Current Opinion in Allergy and Clinical Immunology最新文献_第10页

Role of biologics in severe food allergy. 生物制剂在严重食物过敏中的作用。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.1097/ACI.0000000000000978

Giulio Dinardo, Arianna Cafarotti, Vincenzo Fierro, Maria Cristina Artesani, Cristiana Indolfi, Michele Miraglia Del Giudice, Alessandro Fiocchi

{"title":"Role of biologics in severe food allergy.","authors":"Giulio Dinardo, Arianna Cafarotti, Vincenzo Fierro, Maria Cristina Artesani, Cristiana Indolfi, Michele Miraglia Del Giudice, Alessandro Fiocchi","doi":"10.1097/ACI.0000000000000978","DOIUrl":"10.1097/ACI.0000000000000978","url":null,"abstract":"Purpose of review: This review examine the dynamic landscape of food allergy treatment within the context of emerging biologics. Our purpose is to comprehensively evaluate the potential benefits, challenges, and transformative impact associated with the utilization of biologics in comparison to conventional therapeutic modalities.Recent findings: This document synthesizes recent scientific investigations to various biologics, such as omalizumab, ligelizumab, dupilumab, and tezepelumab, providing a nuanced understanding of their roles in oral immunotherapy, rapid desensitization, and overall food allergy management. Recent studies and clinical trials highlight the impact of anti-IgE treatment on food allergies, revealing critical findings such as dose-related efficacy, facilitation of rapid desensitization in peanut allergies, and the sustained positive outcomes observed in individuals with multifood allergies.Summary: The use of biologics presents a groundbreaking approach in the treatment of food allergies. The multifaceted action of these agents, along with their potential to overcome the challenges associated with traditional therapies, marks a significant advancement. Despite the persisting challenges of economic constraints and the need for further safety studies, biologics offer a promising avenue for improving the quality of life for individuals with food allergies. Ongoing research and collaborative efforts are imperative to fully realize the transformative potential inherent in these emerging therapeutic frontiers.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"138-143"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global burden of pediatric asthma and rhinitis - what we have recently learned from epidemiology. 小儿哮喘和鼻炎的全球负担--我们最近从流行病学中了解到的情况。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-02-21 DOI: 10.1097/ACI.0000000000000975

Sergio de Jesús Romero-Tapia, Luis García-Marcos

引用次数: 0

Editorial introductions. 编辑介绍。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-04-25 DOI: 10.1097/ACI.0000000000000984

引用次数: 0

Precision medicine to personalize medicine in allergic airway disease. 用精准医疗实现过敏性气道疾病的个性化治疗。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.1097/ACI.0000000000000976

Jean Kim

引用次数: 0

New biologics for food allergy. 治疗食物过敏的新型生物制剂。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-28 DOI: 10.1097/ACI.0000000000000981

Jackson P Schuetz, Brent Anderson, Sayantani B Sindher

{"title":"New biologics for food allergy.","authors":"Jackson P Schuetz, Brent Anderson, Sayantani B Sindher","doi":"10.1097/ACI.0000000000000981","DOIUrl":"10.1097/ACI.0000000000000981","url":null,"abstract":"Purpose of review: This review aims to explore role of emerging biologics, including ligelizumab, UB-221, dupilumab, and antialarmins, in food allergy management. With a focus on recent developments, we evaluate their promise in mitigating adverse events during oral immunotherapy (OIT), reducing allergic reactions, and addressing the limitations of current therapeutic options.Recent findings: Antiimmunoglobulin E mAbs, exemplified by omalizumab, demonstrate efficacy in desensitization and safety improvement during multiallergen OIT. Next-generation antibodies like ligelizumab and UB-221 exhibit enhanced potency and unique mechanisms, holding promise for food allergy treatment. Dupilumab, targeting IL-4 receptor alpha, presents potential benefits in decreasing allergen-specific IgE and modifying the atopic march. Exploration of antialarmins, specifically anti-IL-33 (etokimab) and anti-TSLP (tezepelumab), reveals encouraging results, with etokimab showing early success in peanut allergy trials.Summary: Biologics hold promising potential for food allergy treatment. Tailoring therapeutic approaches based on shared decision-making becomes pivotal. While omalizumab remains a significant option, next-generation anti-IgE antibodies and agents targeting alarmins exhibit unique strengths. Dupilumab, despite limited success as monotherapy, shows promise as an adjunct for OIT. Careful consideration of treatment goals, patient preferences, and the evolving landscape of biologics will shape future clinical practice, offering allergists an expanded toolbox for personalized food allergy management.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"147-152"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140317876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision allergy molecular diagnosis applications in food allergy. 精准过敏分子诊断在食物过敏中的应用。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-26 DOI: 10.1097/ACI.0000000000000977

