Calendula officinalis extract enhances wound healing by promoting fibroblast activity and reducing inflammation in mice.

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY
Yalcin Alper Ozturan, Ibrahim Akin
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引用次数: 0

Abstract

Introduction: Despite evidence supporting the therapeutic potential of Calendula officinalis, well-designed and controlled studies are still needed to confirm its beneficial effects on various health conditions, including skin care. This study therefore evaluates the effectiveness of topically administered 5% aqueous Calendula officinalis extract on healing full-thickness skin wounds in male BALB/c mice.

Methods: Seventy-two mice were divided into three groups: CAL (treated with calendula extract), PSS (treated with physiological saline), and NC (negative control/no treatment). Wound healing was assessed over 14 days using planimetric measurements, counting fibroblasts and macrophages, biochemical analyses of growth factors, inflammation markers, hydroxyproline levels, and genomic analyses.

Results: The data obtained show that the application of CAL extract significantly reduces wound areas by day 7 compared to the NC and PSS groups. CAL extract also leads to an increase in fibroblasts, fibroblast growth factor, and hydroxyproline levels, while it reduces macrophages and inflammatory biomarkers levels in the healing wound. Genomic analyses indicate that topical application of CAL extract significantly reduces the expression of inflammatory biomarkers, including matrix metalloproteinases 2 and 9.

Conclusions: These findings show that 5% aqueous CAL extract enhances wound healing promising new insights for the effective topical treatment of skin wounds.

金盏花提取物通过促进成纤维细胞活性和减少小鼠炎症来促进伤口愈合。
导论:尽管有证据支持金盏菊的治疗潜力,但仍需要精心设计和对照的研究来证实其对各种健康状况的有益作用,包括皮肤护理。因此,本研究评估了局部给予5%金盏花水提取物对雄性BALB/c小鼠全层皮肤伤口愈合的有效性。方法:将72只小鼠分为三组:CAL组(金盏菊提取物组)、PSS组(生理盐水组)和NC组(阴性对照/未处理组)。通过平面测量、成纤维细胞和巨噬细胞计数、生长因子生化分析、炎症标志物、羟脯氨酸水平和基因组分析,在14天内评估伤口愈合。结果:与NC组和PSS组相比,CAL提取物在第7天显著减少创面面积。CAL提取物还会增加成纤维细胞、成纤维细胞生长因子和羟脯氨酸水平,同时降低愈合伤口中的巨噬细胞和炎症生物标志物水平。基因组分析表明,局部应用CAL提取物可显著降低炎症生物标志物的表达,包括基质金属蛋白酶2和9。结论:这些研究结果表明,5% CAL水提物促进伤口愈合,为有效的局部治疗皮肤伤口提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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