HPV和宫颈癌的生物学、预防和治疗更新。

IF 2.8 4区 医学 Q2 ONCOLOGY
Emilia Włoszek, Kamila Krupa, Eliza Skrok, Michał Piotr Budzik, Andrzej Deptała, Anna Badowska-Kozakiewicz
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引用次数: 0

摘要

癌症研究中最重要的突破之一是确定了某些人乳头瘤病毒(HPV)基因型的持续感染是宫颈癌的原因。从那时起,一系列的诊断和治疗方法都是基于这一发现而发展起来的。本文旨在介绍hpv相关宫颈癌的生物学、预防和治疗方面的最新进展。介绍了目前关于疫苗接种、诊断测试和宫颈癌治疗的知识状况。介绍了最新的世卫组织疫苗接种指南,并宣布了即将进行的修改。文章的最后部分总结了有前景的新诊断和治疗方法,以及对自我诊断测试、治疗性疫苗的使用和循环无细胞DNA诊断的观点和最新研究成果。尽管近年来取得了重大进展,但基于疫苗接种和检测的战略仍然是防治人乳头瘤病毒相关宫颈癌的基石。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HPV and Cervical Cancer-Biology, Prevention, and Treatment Updates.

One of the most significant breakthroughs in cancer research has been the identification of persistent infection with certain human papillomaviruses (HPV) genotypes as the cause of cervical cancer. Since then, a range of diagnostic and therapeutic methods has been developed based on this discovery. This article aims to describe the latest updates in the biology, prevention, and treatment of HPV-related cervical cancer. The current state of knowledge regarding vaccinations, diagnostic tests, and cervical cancer therapies is presented. The latest WHO guidelines on vaccinations are presented, as well as announcements of upcoming changes. The final part of the article summarizes promising new diagnostic and treatment methods, as well as perspectives and the latest research findings on self-administered diagnostic tests, the use of therapeutic vaccines, and circulating cell-free DNA in diagnosis. Despite the significant progress made in recent years, the strategy based on vaccination and testing remains the cornerstone in the fight against HPV-related cervical cancer.

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来源期刊
Current oncology
Current oncology ONCOLOGY-
CiteScore
3.30
自引率
7.70%
发文量
664
审稿时长
1 months
期刊介绍: Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.
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