The efficacy of HDDPiW-jSB solution on docetaxel-induced alopecia of rats.

IF 1.6 4区医学 Q3 OPHTHALMOLOGY

Cutaneous and Ocular Toxicology Pub Date : 2024-06-01 Epub Date: 2024-01-05 DOI:10.1080/15569527.2023.2300790

Bilgin Demir, Buket Demirci, Canten Tataroglu, Sabri Barutca, Duygu Barutca

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引用次数: 0

Abstract

Objective: Chemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn't have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of newly developed HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model.

Material and methods: Docetaxel (10 mg/kg/week) was administered to the 6-8 months old rats for three weeks. HDDPiW-jSB solution was applied once or twice a week for 4 weeks beginning prior to one week before DTX. Rat hair follicles were evaluated with hematoxylin-eosin and immune-histochemical staining.

Results: In the first stage of this study, alopecia was successfully developed by DTX (10 mg/kg/three times) application. In the second stage of the study, application of HDDPiW-jSB solution, did not change the study parameters significantly on control group. The solution improved the anagen hair follicle count and Bcl-2 levels in the skin samples of DTX-induced alopecic rat groups, especially when applied twice weekly. Additionally, level of Caspase 3 was decreased. HDDPiW-jSB solution was safe when applied on the skin.

Conclusion: Topical HDDPiW-jSB solution could be effective and safe for the protection of DTX-induced alopecia in rat models.

查看原文本刊更多论文

HDDPiW-jSB 溶液对多西他赛引起的大鼠脱发的疗效。

研究目的化疗诱导性脱发（CIA）是癌症患者最常见的副作用之一，但目前尚无有效的药物治疗方法。本研究旨在研究新开发的 HDDPiW-jSB 溶液对多西他赛（DTX）诱导的大鼠脱发模型的保护作用：给 6-8 个月大的大鼠注射多西他赛（10 毫克/千克/周）三周。HDDPiW-jSB 溶液在 DTX 一周前开始使用，每周一次或两次，连续使用 4 周。用苏木精-伊红和免疫组织化学染色法对大鼠毛囊进行评估：在该研究的第一阶段，使用 DTX（10 毫克/千克/三次）成功地导致了脱发。在研究的第二阶段，使用 HDDPiW-jSB 溶液并没有明显改变对照组的研究参数。该溶液改善了 DTX 诱导的脱发大鼠组皮肤样本中的新生毛囊数量和 Bcl-2 水平，尤其是在每周使用两次的情况下。此外，Caspase 3 的水平也有所下降。结论：外用 HDDPiW-jSB 溶液对皮肤是安全的：结论：外用 HDDPiW-jSB 溶液可有效、安全地保护 DTX 引起的脱发大鼠模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cutaneous and Ocular Toxicology 医学-毒理学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.