Pharmacological Investigation of Anticonvulsant Effect of Artemisia Vulgaris on Pentylenetetrazole-Induced Epileptic Seizures in Zebrafish Experimental Model

IF 0.3 Q4 PHARMACOLOGY & PHARMACY

Current Drug Therapy Pub Date : 2024-01-08 DOI:10.2174/0115748855268042231130041958

M. Sharma, G. V. N. Kumar, Pankaj Gupta

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Abstract

Epilepsy is the most common neurological disorder, characterized by abnormal, unpredictable, and recurrent seizures. In the alternative medicine system, Artemisia vulgaris has been used to treat epileptic symptoms since its inception. However, scientific evidence concerning its effect on the treatment of epileptic seizures is not available. The objective of the study is to evaluate the anti-convulsant potential of Artemisia vulgaris in zebrafish experimental models. Zebrafish larvae and adult zebrafish were used as experimental models. Briefly, larvae and adult zebrafish were exposed to 0.5% of the test medicine Artemisia vulgaris mother tincture (ϕ) and its potencies (6CH, 30CH), and valproic acid for 1 hour. After 1 hour of exposure, they were exposed to pentylenetetrazole to record different seizure scores from 1 to 5 using ANY maze video tracking software. Artemisia vulgaris 30CH in zebrafish larvae and Artemisia vulgaris 6CH and 30CH in adult zebrafish delayed the latency score from score 1 to score 5 and were found effective against PTZinduced locomotor activity and seizure duration and intensity. In conclusion, Artemisia vulgaris (6CH and 30CH) has the potential to be a novel treatment for symptomatic epileptic seizures and could be a potential alternative drug candidate for symptomatic treatment of epilepsy.

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青蒿对戊四唑诱导斑马鱼癫痫发作实验模型抗惊厥作用的药理研究

癫痫是最常见的神经系统疾病，其特点是异常、不可预测和反复发作。在替代医学体系中，青蒿自诞生以来一直被用于治疗癫痫症状。本研究的目的是评估青蒿在斑马鱼实验模型中的抗惊厥潜力。简单地说，将斑马鱼幼体和成体暴露于 0.5% 的试验药物青蒿母酊剂（j）及其效力（6CH、30CH）和丙戊酸中 1 小时。斑马鱼幼鱼服用 30CH 青蒿，成年斑马鱼服用 6CH 和 30CH 青蒿后，潜伏期从 1 分延迟到 5 分，对 PTZ 诱导的运动活动、癫痫发作持续时间和强度有效。总之，青蒿（6CH 和 30CH）具有治疗症状性癫痫发作的新潜力，可作为治疗症状性癫痫的潜在替代药物。

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来源期刊

Current Drug Therapy PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.