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New biologics for food allergy. 治疗食物过敏的新型生物制剂。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-28 DOI: 10.1097/ACI.0000000000000981
Jackson P Schuetz, Brent Anderson, Sayantani B Sindher
{"title":"New biologics for food allergy.","authors":"Jackson P Schuetz, Brent Anderson, Sayantani B Sindher","doi":"10.1097/ACI.0000000000000981","DOIUrl":"10.1097/ACI.0000000000000981","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to explore role of emerging biologics, including ligelizumab, UB-221, dupilumab, and antialarmins, in food allergy management. With a focus on recent developments, we evaluate their promise in mitigating adverse events during oral immunotherapy (OIT), reducing allergic reactions, and addressing the limitations of current therapeutic options.</p><p><strong>Recent findings: </strong>Antiimmunoglobulin E mAbs, exemplified by omalizumab, demonstrate efficacy in desensitization and safety improvement during multiallergen OIT. Next-generation antibodies like ligelizumab and UB-221 exhibit enhanced potency and unique mechanisms, holding promise for food allergy treatment. Dupilumab, targeting IL-4 receptor alpha, presents potential benefits in decreasing allergen-specific IgE and modifying the atopic march. Exploration of antialarmins, specifically anti-IL-33 (etokimab) and anti-TSLP (tezepelumab), reveals encouraging results, with etokimab showing early success in peanut allergy trials.</p><p><strong>Summary: </strong>Biologics hold promising potential for food allergy treatment. Tailoring therapeutic approaches based on shared decision-making becomes pivotal. While omalizumab remains a significant option, next-generation anti-IgE antibodies and agents targeting alarmins exhibit unique strengths. Dupilumab, despite limited success as monotherapy, shows promise as an adjunct for OIT. Careful consideration of treatment goals, patient preferences, and the evolving landscape of biologics will shape future clinical practice, offering allergists an expanded toolbox for personalized food allergy management.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"147-152"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140317876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision medicine to personalize medicine in allergic airway disease. 用精准医疗实现过敏性气道疾病的个性化治疗。
IF 2.8 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.1097/ACI.0000000000000976
Jean Kim
{"title":"Precision medicine to personalize medicine in allergic airway disease.","authors":"Jean Kim","doi":"10.1097/ACI.0000000000000976","DOIUrl":"10.1097/ACI.0000000000000976","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this study is to understand the approach to precision medicine and personalized medicine in the management of allergic airway disease.</p><p><strong>Recent findings: </strong>Identification of biomarkers as key tools used in precision medicine has led to the development of multiple biologic drugs being used as new treatments for allergic airway disease.</p><p><strong>Summary: </strong>In addition to these advances, there is still much needed effort to improve the feasibility and utility of integrating biologic omics data of precision medicine with physicochemical, behavioral, psychological, and social data to deliver optimized treatments that is personalized for each individual.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"109-113"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140317899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision allergy molecular diagnosis applications in food allergy. 精准过敏分子诊断在食物过敏中的应用。
IF 2.8 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-26 DOI: 10.1097/ACI.0000000000000977
Sakura Sato, Motohiro Ebisawa
{"title":"Precision allergy molecular diagnosis applications in food allergy.","authors":"Sakura Sato, Motohiro Ebisawa","doi":"10.1097/ACI.0000000000000977","DOIUrl":"10.1097/ACI.0000000000000977","url":null,"abstract":"<p><strong>Purpose of review: </strong>Precision medicine has become important in the diagnosis and management of food allergies. This review summarizes the latest information regarding molecular allergology, an essential component of food allergy managements.</p><p><strong>Recent findings: </strong>Component-resolved diagnostics (CRD) can be used to investigate sensitization to allergens based on symptoms and to reveal co-sensitization and/or cross-sensitization in patients with allergies. The following allergen components are known to be associated with symptoms: ovomucoid from eggs, omega-5 gliadin from wheat, and many storage proteins (Gly m 8 from soy, Ara h 2 from peanut, Cor a 14 from hazelnut, Ana o 3 from cashew nut, Jug r 1 from walnut, and Ses i 1 from sesame). Recent studies on allergens of macadamia nuts (Mac i 1 and Mac i 2), almonds (Pru du 6), fish (parvalbumin and collagen), and shrimp (Pem m 1 and Pem m 14) have provided additional information regarding CRD. In addition, Pru p 7 is a risk factor for systemic reactions to peaches and has recently been found to cross-react with cypress and Japanese cedar pollen.</p><p><strong>Summary: </strong>CRD provides information of individualized sensitization profiles related to symptoms and severity of allergies in patients. Clinical practice based on CRD offers many benefits, such as higher diagnostic accuracy and improved management of individual patients.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"129-137"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspectives in precautionary allergen labelling of prepackaged foods after the FAO/WHO consultation. 粮农组织/世卫组织磋商后预包装食品预防性过敏原标签的前景。
