Current Opinion in Allergy and Clinical Immunology最新文献_第10页

Management and treatment of perioperative hypersensitivity. 围手术期过敏症的管理和治疗。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1097/ACI.0000000000001000

Anna Littlejohns, Louise Savic

{"title":"Management and treatment of perioperative hypersensitivity.","authors":"Anna Littlejohns, Louise Savic","doi":"10.1097/ACI.0000000000001000","DOIUrl":"10.1097/ACI.0000000000001000","url":null,"abstract":"Purpose of review: Perioperative hypersensitivity reactions are rare but potentially catastrophic events. This review acts to summarize recent recommendations for both immediate and poststabilization management of suspected reactions, alongside practical advice for anaesthetists who may be faced with these events.Recent findings: Prompt treatment is essential but may be hampered by delay in recognition. This can occur because there are multiple differential diagnoses for the observed clinical signs as well as variations in clinical presentation. Resuscitation is dependent on the use of adrenaline and fluids. Adrenaline should be administered in small, titrated intravenous boluses. Low-dose infusions should be commenced early if the response to boluses is poor. Large volume fluid resuscitation may be required to maintain adequate circulating volume. Chest compressions are recommended when there is evidence of inadequate perfusion, rather than waiting until cardiac arrest is confirmed. Antihistamines and corticosteroids are no longer recommended in the immediate management phase. Once the patient has been stabilized, it is important to obtain serial tryptase concentrations to aid the subsequent clinic investigation. The decision to proceed or abandon surgery will be based on an individual risk-benefit analysis. All cases of suspected perioperative hypersensitivity, including fatal cases, must be referred for formal investigation.Summary: There have been recent updates to management guidelines in perioperative hypersensitivity. Treatment algorithms, treatment packs and referral packs can all help the anaesthetist manage these complex cases, aid the subsequent investigation and ensure patient safety in the future.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"210-217"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greater mechanistic understanding of the cutaneous pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis can shed light on novel therapeutic strategies: a comprehensive review. 从机理上进一步了解史蒂文斯-约翰逊综合征/毒性表皮坏死溶解症的皮肤发病机制，可为新型治疗策略提供启示：综合综述。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-17 DOI: 10.1097/ACI.0000000000000993

Emeka D Ogiji, Nourah Aboheimed, Kehinde Ross, Calum Voller, Ryan Siner, Rebecca L Jensen, Carol E Jolly, Daniel F Carr

{"title":"Greater mechanistic understanding of the cutaneous pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis can shed light on novel therapeutic strategies: a comprehensive review.","authors":"Emeka D Ogiji, Nourah Aboheimed, Kehinde Ross, Calum Voller, Ryan Siner, Rebecca L Jensen, Carol E Jolly, Daniel F Carr","doi":"10.1097/ACI.0000000000000993","DOIUrl":"10.1097/ACI.0000000000000993","url":null,"abstract":"Purpose of review: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are severe cutaneous adverse drug reactions (SCARs) characterized by widespread epithelial detachment and blistering, which affects the skin and mucocutaneous membranes. To date, therapeutic interventions for SJS/TEN have focused on systematic suppression of the inflammatory response using high-dose corticosteroids or intravenous immunoglobulin G (IgG), for example. No targeted therapies for SJS/TEN currently exist.Recent findings: Though our understanding of the pathogenesis of SJS/TEN has advanced from both an immunological and dermatological perspective, this knowledge is yet to translate into the development of new targeted therapies.Summary: Greater mechanistic insight into SJS/TEN would potentially unlock new opportunities for identifying or repurposing targeted therapies to limit or even prevent epidermal injury and blistering.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"218-227"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive models and applicability of artificial intelligence-based approaches in drug allergy. 人工智能方法在药物过敏中的预测模型和适用性。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1097/ACI.0000000000001002

