Current Drug Therapy最新文献

{"title":"Effects of Orexin Receptor Antagonist on Cognitive Function in Adults: A\u0000Systematic Review","authors":"Divya Jha, Aakriti Garg, M. A. Khan","doi":"10.2174/0115748855292051240327084430","DOIUrl":"https://doi.org/10.2174/0115748855292051240327084430","url":null,"abstract":"\u0000\u0000Orexin receptor antagonists (ORAs) are the emerging class of hypnotics\u0000used for the treatment of insomnia. However, from the available literature, the effect of ORA on\u0000cognitive functions is not clear yet. Therefore, the current study aimed to systematically evaluate the\u0000effect of ORA on cognitive function from available clinical studies.\u0000\u0000\u0000\u0000The extensive literature search was conducted in various databases, including Pubmed,\u0000Embase, Cochrane Library, and clinicaltrials.gov, using suitable keywords. The quality of the included\u0000studies was evaluated using the Cochrane risk of bias tool (ROB2).\u0000\u0000\u0000\u0000We obtained a total of 450 articles from different databases. Finally, 07 articles met the\u0000inclusion criteria and were included in the current systematic review for qualitative analysis. Available\u0000literature showed conflicting results, with few studies showing no impact of ORA on cognitive\u0000function, while others reported dose-dependent adverse effects of ORA on cognitive function. The\u0000risk of bias in included studies was found to be low.\u0000\u0000\u0000\u0000In conclusion, ORA is generally safe in clinical doses. However, it is important to note\u0000that there is a dose-dependent decline in cognitive function after the administration of ORA. Therefore,\u0000clinicians must be careful while prescribing ORA and adjust the dose as per the needs of the\u0000individual patients and the potential risk factors.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro Lipolysis, Stability and Pharmacodynamic Study of Cilnidipine Loaded Self-emulsifying Drug Delivery System","authors":"R. Kadian, Arun Nanda","doi":"10.2174/0115748855257230230919111500","DOIUrl":"https://doi.org/10.2174/0115748855257230230919111500","url":null,"abstract":"\u0000\u0000The aim of this research work was to investigate the potential ability of cilnidipineloaded-\u0000Self-Emulsifying Drug Delivery System (SEDDS) to improve the solubility and oral bioavailability\u0000of cilnidipine.\u0000\u0000\u0000\u0000The limited oral bioavailability of BCS class II drugs restricts the clinical utility of drugs. Self-emulsifying drug delivery systems (SEDDS) are widely used for poorly water-soluble drugs to enhance their solubility and oral bioavailability.\u0000\u0000\u0000\u0000The therapeutic value of drugs is constrained by the low oral bioavailability of BCS\u0000class II drugs. In order to improve the solubility and oral bioavailability of poorly water-soluble\u0000drugs, SEDDS are frequently utilised.\u0000\u0000\u0000\u0000To develop the cilnidipine-loaded-SEDDS formulation, Canola oil as the oil phase, tween\u000080 as the surfactant, and PEG 300 as the co-surfactant were used. The SEDDS formulation was\u0000evaluated based on stability study per ICH guidelines, drug precipitation during in-vitro lipolysis\u0000study under fasted and fed state, and in vivo pharmacodynamic study in Wistar rats. The content of\u0000the drug was determined by assay of SEDDS formulation using the official method of cilnidipine.\u0000\u0000\u0000\u0000The pharmacodynamic study demonstrated that cilnidipine-loaded SEDDS formulation significantly\u0000produced a rapid antihypertensive effect (within 2 h) that lasted for 24 h in comparison to\u0000drug suspension. During the in vitro lipolysis study, the concentration of the drug recovered from\u0000the aqueous phase under both fasted and fed state was more than 90% after 10 minutes, with a minute\u0000amount of drug involved in precipitation. At stability conditions of 30±2 °C/65±5%RH for a\u0000duration of six months, the SEDDS formulation was found to be stable. The content of cilnidipine\u0000in the SEDDS formulation was found to be 98.4%.\u0000\u0000\u0000\u0000A BCS class-II drug's oral bioavailability and dissolution might be improved using the\u0000self-emulsifying drug delivery method.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140750033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innate Immune Effectors and Leishmania: an Overview of Complexities","authors":"R. Tiwari, Afza Ahmad, Rafia Shekh, Ratnakar Shukla, Preeti Bajpai","doi":"10.2174/0115748855295089240322081903","DOIUrl":"https://doi.org/10.2174/0115748855295089240322081903","url":null,"abstract":"\u0000\u0000Leishmaniasis represents a pool of debilitating clinical manifestations affecting several\u0000individuals globally. The disease remains a serious global health and affects individuals in tropical\u0000and subtropical regions. The disease is endemic in several areas of South America, East Africa, the\u0000Indian sub-continent and the Mediterranean basin. The bite of