IF 2.8 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-28 DOI: 10.1097/ACI.0000000000000979
Vincenzo Fierro, Carmen Mazzuca, Sara Urbani, Lamia Dahdah, Veronica Calandrelli, Rocco Luigi Valluzzi, Dinardo Giulio
{"title":"Perspectives in precautionary allergen labelling of prepackaged foods after the FAO/WHO consultation.","authors":"Vincenzo Fierro, Carmen Mazzuca, Sara Urbani, Lamia Dahdah, Veronica Calandrelli, Rocco Luigi Valluzzi, Dinardo Giulio","doi":"10.1097/ACI.0000000000000979","DOIUrl":"10.1097/ACI.0000000000000979","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this review is to provide an overview of the perspectives regarding precautionary allergen labelling (PAL) of prepackaged foods following the consultation conducted by the Food and Agriculture Organization (FAO) and the WHO.</p><p><strong>Recent findings: </strong>The FAO/WHO consultation provided a comprehensive assessment of the current status and practices of PAL implementation worldwide. One of the key findings highlighted by the Expert Committee was the need for improvement in existing PAL systems. It was noted that many countries lacked uniformity in PAL practices, leading to inconsistencies in labelling and potentially misleading information for consumers. Furthermore, the consultation emphasized the importance of PAL being risk-based, taking into account both the amount and frequency of unintended allergen presence (UAP) in food products.</p><p><strong>Summary: </strong>The FAO/WHO consultation shed light on various perspectives and challenges associated with PAL of prepackaged foods. Key findings emphasized the need for improvement in existing PAL systems, including the adoption of a risk-based approach, standardized regulations, and enhanced transparency. Moving forward, collaborative efforts between regulatory agencies, food manufacturers, and consumer advocacy groups will be essential in developing effective PAL strategies that prioritize consumer safety and well being.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"166-170"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140317877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regular consumption following early introduction of allergenic foods and aggressive treatment of eczema are necessary for preventing the development of food allergy in children. 要预防儿童患食物过敏症，就必须在早期引入致敏食物后定期食用，并积极治疗湿疹。
IF 2.8 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-04-09 DOI: 10.1097/ACI.0000000000000983
Tetsuhiro Sakihara
{"title":"Regular consumption following early introduction of allergenic foods and aggressive treatment of eczema are necessary for preventing the development of food allergy in children.","authors":"Tetsuhiro Sakihara","doi":"10.1097/ACI.0000000000000983","DOIUrl":"10.1097/ACI.0000000000000983","url":null,"abstract":"<p><strong>Purpose of review: </strong>Over the past two decades, food allergy prevention strategies have shifted from 'delayed introduction' to 'no delayed introduction' to 'early introduction' of allergenic foods. This article reviews important research in this field published in the early 2020s to support future strategies for food allergy prevention.</p><p><strong>Recent findings: </strong>Recent randomized controlled trials (RCTs), systematic reviews, meta-analyses, and real-world studies have reported that early allergenic food introduction, especially peanut and egg, are effective for preventing food allergies. However, there are also reports that food-induced anaphylaxis admission rates in infants are increasing.</p><p><strong>Summary: </strong>Early allergenic food introduction by itself is not sufficient to prevent the development of food allergies. Recent RCTs (SPADE study and COMEET study) have demonstrated that continued regular cow's milk consumption after early introduction is important for preventing the onset of cow's milk allergy. Furthermore, an RCT (PACI study) reported that early and aggressive anti-inflammatory topical therapy for eczema can contribute to the prevention of egg allergy by suppressing percutaneous sensitization. Food allergies may be prevented through a combination of early food introduction, regular consumption, and active eczema treatment. Further research is needed to develop well tolerated, effective, and practical strategies to prevent food allergies.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"160-165"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Access from healthcare professionals to evidence-based pharmacotherapy in allergy management. 医疗保健专业人员在过敏管理中获得循证药物疗法。
IF 2.8 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-15 DOI: 10.1097/aci.0000000000000989
Daniela Carvalho
{"title":"Access from healthcare professionals to evidence-based pharmacotherapy in allergy management.","authors":"Daniela Carvalho","doi":"10.1097/aci.0000000000000989","DOIUrl":"https://doi.org/10.1097/aci.0000000000000989","url":null,"abstract":"Access to evidence-based pharmacotherapy (EBP) is crucial in effectively managing allergies. Allergy conditions, including rhinitis, asthma, and dermatitis, require treatment guided by scientific evidence. However, healthcare professionals face challenges in accessing relevant information.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":"123 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What molecular allergy teaches us about genetics and epidemiology of allergies. 分子过敏告诉我们过敏的遗传学和流行病学。
