Current Opinion in Allergy and Clinical Immunology最新文献_第4页

Circadian control of innate immunity: molecular mechanisms and implications for allergic disorders. 先天免疫的昼夜节律控制：分子机制及其对过敏性疾病的影响。

IF 2.6 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-09 DOI: 10.1097/ACI.0000000000001176

Ammar Nahas, Daniel Zammit Lupi, Beatriz Nunez Colao, Keith Sacco

{"title":"Circadian control of innate immunity: molecular mechanisms and implications for allergic disorders.","authors":"Ammar Nahas, Daniel Zammit Lupi, Beatriz Nunez Colao, Keith Sacco","doi":"10.1097/ACI.0000000000001176","DOIUrl":"https://doi.org/10.1097/ACI.0000000000001176","url":null,"abstract":"Purpose of review: Circadian clocks are increasingly recognized as fundamental regulators of innate immune function, yet their relevance to allergy and clinical immunology has only recently been clarified. This review summarizes emerging evidence linking circadian regulation of innate immune cells to allergic inflammation and highlights the translational potential of circadian-informed therapeutic strategies.Recent findings: Core clock components are rhythmically expressed in macrophages, mast cells, neutrophils and innate lymphoid cells, where they regulate inflammatory signalling, immunometabolism and activation thresholds. Disruption of these rhythms exaggerates cytokine production, inflammasome activation and mast cell mediator release, contributing to diurnal patterns of allergic disease such as nocturnal asthma. Human and experimental studies demonstrate that circadian misalignment driven by shift work, irregular sleep and mistimed feeding amplifies innate inflammation and worsens allergic outcomes.Summary: Circadian regulation represents an underappreciated dimension of innate immunity in allergic disease. Aligning immunomodulatory therapies, vaccination, and lifestyle interventions with endogenous immune rhythms offers a rational approach to improving efficacy and reducing inflammatory burden. Future studies should prioritize time-stratified clinical trials and direct circadian phenotyping in allergic populations.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biologics for chronic rhinosinusitis with nasal polyps: from downstream cytokine blockade to upstream epithelial targets. 慢性鼻窦炎伴鼻息肉的生物制剂：从下游细胞因子阻断到上游上皮靶点。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-01 Epub Date: 2026-04-04 DOI: 10.1097/ACI.0000000000001146

Farah Dayana Zahedi, Baharudin Abdullah, Pongsakorn Tantilipikorn

{"title":"Biologics for chronic rhinosinusitis with nasal polyps: from downstream cytokine blockade to upstream epithelial targets.","authors":"Farah Dayana Zahedi, Baharudin Abdullah, Pongsakorn Tantilipikorn","doi":"10.1097/ACI.0000000000001146","DOIUrl":"10.1097/ACI.0000000000001146","url":null,"abstract":"Purpose of review: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogenous inflammatory disease that often persist despite optimal medical and surgical treatment. Advances in the understanding of CRS immunopathophysiology have led to the development of biologic therapies targeting specific inflammatory pathways. This review summarizes the current knowledge on the downstream biologics and the latest update on the next generation upstream biologics therapies in CRSwNP, with focus on endotype-driven treatment selection.Recent findings: Biologic therapies targeting downstream mediators of type 2 inflammation, including immunoglobulin E and interleukins interleukin (IL)-4, IL-5 and IL-13, have demonstrated substantial clinical benefit in selected patients. Nevertheless, CRSwNP commonly involves overlapping inflammatory endotypes, which may limit treatment response. Newer biologics targeting upstream epithelial-derived cytokines offer broader approach by modulating multiple inflammatory pathways simultaneously and may address current therapeutic gaps. The development of long-acting biologics also improves treatment convenience and adherence.Summary: Biologic therapy has shifted CRSwNP management towards a more personalized, mechanism-based approach. Upstream-targeted treatments represent an important step forward, particularly for patients with refractory or mixed disease. Future research should focus on biomarker-guided therapy and long-term clinical outcomes.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"149-156"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of platelet-rich plasma on surgical outcomes in chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis. 富血小板血浆对慢性鼻窦炎合并鼻息肉手术结果的影响：一项系统综述和荟萃分析。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-01 Epub Date: 2026-04-04 DOI: 10.1097/ACI.0000000000001148

