Current oncology最新文献_第7页

Chemoradiotherapy Strategies for Immunotherapy-Sensitive Multi-Metastatic Nasopharyngeal Carcinoma: A Comparative Case Report and Literature Review. 对免疫治疗敏感的多发性转移性鼻咽癌的放化疗策略：一个比较病例报告和文献复习。

IF 3.4 4区医学

Current oncology Pub Date : 2025-08-18 DOI: 10.3390/curroncol32080466

Zikun Li, Yuxiang He

{"title":"Chemoradiotherapy Strategies for Immunotherapy-Sensitive Multi-Metastatic Nasopharyngeal Carcinoma: A Comparative Case Report and Literature Review.","authors":"Zikun Li, Yuxiang He","doi":"10.3390/curroncol32080466","DOIUrl":"https://doi.org/10.3390/curroncol32080466","url":null,"abstract":"This study investigates two cases of stage IVb de novo multi-metastatic nasopharyngeal carcinoma (NPC) that responded to immunotherapy but resulted in different outcomes. Case 1 involved a multi-metastatic NPC patient (T4N3M1) with extensive bone and lymphatic metastases and severely impaired physical condition (ECOG PS 2) who showed significant tumor reduction after one cycle of immunotherapy combined with non-platinum chemotherapy, with no radiation exposure. Due to financial difficulties, the patient received intermittent immunotherapy plus chemotherapy and survived 28 months with a good quality of life. Case 2 describes a multi-metastatic NPC patient (T3N2M1) with multi-organ (bone and liver) metastases and good performance status (ECOG PS 0) who underwent standard chemotherapy, immunotherapy, and radiotherapy but experienced rapid progression and died after 21 months. Immunotherapy combined with chemotherapy remains the standard for multi-metastatic NPC patients. Patients responsive to induction chemotherapy gain survival benefits from subsequent radiotherapy. However, the advantages and disadvantages of radiotherapy for immunotherapy-sensitive multi-metastatic NPC patients are still unclear. Radiotherapy (RT) can enhance local control and promote tumor antigen release, thereby complementing immunotherapy; yet it can also damage immune cells, leading to exhaustion and resistance. Therefore, balancing RT and chemotherapy is vital for optimizing immune synergy and preventing immune exhaustion.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pembrolizumab-Induced Simultaneous and Refractory Systemic Capillary Leak and Cytokine Release Syndromes: A Case Report. 派姆单抗诱导的同时和难治性全身毛细血管渗漏和细胞因子释放综合征1例报告。

IF 3.4 4区医学

Current oncology Pub Date : 2025-08-18 DOI: 10.3390/curroncol32080469

Eugénie Roberge-Maltais, Eric Lévesque, Vincent Castonguay, Nicolas Marcoux, Louis-Philippe Grenier, Martin Veilleux

{"title":"Pembrolizumab-Induced Simultaneous and Refractory Systemic Capillary Leak and Cytokine Release Syndromes: A Case Report.","authors":"Eugénie Roberge-Maltais, Eric Lévesque, Vincent Castonguay, Nicolas Marcoux, Louis-Philippe Grenier, Martin Veilleux","doi":"10.3390/curroncol32080469","DOIUrl":"https://doi.org/10.3390/curroncol32080469","url":null,"abstract":"Systemic Capillary Leak Syndrome (SCLS) and Cytokine Release Syndrome (CRS) have both been described as rare but severe adverse reactions induced by Programmed cell death protein 1 (PD-1) inhibitors such as pembrolizumab. We report the case of a 40-year-old woman undergoing treatment with pembrolizumab for a stage 4 cervical squamous cell carcinoma who presented with anasarca, hypotension, hemoconcentration and signs of multisystemic inflammation. After elimination of alternative causes such as nephrotic syndrome, cardiac dysfunction and cirrhosis, she was diagnosed with both pembrolizumab-induced SCLS and CRS. She was successfully treated with a multimodal treatment approach including intravenous immunoglobulins, steroids, diuretics and axitinib for SCLS as well as ruxolitinib for CRS. After several months of hospitalization, her symptoms finally improved with this treatment regimen, and she was able to attain euvolemic state and be discharged from the hospital. This case highlights certain rare and severe adverse effects of treatment with PD-1 inhibitors. Furthermore, it proposes a novel therapeutic approach for similar cases based upon probable underlying physiopathological mechanisms in SCLS and CRS.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Significance of Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score in Liver Transplantation for Hepatocellular Carcinoma. 血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分在肝癌肝移植中的预后意义。

