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Current Opinion in Allergy and Clinical Immunology最新文献

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The risk of anaphylaxis on holidays. 节假日发生过敏性休克的风险。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI: 10.1097/ACI.0000000000001014
Erminia Ridolo, Alessandro Barone, Martina Ottoni, Francesca Nicoletta
{"title":"The risk of anaphylaxis on holidays.","authors":"Erminia Ridolo, Alessandro Barone, Martina Ottoni, Francesca Nicoletta","doi":"10.1097/ACI.0000000000001014","DOIUrl":"10.1097/ACI.0000000000001014","url":null,"abstract":"<p><strong>Purpose of review: </strong>The goal of this review is to summarize the potential causes of anaphylaxis in the different holiday contexts, providing practical suggestions aimed to mitigate the stress challenged by allergic patients because of unfamiliar situations.</p><p><strong>Recent findings: </strong>A regard was reserved to potential food triggers, particularly uncommon ones and typical of certain destinations, and to arthropods responsible for anaphylaxis.</p><p><strong>Summary: </strong>This review highlights the potential risk of anaphylaxis due to the unusual contexts more experienced during holidays (i.e., travels, outdoor activities and eating out). Moreover, it underlines the need for a further allergological education in these cases, in order to prepare allergic patients to avoid and manage undesired situations.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"349-355"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11356676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the appearances: exploring complexities in anaphylaxis differential diagnosis. 超越表象：探索过敏性休克鉴别诊断的复杂性。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1097/ACI.0000000000001016
Stefania Nicola, Luca Lo Sardo, Richard Borrelli, Anna Quinternetto, Nicolò Rashidy, Luisa Brussino
{"title":"Beyond the appearances: exploring complexities in anaphylaxis differential diagnosis.","authors":"Stefania Nicola, Luca Lo Sardo, Richard Borrelli, Anna Quinternetto, Nicolò Rashidy, Luisa Brussino","doi":"10.1097/ACI.0000000000001016","DOIUrl":"10.1097/ACI.0000000000001016","url":null,"abstract":"<p><strong>Purpose of review: </strong>Anaphylaxis is a severe, and potentially life-threatening hypersensitivity reaction whose diagnosis is based on clinical signs and symptoms and their prompt recognition. The presence of mimics and unusual presentations necessitate a careful evaluation and expertise in the field, due to potential diagnostic errors and hence a delay in the treatment.The aim of this review is to analyze and make an overview of the potential differential diagnosis of anaphylaxis, focusing on the clinical challenges of recognizing these conditions effectively among similar others.</p><p><strong>Recent findings: </strong>The presence of mimics and unusual presentations of anaphylaxis necessitate a careful evaluation, emphasizing the importance of a comprehensive diagnostic approach.Tryptase is well known marker of mast cells activation, and a useful tool assisting the diagnosis of anaphylaxis, helping to differentiate it from atypical mimickers.</p><p><strong>Summary: </strong>The differential diagnosis of anaphylaxis comprises a very wide setting, and a systematic approach assessing different categories of cardiovascular, skin, respiratory airway, neuropsychiatric, and hematologic systems, can facilitate recognition of the correct diagnosis of this complex and life-threatening condition.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"313-321"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hymenoptera venom allergy in children and adolescents. 儿童和青少年对膜翅目昆虫毒液过敏。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI: 10.1097/ACI.0000000000001013
Francesca Norelli, Valentina Gueli, Patrizia Bonadonna
{"title":"Hymenoptera venom allergy in children and adolescents.","authors":"Francesca Norelli, Valentina Gueli, Patrizia Bonadonna","doi":"10.1097/ACI.0000000000001013","DOIUrl":"10.1097/ACI.0000000000001013","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review will identify and summarize the published existing data pertaining specifically to Hymenoptera venom allergy in children and adolescents, highlighting the major studies currently available on venom immunotherapy (VIT) and its prognosis in children.</p><p><strong>Recent findings: </strong>The current review covers the incidence and prevalence of Hymenoptera venom allergy (HVA) in children, factors influencing occurrence and severity of reactions (age, sex, comorbidities, etc.), indications to perform diagnostic tests and start VIT in children, different existing VIT protocols and their safety and efficacy.</p><p><strong>Summary: </strong>Hymenoptera venom allergy is the second most common cause of anaphylaxis in children and it considerably affects quality of life. Cutaneous reactions are the most prevalent clinical presentation in children who usually have a more favourable prognosis than adult patients. However, studies on HVA in children and adolescents are still limited. Currently VIT is the only treatment able to modify the natural history of HVA in adults as well as in children, and to protect patients from systemic reactions after subsequent stings.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"322-329"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic landscape of atopic dermatitis. 特应性皮炎的基因状况。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-06-24 DOI: 10.1097/ACI.0000000000001005