Linger Sim, Thevagi Maruthamuthu, Khairudin Abdullah, Baharudin Abdullah

{"title":"Effect of platelet-rich plasma on surgical outcomes in chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis.","authors":"Linger Sim, Thevagi Maruthamuthu, Khairudin Abdullah, Baharudin Abdullah","doi":"10.1097/ACI.0000000000001148","DOIUrl":"10.1097/ACI.0000000000001148","url":null,"abstract":"Purpose of review: This review evaluates the current evidence on the effectiveness of platelet-rich plasma (PRP) as an adjuvant therapy to endoscopic sinus surgery (ESS) in adults with chronic rhinosinusitis with nasal polyps (CRSwNP).Recent findings: Nine randomized controlled trials involving 488 participants were included. PRP significantly improved mucosal healing based on postoperative endoscopic scores, particularly when delivered via injection into the middle meatus or olfactory region. Borderline improvements in olfactory function were observed, with significant benefits when PRP was applied directly to the olfactory region. PRP consistently reduced postoperative pain, scarring or synechiae, bleeding, crusting and oedema. No significant improvement was found in health-related quality of life (SNOT-22). Heterogeneity across studies was substantial, largely due to variations in PRP preparation, delivery methods and outcome assessment.Summary: PRP appears to be a promising adjunct to ESS, offering improvements in mucosal healing and postoperative recovery, with potential but uncertain benefits for olfactory outcomes. Standardized, larger-scale trials are needed to further define optimal administration and long-term efficacy.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"166-175"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in food allergy immunotherapy: oral immunotherapy, epicutaneous immunotherapy, and sublingual immunotherapy. 食物过敏免疫治疗的最新进展：口服免疫治疗、表皮免疫治疗和舌下免疫治疗。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-01 Epub Date: 2026-04-17 DOI: 10.1097/ACI.0000000000001152

Jessica Kobylarz, Hemali Gauri, Sayantani B Sindher

{"title":"Recent advances in food allergy immunotherapy: oral immunotherapy, epicutaneous immunotherapy, and sublingual immunotherapy.","authors":"Jessica Kobylarz, Hemali Gauri, Sayantani B Sindher","doi":"10.1097/ACI.0000000000001152","DOIUrl":"10.1097/ACI.0000000000001152","url":null,"abstract":"Purpose of review: Food allergy immunotherapy strategies including oral, epicutaneous, and sublingual remain some of the most effective therapeutic options for food allergic patients and are currently the only therapeutic options that are expected to have the potential for long-lasting therapeutic benefits after therapy has ended.Recent findings: Recent studies have identified novel ways of implementing food allergy immunotherapy, including the use of real-world foods for oral immunotherapy and sublingual immunotherapy. Other studies have uncovered key mechanisms for how these therapies induce desensitization to food allergens and sustained unresponsiveness. Notably, many of these mechanisms have the potential for monitoring or predicting therapeutic response.Summary: The landscape of food allergy immunotherapy is changing to adapt to the shifting food allergy therapeutic landscape. Many studies are now shifting away from commercial or pharmaceutical products in order to increase accessibility with real world food options.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":"26 3","pages":"201-206"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basophil activation test in food allergy: where are we now? 食物过敏中的嗜碱性粒细胞激活试验：进展如何？

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-01 Epub Date: 2026-04-06 DOI: 10.1097/ACI.0000000000001151

