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Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping. E-cadherin (CDH1)和KSP-cadherin (CDH16)在16q22.1染色体上的定位
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015531
D Baudry, C Jeanpierre
{"title":"Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping.","authors":"D Baudry, C Jeanpierre","doi":"10.1159/000015531","DOIUrl":"https://doi.org/10.1159/000015531","url":null,"abstract":"Cadherins are cellular adhesion molecules. Since disturbance of intracellular adhesion is important for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes. A variety of solid tumors show loss of heterozygosity for the long arm of chromosome 16 (Austruy et al., 1995; Driouch et al., 1997), which is indicative of the potential localization of tumor suppressor genes. The homophilic cell adhesion molecule E-cadherin (CDH1) has been involved in gastric (Becker et al., 1994), breast (Berx et al., 1995) and gynecologic carcinomas (Risinger et al., 1994). This report refined localization of: (1) E-cadherin (CDH1), previously mapped to 16q22.1 on a panel of somatic cell hybrids (Callen et al., 1995) and between WI-9392 and D16S496 on the Genebridge 4 radiation hybrid panel (Hunstman et al., 1998); (2) KSP-cadherin (CDH16), previously mapped to chromosome 16q21-proximal 16q22 by in situ hybridization (Thomson et al., 1998). A more precise localization of these two genes in a publicly available radiation hybrid map will facilitate marker selection for linkage and loss of heterozygosity analyses. Materials and methods","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"88 3-4","pages":"253-4"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015531","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21673211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Identification and characterization of mouse orthologs of the AMMECR1 and FACL4 genes deleted in AMME syndrome: orthology of Xq22.3 and MmuXF1-F3. AMME综合征中缺失的AMMECR1和FACL4基因小鼠同源基因的鉴定和表征：Xq22.3和MmuXF1-F3的同源基因。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015533
F Vitelli, I Meloni, S Fineschi, F Favara, C Tiziana Storlazzi, M Rocchi, A Renieri
{"title":"Identification and characterization of mouse orthologs of the AMMECR1 and FACL4 genes deleted in AMME syndrome: orthology of Xq22.3 and MmuXF1-F3.","authors":"F Vitelli, I Meloni, S Fineschi, F Favara, C Tiziana Storlazzi, M Rocchi, A Renieri","doi":"10.1159/000015533","DOIUrl":"10.1159/000015533","url":null,"abstract":"<p><p>The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. We have now cloned the murine Facl4 and Ammecr1 genes and have mapped both novel murine genes to mouse chromosome X band F1-F3. The murine and human orthologs show 96.5% (FACL4) and 95.2% (AMMECR1) identity at the amino acid level, with conservation of the respective putative subcellular localization signals. Our results show that Facl4 and Ammecr1 are the true murine orthologs of the human genes. Furthermore, the mapping of Facl4 and Ammecr1 to MmuXF1-F3 suggests that this subinterval is orthologous, at least for a portion of Xq22. 3.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"88 3-4","pages":"259-63"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21673213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromosomal localization of the genes encoding ALDH, BMP-2, R-FABP, IFN-gamma, RXR-gamma, and VIM in chicken by fluorescence in situ hybridization. 荧光原位杂交技术在鸡染色体上定位ALDH、BMP-2、R-FABP、ifn - γ、rxr - γ和VIM基因。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015535
M Guttenbach, I Nanda, P M Brickell, R Godbout, P Staeheli, Z E Zehner, M Schmid
{"title":"Chromosomal localization of the genes encoding ALDH, BMP-2, R-FABP, IFN-gamma, RXR-gamma, and VIM in chicken by fluorescence in situ hybridization.","authors":"M Guttenbach,&nbsp;I Nanda,&nbsp;P M Brickell,&nbsp;R Godbout,&nbsp;P Staeheli,&nbsp;Z E Zehner,&nbsp;M Schmid","doi":"10.1159/000015535","DOIUrl":"https://doi.org/10.1159/000015535","url":null,"abstract":"<p><p>Six structural genes encoding ALDH, BMP-2, R-FABP, IFN-gamma, RXR-gamma and VIM were mapped in the chicken by fluorescence in situ hybridization (FISH) using genomic and cDNA clones as probes. The genes were found to be located on four different macrochromosomes: chromosome 1 (IFNG and FABP), chromosome 2 (VIM and ALDH), chromosome 3 (BMP2) and a smaller macrochromosome, most probably chromosome 7 (RXRG). With the exception of IFNG none of the newly mapped sites corresponds to known orthologous regions between chicken and human chromosomes.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"88 3-4","pages":"266-71"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21673215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization. I型磷脂酰肌醇-4-磷酸5激酶(PIP5K1A)在人类染色体带1q22- > q24上的原位杂交。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015545
