Current Drug Therapy最新文献

{"title":"Antioxidant Potential of Thymus willdenowii Boiss & Reut. Aqueous Extract and Effect of its Supplementation on Hyperlipidemia and Paraoxonase-1 Arylesterase Activity in High-Fat Diet-Fed Rats","authors":"H. Elbouny, B. Ouahzizi, K. Sellam, C. Alem","doi":"10.2174/1574885518666230724163758","DOIUrl":"https://doi.org/10.2174/1574885518666230724163758","url":null,"abstract":"\u0000\u0000Thymus willdenowii Boiss & Reut. (T. willdenowii) is a medicinal plant that grows in the Moroccan High Atlas Mountains. It is used in local folk medicine to treat several disorders including cardiovascular disease.\u0000\u0000\u0000\u0000In this study, we aimed to evaluate the antioxidant and anti-hyperlipidemic effects of the traditionally used aqueous extract of T. willdenowii.\u0000\u0000\u0000\u0000The extraction of the plant was assessed using the traditionally used decoction method. Total contents of polyphenols (TPC), flavonoids (TFC), and tannins (TTC) were estimated and in vitro antioxidant assays namely DPPH, FRAP, and TAC were carried out to evaluate its antioxidant potential. Moreover, the anti-hyperlipidemic activity was tested on rats fed a high-fat diet (HFD) containing sucrose (15%), lard (15%), and cholesterol (2%). Thyme extract was given daily at 500 mg/kg.\u0000\u0000\u0000\u0000After 2 months of treatment, lipid profile parameters and arylesterase activity were determined. The findings showed that T. willdenowii extract is rich in phenolic compounds (TPC = 127.34 GAE mg/gE; TFC = 105.43 RE mg/gE; TTC = 24.08 CE mg/gE) and exhibits important antioxidant activity (DPPH IC50 = 0.41 mg/mL; FRAP value = 1.31 Fe2+E mM; TAC value = 322.13 AAE µg/gE). Moreover, T. willdenowii extract significantly reduced the alterations caused by HFD intake by decreasing blood lipids (TC: -28.19 %; TGs: -22.82 %; LDL-C: -35.11 %) and increasing paraoxonase-1 arylesterase activity (+12.83 %).\u0000\u0000\u0000\u0000We conclude that the traditional use of T. willdenowii is effective in the treatment of hyperlipidemia.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45044758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Progressive stratagem outline on diverse Dermatological Clays","authors":"R. Pal, Y. Pal, Merugumolu Vijay Kumar, Deepti Katiyar, Saranya Punniyakotti","doi":"10.2174/1574885518666230721100319","DOIUrl":"https://doi.org/10.2174/1574885518666230721100319","url":null,"abstract":"\u0000\u0000For a very long time, clay has been widely utilized in cosmetics, and it is still one of the most widely used components today. There is clay for every skincare issue and problem, including dryness, irritation, sunburn, and oiliness. Finding the appropriate clay for the skin's type, texture, and needs is the primary consideration. The current effort attempts to compile knowledge on the many dermatological types of clay that are naturally present, their composition, and various views regarding the care, skin nourishment, and benefits needed to suit the various needs of various skin types. The present work aims to gather the information available on the different types of dermatological clays present naturally, their composition, and different perspectives regarding the care and skin nourishment, and their benefits required to suit different needs of different skin types.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45589252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifertile and Estrogenic Effects of Sida acuta root on Experimental Animal Models","authors":"A. Tiwari, D. K. Pradhan, Sujata Karna, M. Mishra, Sunil Singh, K. Mishra, V. Tiwari, Manish Kumar, Ajay Sharma","doi":"10.2174/1574885518666230719125554","DOIUrl":"https://doi.org/10.2174/1574885518666230719125554","url":null,"abstract":"\u0000\u0000Herbal medications have been used for centuries in traditional Indian medicine to reduce fertility in several regions. Among them, Sida acuta (S. acuta) is a traditional herb having antifertility effects with other broad medicinal properties. In this work, it was studied for its effect on fertility in female rats.\u0000\u0000\u0000\u0000The purpose of this research was to conduct effectiveness and safety investigations on S. acuta root, an antifertility plant widely used in Asian countries.\u0000\u0000\u0000\u0000Fertile albino Wistar female rats (200-250 gm) were used for antifertility investigations. The animals were separated into four groups, each with six members, and treated with 200 and 400 mg/kg of the methanolic extract in combination with Ethinyl Estradiol (0.3mg/kg body weight) as per schedule. They all took place for seven days. On the 8th day, every positive rat was decapitated under ether anesthesia, and the uterus and surrounding tissues were taken from it for fast weight measurement.