female Phlebotomine sand establishes\u0000the infection of the Leishmania parasite within human flies belonging to the family Psychodidae\u0000(subfamily: Phlebotominae) of class Diptera. Several species of Leishmania parasite serve as the infectious\u0000trigger associated with varying clinical presentation of the disease. The immune response\u0000against the different parasitizing species varies, resulting in a complex response by innate immune\u0000cells. The present review summarizes some of the key innate immune effector cells involved during\u0000the infection with the Leishmania parasite in a quest to provide a deeper understanding of Leishmania-\u0000mediated immunobiology. The review also summarizes an up-to-date understanding of several\u0000strategies adopted by the parasite to evade immune response mediated by altering the functioning of\u0000some key innate immune effector cells. A better understanding of these immuno-biological events\u0000within the infected individual would help formulate immune-therapeutical interventions against the\u0000disease.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Medicinal Value and Chemical Composition of Flavonoids from Pongamia Pinnata: Recent Work in Drug Advancement and Therapeutics","authors":"Trilochan Satapathy, Yogesh Kumar, R. K. Pandey, S. Shukla, Shiv Kumar Bhardwaj, Beena Gidwani","doi":"10.2174/0115748855288101240320061757","DOIUrl":"https://doi.org/10.2174/0115748855288101240320061757","url":null,"abstract":"\u0000\u0000Traditional medicine in many countries, including those where Pongamia pinnata (L.)\u0000Pierreis grown, uses the plant for a wide variety of purposes, including the treatment of piles, skin\u0000problems, and wounds. The objective of the present study was to discuss the medicinal value and\u0000chemical composition of flavonoids obtained from P. pinnata. All parts of the plant contain several\u0000phytoconstituents responsible for biological activity. These compounds include numerous types of\u0000flavonoid derivatives, such as flavones and flavans, as well as terpenes, steroids, and fatty acids. The\u0000information required about the plant and advancement in therapeutics was gathered from Pubmed,\u0000ScienceDirect and Cochrane Library. Many different types of biological activity, including antioxidant,\u0000antibacterial, anti-inflammatory, and anti-diabetic properties, have been observed in plant products\u0000from this species in pharmacological research. However, more research into the plant's phytochemical\u0000profile and the complicated pharmacological effects is required. This is because our current\u0000understanding of the plant's chemical ingredients and the methods by which they exhibit certain biological\u0000activities is limited. Thus, information regarding active constituents is required to develop\u0000novel therapeutics and additional research on the toxicity of the other chemicals identified from this\u0000plant is necessary.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140789542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of Repurposed Drugs in Diabetes Mellitus: A Current Update","authors":"Nihalini Kalita, M. Pathak, Siba Roy, Pervej Alom Barbhuiya, Lunasmrita Saikia, Tausif Mohammed Sanaur Rahman Mazumder, Saikat Sen","doi":"10.2174/0115748855292471240319055530","DOIUrl":"https://doi.org/10.2174/0115748855292471240319055530","url":null,"abstract":"\u0000\u0000Diabetes is a serious and chronic metabolic disorder that is a result of a\u0000complex interaction of genetic and environmental factors. Diabetes mellitus has become a worldwide\u0000pandemic. Drug discovery has been complicated by the high cost and time required for developing\u0000new drugs/agents. In the last 30 years, the number of FDA-approved medications has declined, boosting\u0000interest in drug repositioning or repurposing. Repurposing existing drugs may be a significant\u0000tool for lowering the financial burden that most nations bear while treating diabetic mellitus.\u0000\u0000\u0000\u0000This comprehensive review aims to elucidate the repurposed pharmaceutical agents for\u0000the treatment of Diabetes Mellitus along with the diverse array of validation techniques employed in\u0000the process.\u0000\u0000\u0000\u0000For this review purpose, the authors have gone through a vast number of article sources\u0000from various scientific databases like Google Scholar, PubMed, and Web of Science.\u0000\u0000\u0000\u0000Drug repurposing led to the discovery of a few anti-diabetic drugs which has been widely\u0000used for other pharmacological effects. Several medications, including celecoxib, buspirone, berberine,\u0000diacerein, methazolamide, and bromocriptine, have been effective in treating diabetic mellitus\u0000by various mechanisms like decreasing insulin resistance, hyperglycemia, inhibiting glucagon secretion\u0000and improving insulin sensitivity.