Current Drug Therapy最新文献

{"title":"Formulation and Evaluation of Hard Lozenges by Using Garlic Tincture","authors":"Anmol Popli, Uditi Handa, Kuldeep Kumar, Prerna Sharma, Kumar Guarve, Ishika Parmar, Lavish Chabra, Kajal Nagpal, Nidhi Rani, Inderjeet Verma","doi":"10.2174/0115748855258962230920111057","DOIUrl":"https://doi.org/10.2174/0115748855258962230920111057","url":null,"abstract":"\u0000\u0000Lozenges are one of the more well-liked and inventive oral confectionery\u0000products in the market. The lozenges also act as solid medications that are flavored, sweetened, and\u0000meant to be sucked into the mouth/pharynx or held over that cavity. Garlic contains anti-microbial\u0000agents which help to reduce the impact of cough and reduce it.\u0000\u0000\u0000\u0000The goal of the current research is to formulate and investigate herbal lozenges by using garlic\u0000tinctures with their antimicrobial action to cure the infection caused by microbes\u0000\u0000\u0000\u0000Hard lozenges were prepared by Heating and congealing techniques and statistical analysis\u0000was done by using one sample chi-square test (IBM SPSS version 20).\u0000\u0000\u0000\u0000Hard lozenges were formulated by using garlic tinctures with minimum excipients. According\u0000to ICH recommendations, stability experiments were conducted. According to the stability investigations,\u0000there were no major changes noticed during the period after the one-month stability test. The antimicrobial\u0000activity was studied under different time intervals after 8-72 hours. The inhibition zone\u0000value for the test sample was found to be 0.1-0.5 mm and for the standard sample was noticed from\u00000.5-0.8 mm, respectively. The statistical test outcome revealed, no remarkable difference shown between\u0000the prepared and the marketed formulation (p>0.05).\u0000\u0000\u0000\u0000From the present work, it was concluded that the prepared lozenges have similar result\u0000with minimum ingredients as compared to the marketed formulation (Tulsi-ginger lozenges). Hence,\u0000the formulation, testing, and antimicrobial activity for oral use in garlic lozenges were effective.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocarrier Mediated Molecular Taregting Strategies For iCD4 Receptors to Combat Anti-Microbial Resistance","authors":"Dilpreet Singh","doi":"10.2174/0115748855285457240213074307","DOIUrl":"https://doi.org/10.2174/0115748855285457240213074307","url":null,"abstract":"\u0000\u0000The emergence and spread of Antimicrobial Resistance (AMR) pose a grave threat to\u0000global public health. In the pursuit of innovative solutions, targeting the immune cell CD4 receptors\u0000(iCD4) has gained momentum as a potential strategy for combating AMR. This abstract explores drug\u0000delivery strategies aimed at harnessing iCD4 receptors to enhance the efficacy of antimicrobial therapies.\u0000The CD4 receptor, primarily found on the surface of T-helper lymphocytes, plays a pivotal role\u0000in immune responses. Recent research has revealed that iCD4 receptors are also expressed on other\u0000immune cells, such as macrophages and dendritic cells, which are integral in the host's defense against\u0000pathogens. Leveraging these receptors as drug targets opens new avenues for the precise delivery of\u0000antimicrobial agents. Various drug delivery systems, including nanoparticles, liposomes, and antibody-\u0000drug conjugates, can be engineered to specifically target iCD4 receptors. These carriers offer\u0000improved drug stability, controlled release, and reduced side effects. Furthermore, the functionalization\u0000of these carriers with ligands that bind selectively to iCD4 receptors ensures targeted drug delivery\u0000to infected tissues. In summary, drug delivery strategies that target iCD4 receptors hold immense\u0000promise for combatting AMR. By delivering antimicrobial agents directly to immune cells involved\u0000in the host defense, we can potentially enhance therapeutic efficacy, reduce side effects, and mitigate\u0000the emergence of resistance. This approach represents a promising avenue for the development of\u0000innovative treatments to address the urgent global challenge of antimicrobial resistance.