Current Opinion in Allergy and Clinical Immunology最新文献_第10页

Understanding the heterogeneity of childhood allergic sensitization and its relationship with asthma. 了解儿童过敏致敏的异质性及其与哮喘的关系。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-02-07 DOI: 10.1097/ACI.0000000000000967

Adnan Custovic, Darije Custovic, Sara Fontanella

{"title":"Understanding the heterogeneity of childhood allergic sensitization and its relationship with asthma.","authors":"Adnan Custovic, Darije Custovic, Sara Fontanella","doi":"10.1097/ACI.0000000000000967","DOIUrl":"10.1097/ACI.0000000000000967","url":null,"abstract":"Purpose of review: To review the current state of knowledge on the relationship between allergic sensitization and asthma; to lay out a roadmap for the development of IgE biomarkers that differentiate, in individual sensitized patients, whether their sensitization is important for current or future asthma symptoms, or has little or no relevance to the disease.Recent findings: The evidence on the relationship between sensitization and asthma suggests that some subtypes of allergic sensitization are not associated with asthma symptoms, whilst others are pathologic. Interaction patterns between IgE antibodies to individual allergenic molecules on component-resolved diagnostics (CRD) multiplex arrays might be hallmarks by which different sensitization subtypes relevant to asthma can be distinguished. These different subtypes of sensitization are associated amongst sensitized individuals at all ages, with different clinical presentations (no disease, asthma as a single disease, and allergic multimorbidity); amongst sensitized preschool children with and without lower airway symptoms, with different risk of subsequent asthma development; and amongst sensitized patients with asthma, with differing levels of asthma severity.Summary: The use of machine learning-based methodologies on complex CRD data can help us to design better diagnostic tools to help practising physicians differentiate between benign and clinically important sensitization.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"79-87"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 vaccination in primary antibody deficiencies: an overview on efficacy, immunogenicity, durability of immune response and safety. 一抗缺乏的SARS-CoV-2疫苗接种:有效性、免疫原性、免疫反应持久性和安全性综述

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-11-14 DOI: 10.1097/ACI.0000000000000955

Gabriella Cusa, Germano Sardella, Giulia Garzi, Davide Firinu, Cinzia Milito

{"title":"SARS-CoV-2 vaccination in primary antibody deficiencies: an overview on efficacy, immunogenicity, durability of immune response and safety.","authors":"Gabriella Cusa, Germano Sardella, Giulia Garzi, Davide Firinu, Cinzia Milito","doi":"10.1097/ACI.0000000000000955","DOIUrl":"10.1097/ACI.0000000000000955","url":null,"abstract":"Purpose of review: This review aims to summarize the current best knowledge on the efficacy of COVID-19 vaccination in vulnerable patients affected by primary antibody deficiencies (PADs), both in patients previously infected and vaccine-immunized, focusing also on the durability, on the need for multiple booster doses and on the safety of anti-SARS-CoV-2 vaccines.Recent findings: Patients vaccinated for SARS-CoV2 have variable humoral response, still showing a tendency towards an increase in antibody titers, with factors such as booster doses, previous infections, age and specific genetic mutations influencing the outcome. Long-lasting cellular responses to SARS-CoV-2 vaccination instead, mostly of the T-cell type, have been observed. Overall, the duration of protection given by vaccinations is sufficient and increased upon further simulations. Furthermore, the safety profile in PID patients is excellent, with most adverse events being transient and mild and no major adverse event reported.Summary: Several studies have emphasized the benefit of vaccinating patients with PADs against the SARS-CoV-2 virus and the necessity of administering booster doses. This review, by gathering the most recent and significant data from the scientific literature, could be helpful in clinical practice in the management of disease prevention in patients affected by primary immunodeficiency and also serve as inspiration for further in-depth clinical research.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"37-43"},"PeriodicalIF":2.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92153142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introductions. 编辑介绍。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-12-20 DOI: 10.1097/ACI.0000000000000957

引用次数: 0

Chronic rhinosinusitis with nasal polyps: eosinophils versus B lymphocytes in disease pathogenesis. 慢性鼻窦炎伴鼻息肉:嗜酸性粒细胞与B淋巴细胞在疾病发病机制中的作用

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-11-27 DOI: 10.1097/ACI.0000000000000959

