Current Opinion in Allergy and Clinical Immunology最新文献_第9页

Biological treatments in childhood asthma. 儿童哮喘的生物治疗

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-02 DOI: 10.1097/aci.0000000000000987

Antonio Nieto-García, María Nieto-Cid, Ángel Mazón-Ramos

引用次数: 0

Health disparities in allergic diseases. 过敏性疾病的健康差异。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-01-30 DOI: 10.1097/ACI.0000000000000972

Samantha R Jacobs, Nicole Ramsey, Mariangela Bagnato, Tracy Pitt, Carla M Davis

{"title":"Health disparities in allergic diseases.","authors":"Samantha R Jacobs, Nicole Ramsey, Mariangela Bagnato, Tracy Pitt, Carla M Davis","doi":"10.1097/ACI.0000000000000972","DOIUrl":"10.1097/ACI.0000000000000972","url":null,"abstract":"Purpose of review: Healthcare disparities impact prevalence, diagnosis, and management of allergic disease. The purpose of this review is to highlight the most recent evidence of healthcare disparities in allergic conditions to provide healthcare providers with better understanding of the factors contributing to disparities and to provide potential management approaches to address them. This review comes at a time in medicine where it is well documented that disparities exist, but we seek to answer the Why , How and What to do next?Recent findings: The literature highlights the socioeconomic factors at play including race/ ethnicity, neighborhood, insurance status and income. Management strategies have been implemented with the hopes of mitigating the disparate health outcomes including utilization of school-based health, distribution of educational tools and more inclusive research recruitment.Summary: The studies included describe the associations between upstream structural and social factors with downstream outcomes and provide ideas that can be recreated at other institutions of how to address them. Focus on research and strategies to mitigate healthcare disparities and improve diverse research participant pools are necessary to improve patient outcomes in the future.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"94-101"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on occupational allergy, including asthma, to soluble platinum salts. 可溶性铂盐职业过敏症和哮喘的最新进展。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-02-05 DOI: 10.1097/ACI.0000000000000963

Dick Heederik, Frits van Rooy

引用次数: 0

Association between silicosis and autoimmune disease. 矽肺病与自身免疫性疾病之间的联系。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-01-24 DOI: 10.1097/ACI.0000000000000966

Elizabeth Miriam Fireman, Einat Fireman Klein

{"title":"Association between silicosis and autoimmune disease.","authors":"Elizabeth Miriam Fireman, Einat Fireman Klein","doi":"10.1097/ACI.0000000000000966","DOIUrl":"10.1097/ACI.0000000000000966","url":null,"abstract":"Purpose of review: There is a well established association between silica inhalational exposure and autoimmune disease, particularly in the context of intense exposure. We will provide in this article an update overview of new sources of silica dust exposure, with evidences of mechanisms from human and animal studies for association between silica and autoimmune diseases, their early detection of silicosis and new options for treatment.Recent findings: New industries such as jewelry polishing, denim jean production, fabrication of artificial stone benchtops, glass manufacturing and glassware has led to re-emergence of silicosis around the world. Silicosis with long term exposure to dust containing crystalline silica has been examined as a possible risk factor with respect to several autoimmune diseases as scleroderma, rheumatoid arthritis, lupus erythematosus, and some types of small vessel vasculitis with renal involvement. The dust may act to promote or accelerate disease development, requiring some other factors to break immune tolerance or initiate autoimmunity. Autophagy, apoptosis, or pyroptosis-related signaling pathways have also been suggested to contribute to the formation of those pathways with coordination of environmental co-exposure that can magnify autoimmune vulnerability.Summary: Better understanding the mechanisms that involve silica -induced autoimmune diseases may contribute to early diagnosis.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"45-50"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139564075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What's new in pediatric asthma and rhinitis phenotypes and endotypes? 小儿哮喘和鼻炎表型与内型的新进展是什么？

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-01-30 DOI: 10.1097/ACI.0000000000000970

