Current Drug TherapyPub Date : 2024-01-08DOI: 10.2174/0115748855268042231130041958
M. Sharma, G. V. N. Kumar, Pankaj Gupta
{"title":"Pharmacological Investigation of Anticonvulsant Effect of Artemisia\u0000Vulgaris on Pentylenetetrazole-Induced Epileptic Seizures in Zebrafish\u0000Experimental Model","authors":"M. Sharma, G. V. N. Kumar, Pankaj Gupta","doi":"10.2174/0115748855268042231130041958","DOIUrl":"https://doi.org/10.2174/0115748855268042231130041958","url":null,"abstract":"\u0000\u0000Epilepsy is the most common neurological disorder, characterized by abnormal,\u0000unpredictable, and recurrent seizures. In the alternative medicine system, Artemisia vulgaris has\u0000been used to treat epileptic symptoms since its inception. However, scientific evidence concerning\u0000its effect on the treatment of epileptic seizures is not available.\u0000\u0000\u0000\u0000The objective of the study is to evaluate the anti-convulsant potential of Artemisia vulgaris\u0000in zebrafish experimental models.\u0000\u0000\u0000\u0000Zebrafish larvae and adult zebrafish were used as experimental models. Briefly, larvae and\u0000adult zebrafish were exposed to 0.5% of the test medicine Artemisia vulgaris mother tincture (ϕ) and\u0000its potencies (6CH, 30CH), and valproic acid for 1 hour. After 1 hour of exposure, they were exposed\u0000to pentylenetetrazole to record different seizure scores from 1 to 5 using ANY maze video tracking\u0000software.\u0000\u0000\u0000\u0000Artemisia vulgaris 30CH in zebrafish larvae and Artemisia vulgaris 6CH and 30CH in adult\u0000zebrafish delayed the latency score from score 1 to score 5 and were found effective against PTZinduced\u0000locomotor activity and seizure duration and intensity.\u0000\u0000\u0000\u0000In conclusion, Artemisia vulgaris (6CH and 30CH) has the potential to be a novel treatment\u0000for symptomatic epileptic seizures and could be a potential alternative drug candidate for symptomatic\u0000treatment of epilepsy.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":"2 3","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}