Rafael Núñez, Inmaculada Doña, José Antonio Cornejo-García

{"title":"Predictive models and applicability of artificial intelligence-based approaches in drug allergy.","authors":"Rafael Núñez, Inmaculada Doña, José Antonio Cornejo-García","doi":"10.1097/ACI.0000000000001002","DOIUrl":"10.1097/ACI.0000000000001002","url":null,"abstract":"Purpose of review: Drug allergy is responsible for a huge burden on public healthcare systems, representing in some instances a threat for patient's life. Diagnosis is complex due to the heterogeneity of clinical phenotypes and mechanisms involved, the limitations of in vitro tests, and the associated risk to in vivo tests. Predictive models, including those using recent advances in artificial intelligence, may circumvent these drawbacks, leading to an appropriate classification of patients and improving their management in clinical settings.Recent findings: Scores and predictive models to assess drug allergy development, including patient risk stratification, are scarce and usually apply logistic regression analysis. Over recent years, different methods encompassed under the general umbrella of artificial intelligence, including machine and deep learning, and artificial neural networks, are emerging as powerful tools to provide reliable and optimal models for clinical diagnosis, prediction, and precision medicine in different types of drug allergy.Summary: This review provides general concepts and current evidence supporting the potential utility of predictive models and artificial intelligence branches in drug allergy diagnosis.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"189-194"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poor statistical reporting: do we have a reason for concern? A narrative review and recommendations. 统计报告不完善：我们有理由担忧吗？叙述性审查和建议。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-08-01 Epub Date: 2024-01-17 DOI: 10.1097/ACI.0000000000000965

Michal Ordak

{"title":"Poor statistical reporting: do we have a reason for concern? A narrative review and recommendations.","authors":"Michal Ordak","doi":"10.1097/ACI.0000000000000965","DOIUrl":"10.1097/ACI.0000000000000965","url":null,"abstract":"Purpose of review: The aim of the review conducted was to present recent articles indicating the need to implement statistical recommendations in the daily work of biomedical journals.Recent findings: The most recent literature shows an unchanged percentage of journals using specialized statistical review over 20 years. The problems of finding statistical reviewers, the impractical way in which biostatistics is taught and the nonimplementation of published statistical recommendations contribute to the fact that a small percentage of accepted manuscripts contain correctly performed analysis. The statistical recommendations published for authors and editorial board members in recent years contain important advice, but more emphasis should be placed on their practical and rigorous implementation. If this is not the case, we will additionally continue to experience low reproducibility of the research.Summary: There is a low level of statistical reporting these days. Recommendations related to the statistical review of submitted manuscripts should be followed more rigorously.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"237-242"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of food allergy based on oral food challenge. 基于口服食物挑战的食物过敏管理。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.1097/ACI.0000000000000980

Seijiro Ishibashi, Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa

{"title":"Management of food allergy based on oral food challenge.","authors":"Seijiro Ishibashi, Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa","doi":"10.1097/ACI.0000000000000980","DOIUrl":"10.1097/ACI.0000000000000980","url":null,"abstract":"Purpose of review: Food allergy is a growing health problem that affects both patients and society in multiple ways. Despite the emergence of novel diagnostic tools, such as component-resolved diagnostics (CRD) and basophil activation tests (BAT), oral food challenge (OFC) still plays an indispensable role in the management of food allergies. This review aimed to highlight the indications and safety concerns of conducting an OFC and to provide insights into post-OFC management based on recent findings.Recent findings: Standardized OFC protocols have regional diversification, especially in Japan and Western countries. Recent studies suggested that the interval between doses should be at least more than an hour. Furthermore, applying a stepwise method tailored to the patient's specific immunoglobulin E level and history of anaphylaxis seems to mitigate these risks. Recent surveys have shown that, following a positive OFC, options other than strict avoidance are also selected.Summary: OFC serves diverse purposes, yet the risks it carries warrant caution. The stepwise protocol appears promising for its safety. Subthreshold consumption following OFC shows potential; however, further research on its efficacy and safety is required. Management following OFC should be tailored and well discussed between clinicians and patients.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"153-159"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of biologics in severe food allergy. 生物制剂在严重食物过敏中的作用。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.1097/ACI.0000000000000978

Giulio Dinardo, Arianna Cafarotti, Vincenzo Fierro, Maria Cristina Artesani, Cristiana Indolfi, Michele Miraglia Del Giudice, Alessandro Fiocchi

