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IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-06-25
Xin Jin, Susana Garcia and Berend Smit*, 
{"title":"","authors":"Xin Jin, Susana Garcia and Berend Smit*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":12.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c00255","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-06-25
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":12.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/ocv011i006_1952243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-06-25
Robert P. Sparks, William Lawless, Anna Kharitonova, Rainer Metcalf, Jamie Nunziata, Grace A. Binder, Sauradip Chaudhuri, Christine S.R. Gambino, Michelle Wilde, Linette S. Harding, Jaret J. Crews, Mansi Gopu, Emilia Dalamangas, Sarah Lawless, Mark Eschenfelder, Robert M. Green, Elizabeth X Nompleggi, Timothy H. Tran, Yan Yang, Donna V. Trask, Paul R. Thompson, Rekha Patel, Niketa A. Patel, Wesley H. Brooks, Guy Bradley, Mildred E. Acevedo-Duncan, Alan C. Mullen, James W. Leahy, Kenyon G. Daniel* and Wayne C. Guida*, 
{"title":"","authors":"Robert P. Sparks, William Lawless, Anna Kharitonova, Rainer Metcalf, Jamie Nunziata, Grace A. Binder, Sauradip Chaudhuri, Christine S.R. Gambino, Michelle Wilde, Linette S. Harding, Jaret J. Crews, Mansi Gopu, Emilia Dalamangas, Sarah Lawless, Mark Eschenfelder, Robert M. Green, Elizabeth X Nompleggi, Timothy H. Tran, Yan Yang, Donna V. Trask, Paul R. Thompson, Rekha Patel, Niketa A. Patel, Wesley H. Brooks, Guy Bradley, Mildred E. Acevedo-Duncan, Alan C. Mullen, James W. Leahy, Kenyon G. Daniel* and Wayne C. Guida*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":12.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.4c01982","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144430094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-06-25
Hao Guo, Chunlei Dong, Qingquan Han, Hongyu Jiang, Hongji Sun, Xuemei Sun, Songlin Zhang* and Huisheng Peng*, 
{"title":"","authors":"Hao Guo, Chunlei Dong, Qingquan Han, Hongyu Jiang, Hongji Sun, Xuemei Sun, Songlin Zhang* and Huisheng Peng*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":12.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c00155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144430097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-06-25
Junyoung Park, Juhee Hahm, Junhyeong Yim, Hyelim Lee, Hwan Min Hwang, Soyeon Lee, Ju-Young Park, Arun Velladurai, Jagadeesh Kumar Gangasani, Hana Cho, Hankum Park, Minju Lee, Jeehee Lee, Hyunuk Eom, Woon Ju Song, Sanghee Lee*, Eunha Kim* and Jongmin Park*, 
{"title":"","authors":"Junyoung Park, Juhee Hahm, Junhyeong Yim, Hyelim Lee, Hwan Min Hwang, Soyeon Lee, Ju-Young Park, Arun Velladurai, Jagadeesh Kumar Gangasani, Hana Cho, Hankum Park, Minju Lee, Jeehee Lee, Hyunuk Eom, Woon Ju Song, Sanghee Lee*, Eunha Kim* and Jongmin Park*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":12.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c00525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144430098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building a Medicinal Chemistry Framework for Bioorthogonal Probes. 构建生物正交探针的药物化学框架。
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-06-17 eCollection Date: 2025-06-25 DOI: 10.1021/acscentsci.5c00917
Markus Staudt, Jonathan C T Carlson
{"title":"Building a Medicinal Chemistry Framework for Bioorthogonal Probes.","authors":"Markus Staudt, Jonathan C T Carlson","doi":"10.1021/acscentsci.5c00917","DOIUrl":"10.1021/acscentsci.5c00917","url":null,"abstract":"<p><p>Screening the tetrazine-protein interactome finds the balance needed for high-performance fluorescent probes.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"823-825"},"PeriodicalIF":12.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-Pot Dual-Wavelength 3D Printing Breaks Free from Support Constraints. 一锅双波长3D打印打破了支持限制。
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-06-09 eCollection Date: 2025-06-25 DOI: 10.1021/acscentsci.5c00958
Jared Cason Head, Syed Muhammad Usama
{"title":"One-Pot Dual-Wavelength 3D Printing Breaks Free from Support Constraints.","authors":"Jared Cason Head, Syed Muhammad Usama","doi":"10.1021/acscentsci.5c00958","DOIUrl":"10.1021/acscentsci.5c00958","url":null,"abstract":"<p><p>The Page and Huang groups employ orthogonal light sources to fabricate freestanding 3D structures that eliminate the need for traditional support material.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"831-833"},"PeriodicalIF":12.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor. 克罗昔利作为人STING受体亚飞摩尔调制剂的发现。