Harsha H Kariyawasam, Louisa K James

{"title":"Chronic rhinosinusitis with nasal polyps: eosinophils versus B lymphocytes in disease pathogenesis.","authors":"Harsha H Kariyawasam, Louisa K James","doi":"10.1097/ACI.0000000000000959","DOIUrl":"10.1097/ACI.0000000000000959","url":null,"abstract":"Purpose of review: To highlight the current evidence that supports the view that eosinophils may not drive disease in chronic rhinosinusitis with nasal polyps (CRSwNP) and the emerging evidence for B cells as an important player in this disease.Recent findings: Eosinophil depletion studies in CRSwNP do not fully support a critical role for eosinophils in CRSwNP. Almost complete eosinophil depletion with dexpramipexole had no impact on polyp size reduction or clinical improvement. Anti-interleukin (IL)-5 and IL-5Rα inhibition were more effective though with less clinical impact when compared to anti-immunoglobulin E (IgE) or IL-4Rα inhibition strategies. As IL-5Rα is also expressed on CRSwNP derived IgE+ and IgG4+ plasma cells to the same extent as eosinophils, improvements in CRSwNP with IL-5 inhibition may suggest a role for B cells over eosinophils in CRSwNP. We review both eosinophils and B cells in the context of CRSwNP and highlight the current evidence that supports an emerging role for B cells.Summary: Despite many aspects of immunopathology in CRSwNP explainable by B cell dysfunction, B cells have so far been ignored in CRSwNP. Further work is needed, as targeting B cells may offer an exciting new therapeutic option in the future.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"15-24"},"PeriodicalIF":2.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderate asthma: burden, mechanisms and therapeutic perspectives. 中度哮喘:负担、机制和治疗前景。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-10-25 DOI: 10.1097/ACI.0000000000000953

Laura De Ferrari, Anna Maria Riccio, Fulvio Braido

引用次数: 0

Endotypic heterogeneity and pathogenesis in chronic rhinosinusitis. 慢性鼻窦炎的内型异质性及其发病机制。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-11-15 DOI: 10.1097/ACI.0000000000000954

Junqin Bai, Bruce K Tan, Atsushi Kato

{"title":"Endotypic heterogeneity and pathogenesis in chronic rhinosinusitis.","authors":"Junqin Bai, Bruce K Tan, Atsushi Kato","doi":"10.1097/ACI.0000000000000954","DOIUrl":"10.1097/ACI.0000000000000954","url":null,"abstract":"Purpose of review: This review aims to provide updates in realms of endotypic heterogeneity, pathogenesis at the molecular level, potential of biomarkers, and cutting-edge scope of biologics in CRS.Recent findings: High-dimensional analyses, such as transcriptomes, and machine learning, have significantly enhanced CRS endotyping, uncovering diverse pathogenetic mechanisms contributing to its heterogeneity. The dynamic process of epithelial remodeling in CRS pathogenesis has gained more clarity and support as exemplified by IL-13 and oncostatin M (OSM) that are shown intricately linked to epithelial barrier dysfunction. Moreover, anti-dsDNA autoantibody, BAFF, periostin, and cystatin SN show promise as potentials biomarkers, offering diagnostic and prognostic value for CRS.Summary: The identification of inflammatory molecules involved in endotype specific signaling pathways provides insights into the underlying mechanisms and verifiable biomarkers for diagnosis and prediction of disease severity. More comprehensive clinical studies should be conducted to facilitate biologics from bench to bedside in treating CRS.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"1-8"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10873077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107590496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction of eosinophilic and neutrophilic inflammation in patients with chronic rhinosinusitis. 慢性鼻窦炎患者嗜酸性粒细胞和中性粒细胞炎症的相互作用。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-11-15 DOI: 10.1097/ACI.0000000000000956

