Current Opinion in Allergy and Clinical Immunology最新文献_第10页

Is allergen immunotherapy a model of personalized treatment in pediatric respiratory allergy? 过敏原免疫疗法是儿科呼吸道过敏症个性化治疗的典范吗？

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-02-12 DOI: 10.1097/ACI.0000000000000968

Gustavo Falbo Wandalsen, Fernando Monteiro Aarestrup, Dirceu Solé

{"title":"Is allergen immunotherapy a model of personalized treatment in pediatric respiratory allergy?","authors":"Gustavo Falbo Wandalsen, Fernando Monteiro Aarestrup, Dirceu Solé","doi":"10.1097/ACI.0000000000000968","DOIUrl":"10.1097/ACI.0000000000000968","url":null,"abstract":"Purpose of review: To review recent evidence on allergen immunotherapy (AIT) as a model of personalized medicine in the treatment of children and adolescents with respiratory allergies.Recent findings: Meta-analysis and systematic review studies continue to point out that AIT is an effective treatment for children with respiratory allergies. Molecular allergy allows the understanding of patient sensitization profiles that frequently change the prescription of AIT. There is still a lack of evidence showing that this personalized prescription of AIT is associated with better clinical outcomes. The nasal allergen challenge has extended the indications of AIT for a new group of subjects with local allergic rhinitis. Patient selection of allergens involved in the increasingly personalized composition of extracts to be used in AIT increasingly characterizes it as personalized medicine.Summary: Despite the numerous studies carried out to identify the best biomarker to evaluate the response to AIT, there is still much disagreement, and clinical assessment (symptoms, quality of life, among others) continues to be the best way to evaluate the therapeutic success of AIT.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"88-93"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of the relationship between allergic bronchopulmonary aspergillosis and asthma. 过敏性支气管肺曲霉菌病与哮喘之间的流行病学关系。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-01-30 DOI: 10.1097/ACI.0000000000000971

Matteo Maule, Joana Vitte, Francesca Ambrosani, Marco Caminati

{"title":"Epidemiology of the relationship between allergic bronchopulmonary aspergillosis and asthma.","authors":"Matteo Maule, Joana Vitte, Francesca Ambrosani, Marco Caminati","doi":"10.1097/ACI.0000000000000971","DOIUrl":"10.1097/ACI.0000000000000971","url":null,"abstract":"Purpose of review: Allergic bronchopulmonary aspergillosis (ABPA) can complicate the natural history of asthmatic patients, especially the more severe ones, worsening disease control and increasing the need for therapies, steroids in particular, and medical care. The aim of the present review is to summarize the latest epidemiological data related to the relationship between asthma and ABPA and to offer a summary of the most recent strategies that could potentially facilitate in the identification of ABPA in asthmatic patients.Recent findings: In the last years, great efforts have been made by researchers worldwide to provide reliable epidemiological data on fungal sensitization and ABPA, especially in severe asthma patients both in adult and pediatric population. Data differ depending on the geographical area and population studied, but pooled data show a concerning 11% of severe asthma patients having ABPA and one out of four asthmatic patients being sensitized to fungi, Aspergillus fumigatus in particular.Summary: Reliable epidemiological data and advances in the diagnostic procedures can facilitate the detection of ABPA among asthmatic patients, improving the management of a still under-recognized and challenging condition.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"102-108"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcome of occupational asthma with different etiology. 不同病因的职业性哮喘的长期疗效。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2023-12-21 DOI: 10.1097/ACI.0000000000000962

Hille Suojalehto, Irmeli Lindström

{"title":"Long-term outcome of occupational asthma with different etiology.","authors":"Hille Suojalehto, Irmeli Lindström","doi":"10.1097/ACI.0000000000000962","DOIUrl":"10.1097/ACI.0000000000000962","url":null,"abstract":"Purpose of review: This review summarizes the recent literature on the long-term outcome of sensitizer-induced and irritant-induced occupational asthma.Recent findings: Recent studies of sensitizer-induced occupational asthma show that after the offending exposure has ceased, most patients report at least partial relief of symptoms. However, in the long term, the diagnosis may negatively impact their careers, incomes, and quality of life. The studies also offer new insights into diisocyanate-induced occupational asthma phenotypes and asthma remission rates. One third of these cases were in remission in long-term after reduction or cessation of exposure. The long-term prognosis of irritant-induced occupational asthma was demonstrated to be poorer than sensitizer-induced occupational asthma. Older age, low fractional exhaled nitric oxide levels and uncontrolled asthma at the time of diagnosis predicted uncontrolled asthma in the long term in patients with irritant and low-molecular-weight sensitizer induced occupational asthma.Summary: Recent studies provide further evidence of the long-term outcome of different occupational asthma phenotypes and the factors that affect them. These findings help us identify patients at risk of poor asthma outcomes, who need close monitoring and support. It should also be borne in mind that occupational asthma diagnosis may have wider-ranging negative impacts on patients' lives.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"64-68"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New causes of occupational allergic contact dermatitis. 职业性过敏性接触性皮炎的新原因。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2023-11-30 DOI: 10.1097/ACI.0000000000000961

