通过原位杂交将激酶家族成员4基因(KIF4A和KIF4B)定位到人类染色体Xq13.1和5q33.1条带上。

M J Ha, J Yoon, E Moon, Y M Lee, H J Kim, W Kim
{"title":"通过原位杂交将激酶家族成员4基因(KIF4A和KIF4B)定位到人类染色体Xq13.1和5q33.1条带上。","authors":"M J Ha, J Yoon, E Moon, Y M Lee, H J Kim, W Kim","doi":"10.1159/000015482","DOIUrl":null,"url":null,"abstract":"The murine KIF4 gene, a member of the kinesin superfamily, is an anterograde microtubule-based motor protein for transporting membranous organelles (Sekine et al., 1994). The recent finding that it binds to murine retroviral gag polyproteins implies that the binding might play an important role in virus assembly (Kim et al., 1998). A combination of RT-PCR with cDNA library screening led to identification of human KIF4 (Genbank accession number AF071592). The nucleotide sequence comprised part of the 5) untranslated region (UTR), an open reading frame (ORF) encoding 1232 amino acids, and the entire 3) UTR. Homologies with the mouse KIF4 were 82 % and 85 % for nucleic acids and amino acids, respectively. Although it was found that human KIF4 associates with HIV gag proteins (Tang et al., in press), the function of human KIF4 is yet to be determined. Here we report the mapping of the KIF4 genes to human chromosomes Xq13.1 and 5q33.1.","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"88 1-2","pages":"41-2"},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015482","citationCount":"18","resultStr":"{\"title\":\"Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.\",\"authors\":\"M J Ha, J Yoon, E Moon, Y M Lee, H J Kim, W Kim\",\"doi\":\"10.1159/000015482\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The murine KIF4 gene, a member of the kinesin superfamily, is an anterograde microtubule-based motor protein for transporting membranous organelles (Sekine et al., 1994). The recent finding that it binds to murine retroviral gag polyproteins implies that the binding might play an important role in virus assembly (Kim et al., 1998). A combination of RT-PCR with cDNA library screening led to identification of human KIF4 (Genbank accession number AF071592). The nucleotide sequence comprised part of the 5) untranslated region (UTR), an open reading frame (ORF) encoding 1232 amino acids, and the entire 3) UTR. Homologies with the mouse KIF4 were 82 % and 85 % for nucleic acids and amino acids, respectively. Although it was found that human KIF4 associates with HIV gag proteins (Tang et al., in press), the function of human KIF4 is yet to be determined. Here we report the mapping of the KIF4 genes to human chromosomes Xq13.1 and 5q33.1.\",\"PeriodicalId\":10982,\"journal\":{\"name\":\"Cytogenetics and cell genetics\",\"volume\":\"88 1-2\",\"pages\":\"41-2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000015482\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cytogenetics and cell genetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000015482\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cytogenetics and cell genetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000015482","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 18

摘要

本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.
The murine KIF4 gene, a member of the kinesin superfamily, is an anterograde microtubule-based motor protein for transporting membranous organelles (Sekine et al., 1994). The recent finding that it binds to murine retroviral gag polyproteins implies that the binding might play an important role in virus assembly (Kim et al., 1998). A combination of RT-PCR with cDNA library screening led to identification of human KIF4 (Genbank accession number AF071592). The nucleotide sequence comprised part of the 5) untranslated region (UTR), an open reading frame (ORF) encoding 1232 amino acids, and the entire 3) UTR. Homologies with the mouse KIF4 were 82 % and 85 % for nucleic acids and amino acids, respectively. Although it was found that human KIF4 associates with HIV gag proteins (Tang et al., in press), the function of human KIF4 is yet to be determined. Here we report the mapping of the KIF4 genes to human chromosomes Xq13.1 and 5q33.1.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信