Current Opinion in Psychiatry最新文献_第4页

Contextualizing innovation in addiction psychiatry: opportunities to deliver precision medicine in a complex clinical system. 成瘾精神病学的情境化创新：在复杂的临床系统中提供精准医疗的机会。

IF 5.9 2区医学

Current Opinion in Psychiatry Pub Date : 2026-07-01 Epub Date: 2026-05-07 DOI: 10.1097/YCO.0000000000001095

Alexander Mario Baldacchino, Joe Schofield, Malgorzata Gosia M Mitka

{"title":"Contextualizing innovation in addiction psychiatry: opportunities to deliver precision medicine in a complex clinical system.","authors":"Alexander Mario Baldacchino, Joe Schofield, Malgorzata Gosia M Mitka","doi":"10.1097/YCO.0000000000001095","DOIUrl":"10.1097/YCO.0000000000001095","url":null,"abstract":"Purpose of review: Current approaches to preventing drug-related harms remain suboptimal. This review describes components of a systems innovation framework for addiction care designed to address escalating drug-related harms and fragmented service delivery through a multidisciplinary, ecosystem-driven approach.Recent findings: Innovative approaches to addiction medicine are needed that integrate clinical research with entrepreneurial execution to address three priority areas of need: real-time risk mitigation using digital phenotyping and wearable biosensors for overdose detection; precision surveillance utilizing AI-informed data ecosystems and wastewater analysis; and next-generation therapeutics, including neuromodulation and nanotechnology-driven drug delivery. This creates an innovative \"biopsychotechnological\" treatment paradigm that moves beyond traditional clinical boundaries.Summary: This framework provides a roadmap for transitioning addiction care from reactive clinical and risk management to innovative and proactive precision medicine. For research, it necessitates a shift toward interdisciplinary validation of \"biopsychotechnological\" models that bridge bench science and community implementation. For clinical practice, this framework offers a blueprint for integrating real-time biosensing and advanced therapeutics into patient care, promising to reduce mortality and support sustainable recovery through ecosystem-informed and individualized care.","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"321-325"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating human and nonhuman intelligence to reduce tobacco's public-health burden. 整合人类和非人类智慧，减少烟草的公共卫生负担。

IF 5.9 2区医学

Current Opinion in Psychiatry Pub Date : 2026-07-01 Epub Date: 2026-05-03 DOI: 10.1097/YCO.0000000000001096

Catalina Lopez-Quintero

{"title":"Integrating human and nonhuman intelligence to reduce tobacco's public-health burden.","authors":"Catalina Lopez-Quintero","doi":"10.1097/YCO.0000000000001096","DOIUrl":"10.1097/YCO.0000000000001096","url":null,"abstract":"Purpose of review: Tobacco use remains the leading preventable cause of death worldwide, while the rise of electronic nicotine products has sparked a new wave of initiation. The urgent need for scalable, multilevel tobacco-control interventions converges with the rapid advances in artificial intelligence (AI). This article reviews the most recent literature on integrating machine- and human expertise to enhance tobacco-cessation strategies within a multilevel framework.Recent findings: Recent advances in predictive analytics, large-language models (LLM), AI chatbots, and related tools create a framework to strengthen tobacco prevention. Predictive analytics merge electronic health records, behavioral surveys, genetics, and real-time sensor data to model the complex multilevel factors that influence quitting. LLMs instantly uncover informative features, revealing novel predictors that shape targeted interventions. AI-driven conversational agents deliver stage-specific counseling and medication guidance, with preliminary trials showing improved engagement and quit rates. Reinforcement learning personalizes messaging, rewards, and medication schedules to optimize outcomes, while natural-language processing of social media provides fine-grained sentiment data to assess policy impact.Summary: Realizing AI's potential to reduce tobacco's public-health burden requires interdisciplinary collaboration, equity-oriented design, external validation, and strong governance. These safeguards can enable scalable, adaptable, and culturally relevant smoking-cessation interventions and facilitate timely, effective tobacco-control policies.","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"314-320"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opportunities and risks of large language models in digital interventions for substance use disorders. 大型语言模型在物质使用障碍数字干预中的机遇和风险。