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Women's Health and Immunity: A Thorough Mapping Micronutrients and Dietary Recommendations","authors":"R. Pal, Y. Pal, M. Chaitanya, Neha Sharma, Anjana Rani, Shubham Kumar, Preeti Srivastava","doi":"10.2174/0115748855284781240202054050","DOIUrl":"https://doi.org/10.2174/0115748855284781240202054050","url":null,"abstract":"\u0000\u0000In particular, throughout life, women's health depends on having an ideal micronutrient\u0000level. Thus, pregnancy outcomes and the long-term health of a woman's offspring are significantly\u0000influenced by her physical and nutritional well-being during the preconception stage. Various nutrients\u0000are required in sufficient amounts to fulfill the requirements at the various phases in the life of\u0000females. Our analysis of the state of nutrition shows illnesses connected to micronutrient deficiencies,\u0000particularly anemia and its related deficiencies. Peer-reviewed publication databases and publicly\u0000available data from international and national sources were targeted in a structured literature search\u0000to sort out the direct or indirect association between the different micronutrients, their levels, sources\u0000and significance in the various stages of life of females. The goal of the current review is to identify\u0000any direct or indirect relationships between the numerous micronutrients, their sources, concentrations,\u0000and importance at different phases of female development.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140449942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Drug Delivery of Nanoparticles for Glaucoma","authors":"Aastha Dangwal, Vikas Bhatt, Shiv Kumar Gupta","doi":"10.2174/0115748855278863240130074330","DOIUrl":"https://doi.org/10.2174/0115748855278863240130074330","url":null,"abstract":"\u0000\u0000The nasolacrimal channels drain the medication from the pre-corneal area, causing the\u0000majority of the ophthalmic medication to be quickly removed following topical instillation. Over the\u0000past thirty years, newer medical techniques, such as in situ gel, nanoparticle, liposome, nanosuspension,\u0000microemulsion, iontophoresis, and occuserts have been created in an effort to overcome these\u0000challenges. These methods gradually and deliberately boost the drug's bioavailability. This article\u0000discusses ocular drug delivery for ophthalmics and its ideal characteristics, and also provides an insight\u0000on the use of nanotechnology in the form of nanoparticles used for the treatment of glaucoma\u0000in the eyes, employing HPH, ultrasonication/HSH, SE, SED technique, SFM, ME technique, SD\u0000method, DE method, PM, FUD, and other techniques to offer continuous and controlled IOP inside\u0000the eye chamber, make drug more ocularly bioavailable, and address a few pharmacological difficulties\u0000in ophthalmology. The creation of new drug delivery methods is currently gaining popularity,\u0000and this can facilitate the development of medicines for diseases that endanger eyesight.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140451692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-awareness Regarding Obesity and Specific Therapy in Patients with\u0000Overweight or Obesity and Cardiovascular Diseases from Moscow Region","authors":"S. Martsevich, Yulia V. Lukina, O. Lerman, N. Kutishenko, A. R. Kiselev, O. Drapkina","doi":"10.2174/0115748855261762231011050708","DOIUrl":"https://doi.org/10.2174/0115748855261762231011050708","url":null,"abstract":"\u0000\u0000Despite the proven effectiveness of lifestyle interventions and specific medications\u0000in the treatment of obesity, little is known about their use in real-world practice. Aim – to\u0000study the awareness of patients about the problem of overweight/obesity, as well as the clinical\u0000practice of non-drug and drug therapy according to the survey.\u0000\u0000\u0000\u0000Eligible patients were recruited from the prospective outpatient registry of\u0000patients with cardiovascular diseases. The design of the study was a cross-sectional cohort singlecentre.\u0000All of the included patients completed a specifically designed questionnaire. The study included\u0000295 patients (mean age 66.8 ± 11.8 years) with a body mass index (BMI) of ≥25 kg/m2. One\u0000hundred eight (36.6%) individuals were overweight, 124 (42.2%) had first-class obesity, 42 (14.2%)\u0000had second-class obesity, and 21 (7.1%) patients had third-class obesity.