Cytogenetics and cell genetics最新文献_第4页

Assignment of the murine def-3 gene (Rbm6) to chromosome 9F1-F2 and its pseudogenes Rbm6-ps1 and Rbm6-ps2 to chromosome 1 by in situ hybridisation. 小鼠def3基因(Rbm6)在9F1-F2染色体上的原位杂交及其假基因Rbm6-ps1和Rbm6-ps2在1号染色体上的原位杂交。

Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015623

Y M Heng, M Fox, F Sablitzky

引用次数: 1

Genomic organization and assignment of VAMP2 to 17p12 by FISH. VAMP2到17p12的基因组组织和FISH定位。

Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015612

G K Zoraqi, S Paradisi, V Falbo, D Taruscio

引用次数: 2

Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol cotransporter (SLC5A3) gene. 小鼠16号染色体端粒区与人类21q22染色体同源，含有渗透调节Na(+)/肌醇共转运蛋白(SLC5A3)基因。

Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015509

K E McVeigh, J J Mallee, A Lucente, B L Barnoski, S Wu, G T Berry

引用次数: 14

Cooperation of selection and meiotic mechanisms in the production of imbalances in reciprocal translocations. 互惠易位失衡产生中的选择合作与减数分裂机制。

Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015476

T Faraut, M A Mermet, J Demongeot, O Cohen

引用次数: 58

Assignment of SYNJ1 to human chromosome 21q22.2 and Synj12 to the murine homologous region on chromosome 16C3-4 by in situ hybridization. 通过原位杂交将SYNJ1定位到人类染色体21q22.2上，将Synj12定位到小鼠染色体16C3-4上的同源区。

Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015493

O Cremona, M Nimmakayalu, C Haffner, P Bray-Ward, D C Ward, P De Camilli

{"title":"Assignment of SYNJ1 to human chromosome 21q22.2 and Synj12 to the murine homologous region on chromosome 16C3-4 by in situ hybridization.","authors":"O Cremona, M Nimmakayalu, C Haffner, P Bray-Ward, D C Ward, P De Camilli","doi":"10.1159/000015493","DOIUrl":"https://doi.org/10.1159/000015493","url":null,"abstract":"Synaptojanin 1 is a polyphosphoinositide phosphatase highly enriched in nerve terminals (McPherson et al., 1996). The NH2-terminal two thirds of the protein encode two distinct inositol phosphatase modules (a 5)-phosphatase domain and a Sac1-like phosphatase domain), while its proline-rich tail interacts with SH3 and EH domain-containing proteins (McPherson et al., 1996; Haffner et al., 1997; Guo et al., 1999; Cremona et al., 1999). Based on its subcellular localization, the putative function of some of its interactors and genetic studies in yeast, synaptojanin 1 was proposed to play a role in clathrin-mediated synaptic vesicle endocytosis, actin function and signaling (Cremona and De Camilli, 1997). Recent studies on knockout mice have shown that the synaptojanin 1 gene is an essential gene whose inactivation produces alteration of synaptic vesicle recycling. In particular, synaptojanin 1, via its effect on the phosphoinositide metabolism, appears to act as a negative regulator of clathrin coats (Cremona et al., 1999). The gene symbol for the human synaptojanin 1 gene is SYNJ1 and the murine gene symbol is Synj1. The mouse gene Synj1 has been previously mapped to mouse X chromosome region D (observation in Woscholski et al., 1998). Our hybridization results refute the X chromosome assignment and extend the known homology between human chromosome 21q22 and mouse chromosome 16C3–4. The mouse gene for synaptojanin 2 (Synj2) was localized elsewhere (chromosome 17A2–3.1, Khvotchev and Sudhof, 1998). Recently, human intersectin, a synaptojanin 1 interactor, has been assigned upstream to the SYNJ1 gene (chromosome 21q22.1→q22.2, Guipponi et al., 1998).","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21622998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. 人类网状结构4基因(RTN4)在2p14- >2p13染色体上的定位

Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015499

J Yang, L Yu, A D Bi, S Y Zhao

{"title":"Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping.","authors":"J Yang, L Yu, A D Bi, S Y Zhao","doi":"10.1159/000015499","DOIUrl":"https://doi.org/10.1159/000015499","url":null,"abstract":"The human reticulon I gene (RTN1) cloned from a smallcell lung cancer (SCLC) NC1-H82 cell line (Roebroek et al., 1993) and mapped to chromosome 14q21→q22 (Kools et al., 1994) has three alternative transcripts (3.4, 2.3, and 1.8 kb) which can produce three different proteins (NSP-A with 776 amino acids, NSP-B with 356 amino acids and NSP-C with 208 amino acids.) with common carboxyl-terminal regions. These proteins are anchored to membranes of the endoplasmic reticulum and are collectively designated reticulons (Senden et al., 1994). The NSP-A and NSP-C proteins are expressed only in SCLC cells with neuroendocrine phenotypes as shown by Northern blot analysis, so it was proposed that the NSP proteins exist in some relationship with the occurrence of neuroendocrine SCLC (van de Velde et al., 1994). Two other genes whose 3)-regions are homologous to that of RTN1 were cloned and mapped to chromosome 19q13.3 and 11q13 respectively (Roebroek et al., 1998; Moreira et al., 1999). Although their functions are still not clear, they are regarded as members of the reticulon gene family and are called RTN2 and RTN3. Recently, a novel gene whose 3)-region is also homologous to that of RTN1 and which also has 3 alternative transcripts (4632, 2235 and 1617 bp, GenBank nos. AF148537, AF148538 and AF087901) was cloned in our laboratory and named RTN4 (including RTN4A, RTN4B and RTN4C) by the HUGO Nomenclature committee. Here, we report that the RTN4 gene was mapped to chromosome 2p14→p13 by using a radiation hybrid mapping panel.","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21623004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization. CIS6的克隆与表达，原位杂交鉴定染色体3p22和2p21。

Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015490

F Magrangeas, F Apiou, S Denis, U Weidle, Y Jacques, S Minvielle

引用次数: 14

The SRY gene HMG-box in micro- and megabats. SRY基因HMG-box在微兆位和兆位。

Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015479

M Bullejos, A Sánchez, M Burgos, R Jiménez, R Díaz De La Guardia

引用次数: 12

Cloning and mapping of murine superoxide dismutase copper chaperone (Ccsd) and mapping of the human ortholog. 小鼠超氧化物歧化酶铜伴侣蛋白(Ccsd)的克隆、定位和人类同源基因定位。

Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015480

S D Moore, M M Chen, D W Cox