IF 3.4 4区医学

Current oncology Pub Date : 2025-08-16 DOI: 10.3390/curroncol32080464

Imam Bakir Bati, Umut Tuysuz, Elif Eygi

{"title":"Prognostic Significance of Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score in Liver Transplantation for Hepatocellular Carcinoma.","authors":"Imam Bakir Bati, Umut Tuysuz, Elif Eygi","doi":"10.3390/curroncol32080464","DOIUrl":"10.3390/curroncol32080464","url":null,"abstract":"Objectives: Hepatocellular carcinoma (HCC) remains a major indication for liver transplantation (LT), but accurate pretransplant risk stratification is critical to improve long-term outcomes. Traditional morphometric criteria such as tumor size and number are limited in predicting recurrence and survival. The HALP (hemoglobin, albumin, lymphocyte, platelet), gamma-glutamyl transpeptidase to platelet ratio (GPR), and FIB-4 indices are emerging systemic inflammatory and nutritional biomarkers that may provide additional prognostic value in HCC patients undergoing LT. Materials and Methods: This retrospective, two-center cohort study included 200 patients who underwent LT for HCC between 2012 and 2023. Preoperative HALP, GPR, and FIB-4 scores were calculated, and their associations with overall survival (OS) and recurrence-free survival (RFS) were assessed using ROC analyses and Cox proportional hazard models. Cut-off values were determined for each biomarker, and survival outcomes were analyzed using Kaplan-Meier methods. Results: A low HALP score (≤0.39) was independently associated with reduced OS but not with RFS. Conversely, low GPR (≤0.45) and FIB-4 (≤3.1) values were significantly associated with both poor OS and higher recurrence risk. Tumor size, number of lesions, and microvascular invasion also independently predicted poor outcomes. Multivariate analysis confirmed HALP, GPR, and FIB-4 as significant preoperative predictors of prognosis in this population. Conclusions: HALP, GPR, and FIB-4 are readily available, cost-effective indices that provide significant prognostic information in HCC patients undergoing LT. Their integration with morphometric criteria may improve pretransplant risk stratification and support individualized clinical decision-making.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Treatment Modalities on Locally Advanced Gastric Cancer-Real-World Data. 治疗方式对局部晚期胃癌的影响-真实世界数据。

IF 3.4 4区医学

Current oncology Pub Date : 2025-08-16 DOI: 10.3390/curroncol32080463

Esma Uguztemur, Banu Oztürk

{"title":"Impact of Treatment Modalities on Locally Advanced Gastric Cancer-Real-World Data.","authors":"Esma Uguztemur, Banu Oztürk","doi":"10.3390/curroncol32080463","DOIUrl":"https://doi.org/10.3390/curroncol32080463","url":null,"abstract":"The optimal sequencing of chemotherapy in locally advanced gastric cancer (LAGC) remains controversial. This study aimed to compare survival outcomes between adjuvant (ACT) and neoadjuvant (NACT) chemotherapy and to identify clinicopathological factors associated with progression-free survival (PFS) and overall survival (OS) in a real-world setting.Methods: We retrospectively analyzed 103 patients with non-metastatic gastric cancer treated between 2014 and 2024. Patients were categorized into ACT (n = 56) and NACT (n = 47) groups. Kaplan-Meier and Cox regression analyses were used to assess survival outcomes and prognostic factors.Results: The NACT group was younger and had more proximal tumors. Median OS was 48.7 months in the ACT group versus 17.7 months in the NACT group (p = 0.048). Median PFS was not reached in the ACT group and was 15.6 months in the NACT group (p = 0.008). Negative surgical margin status was independently associated with improved survival, whereas age was an independent negative prognostic factor for OS. No significant associations were found between OS or PFS and histologic subtype, lymphovascular invasion, perineural invasion, gender, D2 dissection, or type of surgery. Notably, 21% of NACT patients did not proceed to surgery due to progression, treatment intolerance, or refusal.Conclusion: Although ACT was associated with longer PFS and OS in this cohort, these differences are most likely explained by baseline imbalances, patient selection factors, and survivorship bias rather than the timing of chemotherapy itself. These findings highlight the importance of careful patient selection for NACT and underscore the need for prospective, randomized studies to define optimal sequencing strategies in LAGC. Our study contributes descriptive, real-world data rather than definitive evidence of treatment superiority.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Determinants of Compassionate Cancer Care in Older Adults Using Fuzzy Cognitive Mapping. 利用模糊认知映射探讨老年人同情心癌症护理的决定因素。