\u0000\u0000\u0000\u0000252 patients (85.4%) were informed of being overweight/obese, and all of them received\u0000non-drug recommendations for the treatment of obesity. Anti-obesity medications (AOM) were\u0000recommended only to 25 (8.5%) patients: 3 – overweight, 11 – obesity class I, 6 obesity class II,\u0000and 5 – obesity class III. Twenty-one (7.1%) patients took the prescribed medications (84% adherence).\u0000The drugs were more often taken by patients with class II and III disease (40.5% and 57.1%\u0000of patients, respectively). Overweight (8.5%) and class I obesity (18.0%) patients took these drugs\u0000less often (p<0.0001).\u0000\u0000\u0000\u0000The results of the survey have demonstrated good awareness of patients about their\u0000obesity/overweight and quite frequent use of non-drug obesity therapy. However, the rate of AOM\u0000prescription was extremely low.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140451455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory and Wound Healing Potential of Comphora Wightii,\u0000Herbal Ointment on Wistar Rats","authors":"Ishu Garg, Neelam Singh, Ishika Sharma, Jayeeta Dhingra, Kartik Kumar","doi":"10.2174/0115748855264144231124085824","DOIUrl":"https://doi.org/10.2174/0115748855264144231124085824","url":null,"abstract":"\u0000\u0000A herbal approach to Guggulu (Commiphora wightii), as an anti-inflammatory\u0000and wound healing agent is anticipated. Phyto-constituents Guggulusterone, Naringenin, and\u0000myrrhanol were reported for the anti-inflammatory activity of Guggulu. Studies suggests, that sesame\u0000oil (Sesamum indicum L.) and Ratanjot (Arnebia nobilis) also act as potent anti-inflammatory agents..\u0000A combination of all three of these gives a synergistic effect for anti-inflammatory and excisional\u0000wound healing activity.\u0000\u0000\u0000\u0000A simple ointment base, BP and 5% Ratanjot, and Sesame oil were prepared.\u0000All the components, i.e., Guggulu, 5% Ratanjot Sesame oil, and simple ointment base, were added\u0000and triturated uni-directionally until a smooth, homogenous mixture was obtained. 25% w/w (F1) and\u000027% w/w (F2) Guggulu ointment were prepared. Four groups, each with three wistar rats, were studied\u0000for fourteen days. On the fourteenth day, rats were sacrificed, and tissues were collected for histopathological\u0000studies.\u0000\u0000\u0000\u0000F1 was compared against the standard formulation (10% w/w betadine, Win-Medicare) for\u0000excisional wound healing and anti-inflammatory activity in rats. On the foutheenth day, the results\u0000for percentage wound contraction in groups 1 (Negative control, vaseline), 2 (Controlled, ointment\u0000base), 3 (F1), and 4 (positive control, standard) were found to be 12.01, 25.32, 96.14, and 81.23,\u0000respectively.. Results of histopathological studies and H&E staining supported the action of F1, as\u0000skin sections showed the junction of normal skin and wound area. Sub-epithelial tissues showed low\u0000(-) to mild (+) inflammation. Mild oedema (+) was also noted.\u0000\u0000\u0000\u0000The rat group treated with F1 showed maximum wound contraction, healing, and antiinflammatory\u0000activity as per percentage wound contraction and histopathological studies\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140454462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Cefixime Microspheres Utilizing a Natural Polymer\u0000and a Synthetic Polymer","authors":"Deepshi Arora, Yugam Taneja, Anjali Sharma, Prerna Sharma, Jatin, Kumar Guarve, Nidhi Rani, Inderjeet Verma","doi":"10.2174/0115748855269112231215040322","DOIUrl":"https://doi.org/10.2174/0115748855269112231215040322","url":null,"abstract":"\u0000\u0000Microspheres are naturally biodegradable, free-flowing powders with a particle\u0000size of less than 200 micrometres that are comprised of proteins or synthetic polymers. Using\u0000microspheres is a reliable strategy to ensure that the drug is accurately delivered to the target area and\u0000that the right concentration is kept there without having any unfavourable side effects.\u0000\u0000\u0000\u0000The objective of the present study was to create a sustained-release cefixime trihydrate\u0000microsphere delivery system employing natural and synthetic polymers as a carrier and increase therapeutic\u0000effectiveness.\u0000\u0000\u0000\u0000Due to the simplicity of processing, the solvent injection method was used to create microspheres.