IF 5.9 2区医学

Current Opinion in Psychiatry Pub Date : 2026-07-01 Epub Date: 2026-04-29 DOI: 10.1097/YCO.0000000000001088

Marissa de Vries, Michael P Schaub

{"title":"Opportunities and risks of large language models in digital interventions for substance use disorders.","authors":"Marissa de Vries, Michael P Schaub","doi":"10.1097/YCO.0000000000001088","DOIUrl":"10.1097/YCO.0000000000001088","url":null,"abstract":"Purpose of review: Large language models (LLMs) are increasingly integrated into digital mental health tools, yet their role in substance use disorder (SUD) interventions remains poorly understood. This review synthesizes emerging evidence on the opportunities and risks of applying LLMs across the digital SUD care continuum.Recent findings: Studies report promising applications in early detection, personalized support, continuous monitoring, and relapse prevention. LLMs demonstrate capacity to extract substance-use signals from natural language, generate supportive and motivational responses, and interpret narrative data for patient-reported outcomes. However, risks are substantial. LLMs can produce inaccurate or hallucinated content, may reinforce stigma or demographic bias, and can generate misleading or potentially unsafe advice. Privacy concerns are amplified in SUD contexts, where sensitive data are often managed outside regulated healthcare systems. Existing regulatory frameworks such as the EU AI Act or U.S. device regulations, do not yet provide clear governance for anonymous, AI-supported SUD interventions.Summary: LLMs have potential to expand scalable, low-threshold support for SUDs, but their safe deployment requires validation, bias mitigation, transparent data governance, and robust human oversight. Evidence remains preliminary, and clinical integration should proceed cautiously.","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"308-313"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surveillance of emerging drug trends: utilizing the National Drug Early Warning System. 监测新出现的毒品趋势：利用国家毒品早期预警系统。

IF 5.9 2区医学

Current Opinion in Psychiatry Pub Date : 2026-07-01 Epub Date: 2026-03-24 DOI: 10.1097/YCO.0000000000001087

Linda B Cottler, Joseph J Palamar

{"title":"Surveillance of emerging drug trends: utilizing the National Drug Early Warning System.","authors":"Linda B Cottler, Joseph J Palamar","doi":"10.1097/YCO.0000000000001087","DOIUrl":"10.1097/YCO.0000000000001087","url":null,"abstract":"Purpose of review: The U.S. drug landscape is rapidly shifting necessitating early warning surveillance of emerging drug threats. We describe one such surveillance effort from the United States: the National Drug Early Warning System (NDEWS).Recent findings: NDEWS monitors drug indicators with a particular focus on trends in new psychoactive substances (NPS) and emerging adulterants. NDEWS has five major goals: develop a collaboration network, including people with lived experience, initiate methods that deliver the freshest data on drug trends, integrate data from sources to better understand signals, disseminate findings widely, and train the next generation of surveillance scientists. NDEWS collects primary data using venue-based methods (Rapid Street Reporting), Web Monitoring, and 911 (Emergency Medical Service) data, and utilizes secondary data on drug seizures and poisonings. Information is shared bidirectionally with our 16 Sentinel Sites, our Community-Based Health Expert network, and our informal networks which include medical examiners, toxicologists, funeral directors, reporters, and community overdose response workers.Summary: Surveillance of emerging drug trends is increasingly important around the world as patterns of drug use continue to shift. With a focus on NPS and nonlagged data strategies, NDEWS warns communities at risk to prevent serious consequences and death.","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"287-293"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13025665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The myth of digital biomarkers in Alzheimer's disease: how to make them a reality. 阿尔茨海默病中数字生物标志物的神话：如何使它们成为现实。

