{"title":"用分析方法评估叶枯素的植物化学成分、抗氧化剂和抗糖尿病活性","authors":"Rohit Malhotra, Louis Cojandaraj","doi":"10.2174/0115748855270408230925073813","DOIUrl":null,"url":null,"abstract":"\n\nNitophyllum marginale holds potential for medical applications due to its\nbioactive compounds, making it promising for developing new therapeutic interventions. Our study\naims to evaluate the bioactivity of Nitophyllum marginale extracts obtained using methanol and\nchloroform solvents. We focus on analyzing the phytochemical profile, antioxidant activity, and antidiabetic\npotential of seaweed extract in this study. By examining the medicinal properties\nof Nitophyllum marginale, we aim to explore the therapeutic bioactivity potentiality and its prime\nrole in improvising and searching for potential alternatives for seizing Diabetes mellitus.\n\n\n\nThe antioxidant activity of Nitophyllum marginale was evaluated using ABTS,\nDPPH, nitric oxide, lipid peroxidation, and hydrogen peroxide assays. Additionally, alphaglucosidase\ninhibition tests were conducted to evaluate the potential as an antidiabetic agent.\n\n\n\nThe study revealed that extracts from Nitophyllum marginale contain antioxidants that protect\ncells from oxidative stress. These extracts also contain bioactive compounds like alkaloids, flavonoids,\nphenols, saponins, and carbohydrates. These compounds work together to provide antioxidant\nbenefits. Additionally, the extracts showed activity against alpha-glucosidase, which is vital for\nmanaging blood sugar levels.\n\n\n\nThese results emphasize the existence of bioactive metabolites exhibiting phytochemicals,\nantioxidants, and antidiabetic activities obtained from the extract using chloroform and methanol\nsolvents. These findings suggest the potential of Nitophyllum marginale extracts as a natural\nreservoir of antioxidants and antidiabetic agents.\n","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Phytochemicals, Antioxidants, and Antidiabetic Activity of\\nNitophyllum marginale by Using Analytical Approaches\",\"authors\":\"Rohit Malhotra, Louis Cojandaraj\",\"doi\":\"10.2174/0115748855270408230925073813\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nNitophyllum marginale holds potential for medical applications due to its\\nbioactive compounds, making it promising for developing new therapeutic interventions. Our study\\naims to evaluate the bioactivity of Nitophyllum marginale extracts obtained using methanol and\\nchloroform solvents. We focus on analyzing the phytochemical profile, antioxidant activity, and antidiabetic\\npotential of seaweed extract in this study. By examining the medicinal properties\\nof Nitophyllum marginale, we aim to explore the therapeutic bioactivity potentiality and its prime\\nrole in improvising and searching for potential alternatives for seizing Diabetes mellitus.\\n\\n\\n\\nThe antioxidant activity of Nitophyllum marginale was evaluated using ABTS,\\nDPPH, nitric oxide, lipid peroxidation, and hydrogen peroxide assays. Additionally, alphaglucosidase\\ninhibition tests were conducted to evaluate the potential as an antidiabetic agent.\\n\\n\\n\\nThe study revealed that extracts from Nitophyllum marginale contain antioxidants that protect\\ncells from oxidative stress. These extracts also contain bioactive compounds like alkaloids, flavonoids,\\nphenols, saponins, and carbohydrates. These compounds work together to provide antioxidant\\nbenefits. Additionally, the extracts showed activity against alpha-glucosidase, which is vital for\\nmanaging blood sugar levels.\\n\\n\\n\\nThese results emphasize the existence of bioactive metabolites exhibiting phytochemicals,\\nantioxidants, and antidiabetic activities obtained from the extract using chloroform and methanol\\nsolvents. These findings suggest the potential of Nitophyllum marginale extracts as a natural\\nreservoir of antioxidants and antidiabetic agents.\\n\",\"PeriodicalId\":11004,\"journal\":{\"name\":\"Current Drug Therapy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2024-01-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Drug Therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0115748855270408230925073813\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Drug Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115748855270408230925073813","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Evaluation of Phytochemicals, Antioxidants, and Antidiabetic Activity of
Nitophyllum marginale by Using Analytical Approaches
Nitophyllum marginale holds potential for medical applications due to its
bioactive compounds, making it promising for developing new therapeutic interventions. Our study
aims to evaluate the bioactivity of Nitophyllum marginale extracts obtained using methanol and
chloroform solvents. We focus on analyzing the phytochemical profile, antioxidant activity, and antidiabetic
potential of seaweed extract in this study. By examining the medicinal properties
of Nitophyllum marginale, we aim to explore the therapeutic bioactivity potentiality and its prime
role in improvising and searching for potential alternatives for seizing Diabetes mellitus.
The antioxidant activity of Nitophyllum marginale was evaluated using ABTS,
DPPH, nitric oxide, lipid peroxidation, and hydrogen peroxide assays. Additionally, alphaglucosidase
inhibition tests were conducted to evaluate the potential as an antidiabetic agent.
The study revealed that extracts from Nitophyllum marginale contain antioxidants that protect
cells from oxidative stress. These extracts also contain bioactive compounds like alkaloids, flavonoids,
phenols, saponins, and carbohydrates. These compounds work together to provide antioxidant
benefits. Additionally, the extracts showed activity against alpha-glucosidase, which is vital for
managing blood sugar levels.
These results emphasize the existence of bioactive metabolites exhibiting phytochemicals,
antioxidants, and antidiabetic activities obtained from the extract using chloroform and methanol
solvents. These findings suggest the potential of Nitophyllum marginale extracts as a natural
reservoir of antioxidants and antidiabetic agents.
期刊介绍:
Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.