Addiction最新文献

{"title":"Associations of plasma sex-related hormone and protein levels and alcohol dependence.","authors":"Ada Man-Choi Ho, Jennifer R Geske, Vanessa K Pazdernik, T Cameron Waller, Anthony Batzler, Stacey J Winham, Victor M Karpyak","doi":"10.1111/add.70104","DOIUrl":"https://doi.org/10.1111/add.70104","url":null,"abstract":"<p><strong>Background and aims: </strong>Sex-related hormones and proteins may underlie sex differences in alcohol use disorder characteristics and consequences. Previous reports suggest steroid sex hormones may influence alcohol consumption behaviors while proteins that regulate their circulation levels are rarely investigated. Following up on our earlier study of individual sex-related hormones' associations with alcohol dependence (AD), this study measured the associations between the combinations of sex-related hormones and proteins and AD in a larger sample.</p><p><strong>Design: </strong>Sex-stratified case-control comparison and clustering of plasma sex-related hormone and protein levels, plus a genome-wide association study on the AD-associated hormone and protein combinations.</p><p><strong>Setting: </strong>Addiction treatment programs in the United States.</p><p><strong>Participants: </strong>Four hundred treatment-seeking recently abstained AD patients (median = 24.5 days) and 388 age-and-sex-matched controls from a community biobank (male:female ≈ 2:1).</p><p><strong>Measurements: </strong>Plasma levels of total testosterone, estrone (E1), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex hormone binding globulin (SHBG) and albumin.</p><p><strong>Findings: </strong>In males, we found higher E2 [β = 0.13, P<sub>unadjusted</sub> < 0.001, false discovery rate (FDR) = 0.005], progesterone (β = 0.01, P<sub>unadjusted</sub> = 0.025, FDR = 0.054), LH (β = 0.12, P<sub>unadjusted</sub> = 0.017, FDR = 0.044) and albumin (β = 0.09, P<sub>unadjusted</sub> < 0.001, FDR = 0.005) in AD patients than controls; in females, we observed lower E1 (β = -0.24, P<sub>unadjusted</sub> = 0.024, FDR = 0.113) and progesterone (β = -1.86, P<sub>unadjusted</sub> = 0.026, FDR = 0.113) and higher albumin (β = 0.18, P<sub>unadjusted</sub> < 0.001, FDR = 0.001) in AD patients than controls. Three principal components (PCs), reflecting hormone signatures, were statistically significantly associated with AD in each sex: PC1 (TT, E2 and SHBG; β = -0.15, P = 0.016), PC3 (E1, progesterone and albumin; β = 0.28, P = 0.007) and PC4 (SHBG and albumin; β = 0.34, P = 0.001) in males; PC3 (progesterone and albumin; β = -0.38, P = 0.009), PC4 (TT and albumin; β = -0.49, P = 0.001) and PC5 (TT and progesterone; β = 0.54, P = 0.004) in females. Statistically significant SNP × group associations were found in females between PC4 and polymorphisms in RP51004I9.1 (top SNP: rs6082693; P = 5.41E-12) and in males between PC3 and a genomic locus that contained SLC35E4, DUSP18 and OSBP2 (top SNP: rs13053277; P = 1.77E-07).</p><p><strong>Conclusions: </strong>Three sex-related hormone and protein signatures appear to be associated with alcohol dependence in each sex. Peripheral levels of sex-related hormones and proteins, as well as their combinations, could be altered in people with alcohol dependence who have abstained for a few weeks compared with contro","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of acute psychosocial stress on cue-reactivity, attentional bias and implicit associations in women with problematic social network use: An experimental study.","authors":"Annica Kessling, Astrid Müller, Oliver T Wolf, Christian J Merz, Matthias Brand, Elisa Wegmann","doi":"10.1111/add.70099","DOIUrl":"https://doi.org/10.1111/add.70099","url":null,"abstract":"<p><strong>Background and aims: </strong>Situational triggers such as acute stress may exert significant effects on behavioral execution in addictive behaviors potentially leading to increased cue-reactivity and the expression of implicit cognitions. We measured the effects of acute stress on cue-reactivity, attentional bias and implicit associations to stimuli related to online social networks (SN) in problematic social network use (p-SNU) among women.</p><p><strong>Design, setting and participants: </strong>This was a mixed-method, cross-sectional, between-subjects design with 135 female participants recruited in Germany who were assigned to the group with p-SNU (n = 71) or the control group (n = 64) based on a diagnostic interview using DSM-5 criteria for gaming disorder (applied to p-SNU). Participants were randomly exposed to acute stress using the Trier Social Stress Test (TSST) or a placebo-TSST.