Y Xie, L Zhu, G Zhao
{"title":"Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization.","authors":"Y Xie,&nbsp;L Zhu,&nbsp;G Zhao","doi":"10.1159/000015545","DOIUrl":"https://doi.org/10.1159/000015545","url":null,"abstract":"","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"88 3-4","pages":"197-9"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21673934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
cDNA cloning and genomic structure of a novel gene (C11orf9) localized to chromosome 11q12-->q13.1 which encodes a highly conserved, potential membrane-associated protein. 定位于染色体11q12- >q13.1的新基因C11orf9的cDNA克隆和基因组结构，该基因编码高度保守的潜在膜相关蛋白。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015552
H Stöhr, A Marquardt, K White, B H Weber
{"title":"cDNA cloning and genomic structure of a novel gene (C11orf9) localized to chromosome 11q12-->q13.1 which encodes a highly conserved, potential membrane-associated protein.","authors":"H Stöhr,&nbsp;A Marquardt,&nbsp;K White,&nbsp;B H Weber","doi":"10.1159/000015552","DOIUrl":"https://doi.org/10.1159/000015552","url":null,"abstract":"<p><p>We have cloned and characterized a novel gene (C11orf9) mapping to chromosome 11q12-->q13.1. The transcript was initially identified as a partial cDNA sequence in the course of constructing a transcript map of the region between markers D11S1765 and uteroglobin known to encompass the gene causing Best disease. Using a combination of EST mapping, computational exon prediction, RT-PCR, and 5'-RACE its 5. 7-kb full-length cDNA sequence was subsequently obtained. The C11orf9 gene consists of 26 exons spanning 33.1 kb of genomic DNA and is located about 4.3 kb centromeric to FEN1. Biocomputational analysis predicts that its conceptual translation product of 1,111 amino acids contains two transmembrane helices as well as two proline-rich regions. Alignment reveals significant homology to hypothetical peptides from several other species including C. elegans and D. melanogaster, indicating a high degree of conservation throughout evolution. Northern Blot and RT-PCR analyses demonstrate widespread expression of a single transcript but varying degrees of abundance among the individual tissues tested. Mutation analysis of the entire coding sequence excluded C11orf9 as the Best disease gene.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"88 3-4","pages":"211-6"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21673941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization. 通过原位杂交将激酶家族成员4基因(KIF4A和KIF4B)定位到人类染色体Xq13.1和5q33.1条带上。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015482
M J Ha, J Yoon, E Moon, Y M Lee, H J Kim, W Kim
{"title":"Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.","authors":"M J Ha,&nbsp;J Yoon,&nbsp;E Moon,&nbsp;Y M Lee,&nbsp;H J Kim,&nbsp;W Kim","doi":"10.1159/000015482","DOIUrl":"https://doi.org/10.1159/000015482","url":null,"abstract":"The murine KIF4 gene, a member of the kinesin superfamily, is an anterograde microtubule-based motor protein for transporting membranous organelles (Sekine et al., 1994). The recent finding that it binds to murine retroviral gag polyproteins implies that the binding might play an important role in virus assembly (Kim et al., 1998). A combination of RT-PCR with cDNA library screening led to identification of human KIF4 (Genbank accession number AF071592). The nucleotide sequence comprised part of the 5) untranslated region (UTR), an open reading frame (ORF) encoding 1232 amino acids, and the entire 3) UTR. Homologies with the mouse KIF4 were 82 % and 85 % for nucleic acids and amino acids, respectively. Although it was found that human KIF4 associates with HIV gag proteins (Tang et al., in press), the function of human KIF4 is yet to be determined. Here we report the mapping of the KIF4 genes to human chromosomes Xq13.1 and 5q33.1.","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"88 1-2","pages":"41-2"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21623120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Assignment of NUFIP1 (nuclear FMRP interacting protein 1) gene to chromosome 13q14 and assignment of a pseudogene to chromosome 6q12. NUFIP1（核FMRP相互作用蛋白1）基因在染色体13q14和假基因在染色体6q12上的分配。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015580