Giulia Roberto, Salvatore Barberi, Gian Luigi Marseglia, Amelia Licari

{"title":"What's new in pediatric asthma and rhinitis phenotypes and endotypes?","authors":"Giulia Roberto, Salvatore Barberi, Gian Luigi Marseglia, Amelia Licari","doi":"10.1097/ACI.0000000000000970","DOIUrl":"10.1097/ACI.0000000000000970","url":null,"abstract":"Purpose of review: This review explores the evolving landscape of pediatric asthma and rhinitis, focusing on identifying and characterizing different subtypes.Recent findings: Childhood asthma and rhinitis are prevalent respiratory conditions frequently occurring together. To address the need for a precise definition of these diseases, an unbiased and comprehensive phenotyping approach has been undertaken with hypothesis-free analysis of extensive datasets to uncover new relationships among clinical, environmental, and biological characteristics. On the other hand, the concept of endotype is elaborate and multifaceted, representing distinct pathophysiological mechanisms underlying the clinical presentation and requires the identification of reliable biomarkers. The recognition of multiple inflammatory endotypes underscores the need for in-depth characterization, which could revolutionize the treatment landscape.Summary: Comprehending phenotypes and endotypes is crucial for customizing effective and personalized management approaches for children with asthma and rhinitis. More precise and efficient care can be administered through recognition and detailed characterization, ultimately enhancing patients' quality of life.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"73-78"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is allergen immunotherapy a model of personalized treatment in pediatric respiratory allergy? 过敏原免疫疗法是儿科呼吸道过敏症个性化治疗的典范吗？

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-02-12 DOI: 10.1097/ACI.0000000000000968

Gustavo Falbo Wandalsen, Fernando Monteiro Aarestrup, Dirceu Solé

{"title":"Is allergen immunotherapy a model of personalized treatment in pediatric respiratory allergy?","authors":"Gustavo Falbo Wandalsen, Fernando Monteiro Aarestrup, Dirceu Solé","doi":"10.1097/ACI.0000000000000968","DOIUrl":"10.1097/ACI.0000000000000968","url":null,"abstract":"Purpose of review: To review recent evidence on allergen immunotherapy (AIT) as a model of personalized medicine in the treatment of children and adolescents with respiratory allergies.Recent findings: Meta-analysis and systematic review studies continue to point out that AIT is an effective treatment for children with respiratory allergies. Molecular allergy allows the understanding of patient sensitization profiles that frequently change the prescription of AIT. There is still a lack of evidence showing that this personalized prescription of AIT is associated with better clinical outcomes. The nasal allergen challenge has extended the indications of AIT for a new group of subjects with local allergic rhinitis. Patient selection of allergens involved in the increasingly personalized composition of extracts to be used in AIT increasingly characterizes it as personalized medicine.Summary: Despite the numerous studies carried out to identify the best biomarker to evaluate the response to AIT, there is still much disagreement, and clinical assessment (symptoms, quality of life, among others) continues to be the best way to evaluate the therapeutic success of AIT.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"88-93"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of the relationship between allergic bronchopulmonary aspergillosis and asthma. 过敏性支气管肺曲霉菌病与哮喘之间的流行病学关系。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-01-30 DOI: 10.1097/ACI.0000000000000971

Matteo Maule, Joana Vitte, Francesca Ambrosani, Marco Caminati

{"title":"Epidemiology of the relationship between allergic bronchopulmonary aspergillosis and asthma.","authors":"Matteo Maule, Joana Vitte, Francesca Ambrosani, Marco Caminati","doi":"10.1097/ACI.0000000000000971","DOIUrl":"10.1097/ACI.0000000000000971","url":null,"abstract":"Purpose of review: Allergic bronchopulmonary aspergillosis (ABPA) can complicate the natural history of asthmatic patients, especially the more severe ones, worsening disease control and increasing the need for therapies, steroids in particular, and medical care. The aim of the present review is to summarize the latest epidemiological data related to the relationship between asthma and ABPA and to offer a summary of the most recent strategies that could potentially facilitate in the identification of ABPA in asthmatic patients.Recent findings: In the last years, great efforts have been made by researchers worldwide to provide reliable epidemiological data on fungal sensitization and ABPA, especially in severe asthma patients both in adult and pediatric population. Data differ depending on the geographical area and population studied, but pooled data show a concerning 11% of severe asthma patients having ABPA and one out of four asthmatic patients being sensitized to fungi, Aspergillus fumigatus in particular.Summary: Reliable epidemiological data and advances in the diagnostic procedures can facilitate the detection of ABPA among asthmatic patients, improving the management of a still under-recognized and challenging condition.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"102-108"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcome of occupational asthma with different etiology. 不同病因的职业性哮喘的长期疗效。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2023-12-21 DOI: 10.1097/ACI.0000000000000962