\u0000\u0000\u0000\u0000The field of drug repurposing exhibits significant potential in tackling the obstacles presented\u0000by T2DM and other complex diseases. The conventional approaches to drug development have\u0000often been characterized by prolonged durations and high costs, resulting in significant delays in the\u0000discovery of effective medicines for conditions like T2DM. However, the strategy of drug repurposing\u0000presents a more streamlined and economically advantageous method for drug development.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140376749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposomes as Transformative Tools in Drug Delivery, Therapeutics, and\u0000Beyond","authors":"Ashish Srivastava, Anshuman Singh, Parul Srivastava, A. Wal, Pranay Wal, A. Yadav, Awani K Rai","doi":"10.2174/0115748855288237240222072928","DOIUrl":"https://doi.org/10.2174/0115748855288237240222072928","url":null,"abstract":"\u0000\u0000Abstract: Liposomes are spherical vesicles composed of lipid bilayers that have gained significant\u0000attention in the realm of drug delivery and therapeutic applications. They offer several advantages\u0000over traditional drug delivery systems, including:\u0000\u0000-Protection of drugs from degradation and clearance\u0000-Enhanced bioavailability\u0000- Reduced systemic toxicity\u0000- Precise, site-specific drug delivery\u0000\u0000To elucidate the multifaceted aspects of liposomes, from their fundamental structure and composition\u0000to their cutting-edge applications in medicine and biotechnology.\u0000This comprehensive review was conducted through a systematic search of relevant literature on liposomes.\u0000The search was limited to English-language articles published in the past 10 years. A total\u0000of 150 articles were selected for review based on their relevance and impact.\u0000\u0000The review provides a detailed overview of the following aspects of liposomes:\u0000\u0000-Structure and composition\u0000- Mechanism of action\u0000- Targeting strategies\u0000- Preparation methods\u0000- Biomedical and biotechnological applications\u0000\u0000Liposomes are a promising drug delivery platform with the potential to revolutionize the treatment\u0000of various diseases. Their unique properties, including biocompatibility, versatility, and tunability,\u0000render them ideal for encapsulating a wide range of therapeutic agents. The review highlights the\u0000significant progress made in liposome research in recent years, paving the way for their translation\u0000into clinical practice.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140387290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-engineered Multimodal Magnetic Nanoparticles: Scope and Applications","authors":"Ritika Singh, Manoj Kumar Mishra, Prasoon Pandey","doi":"10.2174/0115748855284579240307063006","DOIUrl":"https://doi.org/10.2174/0115748855284579240307063006","url":null,"abstract":"\u0000\u0000Magnetic nanoparticles (MNPs) are one of the classes of nanoparticles that produce magnetic\u0000properties by manipulation using a magnetic field. These MNPs are currently used in the\u0000theranostics disease modification of surface properties of MNPs, achieved by surface engineering,\u0000which provides different applications, such as enhancing thermal and optical properties, biocompatibility,\u0000conductivity and also mechanical and chemical properties. Advancement in the technology\u0000leads to the development of MNPs. For this instance, surface coating is used at molecular and cellular\u0000levels. The uses of coating material are based on organic and inorganic molecules, including polymer,\u0000liposomes, micelles, metal oxide, gold-NPs etc. Using different coatings exhibits multifunction properties,\u0000and this helps reduce toxicity, helps in biomedical applications, maintains stability, restricts\u0000surface fouling, etc. This review provides an in-depth knowledge of surface-engineered magnetic\u0000nanoparticles (MNPs) according to recent developments.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Natural Flavonoids: Pharmacological Targets,\u0000Signaling Pathways, Molecular Mechanisms, and Clinical Perspective on\u0000Parkinson's Disease","authors":"Sushil Giri, Phool Chandra","doi":"10.2174/0115748855292178240223100534","DOIUrl":"https://doi.org/10.2174/0115748855292178240223100534","url":null,"abstract":"\u0000\u0000Parkinson’s disease (PD) is a prominent area of study within the field of neurology, particularly\u0000neurodegenerative disease (ND). The peak incidence of PD occurs in those over the age of\u000045, and the disease’s prevalence rises continuously with age, the incidence of PD has skyrocketed\u0000over the world. A slow decline in neural function characterizes NDs, but the pathophysiological\u0000mechanisms behind this decline remain elusive. Because the pathophysiological mechanisms behind\u0000neurodegeneration are intricate, the clinical issue of finding efficient, multi-target treatments still exists.