\u0000\u0000\u0000\u0000The phytochemical screening revealed the presence of alkaloids, tannins, and flavonoids as secondary metabolites. RP-HPLC analysis was used to determine the concentration of colchicine in S. acuta roots extract, and it was found to have a retention period of 7.35 minutes. The female Wistar rats treated with S. acuta root study showed that the litter weight of the experimental group with MESA (200) was 42.13±0.77 and MESA (400) was 18.53±0.94 lower than the control group 61.5±0.29 which reveals that there was a decrease in litter weight, indicating the potential antifertility activity of the experimental group. It was shown that the extract was more effective in reducing the number of litters born (50 percent) and causing considerable anti-implantation activity (3.29) than the control in postcoital testing. The uterotrophic response was less pronounced than that elicited by ethinylestradiol alone when the extract was administered simultaneously (P<0.01). The estrogenic activity of the extract was, therefore, low at the contraceptive dosage level when taken alone. Both ethinylestradiol and these compounds, on the other hand, showed considerable antiestrogenic properties.\u0000\u0000\u0000\u0000The methanolic extract of S. acuta root showed significant antifertility effects and was found to be safe when used at the effective dosages found in this research.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46258438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silymarin Improves Thyroid Function in Lithium-treated Bipolar Patients: A Randomized, Double-blind, Placebo-controlled Pilot Study","authors":"A. Nili-Ahmadabadi, Sara Ataei, Mohammad Reza Mahdian, A. Ghaleiha, N. Matinnia","doi":"10.2174/1574885518666230710122712","DOIUrl":"https://doi.org/10.2174/1574885518666230710122712","url":null,"abstract":"\u0000\u0000Thyroid dysfunction is one of the most important side effects of lithium carbonate. Silymarin is a flavonolignan extracted from the milk thistle Silybum marianum (L.), which has remarkable antioxidant and therapeutic properties. This clinical trial study aimed to evaluate the effect of silymarin on thyroid function and serum antioxidant status in patients with lithium-treated bipolar disorder.\u0000\u0000\u0000\u0000Bipolar patients with a depression episode and a history of at least six months of lithium use were randomly divided into placebo-control (n=18) and intervention (n=19) groups. In addition to standard medication, patients in the intervention and control groups received silymarin (140 mg) and placebo tablets daily for ten weeks, respectively. Finally, thyroid function and serum antioxidant status were evaluated along with clinical signs at the beginning and the tenth week.\u0000\u0000\u0000\u0000Following the administration of silymarin, a significant increase was observed in total antioxidant capacity (P = 0.004) and total thiol molecules (P = 0.005) levels in serum compared to the placebo group. Although silymarin had no significant effect on serum triiodothyronine (T3) and lithium levels, it could significantly improve the secretory status of thyroid-stimulating hormone (TSH; P = 0.002) and thyroxine (T4; P = 0.02) hormones in comparison to the placebo group.\u0000\u0000\u0000\u0000The current study showed that silymarin might be effective for thyroid function in lithium-treated bipolar patients by improving body’s antioxidant status.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49458726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoemulsion based In-situ Gel for ocular delivery of Brimonidine Tartrate","authors":"B. Prajapati, Uma Patel, Chetna Modi, P. Kendre","doi":"10.2174/1574885518666230626164030","DOIUrl":"https://doi.org/10.2174/1574885518666230626164030","url":null,"abstract":"\u0000\u0000Brimonidine tartrate is currently used to treat glaucoma; however, conventional ocular formulations have some disadvantages in terms of treating disorders like glaucoma, as less than 5% of the drug reaches a posterior segment of the eye; hence, there is a need for sustained treatment.\u0000\u0000\u0000\u0000The objective of this study was to develop a self-nanoemulsion (SNEDDS) in-situ gel of brimonidine tartrate to investigate the sustained-release effect to improve ocular bioavailability.\u0000\u0000\u0000\u0000Oil, surfactant, and co-surfactant were screened using the pseudo-ternary phase diagram (TPD) by aqueous-titration method based on the drug solubility. Nanoemulsions were evaluated for the pH, viscosity, % drug content, % transmittance, dispersibility, particle size, zeta-potential, TEM, and conductivity test. Nanoemulsion was incorporated into in-situ gel and evaluated for gelling capacity, pourability, gel strength, in vitro drug release study, and drug release kinetics.\u0000\u0000\u0000\u0000Castor oil (10%) as oil phase, Acrysol K-140 (10%) as surfactant, and PEG 400 (20%) as co-surfactant were selected in preparation of SNEDDS from TPD. Evaluation parameters of SNEDDS were found in an acceptable range. % Drug release showed the controlled release up to 8 hrs. Optimum % drug content and % CDR were 100.25% and 92.46% after 12hrs, respectively. Optimized SNEDDS in-situ gel followed the Higuchi model via diffusion mechanism having 0.99 R² value and exhibiting sustained release up to 12 hr. Stability study proved no significant changes during storage. In vitro, the ocular irritancy test proved suitable for ocular delivery.