Hille Suojalehto, Irmeli Lindström

{"title":"Long-term outcome of occupational asthma with different etiology.","authors":"Hille Suojalehto, Irmeli Lindström","doi":"10.1097/ACI.0000000000000962","DOIUrl":"10.1097/ACI.0000000000000962","url":null,"abstract":"Purpose of review: This review summarizes the recent literature on the long-term outcome of sensitizer-induced and irritant-induced occupational asthma.Recent findings: Recent studies of sensitizer-induced occupational asthma show that after the offending exposure has ceased, most patients report at least partial relief of symptoms. However, in the long term, the diagnosis may negatively impact their careers, incomes, and quality of life. The studies also offer new insights into diisocyanate-induced occupational asthma phenotypes and asthma remission rates. One third of these cases were in remission in long-term after reduction or cessation of exposure. The long-term prognosis of irritant-induced occupational asthma was demonstrated to be poorer than sensitizer-induced occupational asthma. Older age, low fractional exhaled nitric oxide levels and uncontrolled asthma at the time of diagnosis predicted uncontrolled asthma in the long term in patients with irritant and low-molecular-weight sensitizer induced occupational asthma.Summary: Recent studies provide further evidence of the long-term outcome of different occupational asthma phenotypes and the factors that affect them. These findings help us identify patients at risk of poor asthma outcomes, who need close monitoring and support. It should also be borne in mind that occupational asthma diagnosis may have wider-ranging negative impacts on patients' lives.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"64-68"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New causes of occupational allergic contact dermatitis. 职业性过敏性接触性皮炎的新原因。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2023-11-30 DOI: 10.1097/ACI.0000000000000961

Meghan Clynick, Dorothy Linn Holness

{"title":"New causes of occupational allergic contact dermatitis.","authors":"Meghan Clynick, Dorothy Linn Holness","doi":"10.1097/ACI.0000000000000961","DOIUrl":"10.1097/ACI.0000000000000961","url":null,"abstract":"Purpose of review: Occupational allergic contact dermatitis (OACD) is an important work-related skin disease. Information about the causative agents comes from many sources, including patch test databases, registries, case series and case reports. This review summarizes new information about common causative allergens and diagnosis.Recent findings: Common causes of OACD include rubber components, epoxies and preservatives. New exposure sources for these allergens continue to be described. Often these exposure sources are related to the changing world around us, such as allergens related to smartphones and technology, and personal protective equipment-related exposures during the COVID-19 pandemic. New allergens are also being described, some of which are related to known allergens (e.g. a new epoxy or acrylate component).Accurate diagnosis is critical to effective management of OACD, which may include removing the worker from exposure to the causative allergen. Safety data sheets may not contain complete information and patch testing with specialized series of allergens and workplace materials may be necessary.Summary: This review provides current evidence about causes of OACD and important aspects of diagnosis. This is important for clinical practice to ensure cases of OACD are not missed.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"51-57"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endotypes of occupational asthma. 职业性哮喘的内型。

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-04-01 Epub Date: 2024-01-30 DOI: 10.1097/ACI.0000000000000969

Paola Mason, Marco Biasioli, Filippo Liviero

{"title":"Endotypes of occupational asthma.","authors":"Paola Mason, Marco Biasioli, Filippo Liviero","doi":"10.1097/ACI.0000000000000969","DOIUrl":"10.1097/ACI.0000000000000969","url":null,"abstract":"Purpose of review: To describe recent findings in endotyping occupational asthma by addressing the role of specific biomarkers.Recent findings: Studies on occupational asthma endotypes have focused on immune and inflammatory patterns associated with different occupational exposures to sensitizers or irritants.Sputum neutrophilia has been found in 58.5% patients with occupational asthma caused by high molecular weight (HMW) agents, and work-related dysphonia in patients with occupational asthma was described as associated with sputum neutrophilia too. Neutrophils have been associated also with irritant-induced asthma. The measurement of specific IgE has been confirmed as a valuable diagnostic tool in occupational asthma caused by HMW agents, on the contrary, for most low-molecular-weight agents, the presence of specific IgE has been proven in a small subset of affected workers. Fractional exhaled nitric oxide has been confirmed as a marker of type 2 (T2) inflammation in occupational asthma, mostly when induced by HMW agents (e.g. flour), and it has proved to be more sensitive than spirometry in measuring the efficacy of an intervention.MicroRNA-155 has been shown to contribute to airway inflammation in occupational asthma induced by toluene diisocyanate.Summary: Occupational asthma is heterogeneous, thus monitoring multiple biomarkers is crucial to understand, which inflammatory responses are prevalent.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"58-63"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0