Lavinia Paternoster
{"title":"Genetic landscape of atopic dermatitis.","authors":"Lavinia Paternoster","doi":"10.1097/ACI.0000000000001005","DOIUrl":"10.1097/ACI.0000000000001005","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review summarizes recent advances in identifying genetic risk factors for atopic dermatitis and how these genetic associations are being used to explore the causal relationships between atopic dermatitis and potential risk factors and downstream outcomes.</p><p><strong>Recent findings: </strong>A recent large-scale GWAS meta-analysis has identified 91 genetic loci associated with atopic dermatitis. Rare variant studies have also identified new gain-of-function or loss-of-function variants implicated in atopic dermatitis, particularly for FLG and STAT6/JAK1 . Finally, there has been a surge in utilizing genetic association data to investigate the causal relationships between atopic dermatitis and other traits. Mendelian randomization studies have found that various metabolites and gut microbiota are causal for atopic dermatitis and have causally implicate atopic dermatitis in the development of alopecia areata, diabetes, vascular dementia and some cancers.</p><p><strong>Summary: </strong>The past year has seen a huge increase in the genes implicated for atopic dermatitis and in the use of genetics to explore causal relationships. The latter requires caution in implementation and interpretation, but is a promising area of research. In the coming years, increasing the ethnic diversity of atopic dermatitis genetic studies would be very welcome and the translation of current genetic findings into new drugs will be an exciting area of development.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"409-415"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tryptase in drug-induced anaphylaxis: the need for acute and baseline values. 药物诱发的过敏性休克中的胰蛋白酶：需要急性值和基线值。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1097/ACI.0000000000001012
Moïse Michel, Delphine Giusti, Caroline Klingebiel, Joana Vitte
{"title":"Tryptase in drug-induced anaphylaxis: the need for acute and baseline values.","authors":"Moïse Michel, Delphine Giusti, Caroline Klingebiel, Joana Vitte","doi":"10.1097/ACI.0000000000001012","DOIUrl":"10.1097/ACI.0000000000001012","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this narrative review was to summarize data and official recommendations purporting to paired tryptase determination in patients experiencing drug-induced anaphylaxis, published between January 1, 2023 and June 1, 2024.</p><p><strong>Recent findings: </strong>Three main lines of evidence obtained through paired acute and baseline tryptase determination were identified: diagnostic criterion for hypersensitivity reactions involving systemic mast cell activation; differential diagnostic criterion for hypersensitivity reactions involving other mechanisms of immediate reactions; and added value of acute and baseline tryptase levels for personalized management following drug-induced anaphylaxis: cause, risk of recurrence, underlying mast cell conditions including hereditary α-tryptasemia, familial clusters.</p><p><strong>Summary: </strong>The implementation of existing guidelines which consensually recommend paired tryptase measurement is a persistent unmet need hampering optimal diagnosis of drug-induced anaphylaxis and patient management. Another major unmet need is the lack of standardized recommendations for hereditary α-tryptasemia testing and counselling. Progress in this field is seen at a rapid pace, requiring significant efforts of continued medical education for practicing clinicians and laboratory specialists worldwide.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"293-299"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment options in refractory chronic spontaneous urticaria. 难治性慢性自发性荨麻疹的治疗方案。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-06-19 DOI: 10.1097/ACI.0000000000001006
Yashdeep Singh Pathania
{"title":"Treatment options in refractory chronic spontaneous urticaria.","authors":"Yashdeep Singh Pathania","doi":"10.1097/ACI.0000000000001006","DOIUrl":"10.1097/ACI.0000000000001006","url":null,"abstract":"<p><strong>Purpose of review: </strong>Chronic spontaneous urticaria (CSU) patients sometimes do not respond to second-generation antihistamine, and 10-50% patients do not even respond to four-fold the usual dose of nonsedating H1 antihistamine, which further leads to repeated courses of oral corticosteroids to abate the symptoms. There are third-line agents approved by EAACI guidelines, which include omalizumab and cyclosporine. Certain patients are even resistant to the third-line agents. In this review, various other treatment options will be discussed in patients of refractory CSU.</p><p><strong>Recent findings: </strong>Recently, we demonstrated azathioprine as a possible third-line option, which was found noninferior to cyclosporine in antihistamine refractory CSU. There have been trials, studies, case series and reports, which suggest other putative options for refractory CSU management.</p><p><strong>Summary: </strong>Studies on the management of refractory CSU are accumulating thereby expanding the armamentarium of dermatologists and allergologist against difficult-to-treat urticaria patients.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"416-418"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The collaborative medical practice of the ocular surface: a major role of the allergist/immunologist. 眼表合作医疗实践：过敏/免疫科医生的重要角色。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI: 10.1097/ACI.0000000000001025