</p><p><strong>Measurements: </strong>Participants performed a Cue-Reactivity Paradigm, Implicit Association Test and the Dot Probe Paradigm with SN-related stimuli.</p><p><strong>Findings: </strong>Acute stress led to increased subjective urge to use social networks in both groups [TSST: mean (M) = 2.26, standard deviation (SD) = 0.92, placebo-TSST: M = 2.08, SD = 0.96, F(1,131) = 6.820, P = 0.01, ηp² = 0.029]. In the placebo-TSST condition, the p-SNU group showed increased subjective arousal (p-SNU: M = 2.39, SD = 0.74; control group: M = 1.79, SD = 0.90, t₇₀ = 2.55, P = 0.013, │d│ = 0.30) and urge (p-SNU: M = 2.49, SD = 0.84; control group: M = 1.60, SD = 0.88, t₇₀ = 5.40,  P < 0.001, │d│ = 0.58) and the control group showed increased attentional bias (p-SNU: M = -1.75, SD = 16.11; control group: M = 6.43, SD = 15.3, t₆₇ = 2.136, P = 0.036, │d│ = 0.52). No group difference was found regarding the effects of acute stress on implicit associations to SN-related stimuli or an interaction effect of subjective urge and stress on implicit cognitions.</p><p><strong>Conclusions: </strong>Among women in Germany, acute stress appears to lead to an increased subjective urge for the use of social networks. Women with problematic social network use report higher subjective urge independent of stress, whereas women with non-problematic use report an attentional bias.</p>","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambling website design as a factor in North American betting expansion.","authors":"Luke Clark, Paul William Weston","doi":"10.1111/add.70103","DOIUrl":"https://doi.org/10.1111/add.70103","url":null,"abstract":"","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To determine whether the whole recovery-oriented system of care is greater than the sum of its parts, we must start by describing the parts.","authors":"Ed Day, Suzie Roscoe, Laura Pechey, John Kelly","doi":"10.1111/add.70102","DOIUrl":"https://doi.org/10.1111/add.70102","url":null,"abstract":"","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of treatment retention in opioid use disorder: Subcutaneous injectable versus sublingual buprenorphine.","authors":"Charles Deng, Enrique Oviedo, Marc Fishman, Albert Burgess-Hull","doi":"10.1111/add.70105","DOIUrl":"https://doi.org/10.1111/add.70105","url":null,"abstract":"<p><strong>Background and aims: </strong>Buprenorphine treatment for opioid-use disorder (OUD) is commonly available in both sublingual tablets/films and extended-release subcutaneous injections; however, little is known about differences in patient retention between these two buprenorphine formulations. This study measured retention differences between patients who transitioned from sublingual to subcutaneous injectable buprenorphine and those who remained on sublingual buprenorphine throughout treatment, within a multi-location outpatient addiction treatment practice.</p><p><strong>Design and setting: </strong>This study was an observational propensity score-matched cohort study conducted at a multi-location outpatient addiction practice in Maryland, USA.</p><p><strong>Participants: </strong>Participants included 3609 patients receiving buprenorphine treatment for OUD between June 2019 and February 2024.</p><p><strong>Measurements: </strong>Patient demographics, health history and urine toxicology results. The primary outcome was time-to-dropout in days. Kaplan-Meier and Cox Proportional Hazard models with propensity score matching were used to compare treatment retention between injectable and sublingual buprenorphine receipt.</p><p><strong>Findings: </strong>Overall, 538 patients at the time of their first extended-release buprenorphine injection (INJ) were matched with 538 patients only receiving sublingual buprenorphine (SUB-only). In the unmatched sample, INJ patients were more likely than SUB-only patients to be female (INJ 47.2% vs SUB-only 38.7%, P < 0.001) and more likely to have at least an associate's degree (41.4% vs 33.9%, P < 0.001). After matching, patients who transitioned to INJ buprenorphine had lower retention in treatment compared with patients who remained on SUB buprenorphine. Median (95% confidence interval) time-to-dropout was 269 days (218-313) for INJ patients compared with 389 days (313-592) for SUB-only patients (stratified log-rank test = 13.6, P < 0.001).</p><p><strong>Conclusions: </strong>Among patients receiving medication treatment for opioid use disorder in an outpatient setting, those who transitioned from sublingual to subcutaneous injectable buprenorphine were at an increased risk for dropout compared with matched patients who only received sublingual buprenorphine.