\u0000Microspheres were created with this technology using the sustained-release polymer, sodium\u0000alginate, and active material (drug). The compatibility of components with the drug was evaluated\u0000using XRD and FT-IR. In an in-vitro release research, the dissolving medium was phosphate buffer\u0000at pH 6.8. For the kinetic analysis of the drug release mechanism, graphs for zero-order, first-order,\u0000Higuchi's, Korsmeyer-Peppas, and Hixson-Crowell models were also created.\u0000\u0000\u0000\u0000The best formulation was chosen from the batches, and in-vitro cefixime trihydrate release\u0000studies for various microspheres containing cefixime trihydrate in phosphate buffer (pH 7.4) for 8\u0000hours were performed. The dissolution profiles of formulations F4 and F8 showed that the formulation,\u0000including xanthan gum, F8, released 55.01% more medication in 8 hours than the formulation\u0000using HPMC, F4. X-ray diffraction, swelling index of drug-laden microspheres, and Scanning Electron\u0000Microscopy were used to evaluate formulation F8. The graphs for zero-order, first-order, Higuchi's,\u0000Korsmeyer-Peppas, and Hixson- Crowell models were plotted, and the optimised batch was\u0000discovered to match Higuchi's drug release kinetics with an R2 value of 0.990.\u0000\u0000\u0000\u0000Cefixime trihydrate microspheres can be utilized as a new drug delivery technology to\u0000minimize dose frequency and, as a result, to promote patient compliance.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140455109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effects of Murraya koenigii: Focus on Antihyperlipidemic Property","authors":"Pearl Pinto, Louis Cojandaraj","doi":"10.2174/0115748855278592240131105512","DOIUrl":"https://doi.org/10.2174/0115748855278592240131105512","url":null,"abstract":"\u0000\u0000In the current scenario, discovery of natural bioactive components can be considered as a\u0000major development in treating common ailments. One of the medicinally important herbs is Murraya\u0000koenigii. The biological functions are promoted by the leaves, fruits, roots, and bark of this beautiful\u0000plant. It is the carbazole alkaloids that promote most of the medicinal properties and contribute to the\u0000anti-oxidative properties as well. Terpenoids, Flavonoids, Saponins and Phenols isolated from different\u0000parts of the plant have unique hypocholestrolemic and antidiabetic activities. Among commonly\u0000used alternative therapies, plant sterols present in M. koenigii may help to reduce cholesterol and\u0000triglyceride levels, in turn managing heart diseases. Experimental animal studies are proving the hypolipidemic\u0000ability of M. koenigii. Possible mechanisms involved in exhibiting such an amazing hypolipidemic\u0000ability can be attributed to the phytochemicals, some of which can reduce the absorption\u0000of cholesterol in the intestines or accelerate the catabolism of fats. In contrast, others can inhibit the\u0000enzyme HMG CoA reductase. M. koenigii can inhibit pancreatic lipase. Such a response could be\u0000due to the presence of carbazole alkaloids like Mahanimbin, Isomahanine, Murrayacinine,\u0000Koenimbine, Mahanimboline, Murrayazolinine, Girinimbine etc. These enzymes can be selected for\u0000the pharmaceutical mediation of hypocholesterolemia agents. A triumph over the production of lipids\u0000in the hepatic cells is achieved upon feeding M. koenigii, thereby bringing about a drastic fall in\u0000triglyceride levels. The present review provides a better understanding of the major components of\u0000M. koenigii against dyslipidemia that could serve as an herbal alternative while treating other pathological\u0000conditions. Although various extracts of M. koenigii have numerous medical applications, an\u0000extensive investigation of their toxicity, along with more clinical trials and standardization of protocols,\u0000is required to produce modern drugs from these leaf extracts.\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Advances and Applications of Diagnostic Microfluidic Chip: A\u0000Review","authors":"Garima Katyal, Anuj Pathak, Parul Grover, Vaibhav Sharma","doi":"10.2174/0115748855269330240122100529","DOIUrl":"https://doi.org/10.2174/0115748855269330240122100529","url":null,"abstract":"\u0000\u0000As a developed technology, microfluidics now offers a great toolkit for handling and manipulating suspended samples, fluid samples, and particles. A regular chip is different\u0000from a microfluidic chip. A microfluidic chip is made of a series of grooves or microchannels carved\u0000on various materials. This arrangement of microchannels contained within the microfluidic chip is\u0000connected to the outside by inputs and outputs passing through the chip.