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-06-06 eCollection Date: 2025-06-25 DOI: 10.1021/acscentsci.4c01982
Robert P Sparks, William Lawless, Anna Kharitonova, Rainer Metcalf, Jamie Nunziata, Grace A Binder, Sauradip Chaudhuri, Christine S R Gambino, Michelle Wilde, Linette S Harding, Jaret J Crews, Mansi Gopu, Emilia Dalamangas, Sarah Lawless, Mark Eschenfelder, Robert M Green, Elizabeth X Nompleggi, Timothy H Tran, Yan Yang, Donna V Trask, Paul R Thompson, Rekha Patel, Niketa A Patel, Wesley H Brooks, Guy Bradley, Mildred E Acevedo-Duncan, Alan C Mullen, James W Leahy, Kenyon G Daniel, Wayne C Guida
{"title":"Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor.","authors":"Robert P Sparks, William Lawless, Anna Kharitonova, Rainer Metcalf, Jamie Nunziata, Grace A Binder, Sauradip Chaudhuri, Christine S R Gambino, Michelle Wilde, Linette S Harding, Jaret J Crews, Mansi Gopu, Emilia Dalamangas, Sarah Lawless, Mark Eschenfelder, Robert M Green, Elizabeth X Nompleggi, Timothy H Tran, Yan Yang, Donna V Trask, Paul R Thompson, Rekha Patel, Niketa A Patel, Wesley H Brooks, Guy Bradley, Mildred E Acevedo-Duncan, Alan C Mullen, James W Leahy, Kenyon G Daniel, Wayne C Guida","doi":"10.1021/acscentsci.4c01982","DOIUrl":"10.1021/acscentsci.4c01982","url":null,"abstract":"<p><p>Stimulator of interferon genes (STING) is a transmembrane endoplasmic reticulum (ER) resident protein involved in innate immunity. STING activation occurs by binding of cyclic guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate (2',3'-cGAMP) to STING, which leads to downstream production of type 1 interferons (IFN-1). We generated molecular dynamics (MD) equilibrated agonist and antagonist models of human STING (hSTING) for computer-based screening and now report the discovery of clonixeril (CXL) as the most potent non-nucleotide hSTING modulator discovered to date. We demonstrate <i>in vitro</i> and <i>in cellulo</i> that CXL has two modes of interaction with hSTING, one with an EC<sub>50</sub> above 1 nM and the other with an EC<sub>50</sub> in the 1 fM-100 aM range (10<sup>-15</sup>-10<sup>-16</sup> M). In cell-based experiments, when CXL is titrated below 1 nM, it displays inverse dose-dependent antagonistic behavior toward hSTING. We have substantiated that CXL displays this exceptionally strong inhibitory effect on hSTING mediated IFN-1 production using a THP-1 cell luciferase reporter for interferon regulatory factor 3 (IRF3). Further characterization of CXL was performed in HEK293 cells by using biophysical and biochemical techniques.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"994-1008"},"PeriodicalIF":12.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conformational Plasticity in Amyloid Assemblies: A Paradigm Shift from Structural Rigidity to Functional Adaptability. 淀粉样蛋白组装中的构象可塑性：从结构刚性到功能适应性的范式转变。
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-06-06 eCollection Date: 2025-06-25 DOI: 10.1021/acscentsci.5c00983
Alan H Weible, Xiaoguang Wang
{"title":"Conformational Plasticity in Amyloid Assemblies: A Paradigm Shift from Structural Rigidity to Functional Adaptability.","authors":"Alan H Weible, Xiaoguang Wang","doi":"10.1021/acscentsci.5c00983","DOIUrl":"10.1021/acscentsci.5c00983","url":null,"abstract":"<p><p>The divergence of conformational ensembles of hIAPP in response to different types of mutations and PTMs has been decoded by leveraging the scanning tunneling microscopy-based probability interpretation technique.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"828-830"},"PeriodicalIF":12.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Light-Powered Late-Stage Alkylation of N‑Heteroaromatics in Flow. 流动中N -杂芳烃的光催化后期烷基化。
IF 12.7 1区 化学
ACS Central Science Pub Date : 2025-06-05 eCollection Date: 2025-06-25 DOI: 10.1021/acscentsci.5c00926
Shun Wang, Zhiwei Zuo
{"title":"Light-Powered Late-Stage Alkylation of N‑Heteroaromatics in Flow.","authors":"Shun Wang, Zhiwei Zuo","doi":"10.1021/acscentsci.5c00926","DOIUrl":"10.1021/acscentsci.5c00926","url":null,"abstract":"<p><p>Continuous-flow photochemistry allows late-stage functionalization of N-heteroaromatics with gaseous alkane.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 6","pages":"826-827"},"PeriodicalIF":12.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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