Meghan Clynick, Dorothy Linn Holness

{"title":"New causes of occupational allergic contact dermatitis.","authors":"Meghan Clynick, Dorothy Linn Holness","doi":"10.1097/ACI.0000000000000961","DOIUrl":"10.1097/ACI.0000000000000961","url":null,"abstract":"Purpose of review: Occupational allergic contact dermatitis (OACD) is an important work-related skin disease. Information about the causative agents comes from many sources, including patch test databases, registries, case series and case reports. This review summarizes new information about common causative allergens and diagnosis.Recent findings: Common causes of OACD include rubber components, epoxies and preservatives. New exposure sources for these allergens continue to be described. Often these exposure sources are related to the changing world around us, such as allergens related to smartphones and technology, and personal protective equipment-related exposures during the COVID-19 pandemic. New allergens are also being described, some of which are related to known allergens (e.g. a new epoxy or acrylate component).Accurate diagnosis is critical to effective management of OACD, which may include removing the worker from exposure to the causative allergen. Safety data sheets may not contain complete information and patch testing with specialized series of allergens and workplace materials may be necessary.Summary: This review provides current evidence about causes of OACD and important aspects of diagnosis. This is important for clinical practice to ensure cases of OACD are not missed.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"51-57"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endotypes of occupational asthma. 职业性哮喘的内型。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-01-30 DOI: 10.1097/ACI.0000000000000969

Paola Mason, Marco Biasioli, Filippo Liviero

{"title":"Endotypes of occupational asthma.","authors":"Paola Mason, Marco Biasioli, Filippo Liviero","doi":"10.1097/ACI.0000000000000969","DOIUrl":"10.1097/ACI.0000000000000969","url":null,"abstract":"Purpose of review: To describe recent findings in endotyping occupational asthma by addressing the role of specific biomarkers.Recent findings: Studies on occupational asthma endotypes have focused on immune and inflammatory patterns associated with different occupational exposures to sensitizers or irritants.Sputum neutrophilia has been found in 58.5% patients with occupational asthma caused by high molecular weight (HMW) agents, and work-related dysphonia in patients with occupational asthma was described as associated with sputum neutrophilia too. Neutrophils have been associated also with irritant-induced asthma. The measurement of specific IgE has been confirmed as a valuable diagnostic tool in occupational asthma caused by HMW agents, on the contrary, for most low-molecular-weight agents, the presence of specific IgE has been proven in a small subset of affected workers. Fractional exhaled nitric oxide has been confirmed as a marker of type 2 (T2) inflammation in occupational asthma, mostly when induced by HMW agents (e.g. flour), and it has proved to be more sensitive than spirometry in measuring the efficacy of an intervention.MicroRNA-155 has been shown to contribute to airway inflammation in occupational asthma induced by toluene diisocyanate.Summary: Occupational asthma is heterogeneous, thus monitoring multiple biomarkers is crucial to understand, which inflammatory responses are prevalent.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"58-63"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the heterogeneity of childhood allergic sensitization and its relationship with asthma. 了解儿童过敏致敏的异质性及其与哮喘的关系。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-02-07 DOI: 10.1097/ACI.0000000000000967

Adnan Custovic, Darije Custovic, Sara Fontanella

{"title":"Understanding the heterogeneity of childhood allergic sensitization and its relationship with asthma.","authors":"Adnan Custovic, Darije Custovic, Sara Fontanella","doi":"10.1097/ACI.0000000000000967","DOIUrl":"10.1097/ACI.0000000000000967","url":null,"abstract":"Purpose of review: To review the current state of knowledge on the relationship between allergic sensitization and asthma; to lay out a roadmap for the development of IgE biomarkers that differentiate, in individual sensitized patients, whether their sensitization is important for current or future asthma symptoms, or has little or no relevance to the disease.Recent findings: The evidence on the relationship between sensitization and asthma suggests that some subtypes of allergic sensitization are not associated with asthma symptoms, whilst others are pathologic. Interaction patterns between IgE antibodies to individual allergenic molecules on component-resolved diagnostics (CRD) multiplex arrays might be hallmarks by which different sensitization subtypes relevant to asthma can be distinguished. These different subtypes of sensitization are associated amongst sensitized individuals at all ages, with different clinical presentations (no disease, asthma as a single disease, and allergic multimorbidity); amongst sensitized preschool children with and without lower airway symptoms, with different risk of subsequent asthma development; and amongst sensitized patients with asthma, with differing levels of asthma severity.Summary: The use of machine learning-based methodologies on complex CRD data can help us to design better diagnostic tools to help practising physicians differentiate between benign and clinically important sensitization.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"79-87"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 vaccination in primary antibody deficiencies: an overview on efficacy, immunogenicity, durability of immune response and safety. 一抗缺乏的SARS-CoV-2疫苗接种:有效性、免疫原性、免疫反应持久性和安全性综述