\u0000Furthermore, adequate neuroprotective medicines are currently scarce, necessitating the development\u0000of new therapeutic agents. There is currently no medicine for PD that is without side effects.\u0000The ability of natural flavonoids to lower the risk of PD has contributed to an increase in their popularity\u0000in recent years, models both in vivo and in vitro. Flavonoids are multi-target natural substances\u0000that affect distinct pathogenic pathways in neurodegeneration. As a result, the emphasis has turned to\u0000discovering natural product inhibitors for the treatment of PD. The majority of the results pointed to\u0000flavonoids' beneficial role in the treatment of PD and no adverse events were reported. This review\u0000offered scientific data on the protective and preventative functions of flavonoids. It has been demonstrated\u0000that flavonoids have a neuroprotective effect by activating anti-apoptotic mechanisms that\u0000target mitochondrial dysfunction and produce neurotrophic factors. In addition to having antioxidant,\u0000anti-inflammatory, and protective dopaminergic neurons. Even though no evidence using flavonoids\u0000as a treatment might reverse the abnormal phenotypes of PD patients, it was also indicated that flavonoids\u0000might be promising natural remedies for PD prevention and could be used as therapeutic\u0000agents against PD.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140248298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposome as a Potential Drug Delivery System in Addressing Skin Diseases: A Review","authors":"Shivam Malhotra, Shammy Jindal, Rajni Bala, R. Madaan","doi":"10.2174/0115748855297829240227072642","DOIUrl":"https://doi.org/10.2174/0115748855297829240227072642","url":null,"abstract":"\u0000\u0000It was asserted that the manufacturing of liposomes, which was first disclosed in 1961,\u0000was a useful technology for drug encapsulation. Furthermore, there are several cosmetic items on the\u0000market now that include liposomes. The liposomes are novel drug carrier systems due to their similarity\u0000in lipid composition with the epidermal membrane. As a result, they penetrate the epidermis to\u0000a greater extent, showing enhanced skin absorption and increased effectiveness of the encapsulated\u0000drug molecule.\u0000This review briefly addresses the skin's anatomy, skin conditions, and the topical delivery of drugs\u0000for the treatment of skin diseases with emphasis on psoriasis by utilizing liposomes and other vesicular\u0000drug delivery systems along with challenges and opportunities in the treatment of skin diseases.\u0000When compared to alternative distribution methods, their resemblance to biological membranes enables\u0000entry into the epidermal barrier. Liposomes are good at penetrating the skin more deeply and\u0000reducing therapeutic side effects, which offers hope for the successful treatment of skin problems.\u0000Applying liposomes topically has several benefits, including better skin bioavailability and targeting,\u0000increased skin hydration by surface adhesiveness, protection of skin structure from external stress,\u0000and prolonged dermal release. Further, they have got potential to target the encapsulated drug molecule\u0000into pilosebaceous structure, making them an ideal candidate for the treatment of hair follicles\u0000and sebaceous gland disorder.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140250554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome Derived Nanomaterials for Improved Pulmonary Delivery:\u0000Recent Advancements and Future Prospects","authors":"Dilpreet Singh","doi":"10.2174/0115748855284955240304053519","DOIUrl":"https://doi.org/10.2174/0115748855284955240304053519","url":null,"abstract":"\u0000\u0000The human microbiome, comprising a complex community of microorganisms, has\u0000emerged as a crucial factor in maintaining health and influencing disease states. Recently, there has\u0000been growing interest in harnessing the potential of microbiome-based nanomaterials for enhanced\u0000pulmonary drug delivery. This abstract presents an overview of recent advancements and prospects\u0000in this field. Microbiome-based nanomaterials offer a targeted and personalized approach to pulmonary delivery, leveraging an understanding of the lung microbiome. These nanomaterials can be engineered to encapsulate drugs or therapeutic agents, modulate the lung microbiome, act as diagnostic\u0000tools, regulate immune responses, and facilitate vaccine delivery. While significant progress has been\u0000made, challenges, such as formulation stability, safety, efficacy, and regulatory considerations, need\u0000to be addressed for successful translation into clinical practice. With continued research and technological advancements, microbiome-based nanomaterials hold great promise in revolutionizing pulmonary healthcare, providing novel strategies for the treatment and prevention of respiratory diseases.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140254080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}