Current Drug TherapyPub Date : 2024-06-07DOI: 10.2174/0115748855299918240529063242
Meghna Dheek, Shikha Baghel Chauhan, Indu Singh
{"title":"Nanosphere Precision: Emulsomes Revolutionizing Cancer Targeted Therapy","authors":"Meghna Dheek, Shikha Baghel Chauhan, Indu Singh","doi":"10.2174/0115748855299918240529063242","DOIUrl":"https://doi.org/10.2174/0115748855299918240529063242","url":null,"abstract":"\u0000\u0000Emulsomes have gained attention because they are a novel lipoidal vesicular system that\u0000has an internal solid fat core surrounded by a phospholipid bilayer. Cancer is a complex and broad\u0000term that refers to a group of diseases characterized by the uncontrolled growth and spread of abnormal\u0000cells in the body. In the context of cancer targeting, emulsomes have shown promising potential\u0000due to their ability to improve the solubility, stability, and bioavailability of anticancer drugs, leading\u0000to enhanced therapeutic efficacy and reduced systemic toxicity.\u0000This article addresses emulsomal composition, preparation techniques, and different kinds of emulsomes\u0000loaded with drugs like fluvastatin and raloxifene hydrochloride to target cancer cells. The use\u0000of emulsomes in cancer targeting holds great promise for improving the precision, efficacy, and safety\u0000of cancer treatments.\u0000A comprehensive search of relevant scientific literature was performed. This involved searching databases\u0000such as PubMed, Scopus, Web of Science, and others to identify relevant studies, articles,\u0000and reviews related to the topic.\u0000Emulsomes loaded with specific drugs show promising results in cancer treatment. Examples include\u0000piceatannol-loaded emulsomes for colon cancer, raloxifene hydrochloride-loaded emulsomes for\u0000breast cancer, and fluvastatin-loaded emulsomes for prostate cancer.\u0000Emulsomes represent a cutting-edge approach to cancer drug delivery, offering a versatile and effective\u0000solution to address challenges associated with traditional anticancer formulations. Ongoing research\u0000holds promise for the continued development of personalized cancer therapy.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141373225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the Synergistic Antimicrobial Potential of Garlic and Honey: A\u0000Comprehensive Review","authors":"Priti Yadav, Surendra Lalwani, D. Chanchal, Nidhi Mittal, Jitendra Singh Chaudhary","doi":"10.2174/0115748855287440240529080448","DOIUrl":"https://doi.org/10.2174/0115748855287440240529080448","url":null,"abstract":"\u0000\u0000This article explores the well-established therapeutic attributes of honey and garlic,\u0000renowned for their potent antibacterial effects. This investigation aims to elucidate the synergistic\u0000antibacterial potential resulting from the combined use of these two natural substances.\u0000\u0000\u0000\u0000A comprehensive examination of honey's antibacterial and antifungal characteristics is conducted, delineating its intricate mechanism of action with a focus on hydrogen peroxide and other\u0000phytochemicals. Simultaneously, various processes underpinning the antibacterial properties of garlic\u0000are discussed, with particular emphasis on its key bioactive component, allicin.\u0000\u0000\u0000\u0000This research unveils a novel perspective on the interaction between honey and garlic. It is\u0000intricately analyzed how garlic's bioactive components disrupt microbial cell membranes, while\u0000honey employs diverse tactics to combat illnesses. This interaction opens new possibilities for modern\u0000antibacterial approaches.\u0000\u0000\u0000\u0000Quantitative findings and the significance of the study are discussed in detail. The practical applications of the synergistic antibacterial potential are underscored, emphasizing its relevance\u0000in food preservation and medicinal contexts. The research accentuates the promising use of garlic and\u0000honey blends as natural alternatives to artificial preservatives, with implications for wound care and\u0000infection prevention.\u0000\u0000\u0000\u0000Emphasizing the valuable applications of synergistic antibacterial potential across diverse industries, including food preservation and medicine, this study underscores the importance of\u0000harnessing the combined antibacterial qualities of garlic and honey as a sustainable solution to emerging challenges in food safety and health.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141377251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}