IF 3.4 4区医学

Current oncology Pub Date : 2025-08-16 DOI: 10.3390/curroncol32080465

Dominique Tremblay, Chiara Russo, Catherine Terret, Catherine Prady, Sonia Joannette, Sylvie Lessard, Susan Usher, Émilie Pretet-Flamand, Christelle Galvez, Élisa Gélinas-Phaneuf, Julien Terrier, Nathalie Moreau

{"title":"Exploring Determinants of Compassionate Cancer Care in Older Adults Using Fuzzy Cognitive Mapping.","authors":"Dominique Tremblay, Chiara Russo, Catherine Terret, Catherine Prady, Sonia Joannette, Sylvie Lessard, Susan Usher, Émilie Pretet-Flamand, Christelle Galvez, Élisa Gélinas-Phaneuf, Julien Terrier, Nathalie Moreau","doi":"10.3390/curroncol32080465","DOIUrl":"https://doi.org/10.3390/curroncol32080465","url":null,"abstract":"The growing number of older adults with cancer confront practical and organizational limitations that hinder their ability to obtain care that is adapted to their health status, needs, expectations, and life choices. The integration into practice of evidence-based and institutional recommendations for a geriatric approach and person-centered high-quality care remains incomplete. This study uses an action research design to explore stakeholders' perspectives of the challenges involved in translating the established care priorities into a compassionate geriatric approach in oncology and identify promising pathways to improvement. Fifty-three stakeholders participated in focus groups to create cognitive maps representing perceived relationships between concepts related to compassionate care of older adults with cancer. Combining maps results in a single model constructed in Mental Modeler software to weigh relationships and calculate concept centrality (importance in the model). The model represents stakeholders' collective perspective of the determinants of compassionate care that need to be addressed at different decision-making levels. The results reveal pathways to improvement at systemic, organizational, practice, and societal levels. These include connecting policies on ageing and national cancer programs, addressing fragmented care through interdisciplinary teamwork, promoting person-centered care, cultivating relational proximity, and combatting ageism. Translating evidence-based practices and priority orientations into compassionate care rests on collective capacities across multiple providers to address the whole person and their unique trajectory.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical Guidance for the Expanded Implementation and Provision of Bispecific Antibodies for Diffuse Large B-Cell Lymphoma (DLBCL) Across Canada. 加拿大弥漫性大b细胞淋巴瘤（DLBCL）双特异性抗体扩展实施和提供的实用指南。

IF 3.4 4区医学

Current oncology Pub Date : 2025-08-15 DOI: 10.3390/curroncol32080460

David MacDonald, Robert Puckrin, Pamela Skrabek, Selay Lam, Jai Jayakar, Isabelle Fleury, Christopher Lemieux, Mélina Boutin, Jacqueline Costello