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-11-14 DOI: 10.1097/ACI.0000000000000955

Gabriella Cusa, Germano Sardella, Giulia Garzi, Davide Firinu, Cinzia Milito

{"title":"SARS-CoV-2 vaccination in primary antibody deficiencies: an overview on efficacy, immunogenicity, durability of immune response and safety.","authors":"Gabriella Cusa, Germano Sardella, Giulia Garzi, Davide Firinu, Cinzia Milito","doi":"10.1097/ACI.0000000000000955","DOIUrl":"10.1097/ACI.0000000000000955","url":null,"abstract":"Purpose of review: This review aims to summarize the current best knowledge on the efficacy of COVID-19 vaccination in vulnerable patients affected by primary antibody deficiencies (PADs), both in patients previously infected and vaccine-immunized, focusing also on the durability, on the need for multiple booster doses and on the safety of anti-SARS-CoV-2 vaccines.Recent findings: Patients vaccinated for SARS-CoV2 have variable humoral response, still showing a tendency towards an increase in antibody titers, with factors such as booster doses, previous infections, age and specific genetic mutations influencing the outcome. Long-lasting cellular responses to SARS-CoV-2 vaccination instead, mostly of the T-cell type, have been observed. Overall, the duration of protection given by vaccinations is sufficient and increased upon further simulations. Furthermore, the safety profile in PID patients is excellent, with most adverse events being transient and mild and no major adverse event reported.Summary: Several studies have emphasized the benefit of vaccinating patients with PADs against the SARS-CoV-2 virus and the necessity of administering booster doses. This review, by gathering the most recent and significant data from the scientific literature, could be helpful in clinical practice in the management of disease prevention in patients affected by primary immunodeficiency and also serve as inspiration for further in-depth clinical research.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"37-43"},"PeriodicalIF":2.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92153142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introductions. 编辑介绍。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-12-20 DOI: 10.1097/ACI.0000000000000957

引用次数: 0

Chronic rhinosinusitis with nasal polyps: eosinophils versus B lymphocytes in disease pathogenesis. 慢性鼻窦炎伴鼻息肉:嗜酸性粒细胞与B淋巴细胞在疾病发病机制中的作用

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-11-27 DOI: 10.1097/ACI.0000000000000959

Harsha H Kariyawasam, Louisa K James

{"title":"Chronic rhinosinusitis with nasal polyps: eosinophils versus B lymphocytes in disease pathogenesis.","authors":"Harsha H Kariyawasam, Louisa K James","doi":"10.1097/ACI.0000000000000959","DOIUrl":"10.1097/ACI.0000000000000959","url":null,"abstract":"Purpose of review: To highlight the current evidence that supports the view that eosinophils may not drive disease in chronic rhinosinusitis with nasal polyps (CRSwNP) and the emerging evidence for B cells as an important player in this disease.Recent findings: Eosinophil depletion studies in CRSwNP do not fully support a critical role for eosinophils in CRSwNP. Almost complete eosinophil depletion with dexpramipexole had no impact on polyp size reduction or clinical improvement. Anti-interleukin (IL)-5 and IL-5Rα inhibition were more effective though with less clinical impact when compared to anti-immunoglobulin E (IgE) or IL-4Rα inhibition strategies. As IL-5Rα is also expressed on CRSwNP derived IgE+ and IgG4+ plasma cells to the same extent as eosinophils, improvements in CRSwNP with IL-5 inhibition may suggest a role for B cells over eosinophils in CRSwNP. We review both eosinophils and B cells in the context of CRSwNP and highlight the current evidence that supports an emerging role for B cells.Summary: Despite many aspects of immunopathology in CRSwNP explainable by B cell dysfunction, B cells have so far been ignored in CRSwNP. Further work is needed, as targeting B cells may offer an exciting new therapeutic option in the future.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"15-24"},"PeriodicalIF":2.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderate asthma: burden, mechanisms and therapeutic perspectives. 中度哮喘:负担、机制和治疗前景。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-02-01 Epub Date: 2023-10-25 DOI: 10.1097/ACI.0000000000000953

Laura De Ferrari, Anna Maria Riccio, Fulvio Braido

引用次数: 0