\u0000\u0000\u0000\u0000A sustained-release formulation was obtained by developing brimonidine tartrate SNEDDS in-situ gel as a stable formulation without irritancy during ocular administration.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43092190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowerment Provided by Health Education and its Impact on Self-care: Report of a Pharmaceutical Intervention","authors":"A. M. de Oliveira, Barbara Falaschi Romeiro, João Paulo Vilela Rodrigues, F. Varallo, Leonardo Régis Leira Pereira","doi":"10.2174/1574885518666230606105152","DOIUrl":"https://doi.org/10.2174/1574885518666230606105152","url":null,"abstract":"\u0000\u0000Older people, due to the development of multiple morbidities and in a situation of polypharmacy, become fragile in addition to their own physical and organic aging. For different reasons regarding the treatment, the health care provided, or the physical and mental condition of older people, problems of adherence to pharmacotherapy are present. Pharmaceutical care is an important practice to ensure rational pharmacotherapy for this population. The present study aims to describe the report of pharmacotherapeutic follow-up to a hospitalized older individual with multimorbidity and use of polypharmacy and to highlight an intervention aimed at adherence to pharmacotherapy.\u0000\u0000\u0000\u0000This is the planning of a strategy, aimed at promoting health education, which was carried out during the hospital stay of an older person who was included in the institution's pharmaceutical care services. In addition, at hospital discharge, in order to ensure greater benefits, a bag was made for the correct storage of medicines and a descriptive didactic list on how to use them. In this way, improvements were achieved in the transition of care for this patient.\u0000\u0000\u0000\u0000The importance of developing techniques that promote adherence to pharmacotherapy, especially for fragile populations, such as older people with multiple diseases, and using polypharmacy is suggested. Individualized educational interventions are instructive measures that can contribute to people's autonomy in their self-care.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43354697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayush Kwath: a major contribution of Ayurveda in preventing COVID-19 infection","authors":"Rohit Sharma, Priya Katoch, Kirti Raina, Rohit Kumar Sharma, A. Chaudhary","doi":"10.2174/1574885518666230601150338","DOIUrl":"https://doi.org/10.2174/1574885518666230601150338","url":null,"abstract":"\u0000\u0000Ayush Kwath is an Ayurvedic polyherbal formulation (PHF) of dry Tulsi leaves, Cinnamon bark, Sunthi rhizome, and black pepper fruit.\u0000\u0000\u0000\u0000This PHF contains phytochemicals that help in boosting immunity; hence, it is suggested as a preventive measure against the coronavirus. Ayurveda is an ancient Indian medicine system that offers treatment for various diseases with the help of herbal, animal, or mineral-based formulations. Currently, the entire globe is facing the challenge of combating the COVID-19 pandemic. SARS-CoV-2 virus, a member of a large family of coronaviruses, is the causative agent of COVID-19 (Coronavirus disease 19), which is a highly infectious disease. COVID-19 (Coronavirus disease 19) is a highly infectious disease caused by the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome coronavirus-2) that belongs to a large family of coronaviruses.\u0000\u0000\u0000\u0000Most people who are affected by this virus experience mild to moderate symptoms of pneumonia, but older people or those with weakened immune systems, for example, those suffering from cancer, diabetes, cardiovascular disease, or chronic respiratory diseases, are more likely to develop serious respiratory illnesses. As there is no registered medicine against COVID-19, strengthening the immune system is an effective way to tackle this disease.\u0000\u0000\u0000\u0000Ayush Kwath, a natural immunity booster, has been approved by the Ministry of AYUSH as a prophylactic measure to fight against novel coronavirus infection.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42871915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable Polymeric Microspheres As Drug Carriers For AntiMicrobial Agent","authors":"N. Minocha, Nidhi Bansal, K. Rao, Nikita Yadav","doi":"10.2174/1574885518666230530095329","DOIUrl":"https://doi.org/10.2174/1574885518666230530095329","url":null,"abstract":"\u0000\u0000Microspheres, the novel drug delivery system that offers therapeutic alternatives to single-unit dosage forms, both conventional and quick release. Microspheres are solid microspheres having a diameter of 1–1000 µm. Microspheres can be made utilising various procedures that\u0000vary in their effectiveness and dosage form administration when compared to standard dosage forms.