IF 5.9 2区医学

Current Opinion in Psychiatry Pub Date : 2026-07-01 Epub Date: 2026-04-29 DOI: 10.1097/YCO.0000000000001089

Rhoda Au, Katherine A Gifford, Ioannis Ch Paschalidis, Paul Wighton, Max Levin, Farhad Imam, Niranjan Bose, Abhi Pratap

{"title":"The myth of digital biomarkers in Alzheimer's disease: how to make them a reality.","authors":"Rhoda Au, Katherine A Gifford, Ioannis Ch Paschalidis, Paul Wighton, Max Levin, Farhad Imam, Niranjan Bose, Abhi Pratap","doi":"10.1097/YCO.0000000000001089","DOIUrl":"10.1097/YCO.0000000000001089","url":null,"abstract":"Purpose of review: With an estimated 41.1B digital devices, the term \"digital biomarkers\" has been increasingly bandied about in the research literature. There is, however, a significant disconnect between the presumption of digital biomarkers and the reality of digital biomarkers.Recent findings: The research literature embraces the concept of digital biomarkers without concomitant evidence for validation of digital measures as biomarkers. Unlike imaging or blood-based biomarkers, there is a woeful lack of research dedicated to validating digital measures as biomarkers. This gap also presents an opportunity. Regulatory agencies worldwide have long-standing protocols used by pharmaceutical and biotech companies to stand up quality management systems (QMS) that track research from inception to regulatory approved submissions. The recent United States (US) Food and Drug Administration (FDA) approval of Alzheimer's disease (AD) plasma biomarkers is another example where successful QMS implementation provided the processes and transparency necessary to obtain approval. Regulatory guidelines for digital technology validation are more circumspect on validation pathways of AD digital biomarkers, but FDA provides a framework for building a QMS that could potentially do so.Summary: Building an open source QMS for AD digital biomarker validation will be a critical breakthrough for harnessing the potential of digital technologies for detection, monitoring and treatment of AD and related disorders.","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"331-338"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking urban planning and mental health in the context of urbanization: existing evidence and future directions. 城市化背景下城市规划与心理健康的联系：现有证据和未来方向。

IF 5.9 2区医学

Current Opinion in Psychiatry Pub Date : 2026-07-01 Epub Date: 2026-05-04 DOI: 10.1097/YCO.0000000000001093

Jian Song, Rong Song, Xiaoyu Jin, Rubing Pan, Weizhuo Yi, Hong Su

{"title":"Linking urban planning and mental health in the context of urbanization: existing evidence and future directions.","authors":"Jian Song, Rong Song, Xiaoyu Jin, Rubing Pan, Weizhuo Yi, Hong Su","doi":"10.1097/YCO.0000000000001093","DOIUrl":"10.1097/YCO.0000000000001093","url":null,"abstract":"Purpose of review: Amidst rapid global urbanization, understanding the association between urban planning and mental health is crucial. This review synthesizes fragmented evidence on six core elements - walkability, green spaces, blue spaces, population density, public transport accessibility, and road design-to address gaps in causality and equity, providing timely insights for creating psychologically supportive urban environments.Recent findings: Evidence consistently indicates a moderate protective association between urban green space and mental health. Findings for walkability and population density are highly heterogeneous, often moderated by socioeconomic factors and air pollution. Research on blue spaces and road design remains limited, highlighting significant variability and context-dependence across planning elements.Summary: Methodological challenges, such as establishing causality, simplistic exposure metrics, and inadequate consideration of equity-constrain current evidence. Future research should prioritize longitudinal and natural experiment designs, dynamic multiexposure assessments, and explicit equity integration to generate actionable guidance for urban planning that supports mental well being equitably.","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"347-356"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental health in Russia: recent trends in urban settings. 俄罗斯的心理健康：城市环境中的最新趋势。

IF 5.9 2区医学

Current Opinion in Psychiatry Pub Date : 2026-07-01 Epub Date: 2026-05-15 DOI: 10.1097/YCO.0000000000001094