IF 2.8 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-12 DOI: 10.1097/aci.0000000000000990
Benedetta Biagioni, Enrico Scala, Lorenzo Cecchi
{"title":"What molecular allergy teaches us about genetics and epidemiology of allergies.","authors":"Benedetta Biagioni, Enrico Scala, Lorenzo Cecchi","doi":"10.1097/aci.0000000000000990","DOIUrl":"https://doi.org/10.1097/aci.0000000000000990","url":null,"abstract":"To delineate pertinent information regarding the application of molecular allergology within the realm of both genetic and epidemiological facets of allergic diseases.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":"7 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological treatments in childhood asthma. 儿童哮喘的生物治疗
IF 2.8 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-02 DOI: 10.1097/aci.0000000000000987
Antonio Nieto-García, María Nieto-Cid, Ángel Mazón-Ramos
{"title":"Biological treatments in childhood asthma.","authors":"Antonio Nieto-García, María Nieto-Cid, Ángel Mazón-Ramos","doi":"10.1097/aci.0000000000000987","DOIUrl":"https://doi.org/10.1097/aci.0000000000000987","url":null,"abstract":"The aim is to update the information currently available for the use of biologics in severe asthma in children, in order to facilitate their prescription as far as possible.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":"40 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health disparities in allergic diseases. 过敏性疾病的健康差异。
IF 3 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-01-30 DOI: 10.1097/ACI.0000000000000972
Samantha R Jacobs, Nicole Ramsey, Mariangela Bagnato, Tracy Pitt, Carla M Davis
{"title":"Health disparities in allergic diseases.","authors":"Samantha R Jacobs, Nicole Ramsey, Mariangela Bagnato, Tracy Pitt, Carla M Davis","doi":"10.1097/ACI.0000000000000972","DOIUrl":"10.1097/ACI.0000000000000972","url":null,"abstract":"<p><strong>Purpose of review: </strong>Healthcare disparities impact prevalence, diagnosis, and management of allergic disease. The purpose of this review is to highlight the most recent evidence of healthcare disparities in allergic conditions to provide healthcare providers with better understanding of the factors contributing to disparities and to provide potential management approaches to address them. This review comes at a time in medicine where it is well documented that disparities exist, but we seek to answer the Why , How and What to do next?</p><p><strong>Recent findings: </strong>The literature highlights the socioeconomic factors at play including race/ ethnicity, neighborhood, insurance status and income. Management strategies have been implemented with the hopes of mitigating the disparate health outcomes including utilization of school-based health, distribution of educational tools and more inclusive research recruitment.</p><p><strong>Summary: </strong>The studies included describe the associations between upstream structural and social factors with downstream outcomes and provide ideas that can be recreated at other institutions of how to address them. Focus on research and strategies to mitigate healthcare disparities and improve diverse research participant pools are necessary to improve patient outcomes in the future.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"94-101"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on occupational allergy, including asthma, to soluble platinum salts. 可溶性铂盐职业过敏症和哮喘的最新进展。
IF 2.8 4区 医学
Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-02-05 DOI: 10.1097/ACI.0000000000000963
Dick Heederik, Frits van Rooy
{"title":"Update on occupational allergy, including asthma, to soluble platinum salts.","authors":"Dick Heederik, Frits van Rooy","doi":"10.1097/ACI.0000000000000963","DOIUrl":"10.1097/ACI.0000000000000963","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to evaluate recent literature on occupational platinum salt exposure and allergy and asthma in the context of existing evidence.</p><p><strong>Recent findings: </strong>A major recent development is that large quantitative platinum salt exposure datasets have become available and are finding applications in epidemiological studies. These exposure data are expected to lead to higher quality epidemiological studies focusing on exposure response relations, modifiers of exposure and sensitization risk. The exposure data might also improve medical referral advice as part of medical surveillance studies and contribute to improved evidence on the effectiveness of exposure referral.</p><p><strong>Summary: </strong>Hopefully, the availability of exposure databases form a stimulus for more exposure response studies and risk assessments leading to science based primary prevention approaches. The availability of more detailed exposure data can guide job transfer decisions in occupational clinical practice.</p>","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"69-72"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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