</p>","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"You have to be alive to enjoy the porridge: The role of Goldilocks naloxone dosing in a world of hungry bears.","authors":"Jake R Morgan, Alexander Y Walley","doi":"10.1111/add.70101","DOIUrl":"https://doi.org/10.1111/add.70101","url":null,"abstract":"","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of treating post-traumatic stress disorder in patients with co-occurring substance use disorder with prolonged exposure, eye movement desensitization and reprocessing or imagery rescripting: A randomized controlled trial.","authors":"Sera Lortye, Joanne P Will, Loes A Marquenie, Nick M Lommerse, Nathalie Faber, Anna E Goudriaan, Arnoud Arntz, Marleen M de Waal","doi":"10.1111/add.70097","DOIUrl":"https://doi.org/10.1111/add.70097","url":null,"abstract":"<p><strong>Background and aims: </strong>Post-traumatic stress disorder (PTSD) and substance use disorder (SUD) are highly co-occurring and evidence for the optimal ways of treating PTSD in SUD patients is mixed. Our aim was to compare three different PTSD treatments, each added simultaneously to SUD treatment, with SUD treatment alone in patients with co-occurring SUD-PTSD. These PTSD treatments were: Prolonged Exposure (PE), Eye Movement Desensitization and Reprocessing (EMDR) and Imagery Rescripting (ImRs).</p><p><strong>Design: </strong>A single-blind 4-arm randomized controlled trial with follow-up at 3 months.</p><p><strong>Setting: </strong>Two addiction treatment centers in the Netherlands, providing intra- and extramural care.</p><p><strong>Participants: </strong>209 patients with SUD and co-morbid PTSD were included [mean age 37.5 (standard deviation, SD = 11.99), female sex = 46.4%, mean Clinically Administered PTSD Scale (CAPS) score = 37.35 (SD = 9.28)].</p><p><strong>Interventions: </strong>Participants were randomized to either simultaneous SUD + PE (n = 53), SUD + EMDR (n = 50), SUD + ImRs (n = 55) or to SUD treatment only (n = 51), with the active PTSD treatments consisting of 12 sessions each within 3 months. Standard protocols were used.</p><p><strong>Measurements: </strong>The primary outcome was clinician-administered PTSD symptom severity as measured by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (CAPS-5) at 3 month follow-up. Secondary outcomes included loss of PTSD diagnosis, full remission of PSTD and SUD-severity, also recorded at 3 months.</p><p><strong>Findings: </strong>Compared with SUD only, the mean differences in CAPS-5 score were B = -5.41 [95% confidence interval (CI) = 10.88, 0.05, P = 0.052] for SUD + PE, B = -7.97 (95% CI = -13.57, -2.37, P = 0.006) for SUD + EMDR and B = -10.03 (95% CI = -15.29, -4.77, P < 0.001) for SUD + ImRs. When adjusted for baseline covariates, mean differences were B = -5.81 (95% CI = -11.48, -0.15, P = 0.044) for SUD + PE, B = -8.85 (95% CI = -14.60, -3.10, P = 0.003) for SUD + EMDR and B = -10.75 (95% CI = -15.94, -5.56, P = <0.001) for SUD + ImRs. No between-group differences in SUD outcomes were found.</p><p><strong>Conclusions: </strong>Among people with co-occurring substance use disorder (SUD) and post-traumatic stress disorder (PTSD), trauma-focused PTSD treatment as add-on to SUD treatment appears to be effective in decreasing PTSD severity compared with manualized SUD only treatment and does not appear to increase SUD severity.</p>","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of cessation products, e-cigarettes and cigarette cessation outcomes among adults with substance use problems: Results from 2013-2021 (Waves 1-6) of the Population Assessment of Tobacco and Health (PATH) Study.","authors":"Olufemi Erinoso, Karin Kasza, Christine E Sheffer, Andrew Hyland, Jennifer Pearson","doi":"10.1111/add.70098","DOIUrl":"https://doi.org/10.1111/add.70098","url":null,"abstract":"<p><strong>Aims: </strong>The aim of this study was to examine how prior use of cessation products and daily electronic nicotine delivery systems (ENDS) use was related to past-month cigarette abstinence between and within substance use problems (SUPs) categories. Furthermore, we measured past-year use of cessation products and ENDS among people who smoke cigarettes with high and moderate SUPs compared with those without.</p><p><strong>Design, setting, participants: </strong>Longitudinal study using data from the USA-based Population Assessment of Tobacco and Health (PATH) Study Waves 1-6, collected between 2013/14 and 2021. Data were from adults (ages 18+) who smoked cigarettes in the past-month baseline wave of each wave-pair.