可生物降解聚合物微球作为抗菌剂的药物载体

IF 0.3 Q4 PHARMACOLOGY & PHARMACY
N. Minocha, Nidhi Bansal, K. Rao, Nikita Yadav
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引用次数: 0

摘要

微球是一种新型药物递送系统,为常规和快速释放的单单位剂型提供治疗替代品。微球是直径为1–1000µm的固体微球。与标准剂型相比,微球可以使用不同的有效性和剂型给药程序制成。靶向药物递送的理念是将治疗集中在靶组织中,同时降低药物在非靶组织中的相对浓度。结果,药物被集中在所需的位置。因此,药物对附近的组织没有影响。因此,通过将药物与载体颗粒(如微球、纳米颗粒、脂质体、niosomes等)相结合,调节药物的释放和吸收特性,载体技术为药物递送提供了一种智能的方式。微球是由蛋白质或合成聚合物制成的自然可生物降解材料,可以自由流动。它的配方是可接近的,在感兴趣的部位保持所需的浓度而没有不利的影响,并可靠地将药物特异性地输送到目标部位。微球因其持续释放以及使用可生物降解聚合物将抗癌药物直接用于肿瘤的能力而吸引了人们的兴趣。因此,未来创新药物的给药系统将在很大程度上依赖微球。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biodegradable Polymeric Microspheres As Drug Carriers For AntiMicrobial Agent
Microspheres, the novel drug delivery system that offers therapeutic alternatives to single-unit dosage forms, both conventional and quick release. Microspheres are solid microspheres having a diameter of 1–1000 µm. Microspheres can be made utilising various procedures that vary in their effectiveness and dosage form administration when compared to standard dosage forms. The idea of targeted drug delivery is to concentrate the treatment in the target tissues while lowering the relative concentration of the drug in the non-target tissues. As a result, the medication is concentrated at the desired location. Thus, the medication has no effect on the tissues nearby. Therefore, by combining the drug with carrier particle like microspheres, nanoparticles, liposomes, niosomes, etc., that regulates the release and absorption characteristics of the drug, carrier technology offers an intelligent way for drug delivery. Microspheres are naturally biodegradable materials made of proteins or synthetic polymers that flow freely. Its formulation is approachable, maintaining the desired concentration at the site of interest without unfavorable effects and reliably delivering the drug to the target site with specificity. Microspheres attracted a lot of interest for their sustained release as well as their ability to direct anti-cancer medications to the tumour using biodegradable polymers. Due to this, future drug delivery systems for innovative medications will heavily rely on microspheres.
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来源期刊
Current Drug Therapy
Current Drug Therapy PHARMACOLOGY & PHARMACY-
CiteScore
1.30
自引率
0.00%
发文量
50
期刊介绍: Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.
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