Sakura Sato, Motohiro Ebisawa

{"title":"Precision allergy molecular diagnosis applications in food allergy.","authors":"Sakura Sato, Motohiro Ebisawa","doi":"10.1097/ACI.0000000000000977","DOIUrl":"10.1097/ACI.0000000000000977","url":null,"abstract":"Purpose of review: Precision medicine has become important in the diagnosis and management of food allergies. This review summarizes the latest information regarding molecular allergology, an essential component of food allergy managements.Recent findings: Component-resolved diagnostics (CRD) can be used to investigate sensitization to allergens based on symptoms and to reveal co-sensitization and/or cross-sensitization in patients with allergies. The following allergen components are known to be associated with symptoms: ovomucoid from eggs, omega-5 gliadin from wheat, and many storage proteins (Gly m 8 from soy, Ara h 2 from peanut, Cor a 14 from hazelnut, Ana o 3 from cashew nut, Jug r 1 from walnut, and Ses i 1 from sesame). Recent studies on allergens of macadamia nuts (Mac i 1 and Mac i 2), almonds (Pru du 6), fish (parvalbumin and collagen), and shrimp (Pem m 1 and Pem m 14) have provided additional information regarding CRD. In addition, Pru p 7 is a risk factor for systemic reactions to peaches and has recently been found to cross-react with cypress and Japanese cedar pollen.Summary: CRD provides information of individualized sensitization profiles related to symptoms and severity of allergies in patients. Clinical practice based on CRD offers many benefits, such as higher diagnostic accuracy and improved management of individual patients.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"129-137"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives in precautionary allergen labelling of prepackaged foods after the FAO/WHO consultation. 粮农组织/世卫组织磋商后预包装食品预防性过敏原标签的前景。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-28 DOI: 10.1097/ACI.0000000000000979

Vincenzo Fierro, Carmen Mazzuca, Sara Urbani, Lamia Dahdah, Veronica Calandrelli, Rocco Luigi Valluzzi, Dinardo Giulio

{"title":"Perspectives in precautionary allergen labelling of prepackaged foods after the FAO/WHO consultation.","authors":"Vincenzo Fierro, Carmen Mazzuca, Sara Urbani, Lamia Dahdah, Veronica Calandrelli, Rocco Luigi Valluzzi, Dinardo Giulio","doi":"10.1097/ACI.0000000000000979","DOIUrl":"10.1097/ACI.0000000000000979","url":null,"abstract":"Purpose of review: The purpose of this review is to provide an overview of the perspectives regarding precautionary allergen labelling (PAL) of prepackaged foods following the consultation conducted by the Food and Agriculture Organization (FAO) and the WHO.Recent findings: The FAO/WHO consultation provided a comprehensive assessment of the current status and practices of PAL implementation worldwide. One of the key findings highlighted by the Expert Committee was the need for improvement in existing PAL systems. It was noted that many countries lacked uniformity in PAL practices, leading to inconsistencies in labelling and potentially misleading information for consumers. Furthermore, the consultation emphasized the importance of PAL being risk-based, taking into account both the amount and frequency of unintended allergen presence (UAP) in food products.Summary: The FAO/WHO consultation shed light on various perspectives and challenges associated with PAL of prepackaged foods. Key findings emphasized the need for improvement in existing PAL systems, including the adoption of a risk-based approach, standardized regulations, and enhanced transparency. Moving forward, collaborative efforts between regulatory agencies, food manufacturers, and consumer advocacy groups will be essential in developing effective PAL strategies that prioritize consumer safety and well being.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"166-170"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140317877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regular consumption following early introduction of allergenic foods and aggressive treatment of eczema are necessary for preventing the development of food allergy in children. 要预防儿童患食物过敏症，就必须在早期引入致敏食物后定期食用，并积极治疗湿疹。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-04-09 DOI: 10.1097/ACI.0000000000000983

Tetsuhiro Sakihara

{"title":"Regular consumption following early introduction of allergenic foods and aggressive treatment of eczema are necessary for preventing the development of food allergy in children.","authors":"Tetsuhiro Sakihara","doi":"10.1097/ACI.0000000000000983","DOIUrl":"10.1097/ACI.0000000000000983","url":null,"abstract":"Purpose of review: Over the past two decades, food allergy prevention strategies have shifted from 'delayed introduction' to 'no delayed introduction' to 'early introduction' of allergenic foods. This article reviews important research in this field published in the early 2020s to support future strategies for food allergy prevention.Recent findings: Recent randomized controlled trials (RCTs), systematic reviews, meta-analyses, and real-world studies have reported that early allergenic food introduction, especially peanut and egg, are effective for preventing food allergies. However, there are also reports that food-induced anaphylaxis admission rates in infants are increasing.Summary: Early allergenic food introduction by itself is not sufficient to prevent the development of food allergies. Recent RCTs (SPADE study and COMEET study) have demonstrated that continued regular cow's milk consumption after early introduction is important for preventing the onset of cow's milk allergy. Furthermore, an RCT (PACI study) reported that early and aggressive anti-inflammatory topical therapy for eczema can contribute to the prevention of egg allergy by suppressing percutaneous sensitization. Food allergies may be prevented through a combination of early food introduction, regular consumption, and active eczema treatment. Further research is needed to develop well tolerated, effective, and practical strategies to prevent food allergies.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"160-165"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Access from healthcare professionals to evidence-based pharmacotherapy in allergy management. 医疗保健专业人员在过敏管理中获得循证药物疗法。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-15 DOI: 10.1097/aci.0000000000000989

Daniela Carvalho

引用次数: 0

What molecular allergy teaches us about genetics and epidemiology of allergies. 分子过敏告诉我们过敏的遗传学和流行病学。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-12 DOI: 10.1097/aci.0000000000000990

Benedetta Biagioni, Enrico Scala, Lorenzo Cecchi

引用次数: 0