互惠易位失衡产生中的选择合作与减数分裂机制。

T Faraut, M A Mermet, J Demongeot, O Cohen
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引用次数: 58

摘要

我们使用出生时观察到的染色体不平衡后代的数据,以及精子染色体分析的数据,来研究互惠易位的减数分裂分离。利用来自1597名失衡儿童的数据,我们观察到所有失衡模式的母系起源都存在过剩。这种过剩在3:1不平衡模式中特别明显,我们也观察到母亲年龄的影响,表明与常染色体三体密切相关。此外,对34项已发表的精子染色体分析研究数据的统计分析表明,由于生存能力的原因,在出生时产生特定失衡模式的因素似乎也有利于减数分裂产生这种失衡类型。因此,特定类型的不平衡配子的产生受到不平衡大小的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cooperation of selection and meiotic mechanisms in the production of imbalances in reciprocal translocations.

We have used data from chromosomally unbalanced offspring observed at birth, as well as data from sperm chromosome analysis, to study the meiotic segregation of reciprocal translocations. Using data from a total of 1,597 unbalanced children, we have observed an excess in maternal origin for all modes of imbalance. This excess is particularly marked for the 3:1 unbalanced mode, for which we have also observed a maternal age effect, indicating a close relationship with autosomal trisomies. In addition, a statistical analysis of data from 34 different published studies using sperm chromosome analysis has demonstrated that factors which, for reasons of viability, produce a predisposition for a particular mode of imbalance at birth also appear to favor meiotic production of this type of imbalance. Thus the production of unbalanced gametes of a particular type is influenced by the size of the imbalance.

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