超重和肥胖患者静脉注射免疫球蛋白(IVIG)的最佳体重剂量

IF 0.3 Q4 PHARMACOLOGY & PHARMACY
shima Heidari, Bita Shahrami, Kourosh Sadeghi
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引用次数: 0

摘要

静脉注射免疫球蛋白(IVIG)作为一种国内短缺的昂贵药物,已被广泛用于治疗多种自身免疫性疾病和免疫缺陷综合征。尽管对IVIG治疗指征的研究显著增加,但从药物、疾病状态和一些患者特异性因素(如肥胖)方面调查个体化给药的研究数量有限。本综述的目的是描述各种基于体重的给药方案对IVIG药代动力学参数、疗效、安全性和成本的影响,并为肥胖患者选择最佳给药方法。在收集、审查和分析的128份手稿中,有13份来自Scopus、PubMed和Google scholar。有证据表明,肥胖可能对IVIG的药代动力学、安全性和有效性有影响。合理的方法是根据理想体重或调整后的体重初始剂量,然后根据患者的临床反应调整维持剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optimal Weight-Based Dosing of Intravenous Immunoglobulin (IVIG) among Overweight and Obese Patients
Intravenous immunoglobulin (IVIG), as an expensive medication under a national shortage, has been widely used for the treatment of several autoimmune diseases and immunodeficiency syndromes. Although conducting studies on therapeutic indications of IVIG has increased significantly, a limited number of researches have investigated individualized dosing in terms of the drug, disease state, and some patient-specific factors like obesity. The objective of the review was to describe the impact of various weight-based dosing regimens on the pharmacokinetics parameters, efficacy, safety, and cost of IVIG and to choose the best dosing approach for obese patients. Thirteen of the total 128 manuscripts collected, reviewed, and analyzed were found from Scopus, PubMed, and Google scholar. The evidence suggests that obesity may have an impact on IVIG pharmacokinetics, safety, and efficacy. The logical approach is to initial the dose based on the ideal or adjusted body weight and then modify the maintenance dose according to the patient's clinical response.
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来源期刊
Current Drug Therapy
Current Drug Therapy PHARMACOLOGY & PHARMACY-
CiteScore
1.30
自引率
0.00%
发文量
50
期刊介绍: Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.
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