Yutong Sima, Xiangdong Wang, Luo Zhang

{"title":"Interaction of eosinophilic and neutrophilic inflammation in patients with chronic rhinosinusitis.","authors":"Yutong Sima, Xiangdong Wang, Luo Zhang","doi":"10.1097/ACI.0000000000000956","DOIUrl":"10.1097/ACI.0000000000000956","url":null,"abstract":"Purpose of review: In the past year, the endotype of chronic rhinosinusitis (CRS) has been studied from a new perspective. Eosinophilic and neutrophilic inflammation are not independent processes in the pathogenesis of CRS. In this review, we will focus on recent research on mixed eosinophilic-neutrophilic inflammation in CRS and discuss the mechanism and potential treatments.Recent findings: Traditionally, patients with eosinophilic CRS (ECRS) present with severe clinical manifestations, comorbidities, and a higher recurrence rate. Recent studies have found that approximately 40% of patients with ECRS present with neutrophilic infiltration, while patients with predominantly eosinophilic infiltration along with neutrophilic inflammation present with more complex inflammation, clinical manifestations and exhibit refractory characteristics.Summary: The complex inflammatory profile and refractory clinical characteristics of mixed eosinophilic-neutrophilic inflammation in CRS are current challenges for clinicians. We summarize the features of eosinophilic and neutrophilic inflammation and current studies on the mechanisms of mixed eosinophilic-neutrophilic inflammation and suggest potentially effective therapeutic methods. We hope that this review will help with determining precise treatment options for patients.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"25-31"},"PeriodicalIF":2.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107590497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upper and lower airway interactions in children. 儿童上呼吸道和下呼吸道相互作用。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-12-01 DOI: 10.1097/ACI.0000000000000960

Fernando M de Benedictis

{"title":"Upper and lower airway interactions in children.","authors":"Fernando M de Benedictis","doi":"10.1097/ACI.0000000000000960","DOIUrl":"10.1097/ACI.0000000000000960","url":null,"abstract":"Purpose of review: The aim of the present review was to highlight the interactions between rhinitis, rhinosinusitis and asthma in children and to discuss the most relevant scientific progresses in the pathophysiology and treatment of these combined conditions.Recent findings: Advances in understanding the mechanisms underlying the relationship between upper and lower airways have provided valuable insights into the role of eosinophils in the pathophysiology of inflammatory events and have further delineated the concept of united airway disease. Studies addressed to evaluate the burden of sinonasal system on asthma outcomes showed a parallel severity of upper and lower airway diseases. Histopathology of sinonasal tissue in patients with chronic rhinosinusitis is different in adults and children. Targeted administration of biological agents represents an effective treatment in patients with severe uncontrolled asthma, but specific trials are awaited in children with chronic sinonasal disease.Summary: Allergic rhinitis and rhinosinusitis are important comorbidities in patients with asthma. Improved knowledge of pathogenic mechanisms of inflammation and remodelling in the sinonasal system and the lung has led to new therapeutic approaches in patients with united airway disease and opened interesting perspectives for personalized drug therapies.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"9-14"},"PeriodicalIF":2.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atopic manifestations of inborn errors of immunity. 先天性免疫错误的特应性表现。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2023-12-01 Epub Date: 2023-09-26 DOI: 10.1097/ACI.0000000000000943

Laura Sams, Sonali Wijetilleka, Mark Ponsford, Andrew Gennery, Stephen Jolles

引用次数: 0

Inborn errors of immunity underlying defective T-cell memory. 先天性免疫错误导致T细胞记忆缺陷。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2023-12-01 Epub Date: 2023-10-05 DOI: 10.1097/ACI.0000000000000946

David Boutboul, Capucine Picard, Sylvain Latour

{"title":"Inborn errors of immunity underlying defective T-cell memory.","authors":"David Boutboul, Capucine Picard, Sylvain Latour","doi":"10.1097/ACI.0000000000000946","DOIUrl":"10.1097/ACI.0000000000000946","url":null,"abstract":"Purpose of review: T-cell memory is a complex process not well understood involving specific steps, pathways and different T-cell subpopulations. Inborn errors of immunity (IEIs) represent unique models to decipher some of these requirements in humans. More than 500 different IEIs have been reported to date, and recently a subgroup of monogenic disorders characterized by memory T-cell defects has emerged, providing novel insights into the pathways of T-cell memory generation and maintenance, although this new knowledge is mostly restricted to peripheral blood T-cell memory populations.Recent findings: This review draws up an inventory of the main and recent IEIs associated with T-cell memory defects and their mice models, with a particular focus on the nuclear factor kappa B (NF-κB) signalling pathway, including the scaffold protein capping protein regulator and myosin 1 linker 2 (CARMIL2) and the T-cell co-stimulatory molecules CD28 and OX-40. Besides NF-κB, IKZF1 (IKAROS), a key transcription factor of haematopoiesis and STAT3-dependent interleukin-6 signals involving the transcription factor ZNF341 also appear to be important for the generation of T cell memory. Somatic reversion mosaicism in memory T cells is documented for several gene defects supporting the critical role of these factors in the development of memory T cells with a potential clinical benefit.Summary: Systematic examination of T-cell memory subsets could be helpful in the diagnosis of IEIs.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"491-499"},"PeriodicalIF":2.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41114816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0