>Results: </strong>There were no significant differences in GC-IPL thickness and CMT between SH and NSH (all <i>p</i> > 0.05). Mean, superonasal, superior, superotemporal, inferonasal, inferior GC-IPL (<i>p</i>＜0.001, <i>p</i>＜0.001, <i>p</i>＜0.001, <i>p</i> = 0.003, <i>p</i> = 0.001, and <i>p</i> = 0.005, respectively) were thinner in the SNDR than NSNDR except for inferotemporal GC-IPL thickness and CMT (<i>p</i> = 0.066, <i>p</i> = 0.605, respectively). Mean, superonasal, superior, and inferonasal GC-IPL were thinner in the SDR than NSDR (<i>p</i> = 0.019, <i>p</i> = 0.045, <i>p</i> = 0.037, and <i>p</i> = 0.049, respectively). Multiple regression analysis demonstrated that age (β [SE], -0.141 [0.060]; <i>p</i> = 0.020) and smoking (β [SE], -4.470 [1.015]; <i>p</i>＜0.001) were the most important determinants for mean GC-IPL thickness.</p><p><strong>Conclusion: </strong>Smoking is associated with reduced retinal GC-IPL thickness in male diabetes. Smoking behavior and age are important determinants of mean GC-IPL thickness.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"253-257"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10388826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of hyperbaric oxygen therapy on corneal endothelial structure and anterior segment parameters.","authors":"Murat Garlı,&nbsp;Tuncay Küsbeci,&nbsp;Figen Aydın,&nbsp;Okan Akmaz","doi":"10.1080/15569527.2023.2243499","DOIUrl":"10.1080/15569527.2023.2243499","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the effect of hyperbaric oxygen therapy (HBOT) on corneal endothelial structure and anterior segment parameters in healthy eyes.</p><p><strong>Methods: </strong>17 eyes of 17 patients who were scheduled to receive HBOT for other than ophthalmologic indications were investigated in this prospective study. Central corneal thickness (CCT) and corneal endothelial properties were evaluated using a specular microscope. Endothelial cell density (ECD), average cell area (AVG), coefficient of variation in cell size (CV), percentage of hexagonal cells (HEX), CCT, intraocular pressure (IOP), spherical equivalent (SE), axial length (AL) and anterior chamber depth (ACD) values were measured before the HBOT, after the 1st session, and after the 20th session of therapy.</p><p><strong>Results: </strong>47% of the patients (<i>n</i> = 8) received HBOT because of avascular necrosis, 35% (<i>n</i> = 6) due to sudden hearing loss, 12% (<i>n</i> = 2) for diabetic foot, and 6% (<i>n</i> = 1) for wound infection. The mean IOP was 14,80 mmHg before HBOT, 14,20 mmHg after the 1st session, and 13,73 mmHg after the 20th session. The mean ACD was 3,38 mm before HBOT, 3,34 mm after the 1st session, and 3,16 mm after the 20th session. Although the mean IOP and ACD decreased after HBOT sessions, it was not statistically significant (<i>p</i> > 0.05). A significant reduction was observed in SE values after 20 sessions of HBOT compared to the values measured before HBOT (<i>p</i> = 0,009). The mean ECD was 2572,53 ± 261,51 cells/mm² before HBOT, 2554,47 ± 236,13 after the 1st session, and 2563,13 ± 226,92 after the 20th session. When the corneal properties measured before and after HBOT sessions were compared, no significant difference was found in terms of CCT, ECD, AVG, CV, and HEX (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>We observed no significant change in CCT, corneal endothelial layer properties, and anterior segment morphology after the 1st session, and after the 20th session of HBOT. Although HBOT reduced IOP and ACD, it was not statistically significant. HBOT may lead to a significant decrease in SE values after the 20th session.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"243-247"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10012973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}