Malgorzata Niegowska, Rocco Luigi Valluzzi, Stefania Arasi

{"title":"Basophil activation test in food allergy: where are we now?","authors":"Malgorzata Niegowska, Rocco Luigi Valluzzi, Stefania Arasi","doi":"10.1097/ACI.0000000000001151","DOIUrl":"10.1097/ACI.0000000000001151","url":null,"abstract":"Purpose of review: To highlight the most recent findings on the basophil activation test (BAT) in food allergy, with a focus on advances in assay standardization and logistics, and on emerging clinical applications across major allergens aimed at improving diagnostic accuracy and reducing the need for oral food challenges.Recent findings: Recent literature supports BAT as a useful tool to complement history, skin prick testing, and specific IgE, particularly in equivocal cases where oral food challenge (OFC) would otherwise be required. Evidence is strongest for peanut and sesame, with expanding data for milk, egg, and tree nuts, including algorithm-based approaches for cross-reactive nuts. Methodological advances include delayed processing strategies, streamlined multicentre workflows, and passive/indirect BAT approaches, alongside international initiatives aimed at harmonizing performance across laboratories. However, nonresponder rates, lack of universal thresholds, and heterogeneous performance between foods remain key limitations, and severity prediction is inconsistent across settings.Summary: BAT can enhance diagnostic certainty and may reduce OFC use in selected scenarios, but broader implementation requires harmonized protocols, prospective validation of clinically actionable cut-offs, and robust multicentre outcome studies.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"227-232"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat generation and thermal safety of powered instrumentation in endoscopic sinus surgery. 内窥镜鼻窦手术中动力器械的产热及热安全性。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-01 Epub Date: 2026-03-30 DOI: 10.1097/ACI.0000000000001147

Farah Dayana Zahedi, Pongsakorn Tantilipikorn, Baharudin Abdullah

{"title":"Heat generation and thermal safety of powered instrumentation in endoscopic sinus surgery.","authors":"Farah Dayana Zahedi, Pongsakorn Tantilipikorn, Baharudin Abdullah","doi":"10.1097/ACI.0000000000001147","DOIUrl":"10.1097/ACI.0000000000001147","url":null,"abstract":"Purpose of review: This narrative review aims to summarize current evidence on thermal energy generation during endoscopic sinus surgery (ESS), with particular emphasis on the powered devices, their safe application, and an understanding of device-specific thermal characteristics.Recent findings: Powered instrumentation has become integral to ESS, contributing to improved precision, efficiency, and visualization. However, different powered devices generate heat through distinct mechanisms related to their design, operating principles, and patterns of tissue interaction. Heat-related effects may occur during the use of microdebriders, coblation, radiofrequency, high-speed drills, and laser systems. The risk of thermal injury to sinonasal mucosa, bone, and adjacent critical structures is influenced by both device characteristics and operator-dependent factors, including activation time, contact time, and cooling techniques. Tissue injury depends not only on peak temperatures achieved but also on the duration and cumulative burden of heat exposure.Summary: Appropriate selection and informed use of powered instruments are central to minimizing thermal risk in ESS. A thorough understanding of how different devices generate and dissipate heat, together with attention to modifiable operative factors, can enhance surgical safety and reduce the likelihood of thermal injury.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"157-165"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food allergy at a turning point: from passive management to precision intervention. 转折点上的食物过敏：从被动管理到精准干预。

IF 2.6 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-01 Epub Date: 2026-04-29 DOI: 10.1097/ACI.0000000000001157

Alessandro Fiocchi, Motohiro Ebisawa

引用次数: 0

Food allergy prevention by early introduction. 早期引入预防食物过敏。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-01 Epub Date: 2026-04-08 DOI: 10.1097/ACI.0000000000001160

Lamia Dahdah, Carmen Mazzuca, Sara Urbani, Alessandro Fiocchi

{"title":"Food allergy prevention by early introduction.","authors":"Lamia Dahdah, Carmen Mazzuca, Sara Urbani, Alessandro Fiocchi","doi":"10.1097/ACI.0000000000001160","DOIUrl":"10.1097/ACI.0000000000001160","url":null,"abstract":"Purpose of review: Food allergy prevalence has increased substantially over the past two decades, particularly for peanut and egg, with significant clinical and psychosocial consequences. Earlier recommendations advocating delayed allergen introduction lacked supporting evidence and may have contributed to this trend. This review summarizes current evidence supporting early allergen introduction for primary prevention.Recent findings: Recent advances in immunology demonstrate that oral tolerance is an active process promoted by early gastrointestinal exposure during a critical window in infancy. The dual-allergen exposure hypothesis suggests that impaired skin barrier exposure leads to sensitization, whereas early oral intake induces tolerance. Randomized controlled trials have transformed the field: the LEAP study showed a marked reduction in peanut allergy, and trials such as PETIT demonstrated benefit for heated egg. Meta-analyses confirm high-certainty evidence for peanut and egg, with emerging but less robust data for other allergens.Summary: Early allergen introduction is now a key strategy for food allergy prevention, with important implications for clinical practice and guideline development. Implementation requires attention to safety, appropriate food forms, and local context. Future research should address optimal dosing, duration, and applicability across diverse populations.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"221-226"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stepwise oral food challenge test. 逐步口腔食物激发试验。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-01 Epub Date: 2026-04-10 DOI: 10.1097/ACI.0000000000001149

Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa

{"title":"Stepwise oral food challenge test.","authors":"Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa","doi":"10.1097/ACI.0000000000001149","DOIUrl":"10.1097/ACI.0000000000001149","url":null,"abstract":"Purpose of review: The oral food challenge (OFC) remains the cornerstone procedure for diagnosing food allergies and guiding patient management. Recently, stepwise OFC, a new management strategy starting with very-low-dose (VLD) or low-dose OFC, has been reported. This review critically examines the clinical utility and safety profile of stepwise OFC approaches.Recent findings: The stepwise OFC typically begins with a VLD or low-dose OFC, which is the most critical step in this approach. VLD and low-dose OFCs have been demonstrated to be useful strategies for avoiding complete elimination of causative foods and improving prognosis. Regarding safety considerations, a time interval of 30 min between doses may be insufficient, whereas an interval of at least 1 h is considered appropriate for stepwise OFC.Summary: Stepwise OFCs starting with VLD or low-dose appear to be effective approaches. VLD and low-dose OFCs are well tolerated and effective for avoiding complete elimination of allergenic foods. VLD and low-dose OFCs, as part of stepwise OFC, represent useful strategies for improving the prognosis of children with food allergies.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"193-200"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biologics in IgE-mediated food allergy: where are we know? ige介导的食物过敏中的生物制剂：我们知道什么？

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2026-06-01 Epub Date: 2026-04-08 DOI: 10.1097/ACI.0000000000001158

Lucia Lo Scalzo, Arianna Cafarotti, Stefania Arasi

{"title":"Biologics in IgE-mediated food allergy: where are we know?","authors":"Lucia Lo Scalzo, Arianna Cafarotti, Stefania Arasi","doi":"10.1097/ACI.0000000000001158","DOIUrl":"10.1097/ACI.0000000000001158","url":null,"abstract":"Purpose of review: This review summarizes current evidence on emerging biologics and their evolving role in IgE-mediated food allergy management. The goal is to assess the pros and cons of currently available and under evaluation biologicals.Recent findings: Anti-IgE therapies remain central to biologic-based approaches. Omalizumab improves desensitization rates as monotherapy or when combined with oral immunotherapy (OIT), whose enhances safety and accelerates desensitization efficacy. Next-generation anti-IgE antibodies, including UB-221, show increased potency and promising early results. Less encouraging are data on Dupilumab, targeting IL-4/IL1-3 receptor, in IgE-mediated food allergy. Biologics targeting epithelial alarmins, such as anti-IL-33 (etokimab) and anti-TSLP (tezepelumab), demonstrate encouraging preliminary immunologic and clinical effects, with early success noted in peanut allergy trials. Further research focus is devoted to small molecules and vaccines.Summary: Biologics offer a meaningful advance in food allergy treatment by targeting key immune pathways with an agnostic approach, therefore, independent on the specific antigen-specificity. This may offer the benefit of targeting multiple food allergies and also, eventually, further co-morbidities. There is broad evidence for an excellent safety profile for omalizumab. Studies are ongoing on other biologicals to explore the efficacy alongside the safety. A new era is also opened by the introduction of biosimilar on the market, by dramatically amortizing the economic burden. With the availability of multiple therapeutic options, the challenge for clinicians is to provide a personalized approach, shaped on the specific patient's need.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"207-213"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0