Leonard Bielory
{"title":"The collaborative medical practice of the ocular surface: a major role of the allergist/immunologist.","authors":"Leonard Bielory","doi":"10.1097/ACI.0000000000001025","DOIUrl":"10.1097/ACI.0000000000001025","url":null,"abstract":"","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":"24 5","pages":"356-359"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial introductions. 编辑介绍。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI: 10.1097/ACI.0000000000001021
{"title":"Editorial introductions.","authors":"","doi":"10.1097/ACI.0000000000001021","DOIUrl":"https://doi.org/10.1097/ACI.0000000000001021","url":null,"abstract":"","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":"24 5","pages":"vii-ix"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evolution of cyclosporine treatments for treatment of ocular surface diseases. 环孢素治疗眼表疾病的演变。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1097/ACI.0000000000001017
Anna Flts, Richard Medina, Esen K Akpek
{"title":"The evolution of cyclosporine treatments for treatment of ocular surface diseases.","authors":"Anna Flts, Richard Medina, Esen K Akpek","doi":"10.1097/ACI.0000000000001017","DOIUrl":"10.1097/ACI.0000000000001017","url":null,"abstract":"<p><strong>Purpose of review: </strong>Cyclosporine is a versatile immunomodulatory drug commonly employed in modern medicine. Although cyclosporine was initially used to prevent solid organ transplant rejection, its indications have extended to treat many inflammatory or autoimmune diseases. Cyclosporin is available for use in oral, intravenous, and topical forms, including eye drops to treat corneal and ocular surface conditions. It is naturally advantageous to administer cyclosporin directly into the eye, avoiding potential and dose limiting systemic adverse effects. However, the transition from systemic to topical administration has been a challenging one. This report reviews the evolution of ophthalmic cyclosporine treatment and explores its clinical impacts and future research directions.</p><p><strong>Recent findings: </strong>Latest advancements in formulations - from oil-based solutions to nanomicelle and gel systems and waterless formulations - have improved the therapeutic efficacy and tolerability of topically applied cyclosporine, demonstrating greater effectiveness in treating ocular surface parameters compared to oil-based solution.</p><p><strong>Summary: </strong>Cyclosporine continues to be a safe and effective immunomodulatory drug in the field of ophthalmology to treat various chronic inflammatory ocular surface diseases and dry eye. Currently, there are several commercially available topical preparations available for ophthalmic use each with unique formulation and clinical outcomes.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"360-367"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ocular surface disorders: office procedures for the allergist/clinical immunologist. 眼表疾病：过敏学家/临床免疫学家的诊疗程序。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI: 10.1097/ACI.0000000000001022
Matthew Ryan Norris, Constance Katelaris, Nelson Rosario, Luis Delgado, Andrea Leonardi, Leonard Bielory
{"title":"Ocular surface disorders: office procedures for the allergist/clinical immunologist.","authors":"Matthew Ryan Norris, Constance Katelaris, Nelson Rosario, Luis Delgado, Andrea Leonardi, Leonard Bielory","doi":"10.1097/ACI.0000000000001022","DOIUrl":"10.1097/ACI.0000000000001022","url":null,"abstract":"<p><strong>Purpose of review: </strong>Ocular surface disorders (OSDs) are a prevalent and often debilitating condition encountered in clinical practice, particularly by allergists and clinical immunologists.</p><p><strong>Recent findings: </strong>A comprehensive guide to office procedures for evaluating and managing OSDs, with a specific focus on ocular allergies, would assist in the evaluation process that begins with an initial patient assessment utilizing standardized forms to systematically gather detailed medical history, symptomatology, and environmental exposure data. This structured approach ensures a thorough understanding of the patient's condition and facilitates targeted interventions. In addition to allergy testing, the assessment of the tear film is essential for a comprehensive evaluation of OSDs. The Schirmer test is employed to quantify tear production, providing objective data on tear film adequacy and guiding interventions for tear film deficiencies.</p><p><strong>Summary: </strong>This multifaceted diagnostic approach ensures that all contributing factors to OSDs are identified and appropriately managed. By integrating these office procedures, allergists and clinical immunologists can enhance their diagnostic accuracy and therapeutic efficacy, ultimately improving patient outcomes. This manuscript provides a practical resource, outlining some of the methodologies and clinical applications of each procedure, and highlighting their role in the holistic management of OSDs in allergic patients.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"375-379"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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