\u0000\u0000\u0000\u0000This review includes the current progress in the field of microfluidic chips, their advantages and their biomedical applications in diagnosis.\u0000\u0000\u0000\u0000The various manuscripts were collected in the field of microfluidic chip that have biomedical applications from the different sources like Pubmed,Science direct and Google Scholar, out of\u0000which some were relevant and considered for the present manuscript.\u0000\u0000\u0000\u0000Microfluidic channels inside the chip allow for the processing of the fluid, such as blending\u0000and physicochemical reactions. Aside from its practical, technological, and physical benefits, microscale fluidic circuits also improve researchers' capacity to do more accurate quantitative measurements while researching biological systems. Microfluidic chips, a developing type of biochip, were\u0000primarily focused on miniaturising analytical procedures, especially to enhance analyte separation.\u0000Since then, the procedures for device construction and operation have gotten much simpler.\u0000\u0000\u0000\u0000For bioanalytical operations, microfluidic technology has many advantages. As originally intended, a micro total analysis system might be built using microfluidic devices to integrate\u0000various functional modules (or operational units) onto a single platform. More researchers were able\u0000to design, produce, and use microfluidic devices because of increased accessibility, which quickly\u0000demonstrated the probability of wide-ranging applicability in all branches of biology\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139859236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Advances and Applications of Diagnostic Microfluidic Chip: A\u0000Review","authors":"Garima Katyal, Anuj Pathak, Parul Grover, Vaibhav Sharma","doi":"10.2174/0115748855269330240122100529","DOIUrl":"https://doi.org/10.2174/0115748855269330240122100529","url":null,"abstract":"\u0000\u0000As a developed technology, microfluidics now offers a great toolkit for handling and manipulating suspended samples, fluid samples, and particles. A regular chip is different\u0000from a microfluidic chip. A microfluidic chip is made of a series of grooves or microchannels carved\u0000on various materials. This arrangement of microchannels contained within the microfluidic chip is\u0000connected to the outside by inputs and outputs passing through the chip.\u0000\u0000\u0000\u0000This review includes the current progress in the field of microfluidic chips, their advantages and their biomedical applications in diagnosis.\u0000\u0000\u0000\u0000The various manuscripts were collected in the field of microfluidic chip that have biomedical applications from the different sources like Pubmed,Science direct and Google Scholar, out of\u0000which some were relevant and considered for the present manuscript.\u0000\u0000\u0000\u0000Microfluidic channels inside the chip allow for the processing of the fluid, such as blending\u0000and physicochemical reactions. Aside from its practical, technological, and physical benefits, microscale fluidic circuits also improve researchers' capacity to do more accurate quantitative measurements while researching biological systems. Microfluidic chips, a developing type of biochip, were\u0000primarily focused on miniaturising analytical procedures, especially to enhance analyte separation.\u0000Since then, the procedures for device construction and operation have gotten much simpler.\u0000\u0000\u0000\u0000For bioanalytical operations, microfluidic technology has many advantages. As originally intended, a micro total analysis system might be built using microfluidic devices to integrate\u0000various functional modules (or operational units) onto a single platform. More researchers were able\u0000to design, produce, and use microfluidic devices because of increased accessibility, which quickly\u0000demonstrated the probability of wide-ranging applicability in all branches of biology\u0000","PeriodicalId":11004,"journal":{"name":"Current Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139799400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}