{"title":"Role of biologics in severe food allergy.","authors":"Giulio Dinardo, Arianna Cafarotti, Vincenzo Fierro, Maria Cristina Artesani, Cristiana Indolfi, Michele Miraglia Del Giudice, Alessandro Fiocchi","doi":"10.1097/ACI.0000000000000978","DOIUrl":"10.1097/ACI.0000000000000978","url":null,"abstract":"Purpose of review: This review examine the dynamic landscape of food allergy treatment within the context of emerging biologics. Our purpose is to comprehensively evaluate the potential benefits, challenges, and transformative impact associated with the utilization of biologics in comparison to conventional therapeutic modalities.Recent findings: This document synthesizes recent scientific investigations to various biologics, such as omalizumab, ligelizumab, dupilumab, and tezepelumab, providing a nuanced understanding of their roles in oral immunotherapy, rapid desensitization, and overall food allergy management. Recent studies and clinical trials highlight the impact of anti-IgE treatment on food allergies, revealing critical findings such as dose-related efficacy, facilitation of rapid desensitization in peanut allergies, and the sustained positive outcomes observed in individuals with multifood allergies.Summary: The use of biologics presents a groundbreaking approach in the treatment of food allergies. The multifaceted action of these agents, along with their potential to overcome the challenges associated with traditional therapies, marks a significant advancement. Despite the persisting challenges of economic constraints and the need for further safety studies, biologics offer a promising avenue for improving the quality of life for individuals with food allergies. Ongoing research and collaborative efforts are imperative to fully realize the transformative potential inherent in these emerging therapeutic frontiers.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"138-143"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global burden of pediatric asthma and rhinitis - what we have recently learned from epidemiology. 小儿哮喘和鼻炎的全球负担--我们最近从流行病学中了解到的情况。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-02-21 DOI: 10.1097/ACI.0000000000000975

Sergio de Jesús Romero-Tapia, Luis García-Marcos

引用次数: 0

Editorial introductions. 编辑介绍。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-04-25 DOI: 10.1097/ACI.0000000000000984

引用次数: 0

Precision medicine to personalize medicine in allergic airway disease. 用精准医疗实现过敏性气道疾病的个性化治疗。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.1097/ACI.0000000000000976

Jean Kim

引用次数: 0

New biologics for food allergy. 治疗食物过敏的新型生物制剂。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-28 DOI: 10.1097/ACI.0000000000000981

Jackson P Schuetz, Brent Anderson, Sayantani B Sindher

{"title":"New biologics for food allergy.","authors":"Jackson P Schuetz, Brent Anderson, Sayantani B Sindher","doi":"10.1097/ACI.0000000000000981","DOIUrl":"10.1097/ACI.0000000000000981","url":null,"abstract":"Purpose of review: This review aims to explore role of emerging biologics, including ligelizumab, UB-221, dupilumab, and antialarmins, in food allergy management. With a focus on recent developments, we evaluate their promise in mitigating adverse events during oral immunotherapy (OIT), reducing allergic reactions, and addressing the limitations of current therapeutic options.Recent findings: Antiimmunoglobulin E mAbs, exemplified by omalizumab, demonstrate efficacy in desensitization and safety improvement during multiallergen OIT. Next-generation antibodies like ligelizumab and UB-221 exhibit enhanced potency and unique mechanisms, holding promise for food allergy treatment. Dupilumab, targeting IL-4 receptor alpha, presents potential benefits in decreasing allergen-specific IgE and modifying the atopic march. Exploration of antialarmins, specifically anti-IL-33 (etokimab) and anti-TSLP (tezepelumab), reveals encouraging results, with etokimab showing early success in peanut allergy trials.Summary: Biologics hold promising potential for food allergy treatment. Tailoring therapeutic approaches based on shared decision-making becomes pivotal. While omalizumab remains a significant option, next-generation anti-IgE antibodies and agents targeting alarmins exhibit unique strengths. Dupilumab, despite limited success as monotherapy, shows promise as an adjunct for OIT. Careful consideration of treatment goals, patient preferences, and the evolving landscape of biologics will shape future clinical practice, offering allergists an expanded toolbox for personalized food allergy management.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"147-152"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140317876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0