Anastasia Peshkovskaya, Yulia Chaika

{"title":"Mental health in Russia: recent trends in urban settings.","authors":"Anastasia Peshkovskaya, Yulia Chaika","doi":"10.1097/YCO.0000000000001094","DOIUrl":"10.1097/YCO.0000000000001094","url":null,"abstract":"Purpose of review: With this article, we aimed to outline the most recent data, official statistics, and research findings significant to understand current mental health trends in Russia. Furthermore, we, to the best of our knowledge, for the first time since the publication 'wave' of the pandemic-related articles, address mental health in Russia with particular focus on urbanicity.Recent findings: Major issues of mental health of the youth and the elderly in Russian cities, suicide and its growing rates in certain populations, maternal mental health, and medical personnel mental health were covered in this article. Beyond prevalence, access to care, and changes attributable to urbanization, we briefly discuss how electronic media became an emerging source of data for Russian researchers who investigated mental health in megacities, and address insights on associations between distance of migration track and risk of mental health conditions.Summary: Reported overview of findings can inform future research, policies, and mental health interventions tailored to the complexities of urban populations in Russia, and globally.","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"339-346"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic drug monitoring and pharmacogenomics: complementary tools in neuropsychopharmacology. 治疗药物监测和药物基因组学：神经精神药理学的互补工具。

IF 5.9 2区医学

Current Opinion in Psychiatry Pub Date : 2026-07-01 Epub Date: 2026-05-04 DOI: 10.1097/YCO.0000000000001099

Martina Hahn, Georgios Schoretsanitis, Sibylle Christine Roll

{"title":"Therapeutic drug monitoring and pharmacogenomics: complementary tools in neuropsychopharmacology.","authors":"Martina Hahn, Georgios Schoretsanitis, Sibylle Christine Roll","doi":"10.1097/YCO.0000000000001099","DOIUrl":"10.1097/YCO.0000000000001099","url":null,"abstract":"Purpose of review: Therapeutic drug monitoring (TDM) and pharmacogenomic testing (PGx) are increasingly important in optimizing psychopharmacological treatments. This review highlights the significance of integrating these tools to enhance pharmacological care in psychiatry.Recent findings: TDM has a longstanding tradition in managing psychiatric disorders, showcasing interindividual variability in drug metabolism and response. Recent studies demonstrate that TDM improves symptom control, reduces relapse rates, and decreases hospitalization for patients on psychotropic medications. The introduction of mini-invasive TDM procedures, including point-of-care testing and wearable devices, expands its applicability in real-world settings. Similarly, PGx testing, which assesses genetic variations affecting drug metabolism, has shown a significant increase in remission rates among depressed patients and emphasizes the importance of substrate-specific effects in pharmacogenomics. Recent findings indicate that phenoconversion can alter drug-gene interactions, necessitating careful consideration in treatment planning. Long-read sequencing allows more accurate genotyping results.Summary: The integration of TDM and PGx in clinical practice offers a more personalized approach to psychiatric care, improving treatment outcomes and reducing adverse effects. The development of new guidelines for both TDM and PGx enhances their utility, while emerging technologies may facilitate their implementation. Continuing research in this area is essential for refining these tools, ensuring that clinicians can effectively tailor neuropsychotropic treatments to individual patient needs.","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"326-330"},"PeriodicalIF":5.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urbanization, wildfire exposure, and youth mental health: a narrative review. 城市化、野火暴露与青少年心理健康：一项叙述性回顾。

IF 4.9 2区医学

Current Opinion in Psychiatry Pub Date : 2026-06-11 DOI: 10.1097/YCO.0000000000001102