{"title":"Practical Guidance for the Expanded Implementation and Provision of Bispecific Antibodies for Diffuse Large B-Cell Lymphoma (DLBCL) Across Canada.","authors":"David MacDonald, Robert Puckrin, Pamela Skrabek, Selay Lam, Jai Jayakar, Isabelle Fleury, Christopher Lemieux, Mélina Boutin, Jacqueline Costello","doi":"10.3390/curroncol32080460","DOIUrl":"https://doi.org/10.3390/curroncol32080460","url":null,"abstract":"(1) Background: Bispecific antibodies (BsAbs) for the treatment of relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) can be delivered in ambulatory healthcare settings; however, the safe and effective management of potential side effects, such as cytokine release syndrome (CRS), requires protocolized monitoring and management. (2) Methods: An Expert Working Group (EWG) of nine hematologists from across Canada, with experience in leading BsAb program implementation, combined a review of published literature, a comparison of national/provincial/regional guidance documents and protocols, and their professional experiences to produce an informed framework for BsAb program implementation in various healthcare settings. (3) Results: The EWG supports and recommends the progression of BsAb provision from predominantly inpatient hospital settings to community/ambulatory care settings closer to the patient's home. A seven-step implementation process is outlined to support the safe and effective establishment of such programs, from establishing leadership, through customization of protocols, to education and execution. Strategies and considerations are offered to overcome potential barriers and empower healthcare professionals who are working to establish or improve BsAb programs across Canada. (4) Conclusions: For patients with R/R DLBCL, the safe and effective provision of BsAbs closer to home is both feasible and preferred. This guidance is intended to support the efficient and effective setup or enhancement of BsAb programs in lymphoma.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Adjuvant Cemiplimab in High-Risk Cutaneous Squamous Cell Carcinoma. 辅助用药西米单抗对高危皮肤鳞状细胞癌的影响。

IF 3.4 4区医学

Current oncology Pub Date : 2025-08-15 DOI: 10.3390/curroncol32080459

Annette M Lim, Sandro Porceddu, Danny Rischin

引用次数: 0

High Outcome-Reporting Bias in Randomized-Controlled Trials of Acupuncture for Cancer Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Meta-Epidemiological Study. 针刺治疗癌症化疗引起的恶心和呕吐的随机对照试验的高结果报告偏倚：一项系统评价和荟萃流行病学研究。

IF 3.4 4区医学

Current oncology Pub Date : 2025-08-15 DOI: 10.3390/curroncol32080462

Rachele Penati, Riccardo Vecchio, Roberto Gatto, Anna Odone, Silvia Deandrea

{"title":"High Outcome-Reporting Bias in Randomized-Controlled Trials of Acupuncture for Cancer Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Meta-Epidemiological Study.","authors":"Rachele Penati, Riccardo Vecchio, Roberto Gatto, Anna Odone, Silvia Deandrea","doi":"10.3390/curroncol32080462","DOIUrl":"10.3390/curroncol32080462","url":null,"abstract":"Selective outcome-reporting bias refers to the selective reporting of a subset of study findings. This methodological limitation may occur in cancer-related acupuncture studies, where valid empirical studies on psychometric performance are still lacking. We assessed the risk of selective outcome reporting bias in studies published in English that were included in a systematic review on acupuncture for preventing cancer chemotherapy-induced nausea and vomiting. For each study, we searched for registry availability and, if present, assessed its validity. We described each study outcome (nausea, vomiting, or both) according to the following seven items: type of outcome, domain, specific measurement, specific metric, type of data, methods of aggregation, and timepoint unit and time. Eleven studies published between 1987 and 2019 in English were evaluated. Only four (36%) had a registry, of which only two were prospective and therefore considered valid. Discrepancies were found in the specific measurement of the outcome in two studies and in the specific metric. In many other cases, discrepancies were not evaluable due to missing information. No study reported complete outcomes as planned in the published protocol. Communication about the importance of prospective trial registration, including outcome details, should be enforced to reduce the risk of selective outcome reporting bias in oncology acupuncture studies.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating Fatalism Among Breast Cancer Survivors in a Heterogeneous Hispanic Population: A Cross-Sectional Study. 评估异种西班牙裔人群中乳腺癌幸存者的宿命论：一项横断面研究。

IF 3.4 4区医学

Current oncology Pub Date : 2025-08-15 DOI: 10.3390/curroncol32080461

Liara Lopez Torralba, Brian Sukhu, Maria Eduarda de Azevedo Daruge, Jongik Chung, Victoria Loerzel, Eunkyung Lee