B Bardoni, S Giglio, A Schenck, M Rocchi, J L Mandel
{"title":"Assignment of NUFIP1 (nuclear FMRP interacting protein 1) gene to chromosome 13q14 and assignment of a pseudogene to chromosome 6q12.","authors":"B Bardoni, S Giglio, A Schenck, M Rocchi, J L Mandel","doi":"10.1159/000015580","DOIUrl":"10.1159/000015580","url":null,"abstract":"","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"89 1-2","pages":"11-3"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21735840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9. p53诱导基因EI24/PIG8定位于人类染色体11q23和小鼠染色体9的近端区域。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015620
Z Gu, D J Gilbert, V A Valentine, N A Jenkins, N G Copeland, G P Zambetti
{"title":"The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9.","authors":"Z Gu,&nbsp;D J Gilbert,&nbsp;V A Valentine,&nbsp;N A Jenkins,&nbsp;N G Copeland,&nbsp;G P Zambetti","doi":"10.1159/000015620","DOIUrl":"https://doi.org/10.1159/000015620","url":null,"abstract":"<p><p>Activation of the p53 tumor suppressor leads to either a cell cycle arrest or to apoptosis and the factors that influence these responses are poorly understood. It is clear, however, that p53 regulates these processes by inducing a series of downstream target genes. One recently identified p53-target gene, EI24 (alias PIG8), induces apoptosis when ectopically expressed. To better understand the biological properties of EI24 and its potential relevance to disease, in particular cancer, we determined the chromosomal location and pattern of gene expression of EI24. EI24 is widely expressed in adult tissues and throughout mouse embryogenesis. The genomic locus of EI24 was mapped to the proximal region of mouse chromosome 9 and human chromosome 11q23-->q24, a region frequently altered in human cancers. These results suggest that EI24 may play an important role in the p53 tumor suppressor pathway.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"89 3-4","pages":"230-3"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21800827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. 人类染色体2q31- >q32.1区域2个脆弱位点和7个同源盒基因的聚类。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015651
M Z Limongi, F Pelliccia, L Gaddini, A Rocchi
{"title":"Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1.","authors":"M Z Limongi,&nbsp;F Pelliccia,&nbsp;L Gaddini,&nbsp;A Rocchi","doi":"10.1159/000015651","DOIUrl":"https://doi.org/10.1159/000015651","url":null,"abstract":"<p><p>In this study we have used FISH to examine the relationship between a group of homeobox genes, namely DLX1/DLX2, EVX2 and four HOXD genes (10, 11, 12, 13), that map to region q31 on chromosome 2, and the FRA2G and FRA2H fragile sites located at 2q31 and 2q32.1 respectively. Our results indicate that these homeobox genes lie between the two fragile regions.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"90 1-2","pages":"151-3"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21886957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA. 人分泌素(SCT):基因结构、染色体位置和mRNA的分布。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015658
T E Whitmore, J L Holloway, C E Lofton-Day, M F Maurer, L Chen, T J Quinton, J B Vincent, S W Scherer, S Lok
{"title":"Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA.","authors":"T E Whitmore,&nbsp;J L Holloway,&nbsp;C E Lofton-Day,&nbsp;M F Maurer,&nbsp;L Chen,&nbsp;T J Quinton,&nbsp;J B Vincent,&nbsp;S W Scherer,&nbsp;S Lok","doi":"10.1159/000015658","DOIUrl":"https://doi.org/10.1159/000015658","url":null,"abstract":"<p><p>Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Recently, it has been discussed that secretin deficiency may be implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. In the present study, the human secretin gene (SCT) was isolated from a bacterial artificial chromosome genomic library. SCT contains four exons, with the protein coding regions spanning 713 bp of genomic DNA. Human SCT is similar structurally to the secretin genes of other species. Amino acid conservation, however, is most pronounced within the exon encoding the biologically active mature peptide. Northern blot analysis shows that human SCT transcripts are located in the spleen, intestinal tract, and brain. Radiation hybrid mapping places the SCT locus on chromosome 11p15.5.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"90 1-2","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015658","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21889082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
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