\u0000\u0000\u0000\u0000The idea of targeted drug delivery is to concentrate the treatment in the target tissues\u0000while lowering the relative concentration of the drug in the non-target tissues. As a result, the medication is concentrated at the desired location. Thus, the medication has no effect on the tissues nearby.\u0000Therefore, by combining the drug with carrier particle like microspheres, nanoparticles, liposomes, niosomes, etc., that regulates the release and absorption characteristics of the drug, carrier technology\u0000offers an intelligent way for drug delivery.\u0000\u0000\u0000\u0000Microspheres are naturally biodegradable materials made of proteins or synthetic polymers\u0000that flow freely. Its formulation is approachable, maintaining the desired concentration at the site of\u0000interest without unfavorable effects and reliably delivering the drug to the target site with specificity.\u0000\u0000\u0000\u0000Microspheres attracted a lot of interest for their sustained release as well as their ability\u0000to direct anti-cancer medications to the tumour using biodegradable polymers. Due to this, future drug\u0000delivery systems for innovative medications will heavily rely on microspheres.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42737348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerating Healing of Excisional Wound with a Hydrogel Containing Hyacinth Bean (Dolichos Lablab) Extract in a Rat Model","authors":"P. Gupta, Neelam Singh, R. Goel, Chaitanya Vinayak Narayan, D. Sagar, Aanchal","doi":"10.2174/1574885518666230526124031","DOIUrl":"https://doi.org/10.2174/1574885518666230526124031","url":null,"abstract":"\u0000\u0000Medicinal plants are essential in the treatment of a wide range of illnesses. Dolichos lablab, also known as Hyacinth Bean, is a popular legume crop in India that is rich in natural bioactive compounds. In recognition of its importance in many skin therapies, a hydrogel was prepared. The primary goal of topical formulations is to provide drug contact with the skin while reducing overall absorption. The aim of this study was to evaluate the healing effect of Dolichos lablab extract hydrogel on full-thickness wounds in rats.\u0000\u0000\u0000\u0000Wounds were created on the dorsal surface of Male Albino Wistar rats. Next, the animals were divided into four groups (n = 12). Each group was treated with 200 mg of the allotted topical treatment of blank gel, Dolichos hydrogel and marketed betadine gel. The treatments were applied immediately after the injury and twice daily for up to 14 days. Animals were euthanized on day 14 and some parameters were analyzed such as wound closure rate, Inflammatory cytokines level, oxidative stress profile, collagen hydroxyproline and hexosamine concentration, macroscopic and histopathological evidence.\u0000\u0000\u0000\u0000The findings indicate that Dolichos lablab extract has potent wound healing ability, as evidenced by improved wound closure and tissue regeneration, as well as histopathological parameters. Dolichos hydrogel increased the skin's hydroxyproline level, antioxidant potential, wound contraction, and anti-inflammatory activity by modulating the production of the cytokines TNF-α, IL-1β, and IL-6. This affirms the potency of the wound-healing properties of Dolichos lablab extract.\u0000\u0000\u0000\u0000Dolichos lablab hydrogel is a low-cost herbal medicine which can aid in tissue repair.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43688842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and Extraction of Bioactive Compounds in Ethanolic Extract of Moringa concanensis, Nimmo Leaf, Using Microwave-assisted and Soxhlet Techniques","authors":"Amerendra Singh, Santoshkumar Singh, P. Upadhyay, J. Mishra, V. Vishwakarma","doi":"10.2174/1574885518666230522122556","DOIUrl":"https://doi.org/10.2174/1574885518666230522122556","url":null,"abstract":"\u0000\u0000The extraction of Moringa concanensis (Nimmo leaf) was done in ethanol using Soxhlet and microwave-assisted extraction (MAE) techniques to obtain bioactive compounds.\u0000\u0000\u0000\u0000The standard techniques were used to carry out phytochemical analysis of ethanolic extract. The analysis confirmed the presence of flavonoids, phenols, steroids, alkaloids, terpenoids, glycosides, tannins, and saponins, and also the absence of anthraquinones. Moreover, the extract was evaluated for antioxidant activities using DPPH and ABTS assays. The IC50 value of the extract was also determined.\u0000\u0000\u0000\u0000A clear correlation between the total phenolic content, total flavonoid content, and antioxidant activity of the leaf extracts was obtained.\u0000\u0000\u0000\u0000Conclusion: This study suggests that a high amount of phenolic compounds could be obtained from Moringa concanensis (Nimmo leaf) by using the microwave-assisted extraction technique, which may be responsible for its antioxidant activity.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48117698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}