{"title":"Evaluating Fatalism Among Breast Cancer Survivors in a Heterogeneous Hispanic Population: A Cross-Sectional Study.","authors":"Liara Lopez Torralba, Brian Sukhu, Maria Eduarda de Azevedo Daruge, Jongik Chung, Victoria Loerzel, Eunkyung Lee","doi":"10.3390/curroncol32080461","DOIUrl":"https://doi.org/10.3390/curroncol32080461","url":null,"abstract":"Hispanic breast cancer survivors reported worse quality of life, and fatalism is considered one of the mediators for this disparity. This study aimed to identify the factors associated with fatalism within a diverse Hispanic population. Hispanic origin was self-reported, and the Multidimensional Fatalism Measure questionnaire, a validated tool that measures fatalism across multiple dimensions, was used to assess fatalism. A total of 390 women, consisting of 210 Puerto Ricans, 34 Colombians, 29 Dominicans, 25 Cubans, 24 Venezuelans, 22 Mexicans, and 46 individuals of other Hispanic backgrounds, completed the fatalism assessment. The mean fatalism score was 16.4 (95% CI = 15.8-17.0), characterized by a high internal locus of control and strong religious beliefs, along with moderate beliefs in luck and a low external locus of control. The higher fatalism scores were reported in Dominican, Mexican, and Venezuelan groups, while Colombians reported the lowest score. Multivariable analysis showed that Colombians (β = -4.0), individuals with higher household incomes (β = -2.3 for USD 20,000-USD 75,000, β = -2.4 for ≥75,000), higher education levels (β = -1.9), and those using English more frequently at home (β = -2.0) reported lower fatalism compared to their reference group. To enhance the quality of life for these survivors, culturally tailored interventions should focus on improving perceived control and mitigating fatalism.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Narrative Review of the Roles of Nursing in Addressing Sexual Dysfunction in Oncology Patients. 护理在解决肿瘤患者性功能障碍中的作用述评。

IF 3.4 4区医学

Current oncology Pub Date : 2025-08-14 DOI: 10.3390/curroncol32080457

Omar Alqaisi, Suhair Al-Ghabeesh, Patricia Tai, Kelvin Wong, Kurian Joseph, Edward Yu

{"title":"A Narrative Review of the Roles of Nursing in Addressing Sexual Dysfunction in Oncology Patients.","authors":"Omar Alqaisi, Suhair Al-Ghabeesh, Patricia Tai, Kelvin Wong, Kurian Joseph, Edward Yu","doi":"10.3390/curroncol32080457","DOIUrl":"https://doi.org/10.3390/curroncol32080457","url":null,"abstract":"Sexual dysfunction affects an estimated 50-70% of cancer survivors but remains underrecognized and undertreated, impacting quality of life and emotional well-being. This narrative review involves a comprehensive search of PubMed/MEDLINE, CINAHL, Scopus, Web of Science, and ScienceDirect for English-language publications (January 2010-May 2025), using combined MeSH and free-text terms for 'sexual health', 'cancer', 'nursing', 'roles of nurses', 'immunotherapy', 'targeted therapy', 'sexual health', 'sexual dysfunction', 'vaginal dryness', 'genitourinary syndrome of menopause', 'sexual desire', 'body image', 'erectile dysfunction', 'climacturia', 'ejaculatory disorders', 'dyspareunia', and 'oncology'. We used the IMRAD (Introduction, Methods, Results, and Discussion) approach to identify 1245 records and screen titles and abstracts. Fifty studies ultimately met the inclusion criteria (original research, reviews, and clinical guidelines on oncology nursing and sexual health). Results: All the treatments contributed to reduced libido, erectile dysfunction, dyspareunia, and body image concerns, with a prevalence of 57.5% across genders. Oncology nurses can provide sex education and counseling. Barriers (limited training, cultural stigma, and the absence of protocols) hinder effective intervention. Addressing these issues through sexual health curricula, formal referral systems, and policy reforms can enhance nursing care. Future research should assess the impact of targeted nurse education and the institutional integration of sexual health into cancer care.","PeriodicalId":11012,"journal":{"name":"Current oncology","volume":"32 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12384569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0