</p><p><strong>Measurements: </strong>The predictor was SUP severity (no/low, moderate and high) as assessed using the Global Appraisal of Individual Needs -Short Screener (GAIN-SS). Outcomes at follow-up were: 1. past-month cigarette abstinence and 2. use of cessation aids [any past-year use of counseling, nicotine replacement therapies (NRTs) and medications] and past-year daily ENDS use. We used generalized estimating equation models (GEE) to examine the relationship between SUP status and the outcomes. All models were weighted and adjusted for age, sex, race/ethnicity and daily cigarette use.</p><p><strong>Findings: </strong>Our results show no statistically significant differences in the use of counseling, medications and daily ENDS at follow-up between individuals by their SUP status. However, individuals with high SUP severity (vs no/low) had higher odds of past-year use of NRTs [adjusted odds ratio (aOR) = 1.36; 95% confidence interval (CI) = 1.13-1.64]. Furthermore, individuals with high SUPs (aOR = 0.49; 95% CI = 0.37-0.64) had lower odds of past-month cigarette abstinence at follow-up compared with those with no/low severity. Among individuals with high SUP, 2.88%, 9.42%, 5.77% and 5.49% used counseling, NRTs, cessation medications and daily ENDS, respectively.</p><p><strong>Conclusion: </strong>People with high-severity substance use problems appear to have lower cigarette abstinence than people with low-severity substance use problems, despite no statistically significant differences in the use of most cessation aids.</p>","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying key risk factors for intentional self-harm, including suicide, among a cohort of people prescribed opioid agonist treatment: A predictive modelling study.","authors":"Nicola R Jones, Matthew Hickman, Chrianna Bharat, Suzanne Nielsen, Sarah Larney, Nimnaz Fathima Ghouse, Julia Lappin, Louisa Degenhardt","doi":"10.1111/add.70095","DOIUrl":"https://doi.org/10.1111/add.70095","url":null,"abstract":"<p><strong>Background and aims: </strong>People with opioid use disorder are at increased risk of intentional self-harm and suicide. Although risk factors are well known, most tools for identifying individuals at highest risk of these behaviours have limited clinical value. We aimed to develop and internally validate models to predict intentional self-harm and suicide risk among people who have been in opioid agonist treatment (OAT).</p><p><strong>Design: </strong>Retrospective observational cohort study using linked administrative data.</p><p><strong>Setting: </strong>New South Wales, Australia.</p><p><strong>Participants: </strong>46 330 people prescribed OAT between January 2005 and November 2017.</p><p><strong>Measurements: </strong>Intentional self-harm and suicide prediction within a 30-day window using linked population datasets for OAT, hospitalisation, mental health care, incarceration and mortality. Machine learning algorithms, including neural networks and gradient boosting, assessed over 80 factors during the last 3, 6 and 12 months. Feature visualisation using SHapley Additive exPlanations.</p><p><strong>Findings: </strong>Gradient boosting identified 30 important factors in predicting self-harm and/or suicide. These included the most recent frequency of emergency department presentations; hospital admissions involving mental disorders such as borderline personality, substance dependence, psychosis and depression/anxiety; and recent release from incarceration. The best fitting model had a Gini coefficient of 0.65 [area under the curve (AUC) = 0.82] and was applied to 2017 data to estimate the probability of self-harm and/or suicide. On average 46 people (0.16%) (from a total of 28 000 people in OAT) experienced intentional self-harm or suicide per month. Applying a 0.15% probability threshold, approximately 5167 people were classified as high risk, identifying 69% of all self-harm or suicide cases per month. This figure reduced to 450 per month after excluding people already identified in the previous month.</p><p><strong>Conclusions: </strong>Among people in opioid agonist treatment, administrative linked data can be used with advanced machine learning algorithms to predict self-harm and/or suicide in a 30-day prediction window.</p>","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Everything in moderation, even naloxone.","authors":"Phillip O Coffin","doi":"10.1111/add.70096","DOIUrl":"https://doi.org/10.1111/add.70096","url":null,"abstract":"","PeriodicalId":109,"journal":{"name":"Addiction","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}