Zeyu He, Rongrong Wang, Andy Hickner, Yunyu Xiao

{"title":"Urbanization, wildfire exposure, and youth mental health: a narrative review.","authors":"Zeyu He, Rongrong Wang, Andy Hickner, Yunyu Xiao","doi":"10.1097/YCO.0000000000001102","DOIUrl":"https://doi.org/10.1097/YCO.0000000000001102","url":null,"abstract":"Purpose of review: This narrative review synthesizes recent empirical studies on the mental health impacts of wildfires on children and adolescents, with specific attention to how urbanization modifies risk, access, and recovery. It addresses a critical gap in the literature by examining spatial and infrastructural inequities in post-disaster mental health outcomes while identifying key gaps in this emerging research domain.Recent findings: Youth exposed to wildfires exhibit high rates of PTSD, depression, and anxiety, often persisting well beyond the acute event. Urbanization intensifies these risks by expanding the wildland-urban interface and stratifying access to care. Rural and peri-urban youth face the most significant disruption, from displacement to delayed service access, yet are the least likely to receive sustained, culturally responsive interventions. This review identified a limited evidence base: among studies published since June 2024 that explicitly examined youth mental health and urbanization in wildfire contexts, only three peer-reviewed empirical studies met inclusion criteria. Among the broader wildfire-youth literature, only one employed longitudinal tracking, none used systematic geospatial mapping, and few included Indigenous or marginalized populations. Intervention models such as telehealth, allied health services, and trauma-informed school support show promise but remain unevenly implemented.Summary: The psychological burden of wildfires on youth is enhanced by trauma exposure and spatial inequity. The scarcity of research explicitly addressing urbanization's role in youth wildfire mental health represents a critical gap. Urban planning and mental health policy must be integrated to ensure that services reach underserved regions. Future research should incorporate urban-rural typologies, geospatial analysis, cultural dimensions, and developmental trajectories to inform equitable, place-based interventions for wildfire-exposed youth.","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment trials for negative symptoms in schizophrenia. 精神分裂症阴性症状的治疗试验

IF 5.9 2区医学

Current Opinion in Psychiatry Pub Date : 2026-05-01 Epub Date: 2025-12-29 DOI: 10.1097/YCO.0000000000001067

Louise Birkedal Glenthøj, Mette Ødegaard Nielsen, Merete Nordentoft

{"title":"Treatment trials for negative symptoms in schizophrenia.","authors":"Louise Birkedal Glenthøj, Mette Ødegaard Nielsen, Merete Nordentoft","doi":"10.1097/YCO.0000000000001067","DOIUrl":"10.1097/YCO.0000000000001067","url":null,"abstract":"Purpose of review: Negative symptoms in schizophrenia remain an unmet treatment need. Recent guidelines and meta-analyses suggest that some pharmacological and psychosocial interventions show modest efficacy. Adding to this evidence, this review summarizes randomized clinical trials (RCTs) published between January 2024 and October 2025 on pharmacological, psychosocial, physical, digital, and neuromodulatory interventions targeting negative symptoms.Recent findings: Most recent RCTs were small and methodologically heterogeneous, and effects on negative symptoms were generally modest. Exercise-based and body-oriented interventions, CBT-based interventions, psychosocial programmes, and digital tools were feasible and often associated with within-group improvement, but rarely superior to active controls or treatment as usual; only a larger yoga trial showed clear added benefit. Cognitive remediation did not directly reduce negative symptoms, but recent work indicates that negative symptoms moderate the translation of cognitive gains into functional improvement. Pharmacological trials yielded mixed results, with signals for muscarinic agonist-antagonist treatment, selected repurposed agents, and sulforaphane. Neuromodulation studies, particularly intermittent theta burst stimulation and transcutaneous auricular vagus nerve stimulation, suggested small to moderate improvements that depended on stimulation parameters and treatment duration.Summary: Current evidence confirms that negative symptoms are modifiable and underscores the need for adequately powered, mechanism-informed, multimodal trials with long-term follow-up.","PeriodicalId":11022,"journal":{"name":"Current Opinion in Psychiatry","volume":" ","pages":"216-221"},"PeriodicalIF":5.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0